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Veno-arterial extracorporeal membrane oxygenation for the treatment of obstructive shock caused by venous air embolism:A case report

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World Journal of Clinical Cases 2024年第19期12卷 4016-4021页

作者： Gui-Wei Zhu Yan-Min Li Wen-Hui Yue Jian-xia Sun Xin Zhou Ying-xia Xu Hai-Bo Wang qing-Hai Zhang Department of Critical Care Medicine The First Affiliated Hospital of Shandong Second Medical UniversityWeifang 261000Shandong ProvinceChina Office of Medical Affairs The First Affiliated Hospital of Shandong Second Medical UniversityWeifang 261042Shandong ProvinceChina Department of Hand&Foot Orthopedic Surgery The First Affiliated Hospital of Shandong Second Medical UniversityWeifang 261000Shandong ProvinceChina

BACKGROUND Venous air embolism(VAE)is a potentially lethal condition,with a reported incidence rate of about 0.13%,and the true incidence may be higher since many VAE are *** current treatments for VAE include Durant's maneuver,aspiration and removal of air through venous catheters,and hyperbaric oxygen *** critically ill patients,use of cardiotonic drugs and chest compressions remain useful *** wider availability of extracorporeal membrane oxygenation(ECMO)has brought a new option for VAE *** SUMMARY A 53-year-old female patient with VAE presented to the emergency clinic due to abdominal pain with fever for 1 d and unconsciousness for 2 *** day ago,the patient suffered from abdominal pain,fever,and *** suddenly became unconscious after going to the toilet during the intravenous infusion of ciprofloxacin 2 h ago,accompanied by nausea and vomiting,during which a small amount of gastric contents were *** was immediately sent to a local hospital,where cranial and chest computed tomography showed bilateral pneumonia as well as accumulated air visible in the right ventricle and pulmonary *** condition deteriorated despite endotracheal intubation,rehydration,and other treatments,and the patient was then transferred to our ***-arterial ECMO was applied in our hospital,and the patient's condition gradually *** patient was successfully weaned from ECMO and extubated after two *** ECMO may be an important treatment for patients with VAE in critical condition.

关键词： Venous air embolism Obstructive shock Veno-arterial extracorporeal membrane oxygenation Critical Case report

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Metformin administration in prevention of colorectal polyps in type 2 diabetes mellitus patients

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World Journal of Clinical Cases 2024年第20期12卷 4206-4216页

作者： xiao-qing Wu Li-Hua Deng Qian Xue xia Li Meng-Han Li Jing-Tong Wang Department of Geriatrics Peking University People's HospitalBeijing 100044China

BACKGROUND Colorectal polyps are frequently observed in patients with type 2 diabetes mellitus(DM),posing a significant risk for colorectal ***,a widely prescribed biguanidine drug for type 2 DM,has been suggested to have potential chemoprophylactic effects against various *** To explore the correlation between colorectal polyps and metformin use in type 2 DM *** Type 2 DM patients were categorized into polyp and non-polyp *** this,all patients were categorized into the type 2 DM-metformin,type 2 DM-non-metformin,and non-type 2 DM *** on the baseline colonoscopy results,we performed pairwise comparisons of the incidence of colorectal polyps among the three ***,we analyzed the relationship between colorectal polyps and the duration of metformin use and between the size and number of polyps and metformin ***,we focused on the specific pathological types of polyps and analyzed their relationship with metformin ***,we compared the incidence of polyps between metformin and non-metformin groups according to the interval colonoscopy *** The rate of metformin use in patients with colorectal polyps was 0.502 times that of patients without colorectal polyps[odds ratio(OR)=0.502,95%confidence interval(CI):0.365-0.689;P0.05).Furthermore,the correlations between the duration of metformin use and the incidence of colorectal polyps and between the size and number of polyps and metformin use were not statistically significant(P>0.05).Metformin use did not affect the incidence of colorectal polyps during interval colonoscopy(P>0.05).CONCLUSION Metformin use and colorectal polyp incidence in type 2 DM patients showed a negative correlation,independent of the hypoglycemic effect of metformin.

关键词： Colorectal cancer Colorectal polyps Biguanidine drug Diabetes mellitus Metformin

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Multiomics analyses of two Leonurus species illuminate leonurine biosynthesis and its evolution

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Molecular Plant 2024年第1期17卷 158-177页

作者： Peng Li Meng-xiao Yan Pan Liu Dan-Jie Yang Ze-Kun He Yun Gao Yan Jiang Yu Kong Xin Zhong Sheng Wu Jun Yang Hong-xia Wang Yan-Bo Huang Le Wang xiao-Ya Chen Yong-Hong Hu qing Zhao Ping Xu shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai Chenshan Plant Science Research CenterChineseAcademy of SciencesShanghaiChina College of Life Sciences Shanghai Normal UniversityShanghai 200234China State Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghaiChina University of the Chinese Academy of Sciences Beijing 100049China The Research Center of Chiral Drugs Innovation Research Institute of Traditional Chinese MedicineShanghai University of Traditional Chinese Medicine1200 Cailun RoadShanghai 201203China College of Chemistry and Chemical Engineering Shanghai University of Engineering ScienceShanghai 201620China

The Lamiaceae family is renowned for its terpenoid-based medicinal components,but Leonurus,which has traditional medicinal uses,stands out for its alkaloid-rich ***,the principal active compound found in Leonurus,has demonstrated promising effects in reducing blood lipids and treating ***,the biosynthetic pathway of leonurine remains largely ***,we present the chromosome-level genome sequence assemblies of Leonurus japonicus,known for its high leonurine production,and Leonurus sibiricus,characterized by very limited leonurine *** integrating genomics,RNA sequencing,metabolomics,and enzyme activity assay data,we constructed the leonurine biosynthesis pathway and identified the arginine decarboxylase(ADC),uridine diphosphate glucosyltransferase(UGT),and serine carboxypeptidase-like(SCPL)acyltransferase enzymes that catalyze key reactions in this *** analyses revealed that the UGT–SCPL gene cluster evolved by gene duplication in the ancestor of Leonurus and neofunctionalization of SCPL in ***,which contributed to the accumulation of leonurine specifically in ***,our comprehensive study illuminates leonurine biosynthesis and its evolution in Leonurus.

关键词： Lamiaceae Leonurus japonicus Leonurus sibiricus genome sequence alkaloids leonurine gene cluster biosynthetic pathway evolution

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基于GISSMO失效准则的1500 MPa热成形钢断裂失效模型分析

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塑性工程学报 2024年第9期31卷 207-214页

作者：夏卿杨云张永学黄河科技学院工学部

以CR1000/1500HS为研究对象，基于GISSMO断裂失效准则，设计表征不同失效形式的5种测试试样；基于万能拉伸试验机和DIC测试系统，获取不同试样拉伸过程的力-位移曲线和断裂时刻的极限塑性应变；基于LS-DYNA搭建各失效试样的仿真分析模... 详细信息

以CR1000/1500HS为研究对象，基于GISSMO断裂失效准则，设计表征不同失效形式的5种测试试样；基于万能拉伸试验机和DIC测试系统，获取不同试样拉伸过程的力-位移曲线和断裂时刻的极限塑性应变；基于LS-DYNA搭建各失效试样的仿真分析模型，提取各试样断裂区域的应力三轴度；拟合获得断裂失效曲线和塑性失稳曲线，迭代获取其他模型参数；采用车门防撞梁动态三点弯曲冲击试验和仿真模型对承载特性进行分析；对比GISSMO失效模型、传统应变失效模型与试验测试的力-位移曲线差异，以验证失效模型的准确性。结果表明：Swift和Hockett-Sherby混合硬化模型可准确描述材料的塑性变形行为，关键参数误差小于5%;GISSMO失效模型获得的车门防撞梁承载特性关键参数和承载力-位移曲线与试验测试结果保持一致，误差低于5%;而采用传统应变失效准则获得的结果误差较大，最大位移的误差达到30%;表明基于GISSMO失效准则的材料模型可以准确表征CR1000/1500HS的塑性变形行为及断裂失效行为。

关键词：热成形钢车门防撞梁断裂失效模型 GISSMO断裂失效准则

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重复性联盟组合重构对焦点企业绩效的影响研究

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研究与发展管理 2024年第1期36卷 94-107页

作者：韩炜刘夏青西南政法大学商学院重庆401120

焦点企业与曾经有合作经历的既有联盟伙伴建立联盟以撬动新资源的做法,越来越多地被缺乏联盟经验与联盟资源的企业所采用,并作为其重构联盟组合的一种重要方式。在已有研究较多关注其静态构造的背景下,本文聚焦企业具有重复性特征的联... 详细信息

焦点企业与曾经有合作经历的既有联盟伙伴建立联盟以撬动新资源的做法,越来越多地被缺乏联盟经验与联盟资源的企业所采用,并作为其重构联盟组合的一种重要方式。在已有研究较多关注其静态构造的背景下,本文聚焦企业具有重复性特征的联盟组合重构对焦点企业绩效的影响,以及领导班子断裂带强度和组织冗余的边界约束作用。利用2010—2016年在创业板挂牌上市、与同一个伙伴建立2个以上联盟从而形成重复性联盟组合的上市公司联盟数据,实证检验重复性联盟组合重构对焦点企业绩效的影响。研究结果显示,重复性联盟组合重构与焦点企业绩效之间存在倒U形曲线关系;企业领导班子断裂带强度强化重复性联盟组合重构影响焦点企业绩效的倒U形关系;组织冗余弱化重复性联盟组合重构影响焦点企业绩效的倒U形关系。研究结论深层次解读了联盟组合重构作用于焦点企业绩效提升的规律,增强了对联盟组合“重构—绩效”作用的理论边界解释,揭示了重复性联盟组合重构发挥有效性的机理,深化了联盟组合“重构—绩效”作用的研究情境。

关键词：联盟组合重构企业绩效断裂带强度组织冗余

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High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

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Science China(Life Sciences) 2024年第8期67卷 1635-1647页

作者： Feng-Qi Liu qing-yuan Qu Ying Lei Qi Chen Yu-Xiu Chen Meng-Lin Li Xue-Yan Sun Ye-Jun Wu Qiu-Sha Huang Hai-xia Fu yuan Kong Yue-Ying Li Qian-Fei Wang xiao-Jun Huang xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100074China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the *** soluble immunomodulatory molecules,more sCD25 and sGalectin-9 were detected in ITP *** the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T *** contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell *** a platelet count of 30×10^(9)L^(−1)as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune ***-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of *** conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of *** may offer novel targets to develop personalized immunotherapies.

关键词： immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow

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藏缅语族语言韵律的类型学特征——兼反观汉语韵律的特征

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吉林大学社会科学学报 2024年第4期64卷 5-16,235页

作者：戴庆厦许怡中央民族大学中央民族大学中国少数民族语言文学学院北京100081

韵律是一种有特色的语言现象。运用语言类型学的理论,以藏缅语族50多种语言的语料为依据,描写、分析藏缅语韵律的基本特点,发现藏缅语的韵律包括双数音节、双声叠韵谐韵、元音和谐、辅音和谐、韵母和谐、声调和谐、音节前弱后强、重叠... 详细信息

韵律是一种有特色的语言现象。运用语言类型学的理论,以藏缅语族50多种语言的语料为依据,描写、分析藏缅语韵律的基本特点,发现藏缅语的韵律包括双数音节、双声叠韵谐韵、元音和谐、辅音和谐、韵母和谐、声调和谐、音节前弱后强、重叠八种类型。韵律的产生和发展受语言类型属性、语言经济原则以及人们审美意识的制约。韵律对藏缅语的语音、构词、句法、语义等方面都有重要影响。汉语与藏缅语是亲属语言,同属分析性语言,都具有丰富的韵律特征,可以通过藏缅语对汉语的反观来进一步认识汉语韵律的特征。汉语重句法韵律,藏缅语重词法韵律;汉语韵律重声调,藏缅语韵律不重声调;汉语不同方言的韵律差异较小,而藏缅语不同语言的韵律差异较大。总体上,韵律对汉语的制约力更强。汉语研究必须以亲属语言作为参照,才能加深对汉语的认识,进一步揭示出汉语的历史演变规律。

关键词：藏缅语语言类型学韵律反观汉语

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Organization of microtubule plus-end dynamics by phase separation in mitosis

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Journal of Molecular Cell Biology 2024年第2期16卷 24-35页

作者： Fengrui Yang Mingrui Ding xiaoyu Song Fang Chen Tongtong Yang Chunyue Wang Chengcheng Hu qing Hu Yihan Yao Shihao Du Phil YYao Peng xia Gregory Adams Jr Chuanhai Fu Shengqi xiang Dan Liu Zhikai Wang Kai yuan Xing Liu MOE Key Laboratory for Membraneless Organelles&Cellular Dynamics Hefei National Research Center for Cross-disciplinary SciencesCenter for Advanced Interdisciplinary Science and Biomedicine of IHMDivision of Life Sciences and MedicineUniversity of Science&Technology of ChinaHefei 230027China Anhui Key Laboratory for Cellular Dynamics and Chemical Biology University of Science&Technology of ChinaHefei 230027China Keck Center for Organoids Plasticity Morehouse School of MedicineAtlantaGA 30310USA Hunan Key Laboratory of Molecular Precision Medicine Central South UniversityChangsha 410083China

In eukaryotes,microtubule polymers are essential for cellular plasticity and fate ***-binding(EB)proteins serve as scaffolds for orchestrating microtubule polymer dynamics and are essential for cellular dynamics and chromosome segregation in ***,we show that EB1 forms molecular condensates with TIP150 and MCAK through liquid–liquid phase separation to compartmentalize the kinetochore–microtubule plus-end machinery,ensuring accurate kinetochore–microtubule interactions during chromosome segregation in *** of EB1–TIP150 polymer formation by a competing peptide prevents phase separation of the EB1-mediated complex and chromosome alignment at the metaphase equator in both cultured cells and Drosophila ***220 of EB1 is dynamically acetylated by p300/CBP-associated factor in early mitosis,and persistent acetylation at Lys220 attenuates phase separation of the EB1-mediated complex,dissolves droplets in vitro,and harnesses accurate chromosome *** data suggest a novel framework for understanding the organization and regulation of eukaryotic spindle for accurate chromosome segregation in mitosis.

关键词： phase separation mitosis microtubule dynamics EB1 acetylation

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M_(1)/M_(2)小胶质细胞参与急性耳鸣中枢发病机制的研究进展

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听力学及言语疾病杂志 2024年第5期32卷 470-473页

作者：夏晴张剑宁上海中医药大学附属岳阳中西医结合医院耳鼻咽喉科上海200437

小胶质细胞(microglia cell)是中枢神经系统特有的巨噬细胞,在神经损伤、修复及重塑过程中起重要作用。而中枢听觉通路及边缘系统等功能异常、神经结构及神经重塑是耳鸣中枢机制关注的焦点。M1和M2型小胶质细胞分别通过促炎、抗炎反应... 详细信息

小胶质细胞(microglia cell)是中枢神经系统特有的巨噬细胞,在神经损伤、修复及重塑过程中起重要作用。而中枢听觉通路及边缘系统等功能异常、神经结构及神经重塑是耳鸣中枢机制关注的焦点。M1和M2型小胶质细胞分别通过促炎、抗炎反应参与神经重塑。近年来研究发现小胶质细胞通过释放相关细胞因子,参与急性耳鸣发病过程,但具体机制尚不明确。本文对M1和M2小胶质细胞在急性耳鸣中枢机制中的研究进展进行综述。

关键词：耳鸣 M_(1)/M_(2)小胶质细胞炎症神经营养因子

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“城市更新+文旅”的城市孤岛空间多维拓扑结构与功能重塑研究——以广州市黄埔古村为例

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干旱区资源与环境 2024年第1期38卷 69-74页

作者：唐夕汐夏青田里广东第二师范学院管理学院广州510303 云南大学工商管理与旅游管理学院昆明650500

从列斐伏尔都市社会理论、德勒兹褶子说、阿特金Q分析等理论动力源出发来分析城市孤岛与周边现代化城市排斥与包容的辩证关系,并构建了城市孤岛“C-B”空间4维拓扑结构集合。采用观察法、半结构访谈法、文本分析法等数据获取方法,从历... 详细信息

从列斐伏尔都市社会理论、德勒兹褶子说、阿特金Q分析等理论动力源出发来分析城市孤岛与周边现代化城市排斥与包容的辩证关系,并构建了城市孤岛“C-B”空间4维拓扑结构集合。采用观察法、半结构访谈法、文本分析法等数据获取方法,从历时性拓扑演化的过程中,提炼出黄埔古村“村港一体”的拓扑不变量;从共时性的角度聚焦第四次拓扑结构,探索出“城市更新+文旅”的空间功能重塑模式是黄埔古村为代表的城市孤岛有效实施新时代空间转型发展的具体路径之一。

关键词：城市孤岛空间多维拓扑结构功能重塑城市更新文旅发展

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