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Differential protein expression in substantia nigra induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine in a mouse model of chronic Parkinson’s disease

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Neural Regeneration Research 2008年第5期3卷 482-485页

作者： Wenbin Tu Furong xu guoguang Peng Department of Neurology First Hospital of Chongqing Medical University Chongqing 400016 China

BACKGROUND： To date, a complete protein expression profile of the midbrain substantia nigra in a mouse model of chronic Parkinson＇s disease, induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine （MPTP）, does not exist. In addition, there are no reports of analysis of differential protein expression. OBJECTIVE： To separate and evaluate MPTP-induced differential protein expression through the use of proteomics in the substantia nigra of a mouse model of chronic Parkinson＇s disease. DESIGN： Randomized controlled animal study. SETTING： Department of Neurology, the First Affiliated Hospital, Chongqing Medical University. MATERIALS： Sixteen 8-10-week old, healthy, male, C57BL mice, weighing 20-25 g, and of clean grade, were provided by the Experimental Animal Center of Chongqing Medical University. The experimental animals were disposed according to ethical criteria. MPTP was provided by Sigma Company, USA; Pdquest 2D image analysis software and gelatum/irradiance image analysis system （ChemiDoc XRS） by Bio-Rad, USA; and Voyager DE-PROMALD1-TOF-MS mass spectroscopy analyzer by AB1 Company, USA. METHODS： This study was performed in Chongqing Neurological Laboratory between November 2006 and July 2007. Mice were randomly divided into model and control groups, with 8 mice in each group. Mice in the model group were received a subcutaneous injection of MPTP （25 mg＆g）, twice a week, for five successive weeks, to establish a chronic Parkinson＇s disease model. Mice in the control group received the same volume of a subcutaneous saline injection at the same time points. Mice were sacrificed by anesthesia to rapidly obtain the midbrain for protein separation of the substantia nigra. MAIN OUTCOME MEASURES：（1） 2-ED handbook （Bio-Rad Company） was referenced for two-dimensional electrophoresis, （2） PDQUEST8,0 analytical electrophoresis pattern was adopted to evaluate differential protein expression. （3） Peptide mass finger print map and data were retrieved on http：//***

关键词： Parkinson's disease 1-methyl-4-phenyl-l, 2, 3, 6-tetrahydropyridine mice substantia nigra proteomics

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In-situ growth of vertically aligned nickel cobalt sulfide nanowires on carbon nanotube fibers for high capacitance all-solid-state asymmetric fiber-supercapacitors

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Journal of Energy Chemistry 2020年第2期29卷 209-215页

作者： Na Liu Zhenghui Pan Xiaoyu Ding Jie Yang guoguang xu Linge Li Qi Wang Meinan Liu Yuegang Zhang i-Lab Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123JiangsuChina School of Physical Science and Technology Shanghai Tech UniversityShanghai 200120China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China Department of Physics Tsinghua UniversityBeijing 100084China

Fiber-supercapacitors(FSCs)are promising power sources for miniature portable and wearable electronic ***,the development and practical application of these FSCs have been severely hindered by their low volumetric capacitance and narrow operating *** this work,vertically aligned nickel cobalt sulfide(Ni Co2S4)nanowires grown on carbon nanotube(CNT)fibers were achieved through an in-situ two-step hydrothermal reaction *** as-prepared Ni Co2S4@CNT fiber electrode exhibits a high volumetric capacitance of 2332 F cm-3,benefiting from its superior electric conductivity,large surface area,and rich Faradic redox reaction ***,a Ni Co2S4@CNT//VN@CNT(vanadium nitride nanosheets grown on CNT fibers)asymmetric fiber-supercapacitor(AFSC)was successfully *** device exhibits an operating voltage up to 1.6 V and a high volumetric energy density of 30.64m Wh *** device also possesses outstanding flexibility as evidenced by no obvious performance degradation under various bending angles and maintaining high capacitance after 5000 bending *** work promotes the practical application of flexible wearable energy-storage devices.

关键词： Fiber-supercapacitors Volumetric energy density Nickel cobalt sulfide nanowires Carbon nanotube fiber Wearable energy storage devices

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Infiltrating lithium into carbon doth decorated with zinc oxide arrays for dendrite-free lithium metal anode

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Nano Research 2019年第3期12卷 525-529页

作者： Xianshu Wang Zhenghui Pan Yang Wu Xiaoyu Ding xujia Hong guoguang xu Meinan Liu Yuegang Zhang Weishan Li School of Chemistry and Environment South China Normal University Guangzhou 510006 China i-lab Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Suzhou 215123 China Department of Physics Tsinghua University Beijing 100084 China Engineering Research Center of MTEES (Ministry of Education) Research Center of BMET (Guangdong Province) and Key Laboratory of ETESPG (GHEI) South China Normal University Guangzhou 510006 China

Lithium metal anode for batteries has attracted extensive attentions, but its application is restricted by the hazardous dendritic Li growth and dead Li formation. To address these issues, a novel Li anode is developed by infiltrating molten Li metal into conductive carbon cloth decorated with zinc oxide arrays. In carbonate-based electrolyte, the symmetric cell shows no short circuit over 1,500 h at 1 mA·cm^-2, and stable voltage profiles at 3 mA cm^-2 for ~ 300 h cycling. A low overpotential of ~ 243 mV over 350 cycles at a high current density of 10 mA·cm^-2 is achieved, compared to the seriously fluctuated voltage and fast short circuit in the cell using bare Li metal. Meanwhile, the asymmetric cell withstands 1,000 cycles at 10 C (1 C = 167 mAh·g^-1) compared to the 210 cycles for the cell using bare Li anode. The excellent performance is attributed to the well-regulated Li plating/stripping drive n from the formation of LiZn alloy on the wavy carb on fibers, resulting in the suppress!on of dendrite growth and pulverization of the Li electrode during cycling.

关键词： lithium metal anodes lithium plating/stripping dendrite-free thermal infiltration carbon cloth zinc oxide nanowire arrays

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中国省情综合地图集的内容图谱构建与主题表达可视分析

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武汉大学学报（信息科学版） 2023年第5期48卷 665-677页

作者：黄丽娜许国光武汉大学资源与环境科学学院湖北武汉430079 数字制图与国土信息应用工程自然资源部重点实验室湖北武汉430079 重庆市勘测院重庆401120

省情综合地图集使用专题地图对省域的资源禀赋和社会发展水平进行全面展示,是一项复杂的知识系统。通过对地图集中大量、复杂、非结构化的内容进行模式化重构,建立地图集的内容图谱,挖掘中国省情综合地图集的内容组织规律。首先,构建图... 详细信息

省情综合地图集使用专题地图对省域的资源禀赋和社会发展水平进行全面展示,是一项复杂的知识系统。通过对地图集中大量、复杂、非结构化的内容进行模式化重构,建立地图集的内容图谱,挖掘中国省情综合地图集的内容组织规律。首先,构建图集词汇向量和计算语义相似度,提取图集内容表达的标准主题词;然后,结合图集的“图组→图幅→指标”编排结构,对主题词进行语义层次聚类,构建图集内容表达的树型图谱;在此基础上,挖掘各省综合地图集内容图谱的频繁子图,形成图谱指纹,以此标识出中国省情综合地图集主题表达的共性特征。研究结果表明,中国省情综合地图集的主题内容具有层次化组织特点,可将指纹图谱作为框架,指导省情综合地图集的主题选择和内容组织。借助内容图谱和指纹图谱分析,还可进一步揭示出中国各省综合地图集在内容表达上具有明显的聚类特征和多样性特征。研究结果可为新编省情综合地图集设计提供依据。未来还可进一步探究不同类型地图集的内容图谱构成,丰富地图集设计与编制理论。

关键词：省情综合地图集内容图谱指纹特征可视分析地图集设计

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基于MAPublisher地图集编制——以《重庆市交通图集》为例

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测绘通报 2021年第S2期 74-77页

作者：程飞许国光重庆市勘测院重庆401121

目前,多位学者已针对基于MAPublisher的数据库驱动制图技术展开了较多研究,然而在地图集编制方面,该技术的相关论述较少。以《重庆市交通图集》编制为契机,将基于MAPublisher的图库一体化制图技术应用于地图集编制,总结工作经验,提出了... 详细信息

目前,多位学者已针对基于MAPublisher的数据库驱动制图技术展开了较多研究,然而在地图集编制方面,该技术的相关论述较少。以《重庆市交通图集》编制为契机,将基于MAPublisher的图库一体化制图技术应用于地图集编制,总结工作经验,提出了图库一体化地图集编制技术路线,提高了地图集生产效率,为日后地图集编制提供了参考依据。

关键词：地图集编制 MAPublisher 重庆市交通图集

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High Precision Guidance System of the Gravity-1 Launch Vehicle

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Aerospace China 2024年第1期25卷 56-60页

作者： ZHANG Jie xu guoguang BU Xiangwei Orienspace Technology(Shandong)Co. LtdBeijing 100076

In the development of the Gravity-1 launch vehicle, solid rocket motors without a thrust termination mechanism created great challenges for ascent guidance. To resolve this problem, the Gravity-1 GNC system used cross product guidance in the core 2nd stage, and a nonlinear adaptive guidance algorithm in core 3rd stage, in order to achieve high orbit injection precision. On January 11, 2024, the Gravity-1 launch vehicle successfully carried out its maiden flight from a mobile sea platform off the coast of Haiyang in Shandong province, inserting its payload into a low earth orbit at an altitude of 500 kilometers, validating the guidance algorithm.

关键词： Gravity-1 guidance system high precision

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一种基于人工免疫的网络安全风险检测方法

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计算机工程 2005年第12期31卷 163-165页

作者：许国光李涛王益丰黄旭波四川大学计算机系成都610065

提出了一种针对大规模网络活动进行风险检测的方法。对网络安全环境下的自体非自体给出了定义,根据克隆选择,自体耐受等基本免疫原理,通过计算抗体浓度来检测网络活动中是否存在异常问题。实验表明,该方法具有实时性和定量计算性,是网... 详细信息

提出了一种针对大规模网络活动进行风险检测的方法。对网络安全环境下的自体非自体给出了定义,根据克隆选择,自体耐受等基本免疫原理,通过计算抗体浓度来检测网络活动中是否存在异常问题。实验表明,该方法具有实时性和定量计算性,是网络安全风险检测的一种有效解决方案。

关键词：网络安全抗体亲和力风险检测

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Analysis of the Gravity-1 Sea Launch System and Technical Features

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Aerospace China 2024年第1期25卷 18-27页

作者： ZHANG Tao HUANG Shuai Ma Ma BU Xiangwei xu guoguang Orienspace Technology(Shandong)Co. LtdBeijing 100076

Sea launch has the characteristics of flexible launching points, high landing area safety, and good economy. In recent years, it has become one of the important launch methods. Since 2019, China has carried out a total of 11 successful sea launches. The Gravity-1(YL-1) sea launch system consists of a launch vehicle system and a sea launch platform. The sea launch program includes roll on/roll off boarding, sea mooring, sea maneuvering, anchoring and positioning, system testing, and formal launch. Through the maiden flight of YL-1, the design and manufacturing technology of large tonnage dedicated launch ship, launch vehicle vertical transfer and roll on/roll off boarding technology, anti-shake technology for sea launch, simple inflatable flexible insulation protective cover technology, and remote wireless measurement and control technology have been fully verified.

关键词： YL-1 sea launch system technical features

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Application of Modelica Based Multi- Domain Modeling and Simulation for Gravity-1

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Aerospace China 2024年第1期25卷 47-55页

作者： ZHANG Chi BU Xiangwei xu Lijie WU Kao HOU Shiyuan xu guoguang Orienspace Technology(Shandong)Co. LtdBeijing 100076

In the R&D phase of Gravity-1(YL-1), a multi-domain modeling and simulation technology based on Modelica language was introduced, which was a recent attempt in the practice of modeling and simulation method for launch vehicles in China. It realizes a complex coupling model within a unified model for different domains, so that technologists can work on one model. It ensured the success of YL-1 first launch mission, supports rapid iteration, full validation, and tight design collaboration.

关键词： Modelica Gravity-1 simulation modeling launch vehicle model

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Solid Rocket Booster Thrust Asynchrony Identification Method for Solid Rocket Bundled Rockets With ESO

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Aerospace China 2024年第1期25卷 40-46页

作者： WU Kao ZHANG Chi CHEN Yan xu guoguang BU Xiangwei Oriental Space Technology(Shandong)Co. LtdBeijing 102600

The role of the rocket attitude control system is to execute the required maneuvers for guidance and ensure the stability of the rocket's flight attitude. Attitude control technology has always been one of the key technologies for ensuring the success of rocket flights and has been a core topic in carrier rocket technology research. The Gravity-1 solid carrier rocket is the first solid rocket bundled rocket developed by China, adopting a configuration with four boosters and a core stage bundled together. During the actual flight process, the four booster engines are ignited first, and then, in the event of insufficient control force from the boosters, the core stage engine is ignited to participate in control. To address thrust asynchrony during the descent of the four boosters, an Extended State Observer(ESO) is employed in the control scheme for this flight segment. This involves real-time estimation and compensation of attitude parameters during flight, identification of thrust asynchrony among the boosters, and simultaneous determination of whether the core stage engine is ignited to participate in *** six degrees of freedom simulation analysis and Y1 flight test validation, this method has been proven to be correct and feasible.

关键词： Extended State Observer(ESO) solid booster attitude control thrust asynchrony

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