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Modified intratympanic steroid therapy for sudden sensorineural hearing loss via tympanic tube and gelfoam as a salvage treatment

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Journal of Otology 2024年第1期19卷 19-23页

作者： Sichao Liang Yunshuo Li Zhenping Guo Manlin Lu Xin Li Jia xu Wenjing Chen Juanjuan Gao haijin Yi Department of Otolaryngology Head and Neck SurgeryBeijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing102218China

Background: Sudden sensorineural hearing loss(SSNHL) is a prevalent emergency in ear, nose, and throat practice. Previous studies have demonstrated that intratympanic steroid therapy(IST) can serve as a salvage treatment for SSNHL after the failure of systemic steroid therapy(SST).Objective: This study aimed to analyze the efficacy of modified IST involving the insertion of a tympanic tube and gelfoam as a salvage treatment for patients with SSNHL, and to explore its associated factors.Methods: Totally, 74 patients who were aged 22–81 years with SSNHL were enrolled and allocated to either the control group(n = 25) or the treatment group(n = 49) based on their treatment modalities. All patients received SST lasting for at least 7 days. Subsequently, patients in the treatment group, after SST failure, underwent IST twice a week for 2–6 weeks, while the control group did not. Efficacy was assessed by the improvement in pure tone average at the affected frequency at the beginning and end of IST.Results: Hearing improvement in all patients after IST in the treatment group was 9.71 ± 14.84 dB, with significant improvement at affected frequencies(250-8000 Hz) compared with the control group(P 0.05).Conclusion: The modified IST was demonstrated to be a safe and effective method as a salvage treatment for SSNHL. This study explored the efficacy of a modified IST approach, incorporating the utilization of tympanic tubes and gelfoam as key components. The findings underscore the advantages of gelfoam as a strategic drug carrier placed in the round window niche. By minimizing drug loss, extending action time, and increasing perilymph concentration, gelfoam enhances the therapeutic impact of IST, contributing to improved hearing outcomes in patients with SSNHL.

关键词： Modified intratympanic steroid therapy Sudden sensorineural hearing loss Gelfoam Tympanic tube

A label-free lateral offset spliced coreless fiber MZI biosensor based on hydrophobin HGFI for TNF-α detection

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Optoelectronics Letters 2022年第5期18卷 263-268页

作者： WANG Bo DUAN Shaoxiang ZHANG Hao xu haijin LIU Bo QIAO Mingqiang The Key Laboratory of Molecular Microbiology and Technology Ministry of EducationNankai UniversityTianjin 300071China Institute of Modern Optics Tianjin Key Laboratory of Optoelectronic Sensor and Sensing Network TechnologyNankai UniversityTianjin 300350China School of Life Science Shanxi UniversityTaiyuan 030006China1

A real-time label-free lateral offset spliced coreless fiber(CF)Mach-Zehnder interferometer(MZI)biosensor functionalized with hydrophobin Grifola frondosa I(HGFI)was proposed for the detection of cytokine tumour necrosis factor alpha(TNF-α).The nanolayer self-assembled on the optical fiber surfaces by HGFI rendered the immobilization of probe TNF-αantibody and recognition of antigen TNF-α.Trifluoroacetic acid was utilized to remove the HGFI layer from the glass surface,which was validated by field emission scanning electron microscopy(FESEM)and water contact angle(WCA).Results demonstrated that the processes of HGFI modification,antibody immobilization and specific antibody detection can be monitored in real time.The proposed biosensor exhibited good specificity,repeatability and low detection limit for TNF-α,extending its application in inflammation and disease monitoring.

关键词： fiber interferometer offset

黄河和长江碎屑物质扩散研究——来自江苏沙脊物源示踪的约束

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地球学报 2024年第2期45卷 165-174页

作者：林旭刘海金吴中海三峡大学土木与建筑学院湖北宜昌443002 三峡库区地质灾害教育部重点实验室(三峡大学) 湖北宜昌443002 哈尔滨师范大学地理科学学院黑龙江哈尔滨150080 中国地质科学院地质力学研究所北京100081

研究源-汇系统对于理解岩石风化、河流输砂、泥砂沉积以及陆地和海洋沉积过程具有重要意义。我国江苏省东海岸具有丰富的沉积物供应,在某些沿海地段形成了一系列沙脊,是进行沉积物源-汇过程研究的理想沉积记录之一。但目前对其物源区来... 详细信息

研究源-汇系统对于理解岩石风化、河流输砂、泥砂沉积以及陆地和海洋沉积过程具有重要意义。我国江苏省东海岸具有丰富的沉积物供应,在某些沿海地段形成了一系列沙脊,是进行沉积物源-汇过程研究的理想沉积记录之一。但目前对其物源区来自哪里还未达成共识。我们利用已发表的碎屑锆石U-Pb年龄和钾长石Pb同位素数据,结合江苏沙脊及其周缘区域的数据结果,详细厘定江苏沙脊的物源区,并运用蒙特卡罗反演模型定量评估江苏沙脊潜在物源区对其物质贡献率。结果表明江苏沙脊北部的碎屑物质主要受大别山(45%)和鲁中山区(24%)的共同影响;黄河(29%)、古黄河(27%)和长江(25%)的碎屑物质对江苏沙脊中部的物质组成起重要影响。江苏沙脊南部的物源主要来自长江(68%)。江苏沙脊的出现得益于黄河和长江这样的大陆尺度的大河搬运了丰富的碎屑物质到下游,南黄海西海岸的平坦地貌有利于保存这些碎屑物质,末次冰期后东亚陆架海动力过程(潮汐、海浪和沿岸流等)持续对其改造,这体现了河流-海洋在塑造河口-海岸地貌中的交互作用。

关键词：江苏沙脊黄河长江锆石U-Pb年龄钾长石Pb同位素

Partial melting and crust-mantle interaction in subduction channels:Constraints from experimental petrology

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Science China Earth Sciences 2015年第9期58卷 1700-1712页

作者： ZHANG JunFeng WANG ChunGuang xu haijin WANG Chao xu WenLiang State Key Laboratory of Geological Processes and Mineral Resources School of Earth SciencesChina University of Geosciences Global Tectonic Center School of Earth Sciences China University of Geosciences School of Earth Sciences Jilin University

It is proposed in the subduction channel model that the plate interface interaction is a basic mechanism for the mass and energy exchange between Earth’s surface and interior.The significant difference in composition and nature between continental lithosphere and oceanic lithosphere inevitably leads to variations in deep physical and chemical processes as well as crust-mantle interaction products in these two settings.Many studies of experimental petrology have provided constraints on the potential partial melting and crust-mantle interaction in oceanic subduction channels for silicate and carbonate rocks.The partial melts of mafic and felsic compositions are adakitic or non-adakitic granitic melts depending on melting pressure or depth.A trivial amount of CO2 can lower significantly the melting temperature of peridotites and lead to pronounced enrichment of incompatible elements in carbonate melt.The silica saturated or unsaturated melts can react with mantle-wedge peridotites in subduction channels to generate complex products.However,the existing experiments are mostly dedicated to island arc settings above oceanic subduction zones rather than dehydration melting above continental subduction zones.It is crucial to conduct high pressure and high temperature experiments to investigate all possible reactions between peridotites and crustal materials and their derivatives under the conditions responsible for the slab-mantle interface in continental subduction channels.Experimental results,combined with natural observations,are possible to elucidate the processes of metamorphic dehydration,partial melting and mantle metasomatism in continental subduction channels.

关键词：实验岩石学壳幔相互作用部分熔融通道模型俯冲带大洋岩石圈大陆岩石圈花岗质熔体

Mantle Partial Melting and Melt-peridotite Interaction: A Case Study of Peridotite Xenoliths in Cenozoic Basalt of Nanjing, SE China

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Acta Geologica Sinica(English Edition) 2020年第S1期94卷 67-68页

作者： xu haijin SONG Yanru XIONG Zhiwu School of Earth Sciences China University of GeosciencesWuhan 430074

The peridotite xenoliths are widely distributed in the Cenozoic basalts, Eastern China. However, their petrogenesis is hotly controversial. The peridotite xenoliths of Nanjing are found embedded in Cenozoic alkali basalt. Most of the xenoliths are rounded and small to moderate in size(typically 5~10 cm in diameter), though larger ones have been found. Nearly all small xenoliths are harzburgite and dunite. However, the big ones have zoned structure: lherzolite core and harzburgite or dunite rim with new growth clinopyroxene(Cpx) as eyeliner along their margins. Petrology, mineralogy, and Major and trace element compositions of the Nanjing peridotite xenoliths in the Cenozoic basalts are measured to provide an insight into the nature of their mantle sources and processes. Our works suggest that they were suffered from a partial melting process and subsequently underwent a process of melt-peridotite interaction. The evidences of partial melting are as follows. Firstly, the lherzolite core is mostly composed of olivine(Ol) + orthopyroxene(Opx) + Cpx with minor spinel(Spl), however, the harzburgite or dunite rim is mostly complosed of Ol + Opx with minor Cpx. Secondly, from the lherzolite core to the harzburgite or dunite rim, Ol and Opx contents are gradually increased, inversely, Cpx contents are decreased, and the Spl disappears. Thirdly, Mg# values of Ol are increased from the core(~89.5) to the rim(>92) of the peridotite xenolith, but FeO contents(from 11.0 to 8.1) in Ol are opposite.Forthly, Mg#(from 90 to 93) and Cr#(from 4 to 17) values of the Opx are increased, but its Al2O3 contents(from 5.0 to 2.0) are decreased from the core to the rim. The evidences of meltperidotite interaction are mostly from clinopyroxenes. The clinopyroxenes can roughly divided into two groups: original clinopyroxenes of the peridotite and new growth clinopyroxenes generated by melt-peridotite interaction. The original clinopyroxenes are generally in the inner of peridotite xenoliths such as lherzolite. They are mostly coarse-grained,

关键词： peridotite xenolith partial melting melt-peridotite interaction basalt Nanjing

无信控交叉口网联车辆动态碰撞风险检测与预警策略

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计算机工程与应用 2024年第13期60卷 330-337页

作者：王润民凡海金何佳浚徐志刚赵祥模长安大学西部交通安全与智能控制省部共建协同创新中心西安710018 长安大学信息工程学院西安710018

针对无信控交叉口碰撞事故多发的问题,面向网联人工驾驶环境,研究提出了一种基于车车通信的无信控交叉口网联车辆碰撞动态风险检测与预警策略。在构建典型无信控交叉口场景的基础上,设计了一种基于多项式拟合的车辆轨迹模型;融合利用碰... 详细信息

针对无信控交叉口碰撞事故多发的问题,面向网联人工驾驶环境,研究提出了一种基于车车通信的无信控交叉口网联车辆碰撞动态风险检测与预警策略。在构建典型无信控交叉口场景的基础上,设计了一种基于多项式拟合的车辆轨迹模型;融合利用碰撞到达时间和风险暴露时间作为风险检测指标,构建了一种圆形-双圆车辆模型实现车辆碰撞风险检测;综合考虑了驾驶人异质性及其交互行为,提出一种基于博弈论和遗传算法的两级碰撞预警策略;基于SUMO搭建仿真环境对预警策略的有效性及适用性进行测试分析。结果表明,所提策略能够准确识别出所有的碰撞事件并触发预警,预警成功率达到100%;在不同比例驾驶人组成测试工况下,所提预警策略均能显著降低碰撞率和平均碰撞动能。

关键词：无信控交叉口网联车辆动态风险检测分级预警驾驶人异质性博弈论

遗忘曲线结合混合式学习在ICU护士体外膜肺氧合护理培训中的应用

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中国实用护理杂志 2024年第15期40卷 1142-1148页

作者：刘海金余晓岚尹春萍徐敏君泉州市第一医院急诊重症监护室泉州362000 泉州市第一医院综合重症监护室泉州362000 泉州市第一医院急诊科泉州362000

目的探讨遗忘曲线结合混合式学习在ICU护士体外膜肺氧合(ECMO)护理培训中的应用效果。方法采用随机对照试验方法,2022年6—11月采用整群抽样法选取泉州市第一医院63名ICU护士为研究对象,按院区分为观察组(n=30)和对照组(n=33)。对照组... 详细信息

目的探讨遗忘曲线结合混合式学习在ICU护士体外膜肺氧合(ECMO)护理培训中的应用效果。方法采用随机对照试验方法,2022年6—11月采用整群抽样法选取泉州市第一医院63名ICU护士为研究对象,按院区分为观察组(n=30)和对照组(n=33)。对照组采用传统教学方法培训,观察组采用遗忘曲线结合混合式学习方法培训,比较2组护士培训后1 d、1个月、3个月ECMO理论成绩、技能操作成绩;观察2组护士培训前后ECMO护士核心能力及培训满意度情况。结果对照组男7名,女26名,年龄(27.88±4.36)岁;观察组男6名,女24名,年龄(28.67±4.24)岁。培训前,2组护士理论、技能操作成绩及核心能力比较差异均无统计学意义(均P>0.05)。培训后1 d、1个月、3个月,观察组ECMO理论成绩分别为(80.33±3.11)、(78.13±3.70)、(76.73±3.30)分,高于对照组的(75.18±3.30)、(73.88±2.75)、(70.48±2.96)分,差异均有统计学意义(t=6.36、5.21、7.92,均P<0.01);观察组ECMO技能操作成绩分别为(84.10±4.16)、(82.73±3.71)、(81.50±3.40)分,均高于对照组的(78.09±4.30)、(74.97±4.17)、(71.85±4.03)分,差异均有统计学意义(t=5.63、7.77、10.22,均P<0.01);2组护士ECMO理论成绩、技能操作成绩组间、时间及交互效应差异均有统计学意义(F交互=11.16、84.76,均P<0.05)。培训后,观察组ECMO护士核心能力总分为(280.23±9.23)分,优于对照组的(245.39±14.90)分,差异有统计学意义(t=11.26,P<0.01);观察组护士培训满意度总分及各维度得分分别为(99.17±10.79)、(4.43±0.50)、(4.30±0.53)、(4.57±0.68)、(4.37±0.67)、(4.23±0.57)分,均高于对照组的(84.30±12.61)、(3.67±0.96)、(3.48±0.71)、(3.67±0.74)、(3.73±0.72)、(3.82±0.77)分,差异均有统计学意义(t值为2.42~5.09,均P<0.05)。结论遗忘曲线结合混合式学习应用于ICU护士ECMO护理培训的方法科学可行,有助于护士掌握ECMO理论和技能操作,提升ECMO护士核心能力,提高培训满意度,为ECMO护理培训提供了新方法。

关键词：重症监护病房体外膜氧合作用在职培训遗忘曲线混合式学习

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低领小弧形切口手术治疗甲状腺癌的临床研究

中外医疗 2024年第6期43卷 62-65页

作者：陈柃池贾晓斌徐海进海安市中医院普外科江苏海安226600

目的探究采取低领小弧形切口手术方式治疗甲状腺癌的效果。方法便利选取2020年1月—2023年6月海安市中医院收治的84例甲状腺癌患者为研究对象,按照随机数表法分为两组,对照组(42例)采取传统开放式手术方式治疗,观察组(42例)采取低领小... 详细信息

目的探究采取低领小弧形切口手术方式治疗甲状腺癌的效果。方法便利选取2020年1月—2023年6月海安市中医院收治的84例甲状腺癌患者为研究对象,按照随机数表法分为两组,对照组(42例)采取传统开放式手术方式治疗,观察组(42例)采取低领小弧形切口手术方式治疗。比较两组患者的围术期指标、甲状腺功能、炎症因子水平以及术后并发症发生情况。结果观察组手术所用时间(70.58±10.96)min、住院总时间(5.15±1.02)d均短于对照组,术中出血量(30.31±4.22)mL少于对照组,切口长度(3.75±1.02)cm短于对照组,差异有统计学意义(t=10.287、12.190、20.338、19.834,P均<0.05)。术后,观察组甲状腺功能指标中游离三碘甲状腺原氨酸、血清游离甲状腺素水平均低于对照组,血清促甲状腺激素高于对照组,肿瘤坏死因子α、白介素-6低于对照组,差异有统计学意义(P均<0.05)。观察组并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论手术治疗甲状腺癌疾病可选择低领小弧形切口方式,相较传统开放手术切口更小,术后患者恢复更快,引起炎症反应低,并发症少。

关键词：低领小弧形切口甲状腺癌炎症因子甲状腺功能

人白细胞介素-26慢病毒表达质粒与基因敲除质粒的构建及其在HEK293T细胞中的活性验证

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中国生物制品学杂志 2024年第2期37卷 151-159页

作者：周海金吴珊刘丽媛蒋丹许涛蓝华滔舒纬童徐广贤广东医科大学医学技术学院医学检验系广东东莞523000 宁夏医科大学临床医学院宁夏银川750004

目的构建人白细胞介素(interleukin,IL)-26慢病毒表达质粒与基因敲除质粒,为研究IL-26基因在细胞信号通路及细胞自噬中的功能奠定基础。方法利用RT-PCR从人外周血单个核细胞中扩增IL-26基因序列,克隆至pCDH-CMV-MCS-EF1-copGFP真核表... 详细信息

目的构建人白细胞介素(interleukin,IL)-26慢病毒表达质粒与基因敲除质粒,为研究IL-26基因在细胞信号通路及细胞自噬中的功能奠定基础。方法利用RT-PCR从人外周血单个核细胞中扩增IL-26基因序列,克隆至pCDH-CMV-MCS-EF1-copGFP真核表达载体中,构建过表达质粒;并根据IL-26外显子序列设计4个敲除靶点Exon1sgRNA1、Exon1sgRNA2、Exon3sgRNA1、Exon3sgRNA2,利用CRISPR/Cas9技术构建至lentiCRISPRv2载体中,构建基因敲除质粒。将过表达质粒和基因敲除质粒分别瞬时转染至HEK293T细胞,利用RT-qPCR和Western blot验证IL-26 mRNA和蛋白的表达情况。并对IL-26进行氨基酸序列分析、结构预测及亚细胞定位观察。结果通过酶切、测序鉴定及生物信息学分析显示,IL-26全长516 bp,编码171个氨基酸。IL-26过表达质粒转染的HEK293T细胞与正常对照组相比,IL-26 mRNA水平升高了656.789倍,蛋白质水平升高了1.978倍,差异均有统计学意义(t分别为17.976和7.859,P分别<0.000 1和<0.001)。4个敲除靶点Exon1sgRNA1、Exon1sgRNA2、Exon3sgRNA1、Exon3sgRNA2质粒转染至HEK293T细胞中后,IL-26的表达水平分别下降了0.930、0.980、0.523 3和0.316 9倍,其中Exon3-sgRNA2质粒能够显著下调IL-26的表达(t=7.440,P <0.001)。IL-26蛋白的前22个氨基酸存在信号肽结构,且具有一定的跨膜功能,IL-26存在于细胞质中。结论成功构建了IL-26过表达和基因敲除质粒,为后续IL-26功能的研究奠定了基础。

关键词：白细胞介素-26 过表达质粒基因敲除质粒生物信息学