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Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo Yu Zhenyu Sun Weichen Zheng Liangwei Zhang Yanling Xue Wenning Liu Shoumei xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

雅鲁藏布江缝合带西段东波地幔橄榄岩体钻孔岩心研究

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地质学报 2019年第10期93卷 2486-2508页

作者：王云鹏牛晓露杨经绥李源徐向珍冯光英熊发挥刘飞刘钊田亚洲郭国林连东洋赵一珏地幔研究中心自然资源部深地动力学重点实验室中国地质科学院地质研究所北京100037 中国地质科学院矿产资源研究所自然资源部成矿作用与资源评价重点实验室北京100037 贵州大学资源与环境工程学院贵阳550025 核资源与环境国家重点实验室东华理工大学南昌330013 南京大学地球科学与工程学院南京210023

东波地幔橄榄岩是雅鲁藏布江缝合带内代表性超镁铁岩体,位于缝合带西段,面积超过400km2。为查明岩体成因,在岩体中实施了一口千米深的科学钻探(DSD-1)。除上部有约23m厚的第四系堆积物外,钻孔均钻进在地幔橄榄岩中,孔深1002.06m,岩心采... 详细信息

东波地幔橄榄岩是雅鲁藏布江缝合带内代表性超镁铁岩体,位于缝合带西段,面积超过400km2。为查明岩体成因,在岩体中实施了一口千米深的科学钻探(DSD-1)。除上部有约23m厚的第四系堆积物外,钻孔均钻进在地幔橄榄岩中,孔深1002.06m,岩心采取率96.62%。岩心编录结合显微镜下鉴定将岩心划分出44个岩性单元层,并进一步归并为上、下两套岩性:上部(23.1~340.17m)为含单辉方辉橄榄岩(斜方辉石含量为15~20%,单斜辉石含量不足5%);下部(340.17~1002.06m)为方辉橄榄岩(斜方辉石含量为10%~15%,几乎不含单斜辉石),其中发育薄层状纯橄岩和辉石岩以及辉绿岩脉。矿物学及全岩地球化学研究揭示:①东波地幔橄榄岩以方辉橄榄岩为主,其次为含单辉方辉橄榄岩,它们均具有亏损的全岩地球化学及矿物成分组成,指示它们为经历过中高程度部分熔融后的地幔残余岩石;经历过富水流体(熔体)交代作用,表现为角闪石呈柱状交代斜方辉石;②纯橄岩和辉石岩以透镜状或薄层状脉体发育于方辉橄榄岩中,具有岩浆成因的矿物组成,见交代矿物角闪石,指示它们可能为交代成因;③辉绿岩脉兼具N-MORB和弧玄武岩的化学属性,以低SiO2、高MgO和高Al2O3含量为特征,具有与Western Lau Basin玄武岩一致的REE配分型式,形成于较为成熟的弧后盆地环境。东波地幔橄榄岩(及其中的纯橄岩、辉石岩和辉绿岩脉)在成因上与俯冲带关系密切,都受到了与俯冲带相关地质作用的影响。

关键词：俯冲作用交代作用钻孔岩心东波地幔橄榄岩蛇绿岩雅鲁藏布西藏

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期 204-218页

作者： Chen xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie Qian Hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

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Solar flare forecasting based on a Fusion Model

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Earth and Planetary Physics 2025年第1期9卷 171-181页

作者： YiYang Li ShiYong Huang SiBo Xu ZhiGang Yuan Kui Jiang QiYang xiong RenTong Lin School of Earth and Space Science Technology Hubei Luojia LaboratoryWuhan UniversityWuhan 430072China

Solar flare prediction is an important subject in the field of space *** learning technology has greatly promoted the development of this *** this study,we propose a novel solar flare forecasting model integrating Deep Residual Network(ResNet)and Support Vector Machine(SVM)for both≥C-class(C,M,and X classes)and≥M-class(M and X classes)*** collected samples of magnetograms from May 1,2010 to September 13,2018 from Space-weather Helioseismic and Magnetic Imager(HMI)Active Region Patches and then used a cross-validation method to obtain seven independent data *** then utilized five metrics to evaluate our fusion model,based on intermediate-output extracted by ResNet and SVM using the Gaussian kernel *** results show that the primary metric true skill statistics(TSS)achieves a value of 0.708±0.027 for≥C-class prediction,and of 0.758±0.042 for≥M-class prediction;these values indicate that our approach performs significantly better than those of previous *** metrics of our fusion model’s performance on the seven datasets indicate that the model is quite stable and robust,suggesting that fusion models that integrate an excellent baseline network with SVM can achieve improved performance in solar flare ***,we also discuss the performance impact of architectural innovation in our fusion model.

关键词： solar flare pace weather deep learning Fusion Model

Pore shrinkage capacity of Shajiang black soils(Vertisols)on the North China Plain and its influencing factors

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Pedosphere 2024年第3期34卷 620-630页

作者： Yueming CHEN Zhongbin ZHANG Lei GAO Zichun GUO Peng xiong fahui JIANG Xinhua PENG State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008(China) University of Chinese Academy of Sciences Beijing 100049(China) Jiangxi Agricultural University Nanchang 330045(China)

Different pore sizes present different pore shrinkage capacities in a nonrigid ***,the shrinkage capacities of different pore sizes and their influencing factors are not *** aimed to quantify the shrinkage capacities of different pore sizes(large pores,>50μm;medium pores,0.2-50μm;fine pores,<0.2μm)and determine how soil properties impact soil shrinkage capacity at the regional *** sampling transects from west to east(360 km long,35 samples)and from north to south(190 km long,29 samples)were selected to investigate soil shrinkage capacity and physicochemical properties of at0-20 cm depth in the Vertisol(locally known as Shajiang black soil)region of the North China *** results showed that soil total shrinkage capacity,indicated by the coefficient of linear extensibility(COLE),had a mean value of 0.041-0.051 in the west-east and north-south *** pores had higher pore shrinkage index(PSI)values(0.103-0.109)than medium(0.077-0.096)and fine(0.087-0.091)*** PSI of fine pores showed a fluctuating increasing trend from northwest to southeast,and the fine pore shrinkage capacity determined the COLE(r^(2)=0.789,P<0.001).The PSI of large pores had a significant relationship with soil bulk density(r=0.281,P<0.05)and organic carbon(r=-0.311,P<0.05),whereas those of medium and fine pores were correlated with soil clay content(r=0.381 and 0.687,respectively,P<0.001).In addition,the PSI of fine pores was also correlated with montmorillonite content(r=0.387,P<0.01).It can be concluded that the PSI of large pores is related to anthropogenically influenced soil properties with low stability,whereas those of medium and fine pores are related to pedogenic *** high variability in anthropogenic and pedogenic factors explains the spatial pattern of Vertisol shrinkage capacity on the North China Plain.

关键词： clay content coefficient of linear extensibility pore shrinkage index soil structure spatial distribution swelling

Adaptive-basis decomposition-based low-rank network for efficient non-uniform motion deblurring

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Optoelectronics Letters 2025年第1期21卷 43-50页

作者： CHEN Lei xiong Qingbo ZHANG Wei LI Runde School of Software Henan University School of Applied Technology China University of Labor Relations

In this study, we present a unified sparsity-driven framework that significantly enhances motion deblurring performance by integrating two key components: a custom-designed dataset and a low-rank module(LRM). This framework leverages the inherent sparsity of per-pixel blur kernels to bolster both deblurring accuracy and model interpretability. Firstly, we propose an adaptive-basis decomposition-based deblurring(ADD) approach, which constructs a tailored training dataset to enhance the generalization capacity of the deblurring network. The ADD framework adaptively decomposes motion blur into sparse basis elements, effectively addressing the intricacies associated with non-uniform blurs. Secondly, an LRM is proposed to improve the interpretability of deblurring models as a plug-and-play module, primarily designed to identify and harness the intrinsic sparse features in sharp images. A series of ablation studies have been conducted to substantiate the synergistic advantages of combining the proposed ADD with the LRM for overall improvement in deblurring efficacy. Subsequently, we empirically demonstrate through rigorous experimentation that incorporating the LRM into an existing Uformer network leads to substantial enhancement in reconstruction performance. This integration yields a sparsity-guided low-rank network(SGLRN). Operating under the overarching principle of sparsity, SGLRN consistently outperforms state-of-the-art methods across multiple standard deblurring benchmarks. Comprehensive experimental results, assessed through quantitative metrics and qualitative visual evaluations, provide compelling evidence of its effectiveness. The overall deblurring results are available at Google Drive.

关键词： Image enhancement

大理市下关镇动物源食品中四环素类抗生素残留的检测

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大理学院学报（综合版） 2015年第6期14卷 42-44页

作者：卢跃红罗开敏王光婷吕荣聪孙慧媛熊发辉大理学院农学与生物科学学院云南大理671003 大理学院公共卫生学院云南大理671000

目的:对大理市下关镇市售新鲜猪肉、鸡肉、牛肉、鱼肉及其肝脏中四环素类抗生素残留情况进行检测,以期为该镇动物源食品的监测及消费者食用安全提供理论依据。方法:用高效液相色谱,按照GB/T 5009.116—2003规定对采集的样品进行检测。结... 详细信息

目的:对大理市下关镇市售新鲜猪肉、鸡肉、牛肉、鱼肉及其肝脏中四环素类抗生素残留情况进行检测,以期为该镇动物源食品的监测及消费者食用安全提供理论依据。方法:用高效液相色谱,按照GB/T 5009.116—2003规定对采集的样品进行检测。结果:随机采取的样品均未检测出土霉素(OTC)、四环素(TC)、金霉素(CTC)。结论:大理市下关镇随机采集的本批动物性食品中没有四环素类抗生素残留。

关键词：动物源食品四环素类抗生素残留高效液相色谱

Multifunctional Nacre-Like Nanocomposite Papers for Electromagnetic Interference Shielding via Heterocyclic Aramid/MXene Template-Assisted In-Situ Polypyrrole Assembly

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： xiong, Jinhua Zhao, Xu Liu, Zonglin Chen, He Yan, Qian Lian, Huanxin Chen, Yunxiang Peng, Qingyu He, Xiaodong Harbin Inst Technol Ctr Composite Mat & Struct Natl Key Lab Sci & Technol Adv Composites Special Harbin 150080 Peoples R China

The large-scale, high-strength, super-tough, and multifunctional nacre-like heterocyclic aramid (HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite papers were fabricated using the in-situ assembly of PPy onto the HA/MXene hydrogel *** "brick-and-mortar" layered structure and abundant hydrogen-bonding interactions among MXene, PPy, and HA respond cooperatively to external stress and effectively increase the mechanical properties of HMP nanocomposite *** templating effect from HA/MXene was utilized to guide the assembly of conducting polymers, leading to high electrical conductivity and outstanding electromagnetic interference shielding performance. Robust, ultra-flexible, and multifunctional MXene-based electromagnetic interference (EMI) shielding nanocomposite films exhibit enormous potential for applications in artificial intelligence, wireless telecommunication, and portable/wearable electronic equipment. In this work, a nacre-inspired multifunctional heterocyclic aramid (HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite paper with large-scale, high strength, super toughness, and excellent tolerance to complex conditions is fabricated through the strategy of HA/MXene hydrogel template-assisted in-situ assembly of PPy. Benefiting from the "brick-and-mortar" layered structure and the strong hydrogen-bonding interactions among MXene, HA, and PPy, the paper exhibits remarkable mechanical performances, including high tensile strength (309.7 MPa), outstanding toughness (57.6 MJ m-3), exceptional foldability, and structural stability against ultrasonication. By using the template effect of HA/MXene to guide the assembly of conductive polymers, the synthesized paper obtains excellent electronic conductivity. More importantly, the highly continuous conductive path enables the nanocomposite paper to achieve a splendid EMI shielding effectiveness (EMI SE) of 54.1 dB at an ultra-thin thickness (25.4 mu m) and a high specific EMI SE of 17,204.7 dB cm2 g-1. In addit

关键词： MXene Remarkable mechanical properties Heterocyclic aramid Electromagnetic interference shielding Polypyrrole Multifunctionality

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei Huang Jiayi Wen Xin xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution