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Cost-Effectiveness Analysis of Combined Chemotherapy Regimen Containing Bedaquiline in the Treatment of Multidrug-Resistant Tuberculosis in China

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Biomedical and Environmental Sciences 2023年第6期36卷 501-509页

作者： xu cai hong QIU Ying Peng HE Zi Long HU Dong Mei YUE Xiao CHEN Zhong Dan xu Yuan Yuan ZHAO Yan Lin National Center for Tuberculosis Control and Prevention China CDCBeijing 100226China China National Health Development Research Center Beijing 100226China The University of Sheffield S102TNSheffieldThe United Kingdom The Central South University Changsha 410083HunanChina World Health Organization Representative Office for China Beijing 100600China

Objective This study aims to estimate the cost-effectiveness of the combined chemotherapy regimen containing Bedaquiline(BR)and the conventional treatment regimen(CR,not containing Bedaquiline)for the treatment of adults with multidrug-resistant tuberculosis(MDR-TB)in *** A combination of a decision tree and a Markov model was developed to estimate the cost and effects of MDR patients in BR and CR within ten *** model parameter data were synthesized from the literature,the national TB surveillance information system,and consultation with *** incremental cost-effectiveness ratio(ICER)of BR *** was *** BR(***)had a higher sputum culture conversion rate and cure rate and prevented many premature deaths(decreased by 12.8%),thereby obtaining more quality-adjusted life years(QALYs)(increased by 2.31 years).The per capita cost in BR was as high as 138,000 yuan,roughly double that of *** ICER for BR was 33,700 yuan/QALY,which was lower than China's 1×per capita Gross Domestic Product(GDP)in 2020(72,400 yuan).Conclusion BR is shown to be cost *** the unit price of Bedaquiline reaches or falls below57.21 yuan per unit,BR is expected to be the dominant strategy in China over CR.

关键词： Bedaquiline Cost-effectiveness Multidrug-resistant tuberculosis China

Factors Associated with Diagnostic Delay of Pulmonary Tuberculosis in China

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Biomedical and Environmental Sciences 2022年第1期35卷 73-78页

作者： xu cai hong ZHANG Xiao Meng LIU Yan HU Dong Mei XIA Yin Yin WANG Li ZHANG Hui National Center for Tuberculosis Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Tianjin Center for Tuberculosis Control Tianjin 300041China Department of Critical Care Medicine and Infection Prevention and Control The Second People’s Hospital of Shenzhen&First Affiliated Hospital of Shenzhen UniversityHealth Science CenterShenzhen 518037GuangzhouChina Department of Epidemiology and Biostatistics Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China

Tuberculosis(TB)remains a major public health threat;approximately 10 million new TB cases are recorded worldwide,and more than 1.2 million deaths were caused by TB in 2019[1].The diagnostic delay presents a major obs... 详细信息

关键词： Tuberculosis obstacle threat

Rational design of metal selenides nanomaterials for alkali metal ion(Li^(+)/Na^(+)/K^(+))batteries:current status and perspectives

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Rare Metals 2024年第5期43卷 1906-1931页

作者： Rui Sun Feng xu cai-hong Wang Sheng-Jun Lu Yu-Fei Zhang Hao-Sen Fan College of Materials Science and Metallurgy Engineering Guizhou UniversityGuiyang550025China School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou510006China

Recently,metal selenides have obtained widespread attention as electrode materials for alkali(Li^(+)/Na^(+)/K^(+))batteries due to their promising theoretical capacity and ***,metal selenides,similar to metal oxides and sulfides,also suffer from severe volume explosion during repeated charge/discharge processes,which results in the structure collapse and the following pulverization of electrode ***,it leads to poor cycle stability and influencing their further *** order to solve these issues,some special strategies,including elemental doping,coupling with carbon materials,synthesis of the bimetal selenides with heterostructure,etc.,have been gradually applied to design novel electrode materials with outstanding electrochemical ***,the recent research progress on metal selenides as anodes for alkali ion batteries is summarized,including the regulation of crystal structure,synthesis strategies,modification methods,and electrochemical mechanisms and ***,the challenges of metal selenides and the perspective for future electrode material design are *** is hoped to pave a way for the development of metal selenide electrode materials for the potential applications for alkali metal ion(Li^(+)/Na^(+)/K^(+))batteries.

关键词： Rational design Metal selenides Nanostructure Li^(+) batteries Na^(+) batteries K^(+) batteries

Effects of heat treatment on microstructures and properties of a heterostructured alloy with dissimilar components fabricated by WAAM

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Rare Metals 2024年第9期43卷 4441-4461页

作者： Ming-cai Pan Jun-Qiang xu Yong Peng Ning-Ning Liang Si Lan Qi Zhou Ke-hong Wang School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Controlled Arc Intelligent Additive Manufacturing Technology Nanjing 210094China

Heat treatment significantly influences homogeneous material microstructures and mechanical properties,which can be improved by an optimal heat treatment ***,heat treatment application to heterogeneous materials presents significant challenges due to compositional and microstructural ***,a laminated heterostructured alloy comprising alternating316L stainless steel(SS)and 18Ni300 maraging steel(MS)layers fabricated using wire and arc additive manufacturing was investigated.A solution treatment was applied at900℃for 0.5 ***,the solution-treated and asfabricated(AF)samples were aged at 500℃for 4 h;these samples were denoted SA and AT,*** AT phase compositions and orientations were similar to those of *** SA 316L SS layer resembled that of AF,but the SA 18Ni300 MS layers exhibited a reduced austenite phase fraction and refined grain size,attributable to solid-state *** the AT sample,aging induced the formation of nanoscale acicularωphase and ellipsoidal Ni_(3)Ti,Fe_(2)Mo,and X precipitates in the 18Ni300 MS ***,the SA precipitates contained acicular Fe Ni_(2)and ellipsoidalω,Ni_(3)Ti,and X precipitates,and their fractions were lower than those in AT ***18Ni300 MS layer microhardness in the heat-treated samples increased due to nanoprecipitation,but the 316L SS layer microhardness resembled that of *** AT and SA ultimate tensile strengths increased to(1360±50)and(1473±41)MPa,respectively,attributable to precipitation *** SA 316L SS layer exhibited a high stress-induced martensite fraction,enhancing the ductility of heated samples.

关键词： Laminated heterostructured alloy Heat treatment Wire and arc additive manufacturing Microstructure Mechanical property

Bioinspired nanotransducers for neuromodulation

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Nano Research 2024年第2期17卷 618-632页

作者： Fan Yang Xiang Wu Sa cai Guosong hong Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA Wu Tsai Neurosciences Institute Stanford UniversityStanfordCA 94305USA School of Science Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China

The field of neuromodulation has experienced significant advancements in the past decade,owing to breakthroughs in disciplines such as materials science,genetics,bioengineering,photonics,and *** convergence of these fields has resulted in the development of nanotransducers,devices that harness the synergies of these diverse *** nanotransducers,essential for neuromodulation,often draw inspiration from energy conversion processes found in nature for their unique *** this review,we will delve into the latest advancements in wireless neuromodulation facilitated by optical,magnetic,and mechanical *** will examine their working principles,properties,advantages,and limitations in comparison to current methods for deep brain neuromodulation,highlighting the impact of natural systems on their design and ***,we will underscore potential future directions,emphasizing how continued progress in materials science,neuroscience,and bioengineering might expand the horizons of what is achievable with nanotransducer-enabled neuromodulation.

关键词： bioinspired synthesis neuromodulation mechanoluminescence focused ultrasound nanotransducers sono-optogenetics

Automatic Requirement Dependency Extraction Based on Integrated Active Learning Strategies

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Machine Intelligence Research 2024年第5期21卷 993-1010页

作者： Hui Guan Guorong cai Hang xu Department of Computer Science and Technology Shenyang University of Chemical TechnologyShenyang110142China Key Laboratory of Industrial Intelligence Technology on Chemical Process Shenyang110142China

Since requirement dependency extraction is a cognitively challenging and error-prone task,this paper proposes an automatic requirement dependency extraction method based on integrated active learning *** this paper,the coefficient of variation method was used to determine the corresponding weight of the impact factors from three different angles:uncertainty probability,text similarity difference degree and active learning variant prediction divergence *** combining the three factors with the proposed calculation formula to measure the information value of dependency pairs,the top K dependency pairs with the highest comprehensive evaluation value are selected as the optimal *** the optimal samples are continuously added into the initial training set,the performance of the active learning model using different dependency features for requirement dependency extraction is rapidly ***,compared with other active learning strategies,a higher evaluation measure of requirement dependency extraction can be achieved by using the same number of ***,the proposed method using the PV-DM dependency feature improves the weight-F1 by 2.71%,the weight-recall by 2.45%,and the weight-precision by 2.64%in comparison with other strategies,saving approximately 46%of the labelled data compared with the machine learning approach.

关键词： Requirement dependency dependency extraction dependency features integrated active learning strategies coefficient of variation

Experimental study on performance of spring damping support structure system for large deformation tunnel in soft rock

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Underground Space 2024年第2期15卷 221-243页

作者： Jinfeng xu Xiongyao Xie Zhou Shi Wuqiang cai Dinglun xu Chen xu Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China Key Laboratory of Geotechnical and Underground Engineering Ministry of EducationTongji UniversityShanghai 200092China Zhaotong City Zhaolu Expressway Investment and Development Co. ZhaotongYunnan Province 657000China Institute of Rock Mechanics Ningbo UniversityNingboZhejiang 315211China

According to the convergence confinement theory,it is an effective measure to control the large deformation of high ground stress in fractured soft rock tunnels by using yielding *** yielding support can be classified as either radial or circumferential yielding *** yielding support is achieved by transforming radial displacement into circumferential tangential closure without compromising the support capacity of the primary lining support *** on this,and inspired by the design principle of dampers,a yielding support structure system with spring damping elements as its core was developed,based on the connection characteristics of steel arches in highway tunnel,which can provide increasing support resistance in the yielding deformation *** the mechanical properties of spring damping elements were obtained through indoor axial pressure and flexural *** addition,according to these results with numerical calculations,the yielding support structure system with embedded spring damping elements can reduce the internal force of the support structure by approximately 10%and increase the area of the plastic zone of the surrounding rock by 11.23%,which can fully utilize the self-bearing capacity of surrounding rock and verify the effectiveness of circumferential yielding ***,the spring damping support structure system was designed with reference to the construction process of the tunnel excavated by drilling and blasting method,and the transformation of the spring damping element to spring damping support structure was *** on field test results,surrounding ground pressure for the yielding support optimization scheme was reduced by 40%and more evenly distributed,resulting in the successful application and a reduction in the construction cost of large deformation tunnels in soft rock.

关键词： Soft rock Highway tunnel Convergence confinement method Circumferential yielding support with spring damping element Numerical calculations Field test

Platelet-based bioactive systems guided precision targeting and immune regulation for cancer therapy

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Nano Research 2024年第9期17卷 8269-8284页

作者： Xinyi cai Long Qiu Zhenying Diao Lintao cai Ting Yin hong Pan Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen 518055China School of pharmacy Guangdong Medical UniversityDongguan 523808China Sino-Euro Center of Biomedicine and Health Shenzhen 518024China

The antitumor effects of conventional drug carriers are often attenuated and limited in application by biological barriers associated with tumor heterogeneity and resistance brought about by low tumor *** the rapid development of nanotechnology,naturally derived bioactive materials,and live cell carriers,a promising strategy emerges for targeting the tumor microenvironment(TME)for precision cancer *** unique injury-targeting properties of platelets can significantly extend functional activity,which cannot be achieved with conventional *** this review,three strategies based on platelet-engineered materials are systematically described,namely nanoparticles for platelet membrane camouflage,engineered activated platelets,and targeted-platelets ***-based nanomaterials can effectively coordinate local and distant tumor-host crosstalk with controlled active tumor site recognition and killing effects due to the presence of specific membrane proteins on the surface and the self-secretion of a large number of *** advances in platelets for effectively overcoming biological barriers and reducing immune resistance in cancer immunotherapy applications will be discussed in future clinical *** review provides an overview of recent research advances in platelet-based bioactive material-directed immunotherapy and chemotherapy to inform future antitumor combination therapies.

关键词： platelets bionic targeting immune modulation precision therapy deep penetration

Thyristor-inserted MMC Sub-module Topology with DC Fault Blocking Capability

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CSEE Journal of Power and Energy Systems 2024年第5期10卷 2221-2229页

作者： Cheng Peng Rui Li xu cai Key Laboratory of Control of Power Transmission and Conversion Shanghai Jiao Tong UniversityMinistry of EducationShanghai Jiao Tong UniversityShanghai 200240China.

Modular multilevel converter(MMC)is increasingly being applied to high voltage direct current(HVDC)***,dc short circuit situations restrain the application of a conventional half bridge MMC *** this paper,a new sub-module topology with inserted thyristor can help the MMC system clear a dc side *** states and devices voltage stress of the proposed topology are analyzed and the conduction loss comparison between the proposed topology with several existing topologies with dc fault blocking capability is carried *** show the proposed topology is superior to other topologies in terms of conduction loss while using the same voltage rating ***,compared with traditional half bridge topology,only thyristors and diodes are added in the proposed ***,cost of the proposed topology can be lower than conventional hybrid MMC *** last,the fault blocking capability of the proposed topology is verified in the simulation.

关键词： Fault current limiting high voltage direct current(HVDC)transmission modular multilevel converter(MMC)