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氧化锌纳米粒子与叶绿素a相互作用机制

发光学报 2008年第3期29卷 591-595页

作者：乔虹桥高伟吉徐长山刘玉学陈雪莲徐洪图宁月辉李亚军刘益春东北师范大学先进光电子功能材料研究中心吉林长春130024 通化师范学院物理系吉林通化130002

通过测量叶绿素a苯溶液中加入溶胶-凝胶法制备的氧化锌纳米粒子后的紫外-可见吸收光谱、荧光光谱的变化,研究得出两者通过静电作用相结合,而且由于氧化锌的导带顶低于叶绿素a的第一激发态能级,所以能够产生界面电荷转移,表现在叶绿素a... 详细信息

通过测量叶绿素a苯溶液中加入溶胶-凝胶法制备的氧化锌纳米粒子后的紫外-可见吸收光谱、荧光光谱的变化,研究得出两者通过静电作用相结合,而且由于氧化锌的导带顶低于叶绿素a的第一激发态能级,所以能够产生界面电荷转移,表现在叶绿素a溶液的特征吸收峰在加入纳米粒子后峰位向长波方向移动。用355nm波长的光激发该样品得到的荧光光谱在654nm处出现一个等发射点,并且随着氧化锌量的增多叶绿素a溶液的发光被猝灭且峰位向长波方向移动,当用433nm波长的光激发时(氧化锌在此波长下没有吸收),没有等发射点但仍有猝灭和峰位移动现象,其中猝灭现象根据Stern-Volmer关系可归结为静态猝灭。另外,向离心后得到的氧化锌纳米粒子粉末中滴加叶绿素a,发现在滴加前后其红外光谱中Zn—O键的振动峰发生变化,说明氧化锌纳米颗粒与叶绿素a分子之间存在一定的相互作用,并且可能对叶绿素光合作用产生一定负面影响。

关键词：叶绿素a ZnO纳米粒子荧光猝灭等发射点

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-chang Zeng Jun-Hong Wu Dan-Dan xu Kang He chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

北山二龙包一带加里东早期基性岩地球化学特征及构造环境分析

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资源信息与工程 2021年第2期36卷 16-18页

作者：高志杰王宇昊许常善甘肃省地质调查院甘肃兰州730000

文章以近年来地质找矿的研究热点地区——北山地区为研究地区,选取与成矿关系较为密切的加里东早期基性岩为研究对象,通过野外地质调查,地球化学样品的采集,分析其主量元素、微量元素以及硅酸盐等指标,研究了其地球化学特征。认为二龙... 详细信息

文章以近年来地质找矿的研究热点地区——北山地区为研究地区,选取与成矿关系较为密切的加里东早期基性岩为研究对象,通过野外地质调查,地球化学样品的采集,分析其主量元素、微量元素以及硅酸盐等指标,研究了其地球化学特征。认为二龙包一带加里东早期原始基性岩浆来源于上地幔源区,与蛇绿混杂岩带的形成有密切联系。

关键词：加里东早期地球化学构造环境基性岩

Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： xu Liang Ni-Hui Zhang Zhi-Lai Zhan Guang-Lu chang Yan Gao Xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

Thermo-Economic Modeling and Evaluation of Physical Energy Storage in Power System

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Journal of Thermal Science 2021年第6期30卷 1861-1874页

作者： HU shan LIU chang DING Jie xu Yujie CHEN Haisheng ZHOU xuezhi Institute of Engineering Thermophysics Chinese Academy of ScienceBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China National Energy Large Scale Physical Energy Storage Technologies R&D Center Bijie 551712China

In order to assess the electrical energy storage technologies,the thermo-economy for both capacity-type and power-type energy storage are comprehensively investigated with consideration of political,environmental and social *** for the first time,the Exergy Economy Benefit Ratio(EEBR)is proposed with thermo-economic model and applied to three different storage systems in various scenarios,including pumped storage,compressed air energy storage and flywheel energy *** impact of the total system efficiency,annual utilization hour,life time,and other key factors are also *** results show that the EEBRs of pumped storage and compressed air energy storage under peak load shaving condition and flywheel energy storage under frequency modulation service condition are all larger than zero,which means they are all thermo-economically *** extra consideration of political,environmental and social impact,the exergy cost could reduce by about 25%and the EEBR *** sensitivity analysis indicates the similarity and diversity of influence to EEBR between capacity-type and power-type energy storage *** former is that energy efficiency is the dominated factor for all three storage *** latter is that the difference of exergy benefit mode causes variety in other major *** energy-type storage system,like pumped storage and compressed air storage,the peak-to-valley price ratio is very sensitive in energy *** power-type storage system,like flywheel storage,the mileage ratio is in leading position in auxiliary service benefit by *** the three cases studied,the pumped storage has the best thermo-economy;the compressed air energy storage is the second,and the flywheel energy storage is the *** main reason is that the pumped storage has the least non-exergy cost,and flywheel has the most.

关键词： physical energy storage system thermo-economy exergy economy benefit ratio capacity-type energy storage power-type energy storage

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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Augmentation Quotients for Complex Representation Rings of Generalized Quaternion Groups

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Chinese Annals of Mathematics,Series B 2016年第4期37卷 571-584页

作者： shan chang School of Mathematics Hefei University of Technology

Abstract Denote by Qm the generalized quaternion group of order 4m. Let R（Qm） be its complex representation ring, and △（Qm） its augmentation ideal. In this paper, the author gives an explicit Z-basis for the △n... 详细信息

关键词： Generalized quaternion groups Representation ring Augmentation quotients

Measurement of Attenuation of Ultrasonic Propagating through the Thin Layer Media with Time Delay Spectrum

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Chinese Journal of Mechanical Engineering 2010年第1期23卷 129-134页

作者： WANG Xingguo chang Junjie shan Yingchun TIE Shaodong YAO Man xu Jiujun School of Materials Science and Engineering Dalian University of Technology Dalian 116024 China Transportation ＆ Logistics Engineering College Dalian Maritime University Dalian 116026 China

The ultrasonic attenuation coefficient is one of the most important acoustic parameters to character the performance of a thin layer media, but it can not be measured due to mutual superposition of multiple reflected waves at the same interface in ultrasonic testing. Ultrasonic pulse echo and lamb wave to evaluate the thin layer media can not obtain attenuation coefficient at present. In this paper, analytical method was used to study the acoustics characteristic of thin layer media with the ultrasonic echo testing. Meanwhile, the process of ultrasonic attenuation measurement was presented. Simulation and experimental investigation is focused on a thin layer of rubber. Attenuation coefficient was introduced and evaluation mathematics model was established by the two echoes cross-correlation with and without the thin layer media based on the time delay spectrum. It involved the parameters related to the acoustic properties of the thin layer media. Through calculating the sound velocity and acoustic impedance with the evaluation model, it can deduce the relation between the attenuation coefficient and the frequency. Through analyzing the simulation results, it indicated that the attenuation coefficients were invariable with the varying of the frequency. However, the attenuation coefficients increased with the frequency increasing by ultrasonic testing the thin layer of rubber. The reason was that the attenuation factor was not taken into account during the simulation. This method overcomes shortcomings that the traditional ultrasonic testing can not evaluate the thin layer media whose thickness is less than motivation wavelength. It is a new solution to study the attenuation characteristic and on-line nondestructive evaluation in the thin layer media.

关键词： ultrasonic testing the thin layer media time delay spectrum attenuation coefficient

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丽江市松褐天牛成虫的种群变动规律

西部林业科学 2016年第6期45卷 62-67页

作者：张珍荫牛存菊徐长山曾修洪蔡文翠徐萍陈鹏玉龙县森林病虫害防治检疫站云南丽江674100 丽江市森林病虫害防治检疫站云南丽江674100 华坪县森林病虫害防治检疫站云南华坪674800 永胜县森林病虫害防治检疫站云南永胜674200 云南省林业科学院云南昆明650201

2014年应用诱捕法，在丽江市玉龙县、华坪县、永胜县云南松林对松褐天牛成虫发生发展规律进行了引诱试验。结果表明，4月是华坪、永胜两个试验点松褐天牛成虫的始见期，5月为玉龙试验点松褐天牛的始见期，6月为丽江市松褐天牛成虫羽化... 详细信息

2014年应用诱捕法，在丽江市玉龙县、华坪县、永胜县云南松林对松褐天牛成虫发生发展规律进行了引诱试验。结果表明，4月是华坪、永胜两个试验点松褐天牛成虫的始见期，5月为玉龙试验点松褐天牛的始见期，6月为丽江市松褐天牛成虫羽化活动的高峰期，10月为玉龙点松褐天牛成虫活动结束，11月为华坪和永胜点松褐天牛成虫活动结束；在丽江市海拔2 000-2 600m的云南松林内，松褐天牛均有分布，随海拔的上升，松褐天牛的引诱量随之减少；林缘松褐天牛的引诱量明显高于林内；环境温度条件是影响松褐天牛成虫羽化活动的关键因子。

关键词：松褐天牛引诱种群动态云南松松材线虫病