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Effects of IL-4 on cyclooxygenase-2 and platelet-derived growth factor in the lungs of COPD rats

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Journal of Nanjing Medical University 2007年第3期21卷 169-174页

作者： Yan Li Shengdao xiong Weining xiong yongjian Xu Department of Pulmonary Medicine Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Objective： To explore the role of interleukin 4（IL-4）, expressions of cyclooxygenase-2 （COX-2） and platelet-derived growth factor （PDGF） in the model of chronic obstructive pulmonary disease （COPD）, in the lungs of rats. Methods： Male Wistar rats were used to build up the model of COPD. Rats were randomly divided into the control group and model group, the IL-4 group and the dexamethasone group. The expressions of COX-2, PDGF-A and PDGF-B in the lung tissue were detected by western blotting and RT-PCR. Results： The expressions of COX-2, PDGF-A and PDGF-B in the model group were increased significantly. Those expressions in the IL-4 and dexamethasone group were notably decreased. Conclusion： IL-4 and dexamethasone could interfere in the establishment of COPD. The expressions of COX-2 and PDGF in the lung tissue of COPD were increased significantly and IL-4 and dexamethasone could decrease those expressions.

关键词： interleukin-4 chronic obstructive pulmonary disease cyclooxygenase-2 platelet-derived growth factor

Analysis of composition of gut microbial community in a rat model of functional dyspepsia treated with Simo Tang(四磨汤)

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Journal of Traditional Chinese Medicine 2024年第6期44卷 1168-1176页

作者： WANG Yiying LIU Jianjun xiong yongjian ZHANG Yongli WEN Yuqi XUE Mengli GUO Huishu QIU Juanjuan Centralab the First Affiliated Hospital of Dalian Medical UniversityDalian 116011China Clinical Laboratory of Integrative Medicine the First Affiliated Hospital of Dalian Medical UniversityDalian 116011China Department of Critical Care Medicine the First Affiliated Hospital of Dalian Medical UniversityDalian 116011China

OBJECTIVE: To investigate composition of gut microbial community in a rat model of functional dyspepsia(FD) and to explore the interventional effects of Simo Tang(四磨汤, SMT). METHODS: A rat model of FD was established through the tail-clamping stimulation method. The rat model of FD was assessed by the state of rats, their weight, sucrose preference rate, and intestinal propulsion rate. The DNA was extracted from stool samples after treatment with SMT. Amplified polymerase chain reaction(PCR) products of the 16S r DNA were sequenced using Novase Q6000 after construction of libraries. Composition of gut microbial community in the stool samples was determined and analyzed by cluster analysis, bioinformatic analysis, and analysis of α-diversity and β-***: The rat model of FD was successfully established using the tail-clamping stimulation method. The statistical results of cluster analysis of operational taxonomic units(OTUs) showed that the relative abundance of OTUs in the FD group was the lowest, while it was the highest in the normal(N) group. The composition of microbiome in the four groups was similar at phyla level. Compared with the FD group, the abundance of Firmicutes was downregulated, and the abundance of Proteobacteria and Bacteroidetes was upregulated in the Simo Tang(SMT) and high-dose Simo Tang(SMT.G) groups. The ratio of Bacteroidetes/Firmicutes was also elevated. According to the analysis of α-diversity and β-diversity, the abundance of flora in FD rats was significantly reduced. The treatment using SMT appeared beneficial to improve the diversity of flora. SMT could improve the intestinal flora in FD rats. The results showed that FD rats had intestinal flora imbalance, and species diversity increased. The results suggested that SMT could regulate the disorders of intestinal flora caused by FD. CONCLUDIONS: SMT could restore gut homeostasis and maintain gut flora diversity by modulating the gut microbiota and its associated metabolites in

关键词： gut microbial community composition functional dyspepsia gastrointestinal microbiome abundance of flora Simo Tang

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涡流损耗与介质尺寸的关系

物理与工程 2021年第3期31卷 29-32页

作者：熊永建宁波大学物理科学与技术学院浙江宁波315211

本文讨论涡流热功率随介质尺寸变化规律。考虑圆柱和四方柱导体,受到均匀的正弦交变磁场,推导出涡流损耗的表达式,从而用定量的结果说明大块导体分割为相互绝缘的小导体可以减少涡流损耗。用Comsol软件做数值仿真,验证了理论结果。

关键词：涡流损耗圆柱导体四方柱导体数值仿真

合并肠外表现的炎症性肠病患者英夫利西单抗治疗效果分析

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胃肠病学 2022年第10期27卷 583-588页

作者：陈吟梁丽娜熊永建卢书明贵州省人民医院消化内科 550002 大连医科大学附属第一医院消化内科大连医科大学附属第一医院中心实验室

背景:炎症性肠病(IBD)发病率呈逐年升高的趋势,部分IBD患者合并肠外表现(EIM),且EIM对IBD治疗产生一定的影响。目的:总结合并EIM的IBD患者临床特征,并评价英夫利西单抗(IFX)的治疗效果。方法:回顾性分析2010年1月—2020年12月于大连医... 详细信息

背景:炎症性肠病(IBD)发病率呈逐年升高的趋势,部分IBD患者合并肠外表现(EIM),且EIM对IBD治疗产生一定的影响。目的:总结合并EIM的IBD患者临床特征,并评价英夫利西单抗(IFX)的治疗效果。方法:回顾性分析2010年1月—2020年12月于大连医科大学附属第一医院诊断为IBD且同时合并EIM患者的临床资料,探讨IFX的治疗效果。结果:811例IBD患者中,50例(6.17%)合并EIM。EIM以关节炎(78.00%)、结节性红斑(26.00%)最为常见。52.00%的IBD患者合并1种EIM。合并EIM的UC患者中病变范围累及以E3最常见(68.42%),CD患者以L3最常见(50.00%)。共21例患者接受IFX治疗,用药后第2周HB、ALB明显上升,ESR、CRP、PLT明显下降;第22周83.33%的UC患者转为轻度,70.00%的CD患者进入缓解期。应用IFX后关节炎首次消失时间明显短于未应用IFX组(2.50 d对10.50 d,P<0.05)。CRP升高者关节炎首次消失中位时间亦明显短于CRP正常者(3.00 d对9.00 d,P<0.05)。结论:IBD患者合并EIM以关节炎、结节性红斑较为常见,应用IFX治疗可明显缩短部分EIM首次消失时间。

关键词：炎症性肠病肠外表现关节炎结节性红斑英夫利西单抗治疗

复合材料双钉胶螺混合连接接头多参数优化设计

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宇航材料工艺 2022年第1期52卷 39-44页

作者：李明坤郑艳萍熊勇坚黄飞郑州大学机械与动力工程学院郑州450001

为提高复合材料双钉胶螺混合连接接头的承载能力,本文结合实验和有限元方法,利用ABAQUS建立了有限元模型并验证了其可行性,基于代理模型和遗传算法,对碳纤维复合材料板与钛合金板双钉混合连接结构的板宽、端距和孔距等参数开展了多参数... 详细信息

为提高复合材料双钉胶螺混合连接接头的承载能力,本文结合实验和有限元方法,利用ABAQUS建立了有限元模型并验证了其可行性,基于代理模型和遗传算法,对碳纤维复合材料板与钛合金板双钉混合连接结构的板宽、端距和孔距等参数开展了多参数优化设计。结果表明:二次多项式代理模型的预测结果精度最高;与优化前试验得到的常规混合连接接头的载荷性能相比,优化后的结构承载能力提升了44.35%。

关键词：碳纤维复合材料胶螺混合连接代理模型遗传算法多参数优化

The Diagnosis Value and Its Implication of Impulse Oscillometry in Obstructive Sleep Apnea Syndrome Patients

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2000年第4期20卷 280-282页

作者：刘辉国倪望赵建平熊盛道徐永健张珍祥 Department of Respiratory Diseases Tongji Hospital Tongji Medical University Wuhan

The change of measurements of impulse oscillometry (105) in obstructive sleep apnea syn- drome (OSAS) patients and its mechanism were observed. The respiratory impedance was measured by using IOS technique and polysomnography (PSG) was monitored synchronously in 36 OSAS pa- tients,14 patients with chronic obstructive pulmonary disease (COPD) and 12 normal controls. Re- sults showed that R20 in OSAS group was significantly higher than in COPD group and control group (P<0.01). R5-R20 in OSAS group was lower than that in COPD group, but significantly higher than that in control group(P<0. 01). The levels of R20 and R5-R20 were positively correlated with severity degree of the disease. In addition, apnea-hyponea index (AHI) was positively correlated with R5 and R20 with the correlation index (r)being 0. 66 and 0. 86 respectively. The lowest SO2 was negatively correlated with R5 and R5-R20, with r being-0. 66 and- 0. 79 respectively. The mean SO2 was negatively correlated with R5 and R5-R20 with r being-0. 81 and-0. 69 respectively. IOS technique could be used as a valuable tool for assessing the degree of upper airway obstruction in the patients with OSAS, and could help to explore its pathological mechanism.

关键词： obstructive sleep apnea syndrome impulse oscillometry airway impedance

Increased Expression of PI-3K in Asthmatic Rat T Lymphocytes

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2007年第1期27卷 34-36页

作者：刘谨周世新熊盛道徐永健张珍祥熊维宁 Department of Respiratory Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

In order to explore the expression of PI-3K in T lymphocytes of asthmatic rats and the relationship between PI-3K and activation of T lymphocytes, 24 Wistar rats were randomly divided into 4 groups： normal control group, asthmatic one-week group, asthmatic two-week group and asthmatic four-week group. T cells were purified from blood of each rat and the expression of PI-3K was observed by immunocytochemical fluorescence staining, the serniquantitative fluorescence intensity was measured by HPIAS-2000 analytic software, and the expression of IL-4 in supernatants was detected by ELISA. The results showed that the fluorescence intensity of T lymphocytes in asthmatic groups was significantly higher than that in normal control （P〈0.001）, indicating that the expression of PI-3K in T lymphocytes of asthmatic rats was significantly higher than that in those of normal controls, and the difference between acute and chronic stage asthmatic groups was significant （P〈0.05）. The expression levels of IL-4 protein in supernatants of asthmatic T lymphocytes were significantly higher than those in the normal controls （P〈0.05）. There was a significant positive correlation between the expression of PI-3K in T lymphocytes and the IL-4 protein expression in supernatants （r=0.583, P〈0.01）. It was suggested that PI-3K signal pathway may participate in the processes of activation and other cytological effects of asthmatic T lymphocytes, thus may play an important roles in the pathogenesis of asthma.

关键词： PI-3K asthma T helper 2 cell interleukin-4

Expression of Leukemia Inhibitory Factor in Airway Epithelial Tissue of Asthmatic Rats

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2007年第4期27卷 372-374页

作者：熊维宁曾大雄徐永健熊盛道方慧娟曹勇宋青凤曹超 Department of Respiratory Diseases Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

In order to investigate the expression of leukemia inhibitory factor （LIF） in airway epithelial tissues of normal and asthmatic rats, the influence of dexamethasone and the role of LIF in pathogenesis of asthma, 30 Sprague-Dawley （SD） rats were randomly divided into 3 groups （10 for each group）： normal group, asthma model group, and dexamethasone-interfered group. In asthma model group and dexamethasone-interfered group, asthma rat models were established by intraperitoneal （i.p.） injection of 10% ovalbumin （OVA） and challenge with 1% OVA via inhalation. Rats in dexamethasone-interfered group were pretreated with dexamethasone （2 mg/kg, i.p） 30 min before each challenge. The expression of LIF protein in lung was detected by immunohistochemistry. The results showed that LIF protein was mainly expressed in cytoplasm of bronchial epithelial cells. The expression of LIF protein in the airway epithelial tissue of asthma model group was significantly higher than that in normal group and dexamethasone-interfered group （P〈0.01）, but there was no significant difference between normal group and dexamethasone-interfered group （P〉0.05）. It was concluded that the expression of LIF was increased significantly in the airway epithelial tissue of the asthma rats, and dexamethasone could down-regulate the expression of LIF. It was suggested that LIF might play an important role in the pathogenesis of asthma as an inflammation regulator.

关键词： bronchial asthma leukemia inhibitory factor immunohistochemistry

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思政目标指导下的力学课程设计

物理通报 2022年第12期51卷 74-78页

作者：熊永建连增菊贾曼顾晓宁波大学物理科学与技术学院浙江宁波315211

以力学课程为例提出围绕思政目标进行课程设计的观点,以及凝练育人目标、提炼育人元素、指导课程设计的三步设计课程法.用案例“科学探究的过程”说明针对一次课程实施三步设计的方法,实现用思政的方法论指导知识传授,用专业知识诠释思... 详细信息

以力学课程为例提出围绕思政目标进行课程设计的观点,以及凝练育人目标、提炼育人元素、指导课程设计的三步设计课程法.用案例“科学探究的过程”说明针对一次课程实施三步设计的方法,实现用思政的方法论指导知识传授,用专业知识诠释思政意义,融合提升思政教育与课程质量,为解决思政与课程两张皮问题提供借鉴.

关键词：课程思政力学课程设计科学素养