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The first all-season sample set for mapping global land cover with Landsat-8 data

Science Bulletin 2017年第7期62卷 508-515页

作者： Congcong Li Peng Gong jie wang Zhiliang Zhu Gregory S. Biging Cui Yuan Tengyun Hu Haiying zhang qi wang xuecao Li Xiaoxuan Liu Yidi xu Jing Guo Caixia Liu Kwame O. Hackman Meinan zhang Yuqi Cheng Le Yu Jun Yang Huabing Huang Nicholas Clinton Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System Science Tsinghua University Beijing 100084 China Department of Environmental Science Policy and Management University of California Berkeley. CA 94720-3J 14 USA Joint Center for Global Change Studies Beijing 100875 China State Key Laboratory of Remote Sensing Science Institute of Remote Sensing and Digital Earth Chinese Academy of Sciences Beijing 100101 China United States Geological Survey Restan VA 20192 USA Ministry of Education Key Laboratory for Geospatial Technology for the Middle and Lower Yellow River Regions College of Environment and Planning Henan University Kaifeng 475004 China Googie Inc. 1600 Amphitheatre Pkwy. Mountain View CA 94042 USA

We report the world's first all-season training and validation sample sets for global land cover classification with Landsat-8 *** to this,such samples were only available at a single date primarily from the growing *** is unknown how much limitation such a single-date sample has to mapping global land cover in other seasons of the *** answer this question,we selected available Landsat-8 images from four seasons and collected training and validation samples from *** compared the performances of training samples in different seasons using Random Forest *** found that the use of training samples from any individual season would result in the best overall classification accuracy when validated by samples in the same *** global overall accuracy from combined best seasonal results was 67.2% when classifying the 11 Level-1 classes in the Finer Resolution Observation and Monitoring of Global Land Cover(FROM-GLC) classification *** use of training samples from all seasons(named all-season training sample set hereafter) produced an overall accuracy of 67.0%.We also tested classification within 10° latitude 60° longitude zones using all-season training subsample within each zone and obtained an overall accuracy of 70.2%.This indicates that properly grouped subsamples in space can help improve classification *** the results in this study seem to suggest that it is possible to use an all-season training sample set to reach global optimality with universal applicability in classifying images acquired at any time of a year for global land cover mapping.

关键词： Training sample Validation Latitudinal zones Anytime Anywhere

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Refractory black carbon aerosols in rainwater in the summer of 2019 in Beijing:Mass concentration,size distribution and wet scavenging ratio

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Journal of Environmental Sciences 2023年第10期132卷 31-42页

作者： Shandong Lei Baozhu Ge Hang Liu Jiannong Quan Danhui xu Yuting zhang Weijie Yao Lu Lei Yu Tian qi Liao Xiaoyong Liu jie Li Jinyuan Xin Yele Sun Pingqing Fu Junji Cao Zifa wang Xiaole Pan State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089China National Center for Climate Change Strategy and International Cooperation Ministry of Ecology and EnvironmentBeijing 100035China Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China Institute of Surface-Earth System Science Tianjin UniversityTianjin 300072China Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100190China

Black carbon(BC)aerosols in the atmosphere play a significant role in climate systems due to their strong ability to absorb solar *** lifetime of BC depends on atmospheric transport,aging and consequently on wet scavenging processes(in-cloud and below-cloud scavenging).In this study,sequential rainwater samples in eight rainfall events collected in 2 mm interval were measured by a tandem system including a single particle soot photometer(SP2)and a *** results showed that the volume-weighted average(VWA)mass concentrations of refractory black carbon(rBC)in each rainfall event varied,ranging from 10.8 to 78.9μg/*** highest rBC concentrations in the rainwater samples typically occurred in the first fraction from individual rainfall *** geometric mean median mass-equivalent diameter(MMD)decreased under precipitation,indicating that rBC with larger sizes was relatively aged and preferentially removed by wet scavenging.A positive correlation(R2=0.73)between the VWA mass concentrations of rBC in rainwater and that in ambient air suggested the important contribution of scavenging ***,the contributions of in-cloud and below-cloud scavenging were distinguished and accounted for 74%and 26%to wet scavenging,*** scavenging ratio of rBC particles was estimated to be 0.06 on *** study provides helpful information for better understanding the mechanism of rBC wet scavenging and reducing the uncertainty of numerical simulations of the climate effects of rBC.

关键词： Refractory black carbon Wet deposition Size distribution

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Gene expression responses in zebrafish to short-term high-hydrostatic pressure

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Zoological Research 2022年第2期43卷 188-191页

作者： Ming-Liang Hu Bao-Sheng Wu Wen-jie xu Cheng-Long Zhu Yuan Yuan Wen-qi Lv qiang qiu Hai-Bin zhang Kun wang Chen-Guang Feng School of Ecology and Environment Northwestern Polytechnical UniversityXi’anShaanxi 710072China Key Laboratory of Aquatic Biodiversity and Conservation of the Chinese Academy of Sciences Institute of HydrobiologyChinese Academy of SciencesWuhanHubei 430072China Institute of Deep-Sea Science and Engineering Chinese Academy of SciencesSanyaHainan 572000China University of Chinese Academy of Sciences Beijing 100049China

Hydrostatic pressure is one of the main factors limiting the vertical range of marine ***,little is known about the level of hydrostatic pressure that shallow-water fish can tolerate or how they respond to this potential ***,we applied high-hydrostatic pressure treatment to wild-type AB line zebrafish(Danio rerio)and analyzed transcriptome data following treatment.

关键词： fish treatment hydrostatic

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OsNLP3 enhances grain weight and reduces grain chalkiness in rice

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Plant Communications 2024年第10期5卷 82-99页

作者： Liang-qi Sun Yu Bai jie Wu Shi-Jun Fan Si-Yan Chen Zheng-Yi zhang Jin-qiu Xia Shi-Mei wang Yu-Ping wang Peng qin Shi-Gui Li Ping xu Zhong Zhao Cheng-Bin Xiang Zi-Sheng zhang Division of Life Sciences and Medicine Division of Molecular&Cell BiophysicsHefei National Science Center for Interdisciplinary Sciences at the MicroscaleUniversity of Science and Technology of ChinaThe Innovation Academy of Seed DesignChinese Academy of SciencesHefeiAnhui Province 230027China Experimental Center of Engineering and Materials Science University of Science and Technology of ChinaHefei 230027China Rice Research Institute Anhui Academy of Agricultural ScienceHefeiChina State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Rice Research InstituteSichuan Agricultural UniversityChengduSichuanChina Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai Chenshan Plant Science Research CenterChinese Academy of SciencesShanghaiChina

Grain weight,a key determinant of yield in rice(Oryza sativa L.),is governed primarily by genetic factors,whereas grain chalkiness,a detriment to grain quality,is intertwined with environmental factors such as mineral ***(N)is recognized for its effect on grain chalkiness,but the underlying molecular mechanisms remain to be *** study revealed the pivotal role of rice NODULE INCEPTION-LIKE PROTEIN 3(OsNLP3)in simultaneously regulating grain weight and grain *** investigation showed that loss of OsNLP3 leads to a reduction in both grain weight and dimension,in contrast to the enhancement observed with OsNLP3 ***3 directly suppresses the expression of OsCEP6.1 and OsNF-YA8,which were identified as negative regulators associated with grain ***,two novel regulatory modules,OsNLP3-OsCEP6.1 and OsNLP3-OsNF-YA8,were identified as key players in grain weight ***,the OsNLP3-OsNF-YA8 module not only increases grain weight but also mitigates grain chalkiness in response to *** research clarifies the molecular mechanisms that orchestrate grain weight through the OsNLP3-OsCEP6.1 and OsNLP3-OsNF-YA8 modules,highlighting the pivotal role of the OsNLP3-OsNF-YA8 module in alleviating grain *** findings reveal potential targets for simultaneous enhancement of rice yield and quality.

关键词： OsNLP3 OsCEP6.1 OsNF-YA8 grain weight grain chalkiness rice Oryza sativa L.

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A phase II clinical trial of toripalimab in advanced solid tumors with polymerase epsilon/polymerase delta(POLE/POLD1)mutation

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Signal Transduction and Targeted Therapy 2024年第10期9卷 4543-4553页

作者： Ying Jin Run-jie Huang Wen-Long Guan Zhi-qiang wang Zong-Jiong Mai Yu-Hong Li Jian Xiao Xing zhang qi Zhao Shi-Fu Chen Ming Liu Yan-Xia Shi Feng wang Rui-Hua xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen UniversityGuangzhou510060People’s Republic of China Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical SciencesGuangzhou510060People’s Republic of China Department of Oncology The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai519000People’s Republic of China Department of Medical Oncology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou510100People’s Republic of China Department of Medical Melanoma and Sarcoma Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen UniversityGuangzhou510060People’s Republic of China Bioinformatic Platform Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen UniversityGuangzhou510060People’s Republic of China HaploX Biotechnology Shenzhen518000People’s Republic of China

Patients carrying mutations in polymerase epsilon/polymerase delta have shown positive responses to immune checkpoint ***,prospective trials exploring the efficacy in those with polymerase epsilon/polymerase delta mutations are still lacking.A phase II clinical trial was initiated to evaluate the efficacy of toripalimab,a humanized IgG4K monoclonal antibody to human PD-1,in patients with advanced solid tumors with unselected polymerase epsilon/polymerase delta mutations but without microsatellite instability-high.A total of 15 patients were enrolled,14 of whom were assessed for treatment *** was a 21.4%overall response rate,with a disease control rate of 57.1%.The median overall survival and median progression-free survival were 17.9(95%CI 13.5-not reach)months and 2.5(95%CI 1.4-not reach)months,*** patients with exonuclease domain mutations,the objective response rate was 66.7%(2/3),with a disease control rate of 66.7%(2/3).For those with non-exonuclease domain mutations,the rates were 9.1%(1/11)and 54.5%(6/11),***,patients with PBRM1 gene mutations exhibited a high response rate to toripalimab at 75.0%(3/4).This study showed that neither the exonuclease domain mutations nor non-exonuclease domain mutations could fully predict the efficacy of immunotherapy,urging the need for more investigations to clarify potential immune sensitization differences within polymerase epsilon/polymerase delta mutation variants.

关键词： delta phase neither

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HiFAST:An HIdata calibration and imaging pipeline for FAST

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 182-199页

作者： Yingjie Jing jie wang Chen xu Ziming Liu qingze Chen Tiantian Liang Jinlong xu Yixian Cao Jing wang Huijie Hu Chuan-Peng zhang qi Guo Liang Gao Mei Ai Hengqian Gan xuyang Gao Jinlin Han Ligang Hou Zhipeng Hou Peng Jiang xu Kong Fujia Li Zerui Liu Li Shao Hengxing Pan Jun Pan Lei qian Jinghai Sun Ningyu Tang qingliang Yang Bo zhang Zhiyu zhang Ming Zhu National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 02206China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 55000China Max Planck Institute for Extraterrestrial Physics Garching 85748Germany Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Institute of Computational Cosmology Department of PhysicsUniversity of DurhamDurham DHI 3LEUK CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Deep Space Exploration Laboratory/Department of Astronomy University of Science and Technology of ChinaHefei 230026China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Astrophysics Department of PhysicsUniversity of OxfordOxford OX/3RHUK College of Earth Sciences Guilin University of TechnologyGuilin 541004China Department of Physics Anhui Normal UniversityWuhu 241002China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory of Modern Astronomy and Astrophysics Nanjing UniversityNanjing 20023China

The Five-hundred-meter Aperture Spherical radio Telescope(FAST)has the largest aperture and a 19-beam L-band receiver,making it powerful for investigating the neutral hydrogen atomic gas(HI)in the *** present HiFAST(https://***),a dedicated,modular,and self-contained calibration and imaging pipeline for processing the H?data of *** pipeline consists of frequency-dependent noise diode calibration,baseline fitting,standing wave removal using an FFT-based method,flux density calibration,stray radiation correction,and gridding to produce data *** modules can be combined as needed to process the data from most FAST observation modes:tracking,drift scanning,On-The-Fly mapping,and most of their *** HiFAST,the root-mean-square(RMS)noises of the calibrated spectra from all 19 beams were only slightly(~5%)higher than the theoretical *** results for the extended source M33 and the point sources are consistent with the results from *** moment maps(0,1 and 2)of M33 agree well with the results from the Arecibo Galaxy Environment Survey(AGES)with a fractional difference of less than 10%.For a common sample of 221 sources with signal-to-noise ratio S/N>10 from the Arecibo Legacy Fast ALFA(ALFALFA)survey,the mean value of fractional difference in the integrated flux density,Sint,between the two datasets is approximately 0.005%,with a dispersion of 15.4%.Further checks on the integrated flux density of 23 sources with seven observations indicate that the variance in the flux density of the source with luminous objects(Sint>2.5 Jy km s-1)is less than 5%.Our tests suggest that the FAST telescope,with the efficient,precise,and user-friendly pipeline HiFAST,will yield numerous significant scientific findings in the investigation of the H?in the universe.

关键词： fractional luminous correction

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Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 expression and its relationship with T cell activation in human immunodeficiency virus/acquired immune deficiency syndrome patients with lung-spleen qi deficiency syndrome pattern

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Journal of Traditional Chinese Medicine 2022年第3期42卷 451-457页

作者： LIU Zhen zhang qingyan DENG Bowen SANG Feng wang Danni KANG Ning LI jie zhang Min LIANG Shoupei DUAN Chenchen LIU Zhibin xu qianlei LI qiang Henan Key Laboratory of Viral Diseases Prevention and Treatment of Traditional Chinese Medicine the First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou 450000China Department of Acquired Immune Deficiency Syndrome Treatment and Research Center The First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou 450000China Department of Obstetrics and Gynecology the First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou 450000China Medical Department Medical Department of Zhengzhou People’s HospitalZhengzhou 450000China

OBJECTIVE:To investigate the relationship between antiviral restriction factor Sterile Alpha Motif and Histidine-Aspartic acid domain-containing protein 1(SAMHD1)expression and T cell activation,furthermore,identifying objective indexes of lung-spleen qi deficiency symptom ***:We assessed the profile of T lymphocyte subsets,characteristics of SAMHD1 and human leukocyte antigen DR(HLA-DR)expression in lungspleen qi deficiency *** the same time,people living with human immunodeficiency virus/acquired immune deficiency syndrome(HIV/AIDS)(PLWHA)without obvious clinical symptoms and healthy donors in this area were used as ***:Immunohematologic indexes lower CD4 count,lower CD4/CD8 ratio and higher SAMHD1 level were found in lung-spleen qi deficiency ***,we demonstrated a positive relationship between SAMHD1 and HLA-DR level as well as with interferon factor in lung-spleen qi deficiency syndrome and patients without obvious clinical signs and symptoms ***:These data indicated the positive relationship between SAMHD1 and T cell activation which further elucidated the role of SAMHD1 in cellular immune ***,combination of T lymphocyte subsets counts and SAMHD1 level may be used as clinical and biological reference basis for the differentiation and diagnosis of HIV/AIDS traditional Chinese medicine syndromes.

关键词： HIV acquired immunodeficiency syndrome symptoms complex SAM domain and HD domain-containing protein 1 T-lymphocytes

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Prognostic analysis of patients with combined hepatocellularcholangiocarcinoma after radical resection:A retrospective multicenter cohort study

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World Journal of Gastroenterology 2022年第41期28卷 5968-5981页

作者： Ge zhang Bo-Wen Chen Xiao-Bo Yang Huai-Yuan wang xu Yang Fu-Cun Xie Xiang-qi Chen Ling-Xiang Yu jie Shi Yin-Ying Lu Hai-Tao Zhao Department of Liver Surgery State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College 302 Clinical Medical School Peking University Senior Department of Hepatology The 5^(th) Medical Center of the PLA General Hospital Guangdong Key Laboratory of Epigenetics College of Life Sciences and Oceanography Shenzhen University Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

BACKGROUND Combined hepatocellular-cholangiocarcinoma(cHCC-CCA)is a form of rare primary liver cancer that combines intrahepatic cholangiocarcinoma(ICC)and hepatocellular *** To investigate overall survival(OS)and recurrence-free survival(RFS)after radical resection in patients with cHCC-CCA,and the clinicopathological factors affecting prognosis in two center hospitals of *** We reviewed consecutive patients with cHCC-CCA who received radical resection between January 2005 and September 2021 at Peking Union Medical College and the 5th Medical Center of the PLA General Hospital *** follow-up and clinicopathological characteristics were systematic collected for baseline and prognostic *** Our study included 95 patients who received radical *** majority of these patients were male and 82.7%of these patients were infected with *** mean tumor size was 4.5 cm,and approximately 40%of patients had more than one *** median OS was 26.8(95%CI:18.5-43.0)mo,and the median RFS was 7.27(95%CI:5.83-10.3)*** predictors of OS were CA19-9≥37 U/mL(HR=8.68,P=0.002),Child-Pugh score>5(HR=5.52,P=0.027),tumor number>1(HR=30.85,P=0.002),tumor size and transarterial chemoembolization(TACE)after surgery(HR=0.2,P=0.005).CONCLUSION The overall postoperative survival of cHCC-CCA patients is poor,and most patients experience relapse within a short period of time after *** tumor biomarker(CA19-9,alphafetoprotein)levels,tumor size,and Child-Pugh score can significantly affect *** TACE after surgery prolongs RFS,suggesting that TACE is a possible option for postoperative adjuvant therapy in patients with cHCC-CCA.

关键词： Combined hepatocellular-cholangiocarcinoma Radical resection Clinicopathological factor Integrated nomogram Multicenter cohort

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Orthopedic treatment of the lower limbs in spastic paralysis

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Brain Science Advances 2020年第1期6卷 2-19页

作者： Xiaohong Mu Bowen Deng jie Zeng Houjun zhang Yi Zhao qi Sun jie xu Le wang Lin xu Department of Orthopedics Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China

Spastic paralysis of the limb mainly results from the central lesion,in which spastic cerebral palsy is the common *** to durative muscle spasm in spastic cerebral palsy,it is often accompanied by the formation of secondary musculoskeletal deformities,resulting in limb motor *** on its pathogenesis,surgical treatment is currently applied:selective posterior rhizotomy(SPR)or orthopedic *** primary purpose of early orthopedic surgery was simply to correct limb deformities,which usually led to the recurrence of deformity as a result of the presence of *** the application of SPR,high muscle tone was successfully relieved,but limb deformity was still present ***,this study aimed to elaborate on the management of orthopedic surgery,common deformities of the lower limb,and orthopedic operative methods;discuss the relationship between SPR and orthopedic procedure for limb deformity;and focus on the indications,timing of intervention,and postoperative outcome of different surgical methods.

关键词： musculoskeletal deformity orthopedic surgery spastic cerebral palsy spastic paralysis selective posterior rhizotomy

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Infrared cooling properties of cordierite

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Chinese Physics B 2019年第6期28卷 239-244页

作者： Si-Heng Chen Xiao-Xiong wang Guang-Di Nie qi Liu Jin-Xia Sui Chao Song Jian-Wei Zhu jie Fu Cheng zhang xu Yan Yun-Ze Long College of Physics Qingdao UniversityQingdao 266071China College of Textiles and Clothing Qingdao UniversityQingdao 266071China

Cordierite(Mg2 Al4 Si5 O18) is known for its good thermal shock resistance and it is widely used to improve thermal shock properties of materials. We found that cordierite has good infrared heat dissipation performance. This performance provides an additional means of heat dissipation to assist in the cooling of the metal surface. Spectroscopic tests show that cordierite reflects sunlight in the visible range and emits infrared in the far infrared range, making it potential candidate as an infrared radiative cooling material for daytime use.

关键词： daytime radiative cooling cordierite infrared emitting

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