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Alkylene-functionality in bridged and fused nitrogen-rich poly-cyclic energetic materials:Synthesis,structural diversity and energetic properties

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Defence Technology（防务技术） 2024年第5期35卷 18-46页

作者： Man xu Nanxi Xiang ping Yin Qi Lai Siping Pang School of Materials Science&Engineering Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China

From the standpoint of chemical structures,the organic backbones of energetic materials can be classified into aromatic rings,nonaromatic rings,and open *** the category of aromatic energetic compounds exhibits several advantages in the regulation of energetic properties,the nonaromatic heterocycles,assembling nitramino explosophores with simple alkyl bridges,still have prevailed in benchmark *** methylene bridge plays a pivotal role in the constructions of the classic nonaromatic heterocycle-based energetic compounds,e.g.,hexahydro-1,3,5-trinitro-1,3,5-triazine(RDX)and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine(HMX),whereas ethylene bridge is the core moiety of state-of-the-art explosive 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane(CL-20).In this context,it is of great interest to employ simple and practical bridges to assemble aromatic and nonaromatic nitrogen-rich heterocycles,thereby expanding the structural diversity of energetic materials,e.g.,bridged and fused nitrogen-rich ***,alkyl-bridged poly-heterocycles highlight the potential for the open chain type of energetic *** this review,the development of alkyl bridges in linking nitrogen-rich heterocycles is presented,and the perspective of the newly constructed energetic backbones is summarized for the future design of advanced energetic materials.

关键词： Energetic materials Alkyl bridge strategy Nitrogen-rich azoles Fused heterocycles Azoles

Chronic administration of triclosan leads to liver fibrosis through hepcidin-ferroportin axis-mediated iron overload

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Journal of Environmental Sciences 2024年第3期137卷 144-154页

作者： Jing Liu Lecong Zhang Fang xu ping Zhang Yang Song College of Eco-Environmental Engineering Guizhou Minzu UniversityGuiyang 550025China The Institute of Karst Wetland Ecology Guizhou Minzu UniversityGuiyang 550025China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Triclosan(TCS)has been manufactured as an antibacterial compound for half a ***,it is widely used in various personal care products;however,its potential adverse effects raise a lot of ***,we create a long-term oral administration mouse model and identify the corresponding hepatotoxicity of *** discover that daily intragastric administration of 10 mg/kg TCS to mice for 12 weeks results in severe hepatic *** study displays that hepatic iron increased 18%,23%and 29%upon oral TCS treatment for4,8 and 12 weeks,*** by hepatic iron variation,splenic and duodenal iron are increased,which indicates systemic iron *** only excessive iron accumulated in the liver,abnormal hepatic malondialdehyde,prostaglandin synthase 2 and glutathione peroxidase 4 are pointed to *** study uncovers that hepcidin expression increases 7%,10%,4%in serum and 2.4-,4.8-,and 2.3-fold on transcriptional levels upon TCS exposure for 4,8 and 12 weeks,*** together,the mice in the TCS-treated group show disordered systemic iron homeostasis via the upregulated hepatic hepcidin-ferroportin ***,both hepatic iron overload(systemic level)and hepatocyte ferroptosis(cellular level)are accused of TCS-induced liver ***■,an iron scavenger,significantly ameliorates TCS-induced liver *** summary,this study confirms the impact of TCS on liver fibrosis;a critical signal pathway is also *** significance of the current study is to prompt us to reevaluate the“pros and cons”of TCS applications.

关键词： Triclosan Iron metabolism Hepcidin Hepatotoxicity Liver fibrosis

Brominated flame retardants in surface sediment from Western Guangdong,South China:Occurrence,distribution and toxicity in Caenorhabditis elegans

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Journal of Environmental Sciences 2024年第11期145卷 97-106页

作者： Xiaoxia Chen ping ding Haibo Chen Tingzhen Li Min Zhang Yunjiang Yu Guocheng Hu State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment South China Institute of Environmental SciencesMinistry of Ecology and EnvironmentGuangzhou 510655China Institute for Environmental pollution and health School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China Chongqing Key Laboratory of Water Environment Evolution and Pollution Control in Three Gorges Reservoir Chongqing Three Gorges UniversityChongqing 404000China

Sediment is the ultimate sink of environmental pollutants.A total of 128 surface sediment sampleswere collected from8 rivers and 3 reservoirs in Maoming City,Guangdong *** study assessed the content and distribution of brominated flame retardants in *** acute toxicity effects of tetrabromobisphenol A(TBBPA)and hexabromocyclododecane(HBCDs)in sediments were evaluated using Caenorhabditis elegans as model *** concentration of TBBPA in sediments ranged from not detected(ND)to 12.59μg/kg andwas mainly distributed in the central area,whichwas affected by the emission of TBBPA from residential and *** concentration of HBCDs ranged from ND to 6.31μg/kg,and the diastereoisomer distribution was consistent,showing a trend close to the South China *** composition pattern of HBCDs in the surface sediments from rivers were 41.73%-62.33%,7.89%-25.54%,and 18.76%-40.65%forα-,β-,andγ-HBCD,respectively,and in the sediments from reservoirs were 26.15%-45.52%,7.44%-19.23%,and 47.04%-61.89%forα-,β-,andγ-HBCD,*** the sum of concentrations of TBBPA and HBCD in sediments were above high levels,reactive oxygen species in nematodes significantly increased,resulting in an oxidative stress *** permeabilitywas also enhanced,causing intestinal *** addition,in terms of this study,TBBPA had a greater impact on biotoxicity compared to HBCDs,and more attention should be paid to the toxic effects of the river ecosystem organisms in Maoming City,Guangdong *** study can complement the pollution database in the study area and provide basic data for pollution control.

关键词： Tetrabromobisphenol A(TBBPA) Hexabromocyclododecane(HBCDs) Sediment Caenorhabditis elegans Biotoxicity

Factors affecting meibomian gland area loss in symptomatic adults

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1036-1041页

作者： Si-Cheng ding Jing-Jing Su Qing Zhan Jiao-Man Wang Fang Zheng xu-xuan Fang Dan Cheng ping Guo The Second Clinical Medical College Jinan UniversityShenzhen 518000Guangdong ProvinceChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina Department of Ophthalmology Jinzhou Medical UniversityJinzhou 121000Liaoning ProvinceChina

AIM:To characterize the distribution of meibomian gland(MG)area loss(MGL)and its relationship with demographic characteristics,mites,and ***:This retrospective observational study included patients who visited the Dry Eye Clinic of Shenzhen Eye Hospital between June 2020 and August *** patient characteristics,ocular symptoms,Demodex test results of the eyelid edges,and the results of a comprehensive ocular surface analysis were *** was analyzed using Image J ***:This study enrolled 1204 outpatients aged 20-80(40.70±13.44)y,including 357 males(29.65%)and 847 females(70.35%).The patients were classified into mild(n=155;12.87%),moderate(n=795;66.03%),severe(n=206;17.11%),and extremely severe(n=48;3.99%)MGL *** was significantly larger in female than in male(P=0.006).The degree of MGL also significantly differed in age(P<0.001)and the more numbers of mites with severity(P<0.001).Multivariate disordered multinomial logistic regression analysis identified that female sex,older age,secretory symptoms,and a large number of mites were risk factors for MGL(P<0.05).CONCLUSION:Patients with MGL are more likely to be older,female,more numbers of mites,and increased secretion.

关键词： meibomianglands aging sex symptomatology Demodex

Enhancing cellular behavior in repaired tissue via silk fibroin-integrated triboelectric nanogenerators

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Microsystems & Nanoengineering 2024年第3期10卷 137-147页

作者： Zhelin Li Shuxing xu Zijie xu Sheng Shu Guanlin Liu Jianda Zhou ding Lin Wei Tang Changsha Aier Eye Hospital Aier School of OphthalmologyCentral South UniversityChangshaHunanChina The Xiangya Hospital Central South UniversityChangshaHunanChina Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China Center on Nanoenergy Research School of Physical Science&TechnologyGuangxi UniversityNanning 530004China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Plastic Surgery the Third Xiangya HospitalChangshaHunanChina

Triboelectric nanogenerators(TENGs)have emerged as a promising approach for generating electricity and providing electrical stimuli in medical electronic *** their potential benefits,the clinical implementation of TENGs faces challenges such as skin compliance and a lack of comprehensive assessment regarding their biosafety and ***,further research is imperative to overcome these limitations and unlock the full potential of TENGs in various biomedical *** this study,we present a flexible silk fibroin-based triboelectric nanogenerator(SFB-TENG)that features an on-skin substrate and is characterized by excellent skin compliance and air/water *** range of electrical output generated by the SFB-TENG was shown to facilitate the migration and proliferation of Hy926,NIH-3T3 and RSC96 ***,apoptosis of fibroblast NIH-3T3 cells was observed when the output voltage increased to more than 20 V at a frequency of 2 *** addition,the moderate electrical stimulation provided by the SFB-TENG promoted the cell proliferation cycle in Hy926 *** research highlights the efficacy of a TENG system featuring a flexible and skin-friendly design,as well as its safe operating conditions for use in biomedical *** findings position TENGs as highly promising candidates for practical applications in the field of tissue regeneration.

关键词： overcome spite generating

Analysis on the causes of massive stranding of Yellow Sea green tide on Lianyungang and Rizhao coasts in 2022

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Journal of Oceanology and Limnology 2024年第3期42卷 816-830页

作者： Lingjuan WU Juan HUANG Yi ding Guiyan LIU Shuai HUANG Song GAO Chao YUAN Jiangling xu ping WU Rui HUANG Ruobing WEN Jie MEI North China Sea Marine Forecasting and Hazard Mitigation Center Ministry of Natural ResourcesQingdao 266061China Shandong Key Laboratory of Marine Ecological Environment and Disaster Prevention and Mitigation Qingdao 266061China National Engineering Laboratory for Integrated Aero-Space-Ground-Ocean Big Data Application Technology Xi’an 710129China East China Sea Marine Forecasting and Hazard Mitigation Center Ministry of Natural ResourcesShanghai 200136China North China Sea Ecological Center Ministry of Natural ResourcesQingdao 266033China

In 2022,Yellow Sea green tide caused by Ulva prolifera reached a historic minimum and the coastal areas of Shandong Peninsula were less ***,the largest amount of seaweed biomass has been washed ashore on Lianyungang and Rizhao coasts since *** studied the development pattern of Yellow Sea green tide in 2022,and analyzed the key environmental factors on the growth and drifting,then discussed the possible reasons that resulted in the massive stranding of green tide biomass in Lianyungang and *** show under the combined influence of the east to southeast winds and currents with shoreward anomalies,green tide drifted to the coastal waters between Shandong and Jiangsu provinces and the distribution areas located westward compared with previous years(2008–2021).Floating *** rafts from the coastal waters of Binhai and Sheyang drifted continuously into the coastal waters of Lianyungang and Rizhao,providing important supplements for Yellow Sea green *** green tide in 2022 distributed close to the coastal waters,the abundant nutrients might support their continuous high growth *** addition,the amount of rainfall around Shandong Peninsula from late June to early July were significantly higher than in previous years,which might promote the development of green tide to some extent.

关键词： Yellow Sea green tide stranding biomass development pattern environmental factor

Heat distribution model under hydrogen-rich low-carbon conditions in blast furnace

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Journal of Iron and Steel Research International 2024年第3期31卷 584-594页

作者： Gang Wang Jun xu Kun He Zhong-ping Zou Hao Bai School of Metallurgy and Ecological Engineering University of Science and Technology BeijingBeijing 100083China CISDI Low-Carbon Blast Furnace Research Office MCC Low-Carbon Technology Research InstituteChongqing 401122China

Low carbon development of blast furnaces is one of the key technological directions in the current development of *** to the differences in the physical and chemical properties of hydrogen and carbon,hydrogen-rich media entering a blast furnace will change the heat distribution,thus affecting the stability of ***,a heat distribution model was proposed to study the temperature distribution in a blast furnace,simultaneously considering gas-solid heat exchange,slag and iron melting,and chemical *** model was used to analyze the temperature distribution of a 2300 m^(3) blast furnace and was verified via comparison with actual production ***,the effects of the injection rate of hydrogen-rich media,H2 concentration,and oxygen enrichment rate of the blast on the temperature distribution were *** indicated that the increase in the injection rate of the hydrogen-rich media decreased the amount of direct reduction and led to an increase in the furnace ***,an increase in the oxygen enrichment rate led to a decrease in the furnace temperature,but could reduce the solid fuel ratio,while the change in H2 concentration had less effect on the temperature *** combination of hydrogen-rich media injection and the increase in the oxygen enrichment rate would help to adjust the temperature distribution to the same level as the conventional blast furnace conditions.

关键词： Heat distribution Blast furnace Low-carbon condition Hydrogen enrichment Calculation model

Effects of diamond particle size on microstructure and properties of diamond/Al-12Si composites prepared by vacuum-assisted pressure infiltration

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China Foundry 2024年第4期21卷 360-368页

作者： Jia-ping Fu Can-xu Zhou Guo-fa Mi Yuan Liu School of Materials Science and Engineering Henan Polytechnic UniversityJiaozuo 454100HenanChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

Diamond/aluminium composites have attracted attention in the field of thermal management of electronic packaging for their excellent *** order to solve the interfacial problem between diamond and aluminium,a novel process combining pressure infiltration with vacuum-assisted technology was proposed to prepare diamond/aluminum *** effect of diamond particle size on the microstructure and properties of the diamond/Al-12Si composites was *** results show that the diamond/Al-12Si composites exhibit high relative density and a uniform *** thermal conductivity and coefficient of thermal expansion increase with increasing particle size,while the bending strength exhibits the opposite *** the average diamond particle size increases from 45μm to 425μm,the thermal conductivity of the composites increases from 455 W·m^(-1)·K^(-1)to 713 W·m^(-1)·K^(-1)and the coefficient of thermal expansion increases from 4.97×10^(-6)K^(-1)to 6.72×10^(-6)K^(-1),while the bending strength decreases from 353 MPa to 246 *** research demonstrates that high-quality composites can be prepared by the vacuum-assisted pressure infiltration process and the thermal conductivity of the composites can be effectively improved by increasing the diamond particle size.

关键词： diamond/aluminum composites thermal conductivity electronic packaging vacuum-assisted pressure infiltration

Silencing MFN2 Drives WNT/β-catenin Nucleation to Reduce Sorafenib Sensitivity in Hepatocellular Carcinoma Cells

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Current Medical Science 2024年第4期44卷 789-798页

作者： Chai-ming ZENG Bin SHAO Yan-ping CHEN Gui-sheng ding Department of Geriatric Medicine Shengli Clinical Medical College of Fujian Medical UniversityFujian Key Laboratory of Geriatrics DiseasesFujian Provincial Center for GeriatricsFujian Provincial HospitalFuzhou350001China Department of Rehabilitation Shengli Clinical Medical College of Fujian Medical UniversityFujian Provincial HospitalFuzhou350001China Department of Gynecology Shengli Clinical Medical College of Fujian Medical UniversityFujian Provincial HospitalFuzhou350001China Department of Ultrasonography Shengli Clinical Medical College of Fujian Medical UniversityFujian Provincial HospitalFuzhou350001China

Objective Mitofusin-2(MFN2)is a mitochondrial membrane protein that plays a critical role in regulating mitochondrial fusion and cellular *** further elucidate the impact of MFN2,this study aimed to investigate its significance on hepatocellular carcinoma(HCC)cell function and its potential role in mediating *** This study investigated the effects of silencing and overexpressing MFN2 on the survival,proliferation,invasion and migration abilities,and sorafenib resistance of MHCC97-L HCC *** experiments were conducted using XAV939(aβ-catenin inhibitor)and HLY78(aβ-catenin activator)to further validate these *** Silencing MFN2 significantly promoted the survival and proliferation of MHCC97-L cells,enhanced their invasion and migration capacities,increased the IC50 of sorafenib,reduced the percentage of TUNEL-positive cells,and decreased the expression of proapoptotic ***,silencing MFN2 markedly induced the nuclear translocation ofβ-catenin,increasedβ-catenin acetylation levels and enhanced the expression of the downstream regulatory proteins Snail1 and Vimentin while inhibiting E-cadherin ***,overexpressing MFN2 reversed the effects observed in MHCC97-L cells mentioned *** results confirmed that silencing MFN2 activated theβ-catenin/epithelial-mesenchymal transition(EMT)pathway and reduced the sensitivity of cells to sorafenib,which could be reversed by XAV939 ***,overexpression of MFN2 inhibited theβ-catenin/EMT pathway and increased the sensitivity of cells to sorafenib,which could be altered by *** Low expression of MFN2 in HCC cells promotes the nuclear translocation ofβ-catenin,thereby activating the EMT pathway and mediating resistance to sorafenib.

关键词： mitofusin-2 epithelial-mesenchymal transition sorafenib resistance apoptosis hepatocellular carcinoma