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Efficacy of Chinese Medicine Treatment Based on Syndrome Differentiation for Primary Insomnia:A Randomized Placebo Controlled Triple-Blinded Trial

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Chinese Journal of Integrative Medicine 2024年第10期30卷 867-876页

作者： xiong zhi-yi LU ying HE Li-yun ZHANG Run-shun ZHOU Xue-zhong LI Peng LIU Yan-jiao ZHU Jian-gui YAN Shi-yan LIU Bao-yan International Acupuncture and Moxibustion Innovation Institute School of Acupuncture-Moxibustion and TuinaBeijing University of Chinese MedicineBeijing100029China Department of Biomedical Data Science Stanford University School of MedicineStanfordCA94305USA Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China Guang’anmen Hospital China Academy of Chinese Medical SciencesBeijing100053China School of Computer and Information Technology Beijing Jiaotong UniversityBeijing100044China Beijing Xicheng District Community Healthcare Center Beijing100120China China Academy of Chinese Medical Sciences Beijing100700China

Objective:To assess efficacy of Chinese medicine(CM)on insomnia considering characteristics of treatment based on syndrome ***:A total of 116 participants aged 18 to 65 years with moderate and severe primary insomnia were randomized to the placebo(n=20)or the CM group(n=96)for a 4-week treatment and a 4-week *** CM clinicians independently prescribed treatments for each patient based on syndromes *** primary outcome was change in total sleep time(TST)from *** endpoints included sleep onset latency(SOL),wake time after sleep onset(WASO),sleep efficiency,Pittsburgh Sleep Quality Index(PSQI)and CM ***:The CM group had an average 0.6 h more(95%confidence interval(CI):0.3–0.9,P<0.001)TST and 34.1%(10.3%–58.0%,P=0.005)more patients beyond 0.5 h TST increment than that of the placebo *** was changed–3.3(–3.8 to–2.7)in the CM group,a–2.0(–3.2 to–0.8,P<0.001)difference from the placebo *** CM symptom score in the CM group decreased–2.0(–3.3 to–0.7,P=0.003)more than the placebo *** and WASO changes were not significantly different between *** analysis of prescriptions by these clinicians revealed blood deficiency and Liver stagnation as the most common *** for these clinicians displayed relative stability,while the herbs *** adverse events were mild and were not related to study ***:CM treatment based on syndrome differentiation can increase TST and improve sleep quality of primary *** is effective and safe for primary *** future studies,the long-term efficacy validation and the exploratory of eutherapeutic clinicians'fixed herb formulas should be addressed.(Registration ***01613183).

关键词： primary insomnia Chinese medicine syndrome differentiation randomized controlled trial

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Placebo Response among Different Types of Sham Acupuncture for Low Back Pain:A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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中国结合医学杂志:英文版 2023年第10期29卷 941-950页

作者： xiong zhi-yi LIU Xiao-yu MA Pei-hong SUN Chong-yang SUN Cheng-yi LIU Ting-lan LIU Bao-yan LIU Cun-zhi YAN Shi-yan International Acupuncture and Moxibustion Innovation Institute School of Acupuncture-Moxibustion and TuinaBeijing University of Chinese MedicineBeijing100029China School of Acupuncture-Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin301617China China Academy of Chinese Medical Sciences Beijing100007China

Background: Low back pain(LBP) is a prevalent and debilitating condition that poses a significant burden on healthcare systems. Acupuncture has been proposed as a promising intervention for LBP, but the evidence supporting its specific effect is insufficient, and the use of sham acupuncture as a control in clinical trials presents challenges due to variations in sham acupuncture techniques and the magnitude of the placebo ***: To investigate the magnitude of the placebo response of sham acupuncture in trials of acupuncture for nonspecific LBP, and to assess whether different types of sham acupuncture are associated with different responses. Methods: Four databases including PubMed, EMBASE, MEDLINE, and the Cochrane Library were searched through April 15, 2023, and randomized controlled trials(RCTs) were included if they randomized patients with LBP to receive acupuncture or sham acupuncture intervention. The main outcomes included the placebo response in pain intensity, back-specific function and quality of life. Placebo response was defined as the change in these outcome measures from baseline to the end of treatment. Random-effects models were used to synthesize the results, standardized mean differences(SMDs, Hedges’ g) were applied to estimate the effect size. Results: A total of 18 RCTs with 3,321 patients were included. Sham acupuncture showed a noteworthy pooled placebo response in pain intensity in patients with LBP [SMD –1.43, 95% confidence interval(CI) –1.95 to –0.91, I2=89%]. A significant placebo response was also shown in back-specific functional status(SMD –0.49, 95% CI –0.70 to –0.29, I2=73%),but not in quality of life(SMD 0.34, 95% CI –0.20 to 0.88, I2=84%). Trials in which the sham acupuncture penetrated the skin or performed with regular needles had a significantly higher placebo response in pain intensity reduction, but other factors such as the location of sham acupuncture did not have a significant impact on the placebo ***

关键词： low back pain sham acupuncture placebo response meta-analysis randomized controlled trial

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基于概率统计的压缩机可靠性研究

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化工机械 2024年第5期51卷 764-773页

作者：魏然然郑洪龙郝振凯熊至宜黄伟国家管网集团科学技术研究总院分公司西安热工研究院有限公司中国石油大学(北京)机械与储运工程学院

在统计国家管网现场大型离心压缩机机组2006~2022年运行故障数据的基础上,对数据进行清洗,将离心压缩机系统分为多个子系统进行概率统计,通过历史故障数据进行经验分布拟合与检验,建立了整个离心压缩机及其部件故障数据计算模型。除工... 详细信息

在统计国家管网现场大型离心压缩机机组2006~2022年运行故障数据的基础上,对数据进行清洗,将离心压缩机系统分为多个子系统进行概率统计,通过历史故障数据进行经验分布拟合与检验,建立了整个离心压缩机及其部件故障数据计算模型。除工艺系统服从对数正态分布外,其他服从双参数Weibull分布;所建立的计算模型都有95%以上的置信区间。

关键词：离心压缩机系统可靠性概率统计分布拟合 Weibull分布

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Effect of stress-relief annealing on thermal fatigue cracks for die-casting die steels

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Journal of Iron and Steel Research International 2024年第5期31卷 1164-1176页

作者： zhi-xiong Bai Xiao-chun Wu School of Materials Science and Engineering Shanghai UniversityShanghai200444China

The effect of stress-relief annealing at different stages of thermal fatigue tests on crack growth was investigated using a self-built thermal cycle *** results showed that annealing could limit crack expansion *** reduced dislocation density and released the accumulation of residual *** addition,the strain accumulation in carbides was reduced by this *** was also found that double annealing was even more effective at inhibiting crack expansion compared to single stress-relief *** 1000 cycles,the maximum crack length was reduced by 31.1%and 45.2%for the samples after using the optimal single and double annealing processes,*** single stress-relief annealing,earlier annealing provides more benefit in delaying crack ***,effective double stress-relief annealing requires a suitable time interval between the annealing ***,after 800 cycles,surface hardness decreased significantly accompanied by an increase in the size and number of carbides,and cracks expanded predominantly along grain boundaries.

关键词： Thermal fatigue Steel Carbide Stress-relief annealing Dislocation Residual stress

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Unlocking T cell exhaustion:Insights and implications for CAR-T cell therapy

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3416-3431页

作者： Dian xiong Haijun Yu zhi-Jun Sun State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyFrontier Science Center for Immunology and MetabolismTaikang Center for Life and Medical ScienceWuhan UniversityWuhan 430079China Department of Radiation and Medical Oncology Hubei Province Cancer Clinical Study CenterHubei Key Laboratory of Tumor Biological BehaviorsZhongnan Hospital of Wuhan UniversityWuhan 430071China

Chimeric antigen receptor T(CAR-T)cell therapy as a form of adoptive cell therapy(ACT)has shown significant promise in cancer treatment,demonstrated by the FDA-approved CAR-T cell therapies targeting CD19 or B cell maturation antigen(BCMA)for hematological malignancies,albeit with moderate outcomes in solid ***,despite these advancements,the efficacy of CAR-T therapy is often compromised by T cell exhaustion,a phenomenon that impedes the persistence and effector function of CAR-T cells,leading to a relapse rate of up to 75%in patients treated with CD19 or CD22 CAR-T cells for hematological *** to overcome CAR-T exhaustion employ state-of-the-art genomic engineering tools and single-cell sequencing *** this review,we provide a comprehensive understanding of the latest mechanistic insights into T cell exhaustion and their implications for the current efforts to optimize CAR-T cell *** insights,combined with lessons learned from benchmarking CAR-T based products in recent clinical trials,aim to address the challenges posed by T cell exhaustion,potentially setting the stage for the development of tailored next-generation approaches to cancer treatment.

关键词： Cancer immunotherapy CAR-T therapy T cell exhaustion Tumor immune microenvironment Spatial immune contexture Single-cell technologies CAR-T engineering Combination therapy

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A Semiparametric Additive-multiplicative Rates Model for the Weighted Composite Endpoint of Recurrent and Terminal Events

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Acta Mathematica Sinica,English Series 2024年第4期40卷 985-999页

作者： yi DENG Qiang xiong Shu Wei LI School of Economics and Statistics Guangzhou UniversityGuangzhou 510006P.R.China

Recurrent event data are commonly encountered in many scientific fields,including biomedical studies,clinical trials and epidemiological surveys,and many statistical methods have been proposed for their *** this paper,we consider to use a weighted composite endpoint of recurrent and terminal events,which is weighted by the severity of each event,to assess the overall effects of covariates on the two types of events.A flexible additive-multiplicative model incorporating both multiplicative and additive effects on the rate function is proposed to analyze such weighted composite event process,and more importantly,the dependence structure among the recurrent and terminal events is left *** the estimation,we construct the unbiased estimating equations by virtue of the inverse probability weighting technique,and the resulting estimators are shown to be consistent and asymptotically normal under some mild regularity *** evaluate the finite-sample performance of the proposed method via simulation studies and apply the proposed method to a set of real data arising from a bladder cancer study.

关键词： Additive-multiplicative rates model estimating equation recurrent events terminal event weighted composite endpoint

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A blockchain-empowered authentication scheme for worm detection in wireless sensor network

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Digital Communications and Networks 2024年第2期10卷 265-272页

作者： Yuling Chen xiong Yang Tao Li yi Ren Yangyang Long State Key Laboratory of Public Big Data College of Computer Science and TechnologyGuizhou UniversityGuiyang550025China School of Computing Science University of East AngliaNorwichNR57TJUK

Wireless Sensor Network(WSN)is a distributed sensor network composed a large number of nodes with low cost,low performance and *** special structure of WSN brings both convenience and *** example,a malicious participant can launch attacks by capturing a physical ***,node authentication that can resist malicious attacks is very important to network ***,blockchain technology has shown the potential to enhance the security of the Internet of Things(IoT).In this paper,we propose a Blockchain-empowered Authentication Scheme(BAS)for *** our scheme,all nodes are managed by utilizing the identity information stored on the ***,the simulation experiment about worm detection is executed on BAS,and the security is evaluated from detection and infection *** experiment results indicate that the proposed scheme can effectively inhibit the spread and infection of worms in the network.

关键词： Wireless Sensor Network(WSN) Node authentication Blockchain Tangle Worm detection

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Iron-based layered double hydroxide packed with metal-organic frameworks for enhanced overall water-splitting electrocatalysis

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Tungsten 2024年第4期6卷 859-868页

作者： Long Chen Yun Luo zhi-Peng Yu yi-Kun Cheng Yang Zheng Li He Jia-Hao xiong Wen-Wen Kong Key Laboratory for Green Process of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical Engineering Shihezi University Institute of Scientific Research Luzhou North Chemistry Industry Co.Ltd International Iberian Nanotechnology Laboratory (INL) CAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Key Laboratory of Electronic Information Materials and Devices Center of Materials Science and Optoelectronics Engineering Xinjiang Technical Institute of Physics and Chemistry of CAS

Designing hybrid materials with numerous catalytic active sites,high specific surface area,and interfacial interactions is an effective strategy to improve electrocatalytic *** this work,iron-based metal organic frameworks（Fe-MOFs）@（Co,Ni）Fe-layered double hydroxide（LDH） is successfully constructed using the similar "MOF growing on LDH" strategy for oxygen evolution reaction and hydrogen evolution reaction in the alkaline *** synthesized hybrid materials in this particular way show excellent electrochemical overall water-splitting performance with the cell voltage of 1.62 V at10 mA·cm-2in the alkaline environment due to the optimized adsorption/desorption properties of metal ions on oxygencontaining species and interfacial effects of hybrid ***-MOFs@（Co,Ni）Fe-LDH also exhibits excellent hydrogen and oxygen production efficiency of 370 and 175 μL·min-1,*** work draws on an effective approach to the fabrication of MOF@LDH structures and provides new insights into overall water-splitting in alkaline conditions.

关键词： Electrocatalysis Interfacial interactions Layered double hydroxide Metal–organic frameworks (MOFs) Water splitting

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Summer gregarine infection in Antarctic krill Euphausia superba in the Dumont D’Urville Sea,East Antarctic

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Journal of Oceanology and Limnology 2024年第5期42卷 1651-1658页

作者： yi xiong Sijie ZHAO Guoping ZHU College of Marine Living Resource Sciences and Management Shanghai Ocean UniversityShanghai 201306China Center for Polar Research Shanghai Ocean UniversityShanghai 201306China Polar Marine Ecosystem Group the Key Laboratory of Sustainable Exploitation of Oceanic Fisheries ResourcesMinistry of EducationShanghai 201306China National Engineering Research Center for Oceanic Fisheries Shanghai 201306China

Antarctic krill Euphausia superba plays a key role in the Antarctic food *** trophic linkage between krill and other macro-organisms has been studied in the past decades,but the variability of parasites in krill is less studied and remains poorly ***,it is important to understand the factors that influence abundance and infection of parasites in ***,the relationship between the infection intensity of parasite and krill diet needs to be clarified,which is helpful for understanding the role of parasite in the food *** investigated the abundance of the highly prevalent gregarine parasites in the digestive tract of krill and the factors influencing the gregarine infection to krill in the East *** infection rate of Cephaloidophora pacifica Avdeev,1985 to krill(n=50 individuals)was 94%.The results of generalized linear model show the infection intensity of *** to the host was related significantly to the station,krill size,and maturity stage,but not the food species and abundance in the stomach of *** of *** in krill differed among stations,and the lowest abundance occurred in the station nearest to the *** abundance varied among sexual maturity stages of krill and increased with krill size.

关键词： Cephaloidophora pacifica Euphausiids parasite diet dinoflagellate

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Analysis method and experimental study of ice accumulation detection signal based on Lamb waves

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Chinese Journal of Aeronautics 2024年第8期37卷 388-403页

作者： Yanxin ZHANG Hongjian ZHANG Xian yi Binrui WU Xianlei GUAN Jianjun xiong Key Laboratory of Icing and Anti/De-icing China Aerodynamics Research and Development CenterMianyang 621000China State Key Laboratory of Aerodynamics China Aerodynamics Research and Development CenterMianyang 621000China

A quantitative identification method for in-flight icing has the capability to significantly enhance the safety of aircraft *** guided waves have the unique advantage of detecting icing in a relatively large area,but quantitative identification of ice layers is a *** this paper,a quantitative identification method of ice accumulation based on ultrasonic guided waves is ***,a simulation model for the wave dynamics of piezoelectric coupling in three dimensions is established to analyze the propagation characteristics of Lamb waves in a structure consisting of an aluminum plate and an ice *** wavelet transform method is utilized to extract the Time of Flight(ToF)or Time of Delay(ToD)of S_(0)/B_(1) mode waves,which serves as a characteristic parameter to precisely determine and assess the level of ice ***,an experimental system is developed to evaluate the feasibility of Lamb waves-based icing real-time detection in the presence of spray ***,a combination of the Hampel median filter and the moving average filter is developed to analyze ToF/ToD *** simulation results reveal a positive correlation between geometric dimensions(length,width,thickness)of the ice layer and ToF/ToD of B1 mode waves,indicating their potential as indicators for quantifying ice *** results of real-time icing detection indicate that ToF/ToD will reach greater peak values with the growth of the arbitrary-shaped ice layer until saturation to effectively predict the simulation *** study lays a foundation for the practical application of quantitative icing detection via ultrasonic guided waves.

关键词： Ice Ice accumulation Ultrasonic sensor Ultrasonic guided wave Lamb wave Wavelet transform

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