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Clinical Analysis and Mental Health Survey of Hemophilia Carriers:a Cross-sectional Study

Current Medical Science 2024年第2期44卷 435-440页

作者： Wen WANG Li-juan JIANG Dong-yan CUI ai ZHANG Xiong WANG ai-guo LIU Qun HU Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Laboratory Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Hemophilia carriers(HCs),who are heterozygous for mutations in the clotting factor VIII/clotting factor IX gene(F8 or F9),may have a wide range of clotting factor levels,from very low,similar to afflicted males,to the upper limit of normal,and may experience mental health *** purpose of this study was to provide genetic information on mothers of hemophilia patients and to understand the clotting factor activity and phenotype of ***,we aimed to investigate the mental health status of HCs in ***:A total of 127 hemophilia mothers,including 93 hemophilia A(HA)mothers and 34 hemophilia B(HB)mothers,were enrolled in this *** distance PCR,multiplex PCR,and Sanger sequencing were used to analyze mutations in F8 or *** factor activity was detected by a one-stage clotting *** Symptom Checklist 90(SCL-90,China/Mandarin version)was given to HCs at the same time to assess their mental ***:A total of 90.6%of hemophilia mothers were diagnosed genetically as carriers,with inversion in intron 22 and missense mutations being the most common mutation types in HA and HB carriers,*** median clotting factor level in carriers was 0.74 IU/mL(ranging from 0.09 to 1.74 IU/mL)compared with 1.49 IU/mL(ranging from 0.93 to 1.89 IU/mL)in noncarriers,of which 14.3%of HCs had clotting factor levels of 0.40 IU/mL or below.A total of 53.8%(7/13)of HA carriers with low clotting factor levels(less than 0.50 IU/mL)had a history of bleeding,while none of the HB carriers displayed a bleeding *** total mean score and the global severity index of the SCL-90 for surveyed HCs were 171.00(±60.37)and 1.78(±0.59),respectively.A total of 67.7%of the respondents had psychological symptoms,with obsessive-compulsive disorder being the most prevalent and *** pooled estimates of all nine factors were significantly higher than those in the general population(P<0.05).Conclusions:The detection rate of gene mutations

关键词： hemophilia A hemophilia B mutation carrier mental health

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Dynamics and Thermodynamics of Porous HMX-like Material Under Shock

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Communications in Theoretical Physics 2009年第11期52卷 901-908页

作者： xu ai-guo ZHANG Guang-Cai ZHANG Ping PAN Xiao-Fei ZHU Jian-Shi National Key Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics P.O.Box 8009-26 Beijing 100088 China

Strong shock may induce complex processes in porous *** use the newly developed material-point-methodto simulate such processes in an HMX-like *** pick out relevant information,morphologicalcharacterization is used to treat with the temperature *** the Minkowski functional analysis the dynamics andthermodynamics of the shock wave reaction on porous HMX-like material are *** geometrical and topologicalproperties of the'hot-spots'are *** results indicate that,shocks in porous materials are not simplejump states as classically viewed,but rather are a complex sequence of compressions and *** cover abroad spectrum of *** can use coarse-grained description to the wave series.A threshold value of temperaturepresents a Turing pattern dynamical procedure.A higher porosity is generally preferred when the energetic materialneeds a higher temperature for *** technique of data analysis can be used to other physical quantities,forexample,density,particle velocity,some specific stress,*** a series of studies along the line,one may get a largequantity of information for desiring the fabrication of material and choosing shock strength according to what needed isscattered or connected'hot-spots'.

关键词：多孔材料反应热力学 HMX 动力学闵可夫斯基温度阈值数据分析技术复杂过程

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Saddlepoint Approximation Method in Reliability Analysis:A Review

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2329-2359页

作者： Debiao Meng Yipeng guo Yihe xu Shiyuan Yang Yongqiang guo Lidong Pan Xinkai guo School ofMechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu611731China Institute of Electronic and Information Engineering of UESTC in Guangdong Dongguan523808China Glasgow College University of Electronic Science and Technology of ChinaChengdu611731China Beijing Research Institute of Mechanical&Electrical Technology Ltd.Beijing100083China

The escalating need for reliability analysis(RA)and reliability-based design optimization(RBDO)within engineering challenges has prompted the advancement of saddlepoint approximationmethods(SAM)tailored for such *** article offers a detailed overview of the general SAM and summarizes the method characteristics ***,recent enhancements in the SAM theoretical framework are ***,the mean value first-order saddlepoint approximation(MVFOSA)bears resemblance to the conceptual framework of the mean value second-order saddlepoint approximation(MVSOSA);the latter serves as an auxiliary approach to the *** distinction is rooted in the varying expansion orders of the performance function as implemented through the Taylor *** the saddlepoint approximation and third-moment(SATM)and saddlepoint approximation and fourth-moment(SAFM)strategies model the cumulant generating function(CGF)by leveraging the initial random moments of the *** their optimal application domains diverge,each method consistently ensures superior relative precision,enhanced efficiency,and sustained *** method elucidated is exemplified through pertinent RA or RBDO *** juxtaposing them against alternative strategies,the efficacy of these methods becomes *** outcomes proffered are subsequently employed as a foundation for contemplating prospective theoretical and practical research endeavors concerning *** main purpose and value of this article is to review the SAM and reliability-related issues,which can provide some reference and inspiration for future research scholars in this field.

关键词： Reliability analysis reliability-based design optimization saddlepoint approximation

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Spatiotemporal variation and freeze-thaw asymmetry of Arctic sea ice in multiple dimensions during 1979 to 2020

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Acta Oceanologica Sinica 2024年第3期43卷 102-114页

作者： Yu guo Xiaoli Wang He xu Xiyong Hou CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China University of Chinese Academy of Sciences Beijing 100049China

Arctic sea ice is broadly regarded as an indicator and amplifier of global climate *** rapid changes in Arctic sea ice have been widely ***,the spatiotemporal changes in the horizontal and vertical dimensions of Arctic sea ice and its asymmetry during the melt and freeze seasons are rarely quantified simultaneously based on multiple sources of the same long time *** this study,the spatiotemporal variation and freeze-thaw asymmetry of Arctic sea ice were investigated from both the horizontal and vertical dimensions during 1979–2020 based on remote sensing and assimilation *** results indicated that Arctic sea ice was declining at a remarkably high rate of–5.4×10^(4) km^(2)/a in sea ice area(SIA)and–2.2 cm/a in sea ice thickness(SIT)during 1979 to 2020,and the reduction of SIA and SIT was the largest in summer and the smallest in ***,compared with other sub-regions,SIA showed a sharper declining trend in the Barents Sea,Kara Sea,and East Siberian Sea,while SIT presented a larger downward trend in the northern Canadian Archipelago,northern Greenland,and the East Siberian *** to the seasonal trend of sea ice on sub-region scale,the reduction rate of SIA exhibited an apparent spatial heterogeneity among seasons,especially in summer and winter,i.e.,the sub-regions linked to the open ocean exhibited a higher decline rate in winter;however,the other sub-regions blocked by the coastlines presented a greater decline rate in *** SIT,the sub-regions such as the Beaufort Sea,East Siberian Sea,Chukchi Sea,Central Arctic,and Canadian Archipelago always showed a higher downward rate in all ***,a striking freeze-thaw asymmetry of Arctic sea ice was also *** sea ice changes in different dimensions,sea ice over most regions in the Arctic showed an early retreat and rapid advance in the horizontal dimension but late melting and gradual freezing in the vertical *** amount of sea ice me

关键词： Arctic sea ice sea ice area sea ice thickness spatiotemporal variation freeze-thaw asymmetry

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Enhanced bright green luminescence from GdOF:Ho^(3+) up-conversion phosphor via Yb^(3+) doping

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Journal of Rare Earths 2024年第2期42卷 263-269,I0002页

作者： Linjun Qin Yue guo Jing xu Lixi Wang Qitu Zhang College of Materials Science and Engineering Nanjing Tech UniversityNanjing211816China

In this paper,a series of GdOF-based green phosphors doped with Ho^(3+) and Yb^(3+) ions was prepared by a simple co-precipitation *** crystal structure s and optical prope rties were investigated in *** intensity of the emission of GdOF:Yb^(3+),Ho^(3+) phosphors is enhanced by the effective energy transfer from Yb^(3+) to Ho^(3+),and the optimal luminescence is achieved with the Ho^(3+)doping amount of 0.1 mol%as well as Yb^(3+) doping amount of 5 mol%.Tunable UC emission of samples is achieved by adjusting the doping concentration of Ho^(3+) or Yb^(3+).The purity of the green UC emission is further improved by enhancing the excitation pumping *** addition,logarithmic functions of green,red and nearinfrared radiation intensities were calculated versus logarithmic function of pump power for further study.A possible UC luminescence mechanism between Yb^(3+) and Ho^(3+) is discussed based on powerdependent UC luminescence spectrum and decay *** results suggest that GdOF:Yb^(3+),Ho^(3+)phosphors with bright and high-purity green UC emission have potential applications in the fields of bioimaging,display and illumination.

关键词： Up-conversion GdOF Lanthanide ions Rare earths

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Improved nuclear mass formula with an additional term from the Fermi gas model

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Nuclear Science and Techniques 2024年第5期35卷 131-138页

作者： Xiao-Yu xu Li Deng ai-Xi Chen Hang Yang Amir Jalili Han-Kui Wang School of Science Zhejiang Sci-Tech UniversityHangzhou 310018China

Nuclear mass is a fundamental property of nuclear physics and a necessary input in nuclear *** to the complexity of atomic nuclei and nonperturbative strong interactions,conventional physical models cannot completely describe nuclear binding *** this study,the mass formula was improved by considering an additional term from the Fermi gas *** nuclear masses in the Atomic Mass Evaluation Database were reproduced with a root-mean-square deviation(RMSD)of -1.86 MeV(1.92 MeV).The new mass formula exhibits good performance in the neutron-rich nuclear *** RMSD decreases to 0.393 MeV when the ratio of the neutron number to the proton number is≥1.6.

关键词： Nuclear mass formula Neutron-rich nuclei Fermi-gas model

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Impacts of inter-satellite links on the ECOM model performance for BDS-3 MEO satellites

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Satellite Navigation 2024年第1期5卷 140-154页

作者： Chao Yang Jing guo Xiaolong xu Longyu Wang Qile Zhao GNSS Research Center Wuhan UniversityNo.129 Luoyu RoadWuhan430079China

Inter-satellite link(ISL)plays an essential role in current and future Global Navigation Satellite System(GNSS).In this study,we investigate the impact of ISL observations on precise orbit determination for BeiDou-3 Navigation Satellite System(BDS-3)Medium Earth Orbit(MEO)satellites based on different Extended CODE Orbit Models(ECOM).Thanks to the better observation geometry of the Ka-band ISL data compared to the L-band data for BDS-3 MEO satellites,the ISL solution substantially reduces Orbit Boundary Discontinuity(OBD)errors,except for C30,which suffers from unstable Ka-band hardware *** the external quality analysis,ISL significantly enhances the reliability of the orbit of MEO satellites manufactured by the China Academy of Space Technology(CAST).The standard deviation(STD)of the satellite laser ranging(SLR)residuals is approximately 2.5 cm,and the root mean square(RMS)is reduced by 10–23%compared to L-band ***,the Sun-elongation angle dependent systematic error in SLR residuals nearly vanishes based on the reduced 5-parameter ECOM(ECOM1)or extended 7-parameter ECOM(ECOM2)with ISL *** is because the ISL reduces the correlation between state parameters and solar radiation pressure(SRP)parameters as well as those among SRP parameters,leading to a more accurate estimation of both orbit and SRP perturbations,particularly those along B *** confirms that the deficiency of the SRP models for BDS-3 CAST satellites can be compensated by using better observation geometry from ISL *** the other hand,for the satellite manufactured by Shanghai Engineering Center for Microsatellites(SECM),the ISL allows for a more accurate estimation of the Bc_(1)parameter in the ECOM1 *** only reduces linear systematic error,possibly because the impact generated by the satellite bus cannot be entirely absorbed by the B-direction parameters.

关键词： BDS-3 MEO Inter-satellite link Solar radiation pressure ECOM

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Coordinated Dispatch Based on Distributed Robust Optimization for Interconnected Urban Integrated Energy and Transmission Systems

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 840-851页

作者： Wei xu Yufeng guo Tianhui Meng Yingwei Wang Jilai Yu the School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin 150001China

To improve the economic efficiency of urban integrated energy systems(UIESs)and mitigate day-ahead dispatch uncertainty,this paper presents an interconnected UIES and transmission system(TS)model based on distributed robust ***,interconnections are established between a TS and multiple UIESs,as well as among different UIESs,each incorporating multiple energy *** Bregman alternating direction method with multipliers(BADMM)is then applied to multi-block problems,ensuring the privacy of each energy system operator(ESO).Second,robust optimization based on wind probability distribution information is implemented for each ESO to address dispatch *** column and constraint generation(C&CG)algorithm is then employed to solve the robust ***,to tackle the convergence and practicability issues overlooked in the existing studies,an external C&CG with an internal BADMM and corresponding acceleration strategy is ***,numerical results demonstrate that the adoption of the proposed model and method for absorbing wind power and managing its uncertainty results in economic benefits.

关键词： Distributed robust optimization distributionally robust dispatch urban integrated energy system transmission system external column and constraint generation(C&CG) internal Bregman alternating direction method with multipliers(BADMM)

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Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitor

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2060-2073页

作者： Jing Zhou Mei-Ying Zhang ai-ai Gao Cheng Zhu Tao He James G Herman Ming-Zhou guo School of Medicine NanKai UniversityTianjin 300071China Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Departments of Pathology Characteristic Medical Center of The Chinese People’s Armed Police ForceTianjin 300162China The Hillman Cancer Center University of Pittsburgh Cancer InstitutePittsburghPA 15213United States National Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijing 100853China

BACKGROUND Targeting DNA damage response(DDR)pathway is a cutting-edge *** has been reported that Schlafen-11(SLFN11)contributes to increase chemosensitivity by participating in ***,the detailed mechanism is *** To investigate the role of SLFN11 in DDR and the application of synthetic lethal in esophageal cancer with SLFN11 *** To reach the purpose,eight esophageal squamous carcinoma cell lines,142 esophageal dysplasia(ED)and 1007 primary esophageal squamous cell carcinoma(ESCC)samples and various techniques were utilized,including methylationspecific polymerase chain reaction,CRISPR/Cas9 technique,Western blot,colony formation assay,and xenograft mouse *** Methylation of SLFN11 was exhibited in 9.15%of(13/142)ED and 25.62%of primary(258/1007)ESCC cases,and its expression was regulated by promoter region ***11 methylation was significantly associated with tumor differentiation and tumor size(both P<0.05).However,no significant associations were observed between promoter region methylation and age,gender,smoking,alcohol consumption,TNM stage,or lymph node *** DNA damaged model induced by low dose cisplatin,SLFN11 was found to activate non-homologous end-joining and ATR/CHK1 signaling pathways,while inhibiting the ATM/CHK2 signaling *** silencing of SLFN11 was found to sensitize the ESCC cells to ATM inhibitor(AZD0156),both in vitro and in *** SLFN11 is frequently methylated in human *** of SLFN11 is sensitive marker of ATM inhibitor in ESCC.

关键词： Schlafen-11 Esophageal squamous cell carcinoma DNA methylation Synthetic lethality AZD0156

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Finite-Difference Lattice Boltzmann Scheme for High-Speed Compressible Flow:Two-Dimensional Case

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Communications in Theoretical Physics 2008年第7期50卷 201-210页

作者： GAN Yan-Biao xu ai-guo ZHANG Guang-Cai ZHANG Ping ZHANG Lei LI Ying-Jun China University of Mining and Technology （Beijing） Beijing 100083 China State Key Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics P.O. Box 8009-26 Beijing 100088 China Fundamental Science Department North China Institute of Aerospace Engineering Langfang 065000 China

Lattice Boltzmann (LB) modeling of high-speed compressible flows has long been attempted by *** common weakness of most of previous models is the instability problem when the Mach number ofthe flow is *** this paper we present a finite-difference LB model,which works for flows with flexible ratios ofspecific heats and a wide range of Mach number,from 0 to 30 or *** the discrete-velocity-model by Watari[Physica A 382 (2007) 502],a modified Lax-Wendroff finite difference scheme and an artificial viscosity are *** combination of the finite-difference scheme and the adding of artificial viscosity must find a ba/ance of numericalstability versus *** proposed model is validated by recovering results of some well-known benchmark tests:shock tubes and shock *** new model may be used to track shock waves and/or to study the non-equilibriumprocedure in the transition between the regular and Mach reflections of shock waves,etc.

关键词：高速可压缩流晶格皮尔逊分析差分

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