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Recent advances in the extended finite element method (XFEM) and isogeometric analysis (IGA)

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Science China(Physics,Mechanics & Astronomy) 2016年第12期59卷 80-81页

作者： dandan xu ZhanLi Liu Zhuo Zhuang School of Aerospace Engineering Tsinghua University

The finite element method （FEM） is one of the most popular and efficient methods for computational modeling in scien- tific research and engineering . To expand its application to more complex problems, lots of new ... 详细信息

关键词： XFEM IGA Recent advances in the extended finite element method and isogeometric analysis

Study on interaction between induced and natural fractures by extended finite element method

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Science China(Physics,Mechanics & Astronomy) 2017年第2期60卷 24-37页

作者： dandan xu ZhanLi Liu Zhuo Zhuang QingLei Zeng Tao Wang School of Aerospace Engineering Tsinghua University Beijing 100084 China

Fracking is one of the kernel technologies in the remarkable shale gas revolution. The extended finite element method is used in this paper to numerically investigate the interaction between hydraulic and natural fractures, which is an important issue of the enigmatic fracture network formation in fracking. The criteria which control the opening of natural fracture and crossing of hydraulic fracture are tentatively presented. Influence factors on the interaction process are systematically analyzed, which include the approach angle, anisotropy of in-situ stress and fluid pressure profile.

关键词： hydraulic fracturing natural fracture interaction criterion fluid pressure extended finite element method

Modeling stationary and moving cracks in shells by X-FEM with CB shell elements

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Science China(Technological Sciences) 2014年第7期57卷 1276-1284页

作者： ZENG QingLei LIU ZhanLi xu dandan ZHUANG Zhuo School of Aerospace Tsinghua University

The continuum-based(CB)shell theory is combined with the extended finite element method(X-FEM)in this paper to model crack propagation in shells under static and dynamic *** jump function and asymptotic crack tip solution are adopted for describing the discontinuity and singularity of the crack in *** set method(LSM)is used to represent the crack surface and define the enriched shape *** intensity factors(SIFs)are calculated by the displacement interpolation technique to prove the capability of the method and the maximum strain is applied for the fracture ***,an efficient integration scheme for the CB shell element with cracks is proposed.

关键词： CB shell element X-FEM level set method crack propagation

The Hidden-Layers Topology Analysis of Deep Learning Models in Survey for Forecasting and Generation of the Wind Power and Photovoltaic Energy

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Computer Modeling in Engineering & Sciences 2022年第5期131卷 567-597页

作者： dandan xu Haijian Shao Xing Deng Xia Wang School of Computer Jiangsu University of Science and TechnologyZhenjiang212003China School of Automation Key Laboratory of Measurement and Control for CSEMinistry of EducationSoutheast UniversityNanjing210096China School of Information Science and Technology Nantong UniversityNantong226019China

As wind and photovoltaic energy become more prevalent,the optimization of power systems is becoming increasingly *** current state of research in renewable generation and power forecasting technology,such as wind and photovoltaic power(PV),is described in this paper,with a focus on the ensemble sequential LSTMs approach with optimized hidden-layers topology for short-term multivariable wind power *** methods for forecasting wind power and PV *** physical model,statistical learningmethod,andmachine learning approaches based on historical data are all evaluated for the forecasting of wind power and PV ***,the experiments demonstrated that cloud map identification has a significant impact on PV *** a focus on the impact of photovoltaic and wind power generation systems on power grid operation and its causes,this paper summarizes the classification of wind power and PV generation systems,as well as the benefits and drawbacks of PV systems and wind power forecasting methods based on various typologies and analysis methods.

关键词： Deep learning wind power forecasting PV generation and forecasting hidden-layer information analysis topology optimization

Decoding the Molecular Mechanisms of BRAFV600E-Induced Nevi Formation

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Biomedical and Environmental Sciences 2024年第7期37卷 774-784页

作者： Weizheng Liang Yuxuan Liu dandan xu Wenjie Jiang Rensen Ran Central Laboratory The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000HebeiChina Institute of Molecular Immunology School of Laboratory Medicine and BiotechnologySouthern Medical UniversityGuangzhou 510515GuangdongChina Department of Artificial Intelligence and Data Science Hebei University of TechnologyTianjin 300401China Department of Chemical Biology School of Life SciencesSouthern University of Science and TechnologyShenzhen 518055GuangdongChina

Melanocytes derived from neural crest cells harbor the BRAFV600E mutation,which is the predominant driver of nevus formation in *** mutation leads to malignant cell proliferation and subsequent cell cycle arrest,culminating in oncogene-induced senescence and nevus ***,emerging evidence has highlighted the heterogeneity of cellular senescence markers in BRAFV600E-induced senescent ***,the capacity of melanocytes within nevi to regain their proliferative ability raises questions about the molecular mechanisms by which BRAFV600E,via the mitogen-activated protein kinase signaling pathway,triggers nevus *** study provides an overview and discussion of the molecular mechanisms underpinning BRAFV600E-induced melanocyte nevus formation and the relevant animal models employed for their *** also highlights the significance of elucidating dynamic changes in cytoplasmic and nuclear substrates that interact with phosphorylated extracellular signal-regulated protein kinases 1 and 2 and underscores the value of using targeted BRAFV600E animal models created through gene editing technologies.

关键词： BRAFV600E Melanocytes Nevi Oncogene-induced senescence Animal models

ENRICHED GOAL-ORIENTED ERROR ESTIMATION APPLIED TO FRACTURE MECHANICS PROBLEMS SOLVED BY XFEM

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Acta Mechanica Solida Sinica 2012年第4期25卷 393-403页

作者： Zhijia Lin Zhuo Zhuang Xiaochuan You Heng Wang dandan xu Applied Mechanics Lab. School of AerospaceTsinghua UniversityBeijing 100084China

Based on the concept of constitutive relation error along with the residual of both origin and dual problems, a goal-oriented error estimation method with extended degrees of freedom is developed in this paper. It leads to high quality local error bounds in the problem of fracture mechanics simulation with extended finite element method （XFEM）, which involves enrichment to solve a stress singularity in the crack. Since goal-oriented error estimation with enriched degrees of freedom gives us a chance to evaluate the XFEM simulation, the stress intensity factor calculated by two kinds of XFEM programs developed by ourselves and by commercial code ABAQUS are compared in this work. By comparing the reliability of the stress intensity factor calculation, the accuracy of two programs in different cases is evaluated and the source of error is discussed. A 2-dimensional XFEM example is given to illustrate the computational procedure.

关键词： goal-oriented error estimation extended finite element method fracture mechanics error bounds

Expression Pattern of Peptide and Amino Acid Genes in Digestive Tract of Transporter Juvenile Turbot(Scophthalmus maximus L.)

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Journal of Ocean University of China 2016年第2期15卷 334-340页

作者： xu dandan HE Gen MAI Kangsen ZHOU Huihui xu Wei SONG Fei Key Laboratory of Aquanutrition of Ministry of Agriculture Ocean University of China

Turbot(Scophthalmus maximus L.),a carnivorous fish species with high dietary protein requirement,was chosen to examine the expression pattern of peptide and amino acid transporter genes along its digestive tract which was divided into six segments including stomach,pyloric caeca,rectum,and three equal parts of the remainder of the *** results showed that the expression of two peptide and eleven amino acid transporters genes exhibited distinct *** transporter 1(Pep T1) was rich in proximal intestine while peptide transporter 2(PepT2) was abundant in distal intestine.A number of neutral and cationic amino acid transporters expressed richly in whole intestine including B^0-type amino acid transporter 1(B^0AT1),L-type amino acid transporter 2(LAT2),T-type amino acid transporter 1(TAT1),proton-coupled amino acid transporter 1(PAT1),y^+L-type amino acid transporter 1(y^+LAT1),and cationic amino acid transporter 2(CAT2) while ASC amino acid transporter 2(ASCT2),sodium-coupled neutral amino acid transporter 2(SNAT2),and y^+L-type amino acid transporter 2(y^+LAT2) abundantly expressed in *** addition,system b^(0,+) transporters(rBAT and b^(0,+)AT) existed richly in distal *** findings comprehensively characterized the distribution of solute carrier family proteins,which revealed the relative importance of peptide and amino acid absorption through luminal *** findings are helpful to understand the mechanism of the utilization of dietary protein in fish with a short digestive tract.

关键词： turbot digestive tract amino acid peptide transporter expression pattern

Highly Sensitive Pseudocapacitive Iontronic Pressure Sensor with Broad Sensing Range

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Nano-Micro Letters 2021年第9期13卷 209-222页

作者： Libo Gao Meng Wang Weidong Wang Hongcheng xu Yuejiao Wang Haitao Zhao Ke Cao dandan xu Lei Li School of Mechano-Electronic Engineering Xidian UniversityXian 710071ShaanxiP.R.China CityU-Xidian Joint Laboratory of Micro/Nano-Manufacturing Shenzhen 518057P.R.China Department of Mechanical Engineering City University of Hong KongKowloon 999077Hong Kong SARP.R.China Materials Interfaces Center Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongP.R.China State Key Laboratory for Mechanical Behavior of Materials Xian Jiaotong UniversityNo.28Xianning West RoadXian 710049ShaanxiP.R.China

Flexible pressure sensors are unprecedentedly studied on monitoring human physical activities and ***,improving the response sensitivity and sensing range of flexible pressure sensors is a great challenge,which hinders the devices’practical *** this obstacle,we developed a Ti_(3)C_(2)T_(x)-derived iontronic pressure sensor(TIPS)by taking the advantages of the high intercalation pseudocapacitance under high pressure and rationally designed structural *** achieved an ultrahigh sen-sitivity(S_(min)>200 kPa^(−1),S_(max)>45,000 kPa^(−1))in a broad sensing range of over 1.4 MPa and low limit of detection of 20 Pa as well as stable long-term working durability for 10,000 *** practical application of TIPS in physical activity monitoring and flexible robot manifested its versatile *** study provides a demonstration for exploring pseudocapacitive materials for building flexible iontronic sensors with ultrahigh sensitivity and sensing range to advance the development of high-performance wearable electronics.

关键词： Iontronic sensor Flexible electronics Pressure sensor Pseudocapacitance Ti_(3)C_(2)T_(x)MXene

Gain-of-function mutant p53 in cancer progression and therapy

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Journal of Molecular Cell Biology 2020年第9期12卷 674-687页

作者： Cen Zhang Juan Liu dandan xu Tianliang Zhang Wenwei Hu Zhaohui Feng 1Department of Radiation Oncology Rutgers Cancer Institute of New JerseyRutgers-State University of New JerseyNew BrunswickNJ 08903USA

p53 is a key tumor suppressor,and loss of p53 function is frequently a prerequisite for cancer *** p53 gene is the most frequently mutated gene in human cancers;p53 mutations occur in>50%of all human cancers and in almost every type of human *** of p53 mutations in cancers are missense mutations,which produce the full-length mutant p53(mutp53)protein with only one amino acid difference from wild-type p53 *** addition to loss of the tumor-suppressive function of wild-type p53,many mutp53 proteins acquire new oncogenic activities independently of wild-type p53 to promote cancer progression,termed gain-of-function(GOF).Mutp53 protein often accumulates to very high levels in cancer cells,which is critical for its *** the high mutation frequency of the p53 gene and the GOF activities of mutp53 in cancer,therapies targeting mutp53 have attracted great *** understanding the mechanisms underlying mutp53 protein accumulation and GOF will help develop effective therapies treating human cancers containing *** this review,we summarize the recent advances in the studies on mutp53 regulation and GOF as well as therapies targeting mutp53 in human cancers.

关键词： tumor suppressor p53 mutation gain-of-function tumorigenesis cancer therapy