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大鼠肩袖撕裂重建过程中色氨酸代谢的变化

中华创伤骨科杂志 2024年第5期26卷 435-443页

作者：朱东旭黄晓红朱馨蕊于腾波张英泽青岛大学医学部青岛266000 青岛大学附属医院运动医学科青岛266100 青岛大学附属医院医学研究中心山东省创伤骨科研究所青岛266100 河北医科大学第三医院骨科医院石家庄050051 青岛市市立医院骨外科青岛266071 青岛大学附属医院骨科青岛266100

目的比较骨重塑能力正常和骨重塑能力缺陷大鼠肩袖撕裂(RCT)修复术后色氨酸代谢的差异,探讨色氨酸代谢是否与骨长入有关。方法共选取50只成年雌性Sprague-Dawley(SD)大鼠进行研究,随机选择18只大鼠接受双侧卵巢摘除手术(OVX),设为OVX组;... 详细信息

目的比较骨重塑能力正常和骨重塑能力缺陷大鼠肩袖撕裂(RCT)修复术后色氨酸代谢的差异,探讨色氨酸代谢是否与骨长入有关。方法共选取50只成年雌性Sprague-Dawley(SD)大鼠进行研究,随机选择18只大鼠接受双侧卵巢摘除手术(OVX),设为OVX组;余32只大鼠接受双侧卵巢摘除假手术,设为假手术组。术后3个月,OVX组和假手术组各自随机选择4只大鼠,采用显微计算机断层扫描(Micro-CT)鉴定肱骨头的骨量流失情况。OVX组剩余大鼠进行RCT造模,并接受急性冈上肌横断修复术,设为OVX+RCT组(n=14);假手术组剩余大鼠分别选取14只接受急性冈上肌横断修复术和RCT假手术,分别设为RCT组(n=14)和SO组(n=14)。修复手术后2周检测大鼠抓力,并取出冈上肌腱骨复合体,通过实时荧光定量多聚酶链式反应(qPCR)检测、苏木素伊红(HE)染色和免疫组化(IHC)染色评估新骨生成和骨长入情况,采用超高效液相色谱(UPLC)分析检测色氨酸代谢。结果抓力测试结果表明,SO组大鼠抓力最大,RCT组次之,OVX+RCT组抓力最小,三组间差异有统计学意义(P0.05)。qPCR结果表明,犬尿酸代谢途径的吲哚胺2,3-双加氧酶2的表达量在SO组、RCT组、OVX+RCT组呈递增趋势:OVX+RCT组显著高于SO组,OVX+RCT组的3-羟基邻氨基苯甲酸3,4-双加氧酶的表达量显著高于RCT组和SO组,5-羟色胺代谢途径的单胺氧化酶A亚型和B亚型在SO、RCT、OVX+RCT三组间递增,OVX+RCT组吲哚代谢途径的多巴脱羧酶的表达量显著高于SO组,而细胞色素P450氧化还原酶的表达量在SO、RCT、OVX+RCT三组间递增,以上项目组间差异有统计学意义(P<0.001)。结论大鼠正常肩袖和RCT后修复的肌腱复合体中色氨酸代谢以犬尿酸代谢为主,5-羟色胺代谢次之;在RCT骨重塑中,5-羟色胺代谢途径改变最大,吲哚途径次之。犬尿酸代谢途径的烟酸、黄尿酸含量和5-羟色胺代谢途径的5-羟色氨酸、5-羟色胺、羟基吲哚乙酸、褪黑素及吲哚代谢途径的色氨醇、吲哚乳酸均与骨长入有关。因此,色氨酸代谢与骨长入有关,为RCT寻找潜在治疗靶点。

关键词：色氨酸撕裂伤骨质疏松肩袖撕裂骨插入

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长短期时间序列关联的视频异常事件检测

中国图象图形学报 2024年第7期29卷 1998-2010页

作者：朱新瑞钱小燕施俞洲陶旭东李智昱南京航空航天大学民航学院南京211106

目的多示例学习是解决弱监督视频异常事件检测问题的有力工具。异常事件发生往往具有稀疏性、突发性以及局部连续性等特点,然而,目前的多示例学习方法没有充分考虑示例之间的联系,忽略了视频片段之间的时间关联,无法充分分离正常片段... 详细信息

目的多示例学习是解决弱监督视频异常事件检测问题的有力工具。异常事件发生往往具有稀疏性、突发性以及局部连续性等特点,然而,目前的多示例学习方法没有充分考虑示例之间的联系,忽略了视频片段之间的时间关联,无法充分分离正常片段和异常片段。针对这一问题,提出了一种长短期时间序列关联的二阶段异常检测网络。方法第1阶段是长短期时间序列关联的异常检测网络(long-and-short-term correlated mil abnormal detection framework,LSC-transMIL),将Transformer结构应用到多示例学习方法中,添加局部和全局时间注意力机制,在学习不同视频片段间的空间关联语义信息的同时强化连续视频片段的时间序列关联;第2阶段构建了一个基于时空注意力机制的异常检测网络,将第1阶段生成的异常分数作为细粒度伪标签,使用伪标签训练策略训练异常事件检测网络,并微调骨干网络,提高异常事件检测网络的自适应性。结果实验在两个大型公开数据集上与同类方法比较,两阶段的异常检测模型在UCF-crime、ShanghaiTech数据集上曲线下面积(area under curve,AUC)分别达到82.88%和96.34%,相比同为两阶段的方法分别提高了1.58%和0.58%。消融实验表明了关注时间序列的Transformer模块以及长短期注意力的有效性。结论本文将Transformer应用于时间序列的多示例学习,并添加长短期注意力,突出局部异常事件和正常事件的区别,有效检测视频中的异常事件。

关键词：异常检测 Transformer网络时空注意力多示例学习(MIL) 弱监督

Highly efficient oxygen evolution electrocatalyts based on nanosheet-shaped CuS in situgrownon carbon cloth

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Highly efficient oxygen evolution electrocatalyts based on n...

河南省化学会2020年学术年会

作者： Du Jimin zhu xinrui School of Chemistry and Chemical Engineering Anyang Normal University

In this work,nanosheet-shaped CuS (NS-CuS) is successfully grown on carbon cloth (CC) by a two-step route in combination with electrodeposition and hydrothermal treatment via in situ sulfidations of Cu2O and Cu with exposure to thiourea at 120°C or 24 *** electron microscopy,scanning electron microscopy,X-ray photoelectron spectroscopy,and X-ray diffractometry are performed to characterize the microstructure,mor-phology,composition,and crystal structure of the NS-CuS-CC *** electrochemical measurements demonstrate that the synthesized NS-CuS-CC electrocatalysts possess outstanding oxygen evolution reaction (OER)performance and superior long-term durability in 1 M KOH *** particular,the NS-CuS-CC synthesized via the electrodeposition process at an applied current of 1.5 mA shows a low overpotential for the OER (358 mV at 10 m A/cm2),which is close to that of commercial IrO2(346 mV at 10 m A/cm2).The exceptional OER property is ascribed to the NS-CuS having a large surface area to offer abundant reaction active sites and to the CC network structures supplying more ions and charge transfer channels during the electrocatalytic process.

关键词： Cu S Oxygen evolution reaction Electrocatalyst Water splitting Carbon cloth

Effect of cluster of quaternary ammonium ionic liquids on catalytic performance for CO2 fixation: ONIOM and MD

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Effect of cluster of quaternary ammonium ionic liquids on ca...

中国化学会·第一届全国二氧化碳资源化利用学术会议

作者： xinrui zhu Li Wang College of Chemistry and Chemical Engineering Henan University

Formation of cluster is a popular phenomenon for ionic liquids due to the strong interactions between cation and anion. It would definitely affect the intrinsic properties of ionic liquids and its catalytic activity. Taken the coupling reaction of carbon dioxide and propylene oxide as an example, the effect of quaternary ammonium ionic liquids cluster on its catalytic performance is investigated by combination of ONIOM and molecular dynamics simulations, including quaternary ammonium ionic liquid, hydroxyl functionalized quaternary ammonium ionic liquid, protic quaternary ammonium ionic liquid, and protic hydroxyl functionalized quaternary ammonium ionic liquid. The influence of electrostatic interaction, covalent and non-covalent interactions on the catalytic activity is analyzed by natural bond orbital, electron localization function, and atoms in molecules to explore the critical factors to control the catalytic activity.

关键词： Quaternary ammonium ionic liquid Carbon dioxide Coupling reaction Ionic liquid aggregation

The intrinsic developmental age signal defines an age-dependent climbing behavior in cucumber

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Horticultural Plant Journal 2024年第3期10卷 797-808页

作者： Zezhou Hong xinrui Wang Zipei Fan Jiahao Wang Aiyi Yang Guochao Yan Yong He Huasen Wang zhujun zhu Yunmin Xu College of Horticulture Science Zhejiang Agriculture and Forestry UniversityHangzhouZhejiang 311300China Key Laboratory of Quality and Safety Control for Subtropical Fruit and Vegetable Ministry of Agriculture and Rural AffairsHangzhouZhejiang 311300China Collaborative Innovation Center for Efficient and Green Production of Agriculture in Mountainous Areas of Zhejiang Province HangzhouZhejiang 311300China

The tendril is a climbing organ in cucurbits and functions in physical support and to avoid shading by neighboring ***,how cucurbits produce tendrils to obtain climbing ability is largely *** this study,tendril phenotypes were investigated during different developmental *** results revealed that tendril growth exhibited an age-dependent pattern in *** growth was inhibited,and the tendril was formed as a short tendril[nonfunctional tendril(nonF-tendril),approximately 0.1 cm]during the seedling *** contrast,enhanced cell proliferation and cell expansion led to rapid elongation of the tendril during the climbing stage,and the tendril formed as a functional tendril(F-tendril,approximately 30 cm)to obtain climbing ***-qPCR detection showed that age-dependent tendril growth correlated negatively with the abundance of the conserved age regulator *** induced CsmiR156 to inhibit CsSPLs,and F-tendril formation and climbing ability were delayed in defoliated cucumbers,which confirmed the role of CsmiR156 in regulating tendril growth in ***,exogenous gibberellin(GA)treatment showed that GA positively regulated tendril growth,and RT-qPCR detection showed that the GA bio-synthetic genes and metabolic genes were affected by age pathway,suggesting that the age pathway depended on GA bio-synthetic and metabolic pathway to regulate cell expansion to determine tendril *** summary,our work reveals that change in tendril type is an important marker of phase transition in cucumber,and tendril growth is regulated by an intrinsic developmental age signal,ensuring that the cucumber obtains climbing ability at a suitable age.

关键词： Cucumber Tendril Age CsmiR156 CsSPL Climbing ability

Preparation of MoS2 Material and Study on Its Performance of Supercapacitor

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Preparation of MoS2 Material and Study on Its Performance of...

河南省化学会2018年学术年会

作者： zhu xinrui Du Jimin Liu Yuan College of Chemistry and Chemical Engineering Anyang Normal University

MoS is a very promising energy storage electrode ***,the intrinsic multi-layer pure metal MoS(M-MoS)is rarely studied for *** this experiment,a simple hydrothermal method was used to prepare *** method is to directly prepare HMoNO·4HO with HNCSNH sulfide to prepare *** method is to prepare HMoNO·4HO complexationwithCNHand then use HNCSNH to sulfidize to prepare *** shape of the CV curves of the two different synthesis methods is not much *** the increase of the scanning speed,the position of the peak potential has a small displacement,and the peak current has a significant *** the CV curve,the oxidation-reduction peaks of the MoSnanosheets prepared by in-situ sulfidation are very symmetrical,indicating that the reaction has very good *** MoSnanosheets formed after complexation have a larger specific surface area,improve the utilization of electrode materials,and can provide higher specific capacitance.

关键词： MoS2 nanoparticles specific surface area hydrothermal synthesis supercapacitor

Synergistic cooperation of bi-active hydrogen atoms in protic carboxyl imidazolium ionic liquids to push cycloaddition of CO2 under benign conditions

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Synergistic cooperation of bi-active hydrogen atoms in proti...

中国化学会·第一届全国二氧化碳资源化利用学术会议

作者： Tengfei Wang xinrui zhu Tiegang Ren Li Wang Jinglai Zhang Henan Provincial Engineering Research Center of Green Anticorrosion Technology for Magnesium Alloys College of Chemistry and Chemical Engineering Henan University

Nine protic carboxyl imidazolium ionic liquids are synthesized. Then, they are employed to catalyze the chemical fixation of carbon dioxide(CO) and propylene oxide leading to propylene carbonate in the absence of co-catalyst and organic solvent. HCPImBr presents the best catalytic activity with the product yield of 92% under reaction temperature 120°C, CO initial pressure 1.5 MPa, catalyst amount 0.5 mol%, and reaction time 2.0 h. Even if the reaction temperature and CO initial pressure are decreased to 80°C and 1.0 MPa, respectively, the 85% of product yield would be kept with the 1.0% catalyst dosage along with 12.0 h. With the exception of the most optimal reaction conditions, generality, and recyclability of HCPImBr are also investigated. More importantly, the reaction mechanism is investigated by the density functional theory, which is the first time to report the mechanism for protic carboxyl imidazolium ionic liquids. The catalytic activity of ionic liquids would be further improved with the reasonable combination of cation and anion.

关键词： protic carboxyl imidazolium ionic liquids carbon dioxide epoxide cyclic carbonate mechanism

Friend or foe? Using eye-tracking technology to investigate the visual discrimination ability of giant pandas

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Current Zoology 2024年第4期70卷 430-439页

作者： xinrui Huang Guo Li Guiquan Zhang Zixiang Li Lin Zhao Mengdie zhu Qinghua Xiang Xuefeng Liu Mei Tian Hemin Zhang Christina D.Buesching Dingzhen Liu Ministry of Education Key Laboratory of Biodiversity Science and Ecological EngineeringDepartment of EcologyCollege of Life SciencesBeijing Normal UniversityBeijing 100875China Key Laboratory of State Forestry and Grassland Administration on Conservation Biology of Rare Animals in the Giant Panda National Park China Conservation and Research Center for the Giant PandaSichuan 623004China School of Computer and Information Technology Beijing Jiaotong UniversityBeijing 100044China Beijing Key Laboratoryof CaptiveWildlife Technology Beijing ZooBeijing100044China Department of Biology Irving K.Barber Faculty of ScienceThe University of British ColumbiaOkanagan CampusKelownaBCCanada

The role that visual discriminative ability plays among giant pandas in social communication and individual discrimination has received less attention than olfactory and auditory ***,we used an eye-tracker technology to investigate pupil fixation patterns for 8 captive male giant pandas Ailuropoda *** paired images(N=26)of conspecifics against:1)sympatric predators(gray wolves and tigers),and non-threatening sympatric species(golden pheasant,golden snub-nosed monkey,takin,and red panda),2)conspecifics with atypical fur colora-tion(albino and brown),and 3)zookeepers/non-zookeepers wearing either work uniform or plain *** each session,we tracked the pan-da's pupil movements and measured pupil first fixation point(FFP),fixation latency,total fixation count(TFC),and duration(TFD)of attention to each ***,pandas exhibited similar attention(FFPs and TFCs)to images of predators and non-threatening sympatric *** of golden pheasant,snub-nosed monkey,and tiger received less attention(TFD)than images of conspecifics,whereas images of takin and red panda received more attention,suggesting a greater alertness to habitat or food competitors than to potential ***'TFCs were greater for images of black-white conspecifics than for albino or brown phenotypes,implying that familiar color elicited more *** reacted differently to images of men versus *** images of women only,pandas gave more attention(TFC)to familiar combinations(uniformed zookeepers and plain-clothed non-zookeepers),consistent with the familiarity *** pandas can use visual perception to discriminate intra-specifically and inter-specifically,including details of human appearance,has applications for panda conservation and captive husbandry.

关键词： eye movement tracker giant panda images total fixation duration total pupil fixation count visual discrimination.

江苏省胰十二指肠切除手术情况和预后分析(附2886例报告)

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中华消化外科杂志 2024年第5期23卷 685-693页

作者：陆子鹏高鑫程浩王宁张凯尹杰尹凌帝林佑廷朱心睿王东芝马红钦刘同泰徐永子朱道俊禹亚斌杨扬刘飞潘超唐劲草胡敏杰华志元轩福明夏磊洲钱栋王永王苏苏高文涛仇毓东朱东明苗毅蒋奎荣江苏省胰腺专病质量控制中心南京医科大学第一附属医院(江苏省人民医院)胰腺中心、南京医科大学胰腺研究所南京210029 苏州大学附属第一医院普通外科苏州215006 南京大学医学院附属鼓楼医院普通外科南京210008 江苏省卫生健康委员会质量控制中心管理办公室南京210008 南京医科大学附属明基医院胰腺中心南京210019 常州市第一人民医院普通外科常州213004 南通大学附属医院普通外科南通226006 徐州医科大学附属医院普通外科徐州221004 苏北人民医院普通外科扬州225009 江苏省肿瘤医院普通外科南京210009 中国人民解放军东部战区总医院普通外科南京210016 淮安市第一人民医院普通外科淮安223399 东南大学附属中大医院普通外科南京210009 连云港市第一人民医院普通外科连云港222002 南京市第一医院普通外科南京210012 南京医科大学第二附属医院普通外科南京210003 南京医科大学附属泰州人民医院普通外科泰州225399 无锡市第二人民医院肝胆胰外科无锡214001 盐城市第一人民医院普通外科盐城224006 镇江市第一人民医院普通外科镇江212002 江苏省中医院普通外科南京210004 宿迁市第一人民医院普通外科宿迁223812 不详

目的探讨江苏省开展胰十二指肠切除术的手术情况和围手术期结局,分析术后90 d死亡的影响因素。方法采用回顾性病例对照研究方法。收集2021年3月至2022年12月江苏省胰腺专病质量控制中心中南京医科大学第一附属医院等21家大型三甲医院收... 详细信息

目的探讨江苏省开展胰十二指肠切除术的手术情况和围手术期结局,分析术后90 d死亡的影响因素。方法采用回顾性病例对照研究方法。收集2021年3月至2022年12月江苏省胰腺专病质量控制中心中南京医科大学第一附属医院等21家大型三甲医院收治的2886例行胰十二指肠切除术患者的临床病理资料;男1732例,女1154例;年龄为65(57,71)岁。江苏省胰腺专病质量控制中心在江苏省胰腺疾病质量控制项目的框架之下,采用多中心注册登记研究方法,建立全省统一胰十二指肠切除电子数据库。观察指标:(1)临床特征。(2)术中和术后情况。(3)胰十二指肠切除术后90 d内死亡的影响因素分析。偏态分布的计量资料以M(Q1,Q3)或M(IQR)表示,组间比较采用Mann⁃Whitney U检验。计数资料以绝对数或构成比表示,组间比较采用χ^(2)检验、χ^(2)检验连续性校正、Fisher确切概率法。约登指数最大值确定连续变量最佳分界值。单因素分析根据数据类型采用对应的统计学方法。多因素分析采用Logistic多元回归模型。结果(1)临床特征。2886例行胰十二指肠切除术患者中,2021年和2022年分别为1175例和1711例。21家医院中,8家胰十二指肠切除术年均手术量<36例,10家年均手术量为36~119例,3家年均手术量≥120例。年均手术量≥36例的13家医院施行胰十二指肠切除术2584例,占总数89.536%(2584/2886);年均手术量≥120例的3家医院施行胰十二指肠切除术1357例,占总数47.020%(1357/2886)。(2)术中和术后情况。2886例患者中,手术入路为开腹2397例、微创488例、未知1例;保留幽门情况为保留871例、未保留1952例、未知63例;联合脏器切除情况为联合任何脏器切除305例(含血管切除209例)、未联合脏器切除2579例、未知2例。2885例手术时间为290(115)min,2882例术中出血量为240(250)mL,2880例术中输血率27.153%(782/2880)。2886例患者中,侵入性治疗率为11.342%(327/2883)、非计划重症监护室治疗率为3.087%(89/2883)、再次手术率为1.590%(45/2830),术后住院时间为17(11)d,住院死亡率为0.798%(23/2882),2083例有严重并发症资料的挽救失败率为6.529%(19/291)。2477例患者获得术后90 d随访,术后90 d病死率为2.705%(67/2477)。2886例患者术后并发症情况,总并发症发生率为58.997%(1423/2412),严重并发症发生率为13.970%(291/2083),2078例综合并发症指数为8.7(22.6)。(3)胰十二指肠切除术后90 d内死亡的影响因素分析。多因素分析结果显示:年龄≥70岁、术后侵入性治疗、术后非计划重症监护室治疗是胰十二指肠切除术后90 d内死亡的独立危险因素(优势比=2.403,2.609,16.141,95%可信区间为1.281~4.510,1.298~5.244,7.119~36.596,P<0.05);医院年均手术量≥36例是胰十二指肠切除术后90 d内死亡的独立保护因素(优势比=0.368,95%可信区间为0.168~0.808,P<0.05)。结论江苏省胰十二指肠切除术在部分医院高度集中,术后并发症发生率高,术后90 d死亡风险显著高于住院死亡风险。年龄≥70岁、术后侵入性治疗、术后非计划重症监护室治疗是胰十二指肠切除术后90 d死亡的独立危险因素;医院年均手术量≥36例是术后90 d死亡的独立保护因素。

关键词：胰腺肿瘤胰十二指肠切除围手术期数据库江苏省