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Effects of Zishen Yutai Pills on in vitro Fertilization-Embryo Transfer Outcomes in Patients with Diminished Ovarian Reserve:A Prospective,Open-Labeled,Randomized and Controlled Study

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Chinese Journal of Integrative Medicine 2023年第4期29卷 291-298页

作者： LI Xiu-fang WANG Zhong-qing xu hai-yan LIU Hong SHENG yan xu Jin LI Yuan-mei LIAN Fang The First Clinical College Shandong University of Traditional Chinese MedicineJinan 250014China Center for Reproductive Medicine Shandong UniversityJinan 250021China Medical College of Optometry and Ophthalmology Shandong University of Traditional Chinese MedicineJinan 250014China Department of Traditional Chinese Medicine Jinan Golden Time Health Nursing HospitalJinan 250000China Reproductive and Genetic Center of Integrated Traditional and Western Medicine Affiliated Hospital of Shandong University of Traditional ChineseJinan 250011China Medicine

Objective:To explore the effects of Zishen Yutai Pills(ZYPs)on the quality of oocytes and embryos,as well as pregnancy outcomes in patients with diminished ovarian reserve(DOR)receiving in vitro fertilizationembryo transfer(IVF-ET).The possible mechanisms,involving the regulation of bone morphogenetic protein 15(BMP15)and growth differentiation factor 9(GDF9),were also ***:A total of 120 patients with DOR who underwent their IVF-ET cycle were randomly allocated to 2 groups in a 1:1 *** patients in the treatment group(60 cases)received ZYPs from the mid-luteal phase of the former menstrual cycle by using gonadotropin-releasing hormone(Gn RH)antagonist *** patients in the control group(60 cases)received the same protocol but without *** primary outcomes were the number of oocytes retrieved and high-quality *** outcomes included other oocyte or embryo indices as well as pregnancy *** events were assessed by comparison of the incidence of ectopic pregnancy,pregnancy complications,pregnancy loss,and preterm *** of BMP15 and GDF9 in the follicle fluids(FF)were also quantified with enzymelinked immunosorbent ***:Compared with the control group,the numbers of oocytes retrieved and high-quality embryos were significantly increased in the ZYPs group(both P0.05).The administration of ZYPs did not increase the incidence of adverse *** expressions of BMP15 and GDF9 in the ZYPs group were significantly up-regulated compared with the control group(both P<0.05).Conclus

关键词： Zishen Yutai Pills diminished ovarian reserve in vitro fertilization-embryo transfer oocytes embryos

Syntheses and Crystal Structures of Two Coordination Polymers with Aromatic Dioxide as Bridge Ligands

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Chinese Journal of Structural Chemistry 2007年第2期26卷 214-218页

作者： SHI Jing-Min xu hai-yan ZHANG Feng-Xia WU Chang-Ju LIU Lian-Dong Department of Chemistry Shandong Normal University Jinan 250014 China

Two coordination polymers, namely, two-dimensional complex 1 {[Cu（μ- L）1.5（ClO4）2（H2O）].（H2O）0.5]n （L = pyrazine-1,4-dioxide） and one-dimensional complex 2 [Co（μ-L）Br2（H2O）2]n, have been synthesized with pyrazine-1,4-dioxide as bridging ligands, and their crystal structures were determined by X-ray crystallography. Crystal data for complex 1： monoclinic system, space group C2/c, with a = 23.310（3）, b = 12.2338（17）, c = 10.6075（15） A, β= 110.487（2）°, V = 2833.6（7） A3, Z = 8, C6H9C12CuN3O12.5, Mr = 457.60, Dc = 2.145 g/cm^3, F（000） = 1832 and μ = 1.998 mm^-1; and those for 2： monoclinic system, space group C2/c, with a = 11.012（3）, b = 7.483（2）, c = 11.451（3） A, β = 101.654（4）°, V = 924.2（4） A3, Z = 4, C4HsBr2CoN2O4, Mr = 366.87, Dc = 2.637 g/cm^3, F（000） = 700 and μ = 10.487 mm^-1. 1 shows a two-dimensional sheet structure on the ac plane through the coordination of μ-L bridging ligands with Cu（Ⅱ） ions, while 2 displays a zigzag one-dimensional chain along the c axis via the coordination of μ-L bridging ligand with Co（Ⅱ） ions. Hydrogen bonds in 1 and 2 make the sheets （or chains） connect each other to form a three-dimensional structure.

关键词： Aromatic Dioxide coordination polymers Hydrogen bonds

Syntheses,Crystal Structures and Fluorescence of Cadmium(II) Coordination Polymers with Pyrazine-1,4-dioxide, 2-Methylpyrazine-1,4-dioxide and Thiocyanate as Mixed Bridge Ligands

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Chinese Journal of Structural Chemistry 2006年第10期25卷 1238-1242页

作者： SHI Jing-Min ZHANG Feng-Xia ZHANG Xia xu hai-yan LIU Lian-Dong MA Jian-Ping Department of Chemistry Shandong Normal University Jinan 250014 China

Two Cd（Ⅱ） coordination polymers have been synthesized with pyrazine-1,4-dioxide （L1）, 2-methylpyrazine-1,4-dioxide （L2）, and thiocyanate anion as mixed bridge ligands. Crystal data for complex 1 [Cd（μ1,3-SCN^-）2（L1）]n： monoclinic system, space group P21/n with a = 6.8342（11）, b = 14.349（2）, c = 10.5443（16）°A,β = 98.534（2）°, V = 1022.5（3）°A^3 Z = 4, C6H4CdN4O2S2, Mr = 340.65, Dc = 2.213 g/cm^3, F（000） = 656 and u = 2.527 mm^-1; and those for 2： triclinic system, space group P/ with a = 7.877（3）, b = 8.693（3）, c = 8.754（3） °A, α= 102.297（6）,β= 102.464（6）, γ= 98.480（6）°, V= 560.0（3） °A^3, Z = 2, CTH6CdN4O2S2, Mr = 354.68, Dc = 2.103 g/cm^3, F（000） = 344 and μ= 2.311 mm^-1. 1 shows a three-dimensional network structure, and along the c direction a one-dimensional chain is constructed by the coordination of Cd（Ⅱ） ions with μ1,3-SCN^- ligands, and the L1 bridging ligands made the chains connect each other leading to the formation of a three-dimensional structure. For 2, the one-dimensional chains along the b axis are generated by the coordination of L2 bridging ligands with Cd（Ⅱ） ions, and the chains are further joined by μ1,3-SCN^- bridging ligands forming a two-dimensional sheet structure on the （10 -1 ） plane. Both complexes 1 and 2 exhibit strong fluorescence emission.

关键词： .bridging ligands one-dimensional II Coordination Chinese Struct Chem dioxide and Thiocyanate SCN bridging Fluorescence of Cadmium Mixed Bridge Ligands dioxide Methylpyrazine thiocyanate anion

Long-Term Prognosis of Different Reperfusion Strategies for ST-Segment Elevation Myocardial Infarction in Chinese County-Level Hospitals:Insight from China Acute Myocardial Infarction Registry

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Biomedical and Environmental Sciences 2023年第9期36卷 826-836页

作者： WU Chao ZHANG Qiong Yu LI Ling ZHANG xu Xia CAI Yong Chen yanG Jin Gang xu hai yan ZHAO yan yan WANG yang LI Wei JIN Chen GAO Xiao Jin yanG Yue Jin QIAO Shu Bin Coronary Heart Disease Center Department of CardiologyState Key Laboratory of Cardiovascular DiseaseNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeFuwai HospitalBeijing 100037China Hypertension Center Department of CardiologyState Key Laboratory of Cardiovascular DiseaseNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeFuwai HospitalBeijing 100037China Medical Research&Biometrics Center State Key Laboratory of Cardiovascular DiseaseNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeFuwai HospitalBeijing 100037China Department of Cardiology Tonghua Central HospitalTonghua 134000JilinChina Department of Cardiology The First Hospital of SuihuaSuihua 152054HeilongjiangChina

Objective To evaluate the long-term prognosis of patients with ST-segment elevation myocardial infarction(STEMI)treated with different reperfusion strategies in Chinese county-level hospitals Methods A total of 2,514 patients with STEMI from 32 hospitals participated in the China Acute Myocardial Infarction registry between January 2013 and September *** success of fibrinolysis was assessed according to indirect measures of vascular *** primary outcome was 2-year *** Reperfusion therapy was used in 1,080 patients(42.9%):fibrinolysis(n=664,61.5%)and primary percutaneous coronary intervention(PCI)(n=416,38.5%).The most common reason for missing reperfusion therapy was a prehospital delay>12 h(43%).Fibrinolysis[14.5%,hazard ratio(HR):0.59,95%confidence interval(CI)0.44–0.80]and primary PCI(6.8%,HR=0.32,95%CI:0.22–0.48)were associated with lower 2-year mortality than those with no reperfusion(28.5%).Among fibrinolysistreated patients,510(76.8%)achieved successful clinical reperfusion;only 17.0%of those with failed fibrinolysis underwent rescue *** was no difference in 2-year mortality between successful fibrinolysis and primary PCI(8.8%vs.6.8%,HR=1.53,95%CI:0.85–2.73).Failed fibrinolysis predicted a similar mortality(33.1%)to no reperfusion(33.1%vs.28.5%,HR=1.30,95%CI:0.93–1.81).Conclusion In Chinese county-level hospitals,only approximately 2/5 of patients with STEMI underwent reperfusion therapy,largely due to prehospital *** 30%of patients with failed fibrinolysis and no reperfusion therapy did not survive at 2 *** improvement initiatives are warranted,especially in public health education and fast referral for mechanical revascularization in cases of failed fibrinolysis.

关键词： Acute myocardial infarction Reperfusion therapy Rural Outcome

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纳米生物医学研究的进展与发展趋势

中国生物医学工程学报 2005年第6期24卷 643-648,654页

作者：许海燕中国医学科学院基础医学研究所中国协和医科大学基础医学院北京100005

纳米科技具有巨大的发展潜力和诱人的应用前景,其中的一个重要方向是纳米生物医学。近年来,随着纳米科技与现代医学和生物学的交叉与渗透,纳米生物医学正在迅速形成一个崭新的研究领域,该领域的进步与发展将为现代生物学和医学的研究提... 详细信息

纳米科技具有巨大的发展潜力和诱人的应用前景,其中的一个重要方向是纳米生物医学。近年来,随着纳米科技与现代医学和生物学的交叉与渗透,纳米生物医学正在迅速形成一个崭新的研究领域,该领域的进步与发展将为现代生物学和医学的研究提供全新的技术和视点。文中主要对纳米结构材料及相关纳米技术在组织引导再生与修复、药物的靶向输送和控制释放、纳米尺度物质的生物学效应和安全性评价等几个方面的研究现状及取得的进展进行了综合评述。

关键词：纳米科技生物医学工程药物运送细胞生长健康与安全

Effects of 5-hydroxytryptamine ascending pathways of dorsal raphe nuclei and habenular nucleus on the respiration and blood pressure of rats

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Chinese Medical Journal 2007年第24期120卷 2308-2310页

作者： YU Lei HUANG Min xu hai-yan ZHAO Hua Department of Physiology School of Basic Medical Sciences JilinUniversity Changchun 130021 China

Obstructive sleep apnea syndrome （OSAS） was a disease of breath obstacle happened in the process of sleep. The central mechanism of OSAS has not yet been fully elucidated. Most of studies focused on raphe nuclei and 5-hydroxytryptamine （5-HT）, and showed that brain serotonergic activity might be decreased in OSAS. It is well known that the dorsal and medial raphe nuclei provide almost all the serotonergic innervation to the forebrain. A previous study evaluated the stimulation of the dorsal raphe nuclei （DRN） in the rat inducing mainly pressor and sympathoexcitatory responses.

关键词： habenular nucleus dorsal raphe nuclei respiration blood pressure lidocaine 5-hydroxytryptamine

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基于横摆角速度的ABS整车控制方法的研究

系统仿真学报 2008年第2期20卷 490-493,525页

作者：徐延海西华大学交通与汽车工程学院四川成都610039

ABS的控制策略一般都在单轮模型的基础上开发,显然这样的控制策略不能很好的满足汽车制动过程中的方向稳定性。在ABS逻辑门限控制策略的基础上给出了一种基于横摆角速度的ABS整车控制方法。结合14自由度的汽车动力学模型,利用数值仿真... 详细信息

ABS的控制策略一般都在单轮模型的基础上开发,显然这样的控制策略不能很好的满足汽车制动过程中的方向稳定性。在ABS逻辑门限控制策略的基础上给出了一种基于横摆角速度的ABS整车控制方法。结合14自由度的汽车动力学模型,利用数值仿真技术进行了ABS单轮控制策略、低选控制策略以及整车控制策略下汽车制动性能的分析,并从汽车制动效能以及方向稳定性等参数进行了各种控制策略的比较,结果表明控制方法不仅具有良好的制动效能,同时也有较好的方向稳定性。

关键词： ABS 横摆角速度方向稳定性控制

Changes in different land cover areas and NDVI values in northern latitudes from 1982 to 2015

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Advances in Climate Change Research 2021年第4期12卷 456-465页

作者： xuE Shou-Ye xu hai-yan MU Cui-Cui WU Tong-Hua LI Wang-Ping ZHANG Wen-Xin Irina STRELETSKAYA Valery GREBENETS Sergey SOKRATOV Alexander KIZYAKOV WU Xiao-Dong Cryosphere Research Station on the Qinghai-Tibet Plateau State Key Laboratory of Cryospheric ScienceNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou730000China School of Environmental and Municipal Engineering Lanzhou Jiaotong UniversityLanzhou730070China Key Laboratory of Western China's Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou730000China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai519000China University Cooperation of Polar Research Beijing100875China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou511458China University of Chinese Academy of Sciences Beijing10049China School of Civil Engineering Lanzhou University of TechnologyLanzhou730050China Department of Physical Geography and Ecosystem Science Lund UniversityLundSE-22362Sweden Center for Permafrost(CENPERM) Department of Geosciences and Natural Resource ManagementUniversity of CopenhagenCopenhagenDK-1165Denmark Geographical Faculty Lomonosov Moscow State UniversityMoscow119991Russia.

Climate warming leads to vast changes in the land cover types and plant biomass in the northern high-latitude *** overall trend is of shrubland and tree lines moving northwards,while changes in different land cover types and vegetation growth in response to climate change are largely ***,we selected land areas with latitudes higher than 50°N as the study *** compared the land cover type changes and explored relationships between the normalized difference vegetation index(NDVI)values of different land cover types,air temperature,and precipitation during 1982-2015 based on dynamic *** results indicated that forest and shrubland areas increased as a large area of grassland shifted to forest and *** snow/ice,tundra and grassland largely have decreased from 1982 to *** approximately 277.3×103 km2 of barren land(6.2%of the total barren land area in 1982)changed to tundra,the tundra area still decreased because some tundra shifted to forest and *** NDVI values of tundra significantly increased,but the shrubland showed a decreasing *** in the growing season(June to September)showed the largest positive correlation coefficients with the NDVI values of forest,tundra,grassland,and ***,due to shrubification processes and plant mortality in shrubland areas,the shrubland NDVI showed negative relationship with annual temperature but positively correlated with monthly *** together,although there is large room for improvement of the land cover type data accuracy,our results suggested that the land cover types in high-latitude regions changed significantly,while the NDVI values of the different land cover types showed different responses to climate change.

关键词： Air temperature Arctic Climate change Precipitation NDVI

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针对复杂用户评论的代码质量属性判断

软件学报 2021年第7期32卷 2183-2203页

作者：徐海燕姜瑛云南省计算机技术应用重点实验室云南昆明650504 昆明理工大学信息工程与自动化学院云南昆明650504

随着开发者社区和代码托管平台成为程序员获取代码的主要途径,针对代码的用户评论数量急剧增加.用户在使用代码后给出的评论中包含多种静态和动态的代码质量属性信息,但是由于用户评论多为复杂句,使得评论中包含的代码质量属性难以判断... 详细信息

随着开发者社区和代码托管平台成为程序员获取代码的主要途径,针对代码的用户评论数量急剧增加.用户在使用代码后给出的评论中包含多种静态和动态的代码质量属性信息,但是由于用户评论多为复杂句,使得评论中包含的代码质量属性难以判断.针对复杂用户评论的代码质量属性判断将有助于分析用户评论中的代码质量信息,有助于开发者在了解用户的代码使用情况和用户关注的代码质量属性后有针对性地提升代码质量.提出了针对复杂用户评论的代码质量属性判断方法.首先对复杂用户评论进行分句并构建分句的依存句法关系有向图;然后,应用基于分句的依存句法关系的主题判断规则抽取分句中的主题;接着,根据初始的代码质量属性特征词库识别各主题对应的代码质量属性,并获取各主题的代码质量属性表现与表现结果;最后,基于主题处理规则分析复杂用户评论中的代码质量属性表现与表现结果,产生复杂用户评论中代码质量属性相关结果,并持续扩充初始代码质量属性特征词库.实验结果表明,该方法能够对复杂用户评论的代码质量属性进行有效判断.

关键词：复杂用户评论代码质量属性主题判断规则代码质量属性表现代码质量属性表现结果主题处理规则