检索结果-南通市图书馆

Synthesis and Properties of Ferrocene Conjugated Macrocycles with Illusory Topology of the Penrose Stairs

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2024年第5期40卷 881-886页

作者： xu Jindong LAN Bin ZHU Lingyun xu Hui CHEN Xinyu LI Wenjuan YUAN Yaofeng YAN Jianfeng LI Yuanming Key laboratory of Molecule Synthesis and Function Discovery(Fujian Province university) College of ChemistryFuzhou UniversityFuzhou350108P.R.China Henan Key laboratory of biomolecular Recognition and Sensing College of Chemistry and Chemical EngineeringShangqiu Normal UniversityShangqiu476000P.R.China

Polyferrocene macrocycles hold immense potential in the fields of molecular electronics and electrochemistry,primarily due to their multiple metal ***,developing highly efficient synthetic strategies for constructing these rings remains a significant *** this study,we successfully synthesized triferrocenyl macrocycles using Pt-mediated coupling strategy and determined their configuration using single-crystal X-ray diffraction analysis,revealing a structure reminiscent of the Penrose *** comprehensively investigated the macrocycle’s structure,photophysical properties,and employed density functional theory(DFT)calculations to gain further ***,this macrocycle exhibits several advantageous features,including a flexible structure,good solubility,and a highly efficient synthetic pathway.

关键词： Conjugated macrocycle Organometallic macrocycle Pt-template method

Hybridization chain reaction-based DNA nanomaterials for biosensing,bioimaging and therapeutics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第2期35卷 223-231页

作者： Zhaoyue Lv Mengxue Huang Peiran Li Mengdi xu Chi Yao Dayong Yang Frontiers Science Center for Synthetic Biology Key Laboratory of Systems Bioengineering (MOE)Institute of Biomolecular and Biomedical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Zhejiang Institute of Tianjin university Ningbo 315201China

DNA nanomaterials hold great promise in biomedical fields due to its excellent sequence programmability,molecular recognition ability and *** chain reaction(HCR)is a simple and efficient isothermal enzyme-free amplification strategy of DNA,generating nicked double helices with repeated *** the design of HCR hairpins,multiple nanomaterials with desired functions are assembled by DNA,exhibiting great potential in biomedical ***,the recent progress of HCR-based DNA nanomaterials for biosensing,bioimaging and therapeutics are *** works are exemplified to demonstrate how HCR-based DNA nanomaterials are designed and *** challenges and prospects of the development of HCR-based DNA nanomaterials are *** envision that rationally designing HCR-based DNA nanomaterials will facilitate the development of biomedical applications.

关键词： DNA nanotechnology Hybridization chain reaction DNA nanomaterials Biosensing Bioimaging Therapeutics

Membrane tension evolution and mechanical regulation of melittin-induced membrane poration

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第10期33卷 465-475页

作者： Wanting Zhang Rong xu Wendong Ma Zhao Lin Kai Yang Bing Yuan Center for Soft Condensed Matter Physics and Interdisciplinary Research&School of Physical Science and Technology Soochow UniversitySuzhou 215006China Songshan Lake Materials laboratory Dongguan 523808China Biomedicine Discovery Institute Infection&Immunity ProgramMonash UniversityMelbourneAustralia Beijing national laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Membrane tension plays a crucial role in various fundamental cellular processes,with one notable example being the T cell-mediated elimination of tumor cells through perforin-induced membrane perforation by amplifying cellular ***,the mechanisms governing the regulation of biomolecular activities at the cell interface by membrane tension remain *** this study,we investigated the correlation between membrane tension and poration activity of melittin,a prototypical pore-forming peptide,using dynamic giant unilamellar vesicle leakage assays combined with flickering tension analysis,molecular dynamics simulations,and live cell *** results demonstrate that an increase in membrane tension enhances the activity of melittin,particularly near its critical pore-forming ***,peptide actions such as binding,insertion,and aggregation in the membrane further influence the evolution of membrane *** cell experiments reveal that artificially enhancing membrane tension effectively enhances melittin’s ability to induce pore formation and disrupt membranes,resulting in up to a ten-fold increase in A549 cell mortality when exposed to a concentration of 2.0-μg·mL^(-1)*** findings elucidate the relationship between membrane tension and the mechanism of action as well as pore-forming efficiency of melittin,while providing a practical mechanical approach for regulating functional activity of molecules at the cell-membrane interface.

关键词： membrane tension mechanical regulation membrane poration giant unilamellar vesicle leakage assay

Interaction between tetrasulfophthalocyanines and colloidal titanium dioxide and photoelectric behavior on sensitized microporous TiO_2.electrodes

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1997年第17期42卷 1447-1451页

作者： MAO Haifang, TIAN Hongjian, ZHOU Qingfu, xu Huijun, SHEN Yaochun and LU Zuhong Institute of Photographic Chemistry, Chinese Academy of Sciences, Beijing 100101, China national {2. of {2. and {3..electronics, southeast university, nanjing 2.0096, China Institute of Photographic Chemistry Chinese Academy of Sciences Beijing China national laboratory of {2. and {3..electronics Southeast University Nanjing China

THE photosensitization of wide-band gap semiconductors using organic dyes is the subject of

关键词： phthalocyanine titanium dioxide nanoparticle sensitization.

Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第7期9卷 2936-2952页

作者： Liang Zhao Yizhen Pang Yangfan Zhou Jianhao Chen Hao Fu Wei Guo Weizhi xu Xin xue Guoqiang Su Long Sun Hua Wu Jingjing Zhang Zhanxiang Wang Qin Lin Xiaoyuan Chen Haojun Chen Department of Nuclear Medicine and Minnan PET Center Xiamen Key Laboratory of RadiopharmaceuticalsThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingaporeSingapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Radiation Oncology Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Colorectal Tumor Surgery Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Cardiothoracic Surgery Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingChina Nanomedicine Translational Research Program NUS Center for NanomedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Neurosurgery and Department of Neuroscience Fujian Key Laboratory of Brain Tumors Diagnosis and Precision TreatmentXiamen Key Laboratory of Brain Centerthe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Institute of molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Xiamen Key laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamenChina

Radiotherapy combined with immune checkpoint blockade holds great promise for synergistic antitumor *** radionuclide therapy delivers radiation directly to tumor ***1004 is a fibroblast activation protein(FAP)-targeting radiopharmaceutical,conjugated with the albumin binder Evans Blue,which has demonstrated enhanced tumor uptake and retention in previous preclinical and clinical ***,we demonstrate that^(68)Ga/^(177)Lu-labeled LNC1004 exhibits increased uptake and prolonged retention in MC3..NIH3..-FAP and CT2./NIH3..-FAP tumor *** therapy with^(177)Lu-LNC1004 induced a transient upregulation of PD-L1 expression in tumor *** combination of^(177)Lu-LNC1004 and anti-PD-L1 immunotherapy led to complete eradication of all tumors in MC3..NIH3..-FAP tumor-bearing mice,with mice showing 100%tumor rejection upon ***,single-cell RNA sequencing(scRNA-seq),and TCR sequencing revealed that combination therapy reprogrammed the tumor microenvironment in mice to foster antitumor immunity by suppressing malignant progression and increasing cell-to-cell communication,CD8^(+)T-cell activation and expansion,M1 macrophage counts,antitumor activity of neutrophils,and T-cell receptor diversity.A preliminary clinical study demonstrated that^(177)Lu-LNC1004 was well-tolerated and effective in patients with refractory ***,scRNA-seq of peripheral blood mononuclear cells underscored the importance of addressing immune evasion through immune checkpoint blockade *** was emphasized by the observed increase in antigen processing and presentation juxtaposed with T cell *** conclusion,our data supported the efficacy of immunotherapy combined with^(177)Lu-LNC1004 for cancer patients with FAP-positive tumors.

关键词： immunity retention holds

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

自组装生物分子软物质材料及其物理特性

物理学报 2024年第17期73卷 14-27页

作者：韩旭薛斌曹毅王炜南京大学物理学院固体微结构国家重点实验室南京210093 南京大学脑科学研究院南京210093

自组装生物分子软物质材料是以生物分子或生物分子基元为构建单元,通过自组织过程形成的一类新型软物质材料.因其组成单元的生物特性和其中弱相互作用驱动组装的特征,这类材料通常具有高度生物相容性、可逆组装、动态响应和微结构可控... 详细信息

自组装生物分子软物质材料是以生物分子或生物分子基元为构建单元,通过自组织过程形成的一类新型软物质材料.因其组成单元的生物特性和其中弱相互作用驱动组装的特征,这类材料通常具有高度生物相容性、可逆组装、动态响应和微结构可控性等优势,在生物医学、组织工程和柔性传感等领域中被广泛关注并得到了相关研发和应用.本文简要介绍自组装生物分子软物质材料的基本构建原理和物理特性,并以氨基酸、多肽分子等组装单元为例,对三类自组装生物分子软物质材料(纳米材料、凝胶材料和复合材料)的自组装分子机制、材料构建思路、力学特性和功能应用场景做了具体阐述.我们认为自组装生物分子软物质材料的研究,将从结构单元的发掘和相关特性的表征,向多功能性质定制与前端应用集成方向发展,从而研发出崭新的复合智能生物软物质材料,进一步促进其在生物医学、有机半导体和软体机器人等新兴领域中的应用.

关键词：软物质生物分子多肽组装水凝胶力学特性

维普期刊数据库博看期刊

在线全文

学校读者我要写书评

暂无评论

液相电子显微镜解析高分子动态过程

高分子学报 2024年第2期55卷 235-254页

作者：张德逸李佳烨许准王欢北京大学化学与分子工程学院北京分子科学国家研究中心教育部高分子化学与物理重点实验室北京100871

电子显微镜被广泛用于表征高分子的形态、晶态结构、机械性质及组装行为,其在溶液态高分子的动态过程研究的应用中刚刚起步.近年来,由于在电镜真空腔中能稳定封存液体样品的纳米技术的发展以及对电子束与样品的作用机制的逐渐清晰,液相... 详细信息

电子显微镜被广泛用于表征高分子的形态、晶态结构、机械性质及组装行为,其在溶液态高分子的动态过程研究的应用中刚刚起步.近年来,由于在电镜真空腔中能稳定封存液体样品的纳米技术的发展以及对电子束与样品的作用机制的逐渐清晰,液相电镜实验实现了对溶液态高分子的高时空分辨、原位、实时、时空的“分子录影”.单分子原位成像实验提供了新的机遇去探索被传统系综测量掩盖的分子动力学行为.我们总结了液相电镜技术在高分子单链物理性质、单分子反应、组装体与组装行为、相分离等领域的研究进展,阐述了其中实验难点以及核心技术突破,详细讨论了电子束与样品相互作用和单分子成像实验揭示的关于高分子科学的新现象、新问题和新思考.最后,展望了突破目前纳米级空间分辨率和百毫秒时间分辨率可行的方案、面临的挑战和所需的技术支持,以及该目标实现后将给我们带来新的研究机遇.

关键词：液相电镜高分子动力学单分子成像图像处理

Nanostructured ZnO for biosensing applications

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2013年第21期58卷 2563-2566页

作者： xu chunxiang YANG Chi GU BaoXiang FANG ShengJiang State Key laboratory of Bioelectronics School of Electronic Science and Engineering Southeast University Department of Resources and Environment Engineering Henan Institute of Engineering

Based on the unique properties, nanostructured ZnO could provide a stable immobilization for biomolecules retaining their biological activity. It has been recently developed as a nice candidate for the construction of biosensors with enhanced analytical performance. In this paper, we reviewed the progress in adapting nanostructured ZnO for several predominantly in biosensing applications based on enzymic reaction, immunoreaction, and molecular compitation. We also described several important considerations when working with nanostructured ZnO mainly centered on the fabrications of ZnO and appropriate strategies for biosensor construction (e.g. modified electrodes and multilayered immobilization).

关键词：生物传感器纳米ZnO 应用纳米氧化锌生物分子生物活性纳米结构修饰电极

Spectral behavior of 8-hydro-xyquinoline aluminum in nanometer-sized holes of porous alumina

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2001年第21期46卷 1839-1841页

作者： xu chunxiang xuE Qinghua BA Long ZHAO Bing GU Ning GUI Yiping Department of Electronic Engineering Southeast UniversityNanjing 210096China national laboratory of {2. and {3..electronics Southeast UniversityNanjing 210096China

The porous alumina have been prepared by anodization and an organic molecule 8-hydroxyquinoline aluminum (Alq3..has been impregnated in the pores. The morphology measured through atomic force microscopy shows that the size of the pores is about 10 nm. A blue-shift photoluminescence of Alq3..n nanometer-sized hole is close to that of the monomers. The measured spectral characteristics demonstrate the limitation of the porous alumina to the emission of Alq3.

关键词： porous alumina nanometer blue-shift dimer monomer.