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Production induced fracture closure of deep shale gas well under thermo-hydro-mechanical conditions

Petroleum Science 2024年第3期21卷 1796-1813页

作者： Shi-Ming Wei yang Xia Yan Jin xu-yang guo Jing-Yu Zi Kai-xuan Qiu Si-Yuan Chen College of Science China University of Petroleum(Beijing)Beijing102249China CNOOC Research Institute Ltd Beijing100028China The University of Hong Kong Hong Kong999077China

Deep shale gas reservoirs have geological characteristics of high temperature,high pressure,high stress,and inferior ability to pass through *** multi-stage fractured horizontal well is the key to exploiting the deep shale gas ***,during the production process,the effectiveness of the hydraulic fracture network decreases with the closure of fractures,which accelerates the decline of shale gas *** this paper,we addressed the problems of unclear fracture closure mechanisms and low accuracy of shale gas production prediction during deep shale gas *** we established the fluid—solid—heat coupled model coupling the deformation and fluid flow among the fracture surface,proppant and the shale *** the fluid—solid—heat coupled model was applied to the fracture network,it was well solved by our numerical method named discontinuous discrete fracture *** with the conventional discrete fracture method,the discontinuous discrete fracture method can describe the three-dimensional morphology of the fracture while considering the effect of the change of fracture surface permeation coefficient on the coupled fracture—matrix flow and describing the displacement discontinuity across the *** simulations revealed that the degree of fracture closure increases as the production time proceeds,and the degree of closure of the secondary fractures is higher than that of the primary *** creep and proppant embedment both increase the degree of fracture *** reduction in fracture surface permeability due to proppant embedment reduces the rate of fluid transfer between matrix and fracture,which has often been overlooked in the ***,it significantly impacts shale gas production,with calculations showing a 24.7%cumulative three-year yield *** study is helpful to understand the mechanism of hydraulic fracture ***,it provides the theoretical guidance for maintaining the long

关键词： Shalegas Fracture closure Fluid-solid-heat coupling Discontinuous discrete fracture

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Theoretical insights into thermal transport and structural stability mechanisms of triaxial compressed methane hydrate

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Chinese Physics B 2024年第9期33卷 494-504页

作者： Dong-Sheng Chen Ting-Ting Miao Cheng Chang xu-yang guo Meng-Yan Guan and Zhong-Li Ji Beijing Key Laboratory of Process Fluid Filtration and Separation College of Mechanical andTransportation EngineeringChina University of Petroleum-BeijingBeijing 102249China State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum-BeijingBeijing 102249China

The heat transfer and stability of methane hydrate in reservoirs have a direct impact on the drilling and production efficiency of hydrate resources,especially in complex stress environments caused by formation *** this study,we investigated the thermal transport and structural stability of methane hydrate under triaxial compression using molecular dynamics *** results suggest that the thermal conductivity of methane hydrate increases with increasing compression *** phonon transport mechanisms were identified as factors enhancing thermal *** low compressive strains,a low-frequency phonon transport channel was established due to the overlap of phonon vibration peaks between methane and water *** high compressive strains,the filling of larger phonon bandgaps facilitated the opening of more phonon transport ***,we found that a strain of􀀀0.04 is a watershed point,where methane hydrate transitions from stable to ***,a strain of􀀀0.06 marks the threshold at which the diffusion capacities of methane and water molecules are at their *** a higher strain of􀀀0.08,the increased volume compression reduces the available space,limiting the diffusion ability of water and methane molecules within the *** synergistic effect of the strong diffusion ability and high probability of collision between atoms increases the thermal conductivity of hydrates during the unstable period compared to the stable *** findings offer valuable theoretical insights into the thermal conductivity and stability of methane hydrates in reservoir stress environments.

关键词： methane hydrate molecular dynamics thermal transport triaxial compression structural stability

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Waveguide electro-optic modulators based on self-assembled material systems

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光学精密工程 2005年第5期13卷 554-560页

作者： LIU Zhi-fu MA Jing SUN De-gui xu guo-yang HO Seng-Tiong ZHU Pei wang KANG Hu Antonio Facchetti Tobin J. Marks Department of Electrical and Computer Engineering Northwestern University Evanston IL 60208 USA Department of Chemistry and Materials Research Center Northwestern University Evanston IL 60208 USA

Fabrication and characterization of electro-optic modulators based on the novel organic electro-optic materials composed of self-assembled superlattices (SAS) were presented, both wet-dipping self-assembly and vapor phase deposition approaches were discussed. Prototype waveguide electro-optic modulators were fabricated using SAS films integrated with low-loss polymeric materials functioning as partial guiding and cladding *** electro-optic thin film materials including DTPT and PEPCOOH grown from the vapor phase were used for fabrication and test of electro-optic prototype modulators. Finally,the EO coefficient of tens of pm/V was obtained,which can sufficiently support high-speed and small size EO modulators.

关键词：电子波导光电子调节器 SAS 薄膜

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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao Qin Dong Dan Zou Zhijun yang Lili guo Ruxiang xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

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Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： guo-Fu xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

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Small-Scale Duplications Play a Significant Role in Rice Genome Evolution

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Rice science 2005年第3期12卷 173-178页

作者： guo Xin-yi xu guo-hua ZHANG yang Hu Wei-min FAN Long-jiang Institute of Crop Science/Institute of Bioinformatics Zhejiang University Hangzhou 310029 China

Genes are continually being created by the processes of genome duplication （ohnolog） and gene duplication （paralog）. Whole-genome duplications have been found to be widespread in plant species and play an important role in plant evolution. Clearly un-overlapping duplicated blocks of whole-genome duplications can be detected in the genome of sequenced rice （Oryza sativa）. Syntenic ohnolog pairs （ohnologues） of the whole-genome duplications in rice were identified based on their syntenic duplicate lines. The paralogs of ohnologues were further scanned using multi-round reciprocal BLAST best-hit searching （E〈e^-14）. The results indicated that an average of 0.55 sister paralogs could be found for every ohnologue in rice. These results suggest that small-scale duplications, as well as whole-genome duplications, play a significant role in the two duplicated rice genomes.

关键词： small-scale duplication ohnologue genome evolution Oryza sativa Arabidopsis

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两种导管塑形方法在视可尼喉镜引导双腔气管导管插管中的比较

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北京大学学报（医学版） 2016年第6期48卷 1038-1042页

作者：许挺李民徐懋郭向阳北京大学第三医院麻醉科北京100191

目的:采用视可尼喉镜引导双腔气管导管插管,将导管气管腔开口分别置于塑形后导管远端弯曲的凸面和凹面,比较这两种不同塑形方法在插管时的有效性和安全性。方法:对行择期胸外科手术并需进行左双腔气管导管插管的患者,采用视可尼喉镜引... 详细信息

目的:采用视可尼喉镜引导双腔气管导管插管,将导管气管腔开口分别置于塑形后导管远端弯曲的凸面和凹面,比较这两种不同塑形方法在插管时的有效性和安全性。方法:对行择期胸外科手术并需进行左双腔气管导管插管的患者,采用视可尼喉镜引导双腔气管导管插管,根据气管导管塑形方式将患者随机分为U组和T组,患者使用的双腔气管导管均沿视可尼喉镜镜杆塑形,T组塑性后导管的气管腔开口置于导管远端弯曲的凸面,U组气管腔开口置于导管远端弯曲的凹面。全麻诱导后,采用塑形后的导管在视可尼喉镜引导下插管,记录患者视可尼喉镜插管操作时间、插管次数、支气管插管错位、纤维支气管镜定位时间、插管总时间及是否有口唇和牙齿损伤,评估术后1 h及24 h患者声音嘶哑及咽喉疼痛情况。结果:136例患者完成本研究,每组68例。U组患者视可尼插管操作时间少于T组[(35.1±6.1)s vs.39.6±11.8)s,P=0.007],两组一次插管成功率(92.6%vs.88.2%,P=0.561)差异无统计学意义;U组插管阻力评分更低;T组支气管插管错位的例数少于U组(4 vs.13,P=0.020),纤维支气管镜定位时间更短[(44.1±20.9)s vs.(53.6±29.2)s,P=0.032];两组患者插管总时间以及两组口唇、牙齿损伤发生率差异均无统计学意义;声音嘶哑发生率和严重程度评估,术后1 h时U组均低于T组;而在咽喉疼痛发生率和严重程度方面,术后1 h和24 h时U组均低于T组。结论:使用视可尼喉镜引导左双腔气管导管插管时,将导管沿视可尼镜杆塑形,使其气管腔开口位于塑形后导管远端弯曲的凹面能够节省视可尼喉镜插管操作时间,并减少术后咽喉疼痛及声音嘶哑的发生率和严重程度,但这种塑形方法会增加支气管插管错位的发生率以及纤维支气管镜定位导管位置所花费的时间。

关键词：插管法,气管内喉镜有效性研究

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A surface engineering strategy for the stabilization of zinc metal anodes with montmorillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 94-105页

作者： Wenbo Wang Ruifeng xu xu Zhang Peiyu Wang Bao yang Bingjun yang Juan yang Kailimai Su Pengjun Ma Yanan Deng Xianfeng Fan Wanjun Chen Key Laboratory for Electronic Materials College of Electrical Engineering Northwest Minzu University Resource Chemistry and Energy Materials Research Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for Materials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the domain of electrochemical energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering modification strategy for coating the montmorillonite （MMT） layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the MMT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction kinetics of zinc *** functional theory（DFT） calculations and water contact angle （CA） tests prove that MMT@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the MMT@Zn||MMT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 mA cm-2and 0.125 m A h cm-2,even exceeding 1800 h long cycling under harsh conditions of 5 m A cm-2and 1.25 m A h *** MMT@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.

关键词： Surface engineering strategy Montmorillonite layer Protection mechanism of Zn anode Cycling stability Aqueous zinc ion batteries

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Studies of chemical constituents of the barks of ***(Hemsl.)Sarg.×*** L.

Studies of chemical constituents of the barks of ***(Hemsl.)...

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中国化学会第十一届全国天然有机化学学术会议

作者： Bing Sun Jin-Hui Chen Rui yang Dong-Ting yang guo-xu yang Ai-Qun Jia Ji-Sen Shi School of Environmental and Biological Engineering.Nanjing University of Science and Technology Key Laboratory of Forest Genetics and Biotechnology of Ministry of Education Nanjing Forestry University

The Liriodendron *** belongs to *** are only two species now,*** L ***(Hemsl.)Sang..The hybrid of the two species has many values,for example vigorous growth,nice flows,beautiful tree form,no diseases,no insects and strong adaptive *** crude extract of Liriodendron tulipifera used to be a substitute of quimlime to treat malaria,

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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang Chen Zhifeng Chen Menghua Li Weiwei guo Shuolong Yuan Liangwei xu Chang Lin Xi Shi Wei Chen Shiming yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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