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Early prediction of growth patterns after pediatric kidney transplantation based on height-related single-nucleotide polymorphisms

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Chinese Medical Journal 2024年第10期137卷 1199-1206页

作者： Yi Feng Yonghua Feng Mingyao Hu Hongen xu Zhigang Wang Shicheng xu Yongchuang Yan Chenghao Feng Zhou Li guiwen Feng Wenjun Shang Department of Renal Transplantation The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Precision Medicine Center Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450052China

Background:Growth retardation is a common complication of chronic kidney disease in children,which can be partially relieved after renal *** study aimed to develop and validate a predictive model for growth patterns of children with end-stage renal disease(ESRD)after kidney transplantation using machine learning algorithms based on genomic and clinical ***:A retrospective cohort of 110 children who received kidney transplants between May 2013 and September 2021 at the First Affiliated Hospital of Zhengzhou University were recruited for whole-exome sequencing(WES),and another 39 children who underwent transplant from October 2021 to March 2022 were enrolled for external *** on previous studies,we comprehensively collected 729 height-related single-nucleotide polymorphisms(SNPs)in exon *** machine learning algorithms and 10-fold cross-validation analysis were employed for model ***:The 110 children were divided into two groups according to change in height-for-age *** univariate analysis,age and 19 SNPs were incorporated into the model and *** random forest model showed the best prediction efficacy with an accuracy of 0.8125 and an area under curve(AUC)of 0.924,and also performed well in the external validation cohort(accuracy,0.7949;AUC,0.796).Conclusions:A model with good performance for predicting post-transplant growth patterns in children based on SNPs and clinical variables was constructed and validated using machine learning *** model is expected to guide clinicians in the management of children after renal transplantation,including the use of growth hormone,glucocorticoid withdrawal,and nutritional supplementation,to alleviate growth retardation in children with ESRD.

关键词： Growth Machine learning Pediatric kidney transplantation Single-nucleotide polymorphism

Chemo-and Biostratigraphy of the Jurassic Oil Shales from the Qiangtang Basin,Northern Tibet,China:A Case Study of the Toarcian Oceanic Anoxic Event

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Acta Geologica Sinica(English Edition) 2017年第2期91卷 630-643页

作者： CHEN Lan xu guiwen DA xuejuan YI Haisheng ZHU Zhangxiong HUANG Zhaohui LI Xiaogang Chongqing University of Science and Technology Chongqing 401331China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of Sciences99 West Lincheng RoadGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China Institute of Sedimentary Geology Chengdu University of TechnologyChengdu 610059SichuanChina

The marine oil shales of the Qiangtang Basin, northern Tibet, exposed in the Biluo Co, Tuonamu, Shenglihe and Changsheshan areas are believed to be important petroleum source rocks. This work comprehensively analyzed the carbon isotopes, trace elements, and calcareous nannofosills, ammonites and bivalves of the Biluo Co section in the Qiangtang Basin. The organic carbon isotopes show a positive excursion close to 2.17‰（relative to PDB）, which, albeit significantly smaller, may also be associated with other Early Toarcian Oceanic Anoxic Events（T-OAE） in the European epicontinental seas and the Tethyan continental margins. Coinciding with the Early Toarcian transgression, the oxygen deficiency in bottom water had led to dysoxic-anoxic conditions and deposition of black shales lacking benthic fauna. Under such condition, the redox-sensitive trace metals such as Mo, V, Ni, Cr, and U were enriched, in conjunction with high planktonic productivity of Watznaueriaceae calcareous nannofossils. Comparison of the results with the records of chemo-and biostratigraphy, as well as the palaeogeography during the Early Jurassic suggests that the anoxia linked to the Early Toarcian oceanic anoxic event was mainly caused by the high surface water temperature, sea-level rise and an increase of surface water productivity.

关键词： oil shales geochemistry palaeontology T-OAE northern Tibet Proto-Tethys

Jurassic Black Shales Facies from Qiangtang Basin (Northern Tibet): Rare Earth and Trace Elements for Paleoceanographic Implications

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Acta Geologica Sinica(English Edition) 2013年第2期87卷 540-554页

作者： CHEN Lan YI Haisheng TSAI Louis Loung-Yie xu guiwen DA xuejuan LIN Andrew Tien-Shun College of Petroleum Engineering Chongqing University of Science and Technology Institute of Applied Geology National Central University Institute of Geophysics National Central University Institute of Sedimentary Geology Chengdu University of Technology State Key Laboratory of Oil/Gas Reservoir Geology and Exploitation Chengdu University of Technology

The Biluo Co and Amdo 114 station, northern Tibet, cropping out the Early Toarcian and Middle-Late Tithonian （Jurassic） organic-rich black shales, have been a focus to petroleum geologists in discussing their oil-producing potential. This paper first reports the trace elements and rare earth elements to discuss the paleoenvironments, redox conditions and sedimentary mechanisms of those black shales. Both sections exhibit variation in trace element abundances with concentrations 〈0.1 ppm to 760 ppm, mostly enriched in V, Cr, Ni, Cu, Zn, Mo, Ba and U. Element ratios of Ni/Co, V/Cr, U/Th and V/（V＋Ni） plus U were used to identify redox conditions. The shale-normalized rare earth element （REE） patterns are characterized by the flat-shale type with instable Ce anomalies and very weekly positive Eu anomalies. Positive Ceanom values are significant with values varying between - 0.064 and 0.029 in Biluo Co, which may be interpreted as release of REE and input of riverine terrestrial matter with rich Ce （resulting in pH change） during the anoxic conditions. In the middle parts of Amdo 114 station, distinct negative Ceanom values are observed （-0.238 to -0.111） and associated surface water warming were interpreted as being related to a major sea level rise. In contrast, the formation of the black shales in the lower and upper part of the studied succession took place during a cooler （Ceanom values 〉-0.10）, lower surface water productivity, and lower sea-level stage. Thus, we emphasize the role of different factors that control the formation of local and regional black shales. The most important factors are sea-level fluctuations and increasing productivity.

关键词： Jurassic black shale facies rare earth and trace elements paleoceanography northern Tibet

Triplet-triplet annihilation upconversion materials as electrophoretic inks

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Chinese Chemical Letters 2024年第3期35卷 439-442页

作者： Qiaoyu Zhang guiwen Luo Jinping Chen Tianjun Yu Rui Hu Guoqiang Yang Yi Zeng Yi Li Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Key Laboratory of Photochemistry Institute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Luminescent materials that can be reversibly switched by electric field stimulation are attractive since the potential application for optoelectronic *** we report a triplet-triplet annihilation upconversion(TTA-UC)system with electrophoretic response which is developed as the electrophoretic *** TTA-UC system consists of an ionic derivative of 9,10-diphenyl anthracene(DPA)as the annihilator and Pt(II)octaethylporphyrin(PtOEP)as the *** applying an electric field,migration and enrichment of positively charged DPA derivatives towards the cathode results in a 20%enhancement of TTA-UC.A quasi-solid film for electrically writing is made using the electrophoretic TTA system as the ink and a platinum electrode as a *** prototype of TTA-UC ink demonstrates unique luminescence functions upon electrically writing and erasing,providing a promising strategy to develop electronic devices for display,information storage and encryption.

关键词： Triplet-triplet annihilation Photon upconversion Electrophoresis Electrophoretic ink Luminescence display

Evidence for distortion-induced local electric polarization in α-RuCl3

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Science China(Physics,Mechanics & Astronomy) 2024年第9期Mechanics & Astronomy) .卷 169-177页

作者： Xinrun Mi De Hou Xiao Wang Sabreen Hammouda Caixing Liu Zijian Xiong Han Li Yan Liu guiwen Wang Aifeng Wang Yisheng Chai Yang Qi Wei Li Xiaoyuan Zhou Yixi Su D.I.Khomskii Mingquan He Zhigao Sheng Young Sun College of Physics Center of Quantum Materials and DevicesChongqing University Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryHefei Institutes of Physical ScienceAnhuiChinese Academy of Sciences University of Science and Technology of China Jülich Centre for Neutron Scienceat Heinz Maier-Leibnitz Zentrum(JCNS-MLZ) Forschungszentrum Jülich GmbH School of Physics Beihang University Analytical and Testing Center Chongqing University State Key Laboratory of Surface Physics Department of PhysicsFudan University CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of Sciences Ⅱ.Physikalisches Institut Universit?t zu K?ln

The spin-orbit assisted Mott insulator α-RuCl3is a prime candidate for material realization of the Kitaev quantum spin *** little attention has been paid to charge degrees of freedom, charge effects, such as electric polarization, may arise in this system. Here, we report distortion-induced local electric polarization in α-RuCl3as evidenced by single-crystal X-ray diffraction,second harmonic generation（SHG） and dielectric measurements. The SHG signal appears at room temperature and develops substantially in the Kitaev paramagnetic state when short-range spin correlations come into play. Despite sizable pyroelectric currents in the Kitaev paramagnetic state, the absence of hysteresis in the polarization-electric field（P-E） points to the shortrange nature of electric polarization. This localized electric polarization is likely the result of distortion-induced charge dimerization, achieved through virtual hopping-induced charge redistribution. In addition, the electric polarization is boosted by short-range spin correlations via spin-phonon coupling in the Kitaev paramagnetic state. Our results emphasize the importance of charge degrees of freedom in α-RuCl3, which establish a novel platform to investigate charge effects in Kitaev materials.

关键词： Mott insulator Kitaev quantum spin liquid electric polarization

漓江流域“三生”功能时空分异特征及动态模拟

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水土保持研究 2024年第2期31卷 431-442页

作者：蓝贵文张凡吴静江凡桂林理工大学测绘地理信息学院广西桂林541006 广西壮族自治区自然资源生态修复中心南宁530022

[目的]揭示漓江流域“三生”功能时空分布动态变化特征,模拟预测自然发展、生态保护情景下漓江流域“三生”功能指数变化趋势,为喀斯特地区流域可持续发展提供决策参考。[方法]基于2010年、2015年及2020年漓江流域土地利用数据,采用重... 详细信息

[目的]揭示漓江流域“三生”功能时空分布动态变化特征,模拟预测自然发展、生态保护情景下漓江流域“三生”功能指数变化趋势,为喀斯特地区流域可持续发展提供决策参考。[方法]基于2010年、2015年及2020年漓江流域土地利用数据,采用重心模型及PLUS模型等方法,开展了“三生”功能重心迁移、“三生”功能指数时空变化及模拟研究。[结果](1)2010—2020年,生产、生活功能指数整体分别提升0.77%,23.85%,高值区分别集中在低海拔地区和桂林市区;生态功能指数整体下降1.39%,高值区沿高海拔地区分布。(2)2010—2020年,“三生”功能变化幅度的大小为生产功能<生活功能<生态功能。其中,后阶段生产、生活功能增强区面积分别较前阶段上升了4.0%,11.6%,功能减弱区面积分别下降了3.2%,9.4%,生态功能增强区和减弱区面积则分别较前阶段下降16.4%和增加17.3%。(3)10年间,生产功能和生活功能重心整体上向西北方向移动,生态功能重心整体上向东南方向移动。(4)自然发展情景下,2030年生产、生活功能均值比2020年分别提升0.278,0.4,生态功能均值下降0.138;生态保护情景下,2030年生产、生活、生态功能均值比2020年分别提升0.421,0.211,0.06。[结论]生产、生活功能整体上有所增强,生态功能则有所减弱,但生态功能的整体变化幅度最大。生态保护情景模拟结果更符合《桂林市国土空间总体规划(2021—2035)》发展目标。

关键词： “三生”功能情景模拟 PLUS模型漓江流域

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房价、租金二元视角下的城市更新外部经济效应研究——以重庆实证案例为基础

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城市发展研究 2024年第1期31卷 121-128页

作者：庄陶之袁梦刘贵文重庆大学管理科学与房地产学院

以重庆市主城区城市更新为研究对象，采用特征价格模型和双重差分模型结合的方法，从房价和租金的二元视角分析了城市更新的外部经济效应，并对比包括更新方式、投资规模及区位条件等项目特征下其外部效应的异质性。结果显示：(1)城市... 详细信息

以重庆市主城区城市更新为研究对象，采用特征价格模型和双重差分模型结合的方法，从房价和租金的二元视角分析了城市更新的外部经济效应，并对比包括更新方式、投资规模及区位条件等项目特征下其外部效应的异质性。结果显示：(1)城市更新对周边地区产生了显著的负外部经济效应，对距离项目不同范围内的房价和租金产生的影响不同；(2)获取投资额较少、所处区位条件较差的城市更新项目产生的负面影响更小；(3)不同改造类型的城市更新项目产生负外部经济效应的大小和范围存在差异，保护修缮类项目的负面影响随投资额和区位条件的提高而增加，拆旧建新类项目所处区位条件改善导致周边房价的加速下降，改造提升类项目不受投资额和区位条件的影响。

关键词：外部经济效应城市更新住房价格租金双重差分重庆

CO_(2)催化加氢制备C_(1)产物的反应路径与催化剂研究进展

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低碳化学与化工 2024年第3期49卷 1-8页

作者：黄艳王贵文杨龙徐冬高腾飞国能锦界能源有限责任公司陕西神木719319 国家能源集团新能源技术研究院有限公司北京102209

通过二氧化碳(CO_(2))催化加氢制备碳基燃料和高值化学品是一种极具应用前景的碳减排技术,但其工业化仍面临许多挑战。针对CO_(2)催化加氢制备的C_(1)产物,包括甲酸(HCOOH)、一氧化碳(CO)、甲醇(CH_(3)OH)和甲烷(CH_(4)),从反应路径、... 详细信息

通过二氧化碳(CO_(2))催化加氢制备碳基燃料和高值化学品是一种极具应用前景的碳减排技术,但其工业化仍面临许多挑战。针对CO_(2)催化加氢制备的C_(1)产物,包括甲酸(HCOOH)、一氧化碳(CO)、甲醇(CH_(3)OH)和甲烷(CH_(4)),从反应路径、催化工艺等方面综述了相关研究进展。首先,总结了CO_(2)催化加氢生成不同C_(1)产物的反应路径及其竞争关系。随后,针对CO_(2)催化加氢催化剂的改性方式,讨论了不同催化剂的催化性能。最后,对CO_(2)催化加氢催化剂的未来发展方向进行了展望。

关键词： CO_(2) C_(1)产物催化加氢反应路径催化剂

Manganese Deposits and Environments Contaminated by Manganese Mine Tailings in Chongqing Area

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Manganese Deposits and Environments Contaminated by Manganes...