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Factors Defining the Development of Severe Illness in Patients with COVID-19:A Retrospective Study

Biomedical and Environmental Sciences 2021年第12期34卷 984-991页

作者： xiong yi bai TIAN Ya Xin MA Yan YANG Wei LIU Bin RUAN Lian Guo LU Cheng HUANG Lu Qi Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Infectious Diseases JinYinTan HospitalWuhan 430024HubeiChina National Resource Center for Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China

Objective Early triage of patients with coronavirus disease 2019(COVID-19) is pivotal in managing the disease. However, studies on the clinical risk score system of the risk factors for the development of severe disease are limited. Hence, we conducted a clinical risk score system for severe illness, which might optimize appropriate treatment *** We conducted a retrospective, single-center study at the JinyinTan Hospital from January 24,2020 to March 31, 2020. We evaluated the demographic, clinical, and laboratory data and performed a10-fold cross-validation to split the data into a training set and validation set. We then screened the prognostic factors for severe illness using the least absolute shrinkage and selection operator(LASSO)and logistic regression, and finally conducted a risk score to estimate the probability of severe illness in the training set. Data from the validation set were used to validate the *** A total of 295 patients were included. From 49 potential risk factors, 3 variables were measured as the risk score: neutrophil to lymphocyte ratio(OR, 1.27;95% CI, 1.15–1.39), albumin(OR,0.76;95% CI, 0.70–0.83), and chest computed tomography abnormalities(OR, 2.01;95% CI, 1.41–2.86)and the AUC of the validation cohort was 0.822(95% CI, 0.7667–0.8776).Conclusion This report may help define the potential of developing severe illness in patients with COVID-19 at an early stage, which might be related to the neutrophil to lymphocyte ratio, albumin, and chest computed tomography abnormalities.

关键词： COVID-19 Risk factors Severe illness Nomogram

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Treatment Outcomes in COVID-19 Patients with Brucellosis:Case Series in Heilongjiang and Systematic Review of Literature

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Biomedical and Environmental Sciences 2023年第10期36卷 930-939页

作者： YANG Man Li WANG Jing Ya ZONG Xing Yu GUAN Li LI Hui Zhen xiong yi bai LIU Yu Qin LI Ting JI Xin Yu SHANG Xi Yu ZHANG Hui Fang GUO Yang GONG Zhao Yuan ZHANG Lei TONG Lin CHEN Ren Bo FAN yi Pin QIN Jin WANG Fang LIN Gang SHI Nan Nan WANG Yan Ping MA Yan Nanjing University of Chinese Medicine Nanjing 210023JiangsuChina Community Health Service Management Center Dongcheng DistrictBeijing 100700China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Infectious Disease Hospital of Heilongjiang Province Harbin 150030HeilongjiangChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Beijing University of Chinese Medicine Beijing 101121China

Objective Clinical characteristics and outcome in COVID-19 with brucellosis patients has not been well demonstrated,we tried to analyze clinical outcome in local and literature COVID-19 cases with brucellosis before and after *** We retrospectively collected hospitalization data of comorbid patients and prospectively followed up after discharge in Heilongjiang Infectious Disease Hospital from January 15,2020 to April29,***,epidemiological,clinical symptoms,radiological and laboratory data,treatment medicines and outcomes,and follow up were analyzed,and findings of a systematic review were *** A total of four COVID-19 with brucellosis patients were *** patient had active brucellosis before covid and 3 patients had nonactive brucellosis before *** median age was54.5 years,and all were males(100.0%).Two cases(50.0%)were moderate,and one was mild and asymptomatic,*** cases(75.0%)had at least one comorbidity(brucellosis excluded).All4 patients were found in COVID-19 nucleic acid *** C and D had only headache and fever on admission,*** cases were treated with Traditional Chinese medicine,western medicines for three cases,no adverse reaction occurred during *** patients were cured and ***,one case(25.0%)had still active brucellosis without re-positive COVID-19,and other three cases(75.0%)have no symptoms of discomfort except one case fell fatigue and anxious during the follow-up period after *** the literature review,two similar cases have been reported in two case reports,and were both recovered,whereas,no data of follow up after *** These cases indicate that COVID-19 patients with brucellosis had favorable outcome before and after *** clinical studies should be conducted to confirm our findings.

关键词： COVID-19 Brucellosis Treatment outcomes Sequelae Relapse

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主动式设计活跃的成因及思考

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景德镇学院学报 2016年第5期31卷 133-136页

作者：熊一百福建艺术职业学院福州350100

2015年,习近平提出加强"供给侧结构性改革"。创造新供给,才能更好地激活新需求。主动式设计现象作为一种创新形式,一直隐性存在,并未引起普遍关注。因此,聚焦中外主动式设计的成功例证,从设计发展史、消费需求、经济环境三个方面,探究... 详细信息

2015年,习近平提出加强"供给侧结构性改革"。创造新供给,才能更好地激活新需求。主动式设计现象作为一种创新形式,一直隐性存在,并未引起普遍关注。因此,聚焦中外主动式设计的成功例证,从设计发展史、消费需求、经济环境三个方面,探究主动式设计活跃的成因,并思考其对当下创新发展产生的作用,为创新实践提供理论依据。

关键词：设计创新主动美学经济供侧改

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知识驱动的产品设计情境探讨

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淮海工学院学报（人文社会科学版） 2015年第5期13卷 69-71页

作者：熊一百福建艺术职业学院美术系福建福州350001

工业设计过程中,对情境知识的研究会涉及感性和思维两个方面,这是设计研究难点问题。为了进一步探讨情境在实际工作中的作用,提出了知识驱动设计情境方式的概念,对产品进行研究时,从问题情境着手,进一步深入到求解情境和结果情境中。基... 详细信息

工业设计过程中,对情境知识的研究会涉及感性和思维两个方面,这是设计研究难点问题。为了进一步探讨情境在实际工作中的作用,提出了知识驱动设计情境方式的概念,对产品进行研究时,从问题情境着手,进一步深入到求解情境和结果情境中。基于问题情境、求解情境以及结果情境,在产品组成原理上进行创新,探讨知识驱动产品设计的关键技术。

关键词：知识驱动产品设计情境探究

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基于网络药理学和体外实验研究金荞麦治疗急性肺损伤的分子机制

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中国中药杂志 2021年第18期46卷 4816-4823页

作者：耿琦刘斌赵鹏程熊一白李立易剑峰吕诚宜春学院化学与生物工程学院江西宜春336000 中国中医科学院中医临床基础医学研究所北京100700 西北工业大学生命学院陕西西安710000

基于网络药理学及急性肺损伤(acute lung injury,ALI)体外模型方法探索金荞麦及其主要活性成分治疗急性肺损伤的作用机制。通过TCMSP数据库,结合口服生物利用度、类药性作为限定条件获取金荞麦主要活性成分。检索PubChem数据库获得金荞... 详细信息

基于网络药理学及急性肺损伤(acute lung injury,ALI)体外模型方法探索金荞麦及其主要活性成分治疗急性肺损伤的作用机制。通过TCMSP数据库,结合口服生物利用度、类药性作为限定条件获取金荞麦主要活性成分。检索PubChem数据库获得金荞麦活性成分相关靶蛋白,在GeneCards数据库收集与ALI相关靶基因,应用STRING 11.0构建化合物靶蛋白-ALI靶基因相互作用(PPI)网络,借助IPA生物网络分析平台对金荞麦潜在化合物靶蛋白与ALI靶基因共同作用的通路进行比较分析,预测金荞麦治疗ALI的潜在关键靶点和信号通路。最后,通过金荞麦活性成分表儿茶素(epicatechin,EC)干预脂多糖诱导的RAW264.7细胞进行体外实验,对潜在关键靶点及通路进行验证。网络药理学结果显示,表儿茶素、原花青素B1、木犀草素等15种潜在活性成分可能通过RELA(P65)等关键靶点,作用于核因子-κB(nuclear transcription factor-κB,NF-κB)信号通路、转化生长因子-β(transforming growth factor-β,TGF-β)信号通路、腺苷酸激活蛋白激酶[adenosine 5'-monophosphate(AMP)-activated protein kinase,AMPK]信号通路等发挥治疗ALI作用。体外实验结果显示,25μmol·^(L-1)的EC与细胞共同培养24 h时与对照组相比细胞存活率差异无统计学意义,其发挥抗炎作用主要通过抑制NF-κB信号通路中p65磷酸化蛋白的表达水平,从而下调其下游促炎因子肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-1β(interleukin-1β,IL-1β)、一氧化氮(nitric oxide,NO)表达,上调抑炎因子白细胞介素-10(interleukin-10,IL-10)表达。以上结果表明,金荞麦主要通过抑制NF-κB信号通路中p65蛋白的磷酸化,进而下调信号通路下游促炎细胞因子发挥治疗ALI作用。

关键词：金荞麦急性肺损伤网络药理学分子机制

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Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen Jing Sun Xue-Ting bai Qian Zhang Zi-Han Li yi-Xin Zhang Rong-Xuan Xu Wei Wu Zhi-Han Yao Chun-Wen Pu Xiao-Feng Li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

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Effects of culture conditions on ligninolytic enzymes and protease production by Phanerochaete chrysosporium in air

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Journal of Environmental Sciences 2008年第1期20卷 94-100页

作者： xiong Xiaoping WEN Xianghua bai Yanan QIAN yi State Key Joint Laboratory of Environmental Simulation and Pollution Control Department of Environmental Science and Engineering Tsinghua University Beifing 100084 China.

The production of ligninolytic enzymes and protease by Phanerochaete chrysosporium was investigated under different culture conditions. Different amounts of medium were employed in free and immobilized culture, together with two kinds of medium with different C/N ratios. Little lignin peroxidase （LIP）（〈 2 U/L） was detected in free culture with nitrogen-limited medium （C/N ratio： 56/2.2, in mmol/L）, while manganese peroxidase （MnP） maximum activity was 231 and 240 U/L in 50 and 100 ml medium culture, respectively. Immobilized culture with 50 ml nitrogen-limited medium gave the highest MnP and LiP production with the maximum values of 410 and 721 U/L separately on the day 5; however, flasks containing 100 ml nitrogen-limited medium only produced less MnP with a peak value of 290 U/L. Comparatively, carbon-limited medium （C/N ratio： 28/44, in mmol/L） was adopted in culture but produced little MnP and LiE Medium type had the greatest impact on protease production. Large amount of protease was produced due to glucose limitation. Culture type and medium volume influence protease activity corporately by affecting oxygen supply. The results implied shallow immobilized culture was a possible way to gain high production of ligninolytic enzymes.

关键词： protease culture conditions ligninolytic enzymes Phanerochaete chrysosporiurn

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朱惠蓉治疗大肠癌用药规律研究

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上海中医药杂志 2016年第3期50卷 18-20页

作者：熊一白朱惠蓉武清张怡程悦蕾上海中医药大学附属龙华医院肿瘤科上海200032 上海中医药大学附属曙光医院上海201203

应用数据挖掘技术研究朱惠蓉教授治疗大肠癌的用药规律。用药注重清热解毒、健脾化痰、养阴润燥,药物多寒温并用,且善于应用药对。

关键词：大肠癌用药规律朱惠蓉

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Temperature effect on buckling properties of ultra-thin-walled lenticular collapsible composite tube subjected to axial compression

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Chinese Journal of Aeronautics 2014年第5期27卷 1312-1317页

作者： bai Jiangbo xiong Junjiang School of Transportation Science and Engineering Beihang University

This paper seeks to outline the temperature effect on the buckling properties of ultra-thin-walled lenticular collapsible composite tube（LCCT） subjected to axial *** buckling tests of the LCCT specimens subjected to axial compression were carried out on INSTRON-500 N servo-hydraulic machine in dry state and at the temperatures of 25 C, 100 C and 80 C. The load–displacement curves and buckling initiation loads were measured and the buckling initiation mechanism was discussed from experimental observations. Experiments show that the buckling initiation load, on average, is only about 2.2% greater at the low temperature of 80 C than at the room temperature of 25 C due to the material hardening, demonstrating an insignificant increase in the buckling initiation load, whereas it is about 19.5% lower at the high temperature of 100 C than at the room temperature owing to the material softening, implying a significant decrease in the buckling initiation load. The failure mode of the LCCT in axial compression tests at three different temperatures can be reckoned to be characteristic of the buckling initiation and propagation around the central region until rupture. The finite element（FE） model is presented to simulate the buckling initiation mechanism based on the eigenvalue-based methodology. Good correlation between experimental and numerical results is achieved.

关键词： Axial compression Buckling Composite Finite element analysis Lenticular collapsible tube

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Effect of stress-relief annealing on thermal fatigue cracks for die-casting die steels

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Journal of Iron and Steel Research International 2024年第5期31卷 1164-1176页

作者： Zhi-xiong bai Xiao-chun Wu School of Materials Science and Engineering Shanghai UniversityShanghai200444China

The effect of stress-relief annealing at different stages of thermal fatigue tests on crack growth was investigated using a self-built thermal cycle *** results showed that annealing could limit crack expansion *** reduced dislocation density and released the accumulation of residual *** addition,the strain accumulation in carbides was reduced by this *** was also found that double annealing was even more effective at inhibiting crack expansion compared to single stress-relief *** 1000 cycles,the maximum crack length was reduced by 31.1%and 45.2%for the samples after using the optimal single and double annealing processes,*** single stress-relief annealing,earlier annealing provides more benefit in delaying crack ***,effective double stress-relief annealing requires a suitable time interval between the annealing ***,after 800 cycles,surface hardness decreased significantly accompanied by an increase in the size and number of carbides,and cracks expanded predominantly along grain boundaries.

关键词： Thermal fatigue Steel Carbide Stress-relief annealing Dislocation Residual stress

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