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Journal of Molecular Cell Biology 2020年第9期12卷 669-673页

作者： Xiaobin Yu jianming xu Department of Molecular and Cellular Biology Dan L.Duncan Comprehensive Cancer CenterBaylor College of MedicineHoustonTX 77030USA

Cancer initiation and progression are usually triggered by protooncogene activation and/or tumor suppressor gene inactivation and promoted by further genomic and epigenetic alterations that reprogram cell gene expression,metabolism,proliferation,differentiation,and *** or mutation-activated tyrosine kinase receptors and their signaling components,such as HER2,EGFR,Src,RAS,PI3K,and AKT,steroid hormone receptors,such as estrogen receptor and androgen receptor,and other cell growth and cell cycle regulators induce carcinogenesis or promote cancer cell growth,survival,and ***,many therapeutic drugs have been developed and used to target these molecules for treating different cancers(Supplementary Table S1).Although these drugs have significantly improved cancer treatments,most oncogenic factors are also expressed in normal cells and required for normal physiological ***,the drugs of anti-oncogenic factors also result in severe adverse effects on cancer *** ideal anti-cancer drug should specifically kill cancer cells without affecting normal cellular function,which requires identifying targets essential for cancer cells but non-essential for normal ***,these cancer-selective targets required for cancer cell survival may or may not be the classic oncogenes that have attracted extensive attention for drug development.

关键词： drugs metabolism alterations

Phosphorus utilization and microbial community in response to lead/iron addition to a waterlogged soil

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Journal of Environmental Sciences 2009年第10期21卷 1415-1423页

作者： ZHONG Shunqing WU Yuping xu jianming Institute of Soil and Water Resources and Environmental Science Zhejiang University Hangzhou 310029 China. Department of Resource Environment and Tourism Management Hengyang Normal University Hengyang 421008 China Zhejiang Provincial Key Laboratory of Subtropic Soil and Plant Nutrition Hangzhou 310029 China

Constructed wetlands have emerged as a viable option for helping to solve a wide range of water quality problems. However, heavy metals adsorbed by substrates would decrease the growth of plants, impair the functions of wetlands and eventually result in a failure of contaminant removal. Typha latifolia L., tolerant to heavy metals, has been widely used for phytoremediation of Pb/Zn mine tailings under waterlogged conditions. This study examined effects of iron as ferrous sulfate （100 and 500 mg/kg） and lead as lead nitrate （0, 100, 500 and 1000 mg/kg） on phosphorus utilization and microbial community structure in a constructed wetland. Wetland plants （T. latifolia） were grown for 8 weeks in rhizobags filled with a paddy soil under waterlogged conditions. The results showed that both the amount of iron plaque on the roots and phosphorus adsorbed on the plaque decreased with the amount of lead addition. When the ratio of added iron to lead was 1：1, phosphorus utilized by plants was the maximum. Total amount of phospholipids fatty acids （PLFAs） was 23%-59% higher in the rhizosphere soil than in bulk soil. The relative abundance of Gram-negative bacteria, aerobic bacteria, and methane oxidizing bacteria was also higher in the rhizosphere soil than in bulk soil, but opposite was observed for other bacteria and fungi. Based on cluster analysis, microbial communities were mostly controlled by the addition of ferrous sulfate and lead nitrate in rhizosphere and bulk soil, respectively.

关键词： phosphorus lead PLFA iron plaque microbial community waterlogged soil

Robust Finite-Time Trajectory Tracking Control of Wheeled Mobile Robots with Parametric Uncertainties and Disturbances

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Journal of Systems Science & Complexity 2019年第5期32卷 1358-1374页

作者： GUO Yijun YU Li xu jianming College of Information Engineering Zhejiang University of Technology

In this paper, a robust finite-time tracking control scheme is proposed for wheeled mobile robots with parametric uncertainties and disturbances. To eliminate the effect of lumped uncertainties,a nonlinear extended state observer(NESO) is employed to estimate the unknown states as well as uncertainties, and the corresponding coefficients are tuned via pole placement technique. Based on the observation values, the finite-time sliding mode controller is presented to guarantee that both the sliding mode variables and tracking errors converge to zero within finite time. Simulation results are given to demonstrate the effectiveness of the proposed control method.

关键词： Finite-time sliding mode control nonlinear extended state observer trajectory tracking wheeled mobile robot

Current progress in cancer treatment by targeting FGFR signaling

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Cancer Biology & Medicine 2023年第7期20卷 490-499页

作者： Sicheng Du Ying Zhang jianming xu Department of Graduate Administration Chinese People’s Liberation Army(PLA)General HospitalBeijing 100853China Department of Oncology The Fifth Medical Center of the PLA General HospitalBeijing 100071China

Fibroblast growth factor receptors(FGFRs),a family of transmembrane receptors with intracellular tyrosine kinase domains,and fibroblast growth factors(FGFs)form the FGF/FGFR signaling pathways,which participate in cel... 详细信息

关键词： carcinogenesis treatment cancer

Adsorption characteristic of bensulfuron-methyl at variable added Pb^(2+) concentrations on paddy soils

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Journal of Environmental Sciences 2009年第8期21卷 1129-1134页

作者： WU Weihong WANG Haizhen xu jianming XIE Zhengmiao Department of Environmental Science and Engineering Hangzhou Dianzi University Hangzhou 310018 Chin College of Environmental and Natural Resource Sciences Zhejiang University Hangzhou 310029 China Zhejiang Provincial Key Laboratory of Subtropic Soil Science and Plant Nutrition Hangzhou 310029 China

The combined pollution of heavy metal Pb^2＋ and bensulfuron-methyl （BSM）, originating from chemical herbicides, in agroecological environments has become commonplace in southern China. The adsorption of BSM on three paddy soils in the presence of Pb^2＋ was examined using high-performance liquid chromatograph （HPLC）. Results indicated that adsorption of BSM could accurately be described by a Freundlich isotherm equation with correlation constant （R）〉 0.98, irrespective of the presence of spiked Pb^2＋. Of the various factors influencing BSM sorption, soil pH appeared to be the most influential. The constant Kf of Freundlich isotherm equation tended to increase with increasing Pb^2＋ concentration in soil which indicated that the spiked of Pb^2＋ in paddy soils would promote the sorption of BSM. AGo of BSM in three paddy soils was less than 40 kJ/mol in all treatments, indicating the adsorption of BSM is mainly physical in nature. The elution of soil dissolved organic matter （DOM） enhanced the adsorption of BSM in paddy soils. The mechanisms involved in the promotion effects of the spiked Pb^2＋ on BSM adsorption might be the modified surface characteristics of paddy soil solids due to the soil acidification and the increase of soil organic matter concentration because of DOM binding.

关键词： bensulfuron-methyl adsorption paddy soils Pb pollution

High-quality quasi-monochromatic near-field radiative heat transfer designed by adaptive hybrid Bayesian optimization

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Science China(Technological Sciences) 2022年第12期65卷 2910-2920页

作者： ZHANG WenBin WANG BoXiang xu jianming ZHAO ChangYing Institute of Engineering Thermophysics MOE Key Laboratory for Power Machinery and EngineeringSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Space Power-Sources Technology Shanghai Institute of Space Power-SourcesShanghai 200245China

The increasing demand for versatile and high-quality near-field radiative heat transfer(NFRHT) has created a critical need for a design approach that can handle numerous candidate structures. In this work, we employ and develop an adaptive hybrid Bayesian optimization(AHBO) algorithm to design the high-quality quasi-monochromatic NFRHT. The candidate materials include hexagonal boron nitride, silicon carbide, and doped silicon. The high-quality quasi-monochromatic NFRHT is optimized over 1.0 × 10^(8) candidate structures to maximize the evaluation factor. It is worth noting that only 2.6% of the candidate structures needed to be calculated to identify the optimal structure. The optimal structure of quasi-monochromatic NFRHT is an aperiodic multilayer metamaterial that differs from conventional periodic multilayer structures. Moreover, we investigate the robustness and mechanisms of the optimal quasi-monochromatic NFRHT with respect to the vacuum gap distance and the temperature difference between the emitter and receiver. In addition, the high-quality multi-peak NFRHT is designed using the AHBO algorithm by improving the definition of the evaluation factor. The results demonstrate that the AHBO algorithm is efficient in designing high-quality quasi-monochromatic and multi-peak NFRHT, and it can be further expanded to other structural designs in the field of energy conversion.

关键词： near-field radiative heat transfer adaptive hybrid Bayesian optimization quasi-monochromaticity evaluation factor inverse design

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Influence of Rare Earth(Ce and La) Addition on the Performance of Al-3.0 wt%Mg Alloy

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Journal of Wuhan University of Technology(Materials Science) 2017年第3期32卷 611-618页

作者：张欣王泽华 ZHOU Zehua xu jianming College of Mechanics and Materials Hohai University Nanjing 210098 China Zhangjiagang Hongji Aluminum Co. Ltd. Suzhou 215600 China

The influences of rare earth elements（cerium and lanthanum） on the microstructure and phases of Al-3.0 wt%Mg alloys used for electromagnetic shielding wire were characterized by scanning electron microscopy（SEM）, energy-dispersive spectroscopy（EDS）, X-ray diffraction（XRD） and differential scanning calorimetry（DSC）. The mechanical properties and electrical resistivity were also investigated. The results indicated that a certain content of rare earth could improve the purification of the aluminum molten, enhance the strength, and reduce the electrical resistivity of Al-3.0 wt%Mg alloys. The strength reached the top value when RE content was 0.3 wt% while the alloy with 0.2 wt% RE addition had the smallest electrical resistivity. The elongation varied little when RE addition was no more than 0.2 wt%. But the excessive addition of rare earth would be harmful to the microstructure and properties of Al-3.0 wt%Mg alloys.

关键词： Al-3.0 wt%Mg alloy Ce and La additions microstructure mechanical property electrical resistivity

Impact of meteorological conditions on a nine-day particulate matter pollution event observed in December 2013,Shanghai,China

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Particuology 2015年第3期13卷 69-79页

作者： jianming xu Fengxia Yan Ying Xie Fengyun Wang Jianbin Wu Qingyan Fu Shanghai Meteorological Bureau Meteorological Center of Traffic Management Bureau of East China Shanghai Environmental Monitoring Center

A severe particulate matter pollution event occurred in Shanghai from 1 to 9 December 2013. The mean hourly mass concentrations of PM2.5 and PM10 were 211.9 and 249.0 μg/m3, respectively. Reanalysis data, in situ, and remote-sensing measurements were used to examine the impacts of meteorological conditions on this event. It was found that the synoptic pattern of weak pressure, the reduced planetary boundary layer height, and the passage of two cold fronts were key factors causing the event. Four stages were identified during this event based on the evolution of its PM2.5 levels and weather conditions. The highest concentration of PM2.5 （602 μg/m3） was observed in stage 3. High PM2.5 concentrations were closely associated with a low local ventilation index, with an average of 505 m2/s, as well as with the influx of pollutants from upstream, transported by the cold fronts.

关键词： Particulate matterPM2.5Pollution eventPlanetary boundary layerCold frontUrban air pollution

A systematic understanding of microbial reductive dechlorination towards an improved“one health”soil bioremediation:A review and perspective

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Science China(Technological Sciences) 2024年第10期67卷 3009-3031页

作者： HE Yan LI ShuYao YUAN Jing CHENG Jie DOU JiBo YANG xueLing xu jianming Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment Institute of Soil and Water Resources and Environmental ScienceCollege of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Environment Remediation and Ecological Health Ministry of EducationHangzhou 310058China Microbiome Network and Department of Agricultural Biology Colorado State UniversityFort Collins CO 80523USA Departments of Chemistry and Chemical&Biomolecular Engineering Institute for Functional Intelligent Materials(I-FIM)National University of SingaporeSingapore 119077Singapore

Chlorinated organic pollutants(COPs),both emerging and traditional,are typical persistent pollutants that harm soil health *** mediated reductive dechlorination is the optimal way to completely remove COPs from anaerobic soil through a redox reaction driven by electron transfer during microbial anaerobic ***,the dechlorinated depletion of COPs in situ often interacts with multiple element biogeochemical activities,e.g.,methanogenesis,sulfate reduction,iron reduction,and *** the relevance of biogeochemical cycles between COPs and multiple elements and the coupled mechanisms involved,thus,helps to develop effective pollution control strategies with the balance between pollution degradation and element cycles in heterogeneous soil,ultimately contributing to“one health”*** this review,we summarized the microbial-chemical coupling redox processes and the driving factors,elucidated the interspecies metabolites exchange and electron transfer mechanisms within COP-dechlorinating communities,and further proposed a detailed design,construction,and analysis framework of engineering COP-dechlorinating microbiomes via“top-down”selfassembly and“bottom-up”synthesis to pave the way from laboratory to practical field ***,we delve into the major challenges and perspectives surrounding the design of state-of-the-art synthetic microbial *** goal is to improve the understanding of the microbial-mediated coupling between reductive dechlorination and element biogeochemical cycling,with a particular focus on the implications for health-integrated soil bioremediation under the“one health”concept.

关键词： reductive dechlorination biogeochemical redox processes interspecies interaction synthetic microbiomes anaerobic soils

A Modified Tikhonov Regularization Method for a Cauchy Problem of the Biharmonic Equation

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Journal of Mathematical Research with Applications 2024年第3期44卷 359-386页

作者： Fan YANG jianming xu Xiaoxiao LI School of Science Lanzhou University of Technology

In this paper, the Cauchy problem of biharmonic equation is considered. This problem is ill-posed, i.e., the solution(if exists) does not depend on the measurable data. Firstly, we give the conditional stability result under the a priori bound assumption for the exact ***, a modified Tikhonov regularization method is used to solve this ill-posed *** the a priori and the a posteriori regularization parameter choice rule, the error estimates between the regularization solutions and the exact solution are obtained. Finally, some numerical examples are presented to verify that our method is effective.

关键词： Biharmonic equations inverse problem Cauchy problem Tikhonov regularization method