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Auxin response factor 6A regulates photosynthesis,sugar accumulation,and fruit development in tomato

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Horticulture Research 2019年第1期6卷 678-693页

作者： Yujin Yuan Xin xu Zehao Gong Yuwei Tang Mengbo Wu Fang Yan Xiaolan Zhang Qian Zhang Fengqing Yang Xiaowei hu Qichen Yang Yingqing Luo lihua Mei Wenfa Zhang cai-Zhong Jiang Wangjin Lu Zhengguo Li Wei Deng Key Laboratory of Plant Hormones and Development Regulation of Chongqing School of Life SciencesChongqing University401331 ChongqingChina School of Chemistry and Chemical Engineering Chongqing University400044 ChongqingChina College of Basic Science Tianjin Agricultural University300384 TianjinChina Department of Plant Sciences University of CaliforniaDavisCA 95616USA Crops Pathology and Genetics Research Unit United States Department of AgricultureAgricultural Research ServiceDavisCA 95616USA State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Guangdong Provincial Key Laboratory of Postharvest Science of Fruits and Vegetables College of HorticultureSouth China Agricultural University510642 GuangzhouChina

Auxin response factors(ARFs)are involved in auxin-mediated transcriptional regulation in *** this study,we performed functional characterization of SlARF6A in ***6A is located in the nucleus and exhibits transcriptional activator *** of SlARF6A increased chlorophyll contents in the fruits and leaves of tomato plants,whereas downregulation of SlARF6A decreased chlorophyll contents compared with those of wild-type(WT)*** of chloroplasts using transmission electron microscopy indicated increased sizes of chloroplasts in SlARF6A-overexpressing plants and decreased numbers of chloroplasts in SlARF6A-downregulated *** of SlARF6A increased the photosynthesis rate and accumulation of starch and soluble sugars,whereas knockdown of SlARF6A resulted in opposite phenotypes in tomato leaves and ***-sequence analysis showed that regulation of SlARF6A expression altered the expression of genes involved in chlorophyll metabolism,photosynthesis and sugar ***6A directly bound to the promoters of SlGLK1,CAB,and RbcS genes and positively regulated the expression of these *** of SlARF6A also inhibited fruit ripening and ethylene production,whereas downregulation of SlARF6A increased fruit ripening and ethylene ***6A directly bound to the SAMS1 promoter and negatively regulated SAMS1 *** together,these results expand our understanding of ARFs with regard to photosynthesis,sugar accumulation and fruit development and provide a potential target for genetic engineering to improve fruit nutrition in horticulture crops.

关键词： sugar metabolism photosynthesis

斑马鱼模型在化妆品功效评价研究中的应用进展

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中国实验动物学报 2023年第4期31卷 541-548页

作者：郑丹阳徐梦漪李淑敏朱永闯龚盛昭蔡丽华胡翠萍广东轻工职业技术学院广州510300 广州番禺职业技术学院广州511483 广东省绿色日用化工工程技术研究中心广州510300 仲恺农业工程学院广州510225

斑马鱼具有个体小、易饲养、胚胎透明、易观察等优势,是一种广泛应用于医学和毒理学研究的模式生物。因其具有可高通量筛选、测试周期短、实验结果可信度高等优势,近年,斑马鱼逐步用于化妆品功效评价,且成为化妆品行业认可的评价方式,... 详细信息

斑马鱼具有个体小、易饲养、胚胎透明、易观察等优势,是一种广泛应用于医学和毒理学研究的模式生物。因其具有可高通量筛选、测试周期短、实验结果可信度高等优势,近年,斑马鱼逐步用于化妆品功效评价,且成为化妆品行业认可的评价方式,也是学者们研究的热点。目前,化妆品功效种类繁多,而斑马鱼模型评价标准正逐步完善,本文阐述了斑马鱼模型在化妆品美白、抗炎、抗氧化等功效评价中的应用进展。

关键词：斑马鱼化妆品功效评价

解热镇痛药在儿童发热对症治疗中处方审核建议

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中华实用儿科临床杂志 2022年第9期37卷 653-659页

作者：刘小会季兴胡利华贾运涛孙华君卢庆红张胜男赵瑞玲张顺国孙燕燕闫美兴郝丽娜蔡和平许静朱增燕徐华缪静陆晓彤陈泽彬成华林芸竹陈瑞杰赵昕刘振国张君莉姜玉武万朝敏卢根高恒妙殷菊申昆玲徐保平王晓玲国家儿童医学中心首都医科大学附属北京儿童医院药学部北京100045 南京医科大学附属儿童医院药学部南京210008 重庆医科大学附属儿童医院药学部重庆400014 上海市儿童医院上海交通大学医学院附属儿童医院药学部上海200040 江西省儿童医院药学部南昌330006 河南省儿童医院药学部郑州450018 山西省儿童医院药剂科太原030013 国家儿童医学中心上海交通大学医学院附属上海儿童医学中心药学部上海200127 天津市儿童医院药剂科天津300134 青岛大学附属妇女儿童医院药学部青岛266034 山东大学附属儿童医院(济南市儿童医院)药学部济南250022 安徽省儿童医院临床药学部合肥230000 苏州大学附属儿童医院药剂科苏州215025 华中科技大学同济医学院附属武汉儿童医院药学部武汉430016 浙江大学医学院附属儿童医院药学部杭州310005 上海交通大学医学院附属新华医院药剂管理科上海200092 深圳市儿童医院药学部深圳518026 西安市儿童医院药学部西安710002 四川大学华西第二医院药学部四川大学华西第二医院循证药学中心出生缺陷与妇儿疾病教育部重点实验室成都610041 温州医科大学附属第二医院药学部温州325027 湖南省儿童医院药学部长沙410007 西北妇女儿童医院药剂科西安710061 首都儿科研究所附属儿童医院药学部北京100020 北京大学第一医院儿科北京100034 四川大学华西第二医院儿科出生缺陷与妇儿疾病教育部重点实验室成都610041 广州市妇女儿童医疗中心呼吸科广州510620 国家儿童医学中心首都医科大学附属北京儿童医院重症医学科北京100045 国家儿童医学中心国家呼吸系统疾病临床医学研究中心首都医科大学附属北京儿童医院呼吸科北京100045

解热镇痛药是目前儿童处方量较大的药品, 我国儿童解热镇痛药在临床应用中仍存在一些不合理用药现象, 影响治疗效果, 甚至对儿童用药安全造成隐患。本文从儿童发热对症治疗中解热镇痛药的适应证、剂型/给药途径、用药剂量适宜性、患儿... 详细信息

解热镇痛药是目前儿童处方量较大的药品, 我国儿童解热镇痛药在临床应用中仍存在一些不合理用药现象, 影响治疗效果, 甚至对儿童用药安全造成隐患。本文从儿童发热对症治疗中解热镇痛药的适应证、剂型/给药途径、用药剂量适宜性、患儿的病理生理特性个体差异以及药物相互作用等方面提出建议, 供广大药师开展处方审核时参考。

关键词：解热镇痛药发热处方建议

儿科常用H_(1)抗组胺药处方审核专家共识

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中华实用儿科临床杂志 2023年第10期38卷 733-739页

作者：胡利华刘璐陈慧颖蔡和平葛文彤韩志英皇惠杰季兴贾运涛菅凌燕姜楠楠李中李莉梁华刘传合卢庆红卢旭马俊娥缪静任艳丽尚云晓申昆玲孙华君孙金峤孙燕燕汤建萍王红王良录王晓川喜雷徐华徐子刚闫美兴殷勇张胜男张中平赵昕赵德育周薇向莉王晓玲国家儿童医学中心首都医科大学附属北京儿童医院药学部北京100045 青岛大学附属妇女儿童医院药学部青岛266034 安徽省儿童医院临床药学部合肥230022 国家儿童医学中心首都医科大学附属北京儿童医院耳鼻咽喉头颈外科北京100045 山西省儿童医院呼吸科太原300013 国家儿童医学中心首都医科大学附属北京儿童医院过敏反应科北京100045 南京医科大学附属儿童医院药学部南京210008 重庆医科大学附属儿童医院药学部重庆400014 中国医科大学附属盛京医院药学部沈阳110004 大连市妇女儿童医疗中心(集团)药剂科大连116011 国家儿童医学中心首都医科大学附属北京儿童医院眼科北京100045 成都市妇女儿童中心医院药学部成都611731 首都儿科研究所附属儿童医院变态反应科北京100020 江西省儿童医院药学部南昌330006 北京市通州区妇幼保健院儿科北京101100 民航总医院儿科北京100123 浙江大学医学院附属儿童医院药剂科杭州310052 郑州大学第三附属医院药学部郑州450052 中国医科大学附属盛京医院小儿呼吸内科沈阳110004 国家儿童医学中心国家呼吸系统疾病临床医学研究中心首都医科大学附属北京儿童医院呼吸科北京100045 上海市儿童医院上海交通大学医学院附属儿童医院药学部上海200062 国家儿童医学中心复旦大学附属儿科医院临床免疫科上海201102 天津市儿童医院药剂科天津300134 湖南省儿童医院皮肤科长沙410007 北京协和医院变态反应科北京100730 华中科技大学同济医学院附属武汉儿童医院药学部武汉430019 国家儿童医学中心首都医科大学附属北京儿童医院皮肤科北京100045 国家儿童医学中心上海交通大学医学院附属上海儿童医学中心呼吸内科上海200127 河南省儿童医院药学部郑州450018 河北省儿童医院呼吸三科石家庄050031 湖南省儿童医院药学部长沙410007 南京医科大学附属儿童医院呼吸科南京210008 北京大学第三医院儿科北京100191

H_(1)抗组胺药广泛用于各种过敏性疾病的治疗,但在儿科的安全合理应用仍存在诸多挑战,且缺乏专门针对儿童使用H_(1)抗组胺药的处方审核相关的指导文件。现从H_(1)抗组胺药在儿科使用的适应证、剂量、给药途径、患儿的病理生理特性以及... 详细信息

H_(1)抗组胺药广泛用于各种过敏性疾病的治疗,但在儿科的安全合理应用仍存在诸多挑战,且缺乏专门针对儿童使用H_(1)抗组胺药的处方审核相关的指导文件。现从H_(1)抗组胺药在儿科使用的适应证、剂量、给药途径、患儿的病理生理特性以及药物相互作用等方面提出建议,制定本共识,供临床医师和药师参考。

关键词： H_(1)抗组胺药儿童过敏性疾病处方审核专家共识

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua cai Wenyong cai Wujun cai Yijian cai Yizhou cai Yuchen cai Haiying cai huacheng cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen hua-Xing Chen huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen xun Chen xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhu&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise