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Multifunctional hydrogels for chronic wounds repairing

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Biosurface and Biotribology 2023年第4期9卷 85-100页

作者： Xiao Wang Rong Hu lu Han xiong lu School of Materials Science and Engineering Key Lab of Advanced Technologies of MaterialsMinistry of EducationSouthwest Jiaotong UniversityChengduChina Institute of Biomedical Engineering College of MedicineSouthwest Jiaotong UniversityChengduChina Key Laboratory of Marine Drugs Ministry of EducationSchool of Medicine and PharmaceuticsOcean University of ChinaQingdaoChina

Because of their tissue-like mechanical performances,high biocompatibility,and adjust-able functionality,hydrogels have become increasingly attractive materials for promoting wound healing.Chronic wounds include burn,diabetic,and infected wounds.Unlike common incision wounds,chronic wounds are more challenging to heal.To meet the clinical needs,multifunctional hydrogels should be fabricated and investigated.To guide future studies on the fabrication of hydrogel-based chronic wound dressings,a review of advanced multifunctional hydrogels is necessary.Various hydrogels with advanced properties,such as antibacterial,antioxidant,bioadhesive,anti-inflammatory,and wound healing properties,that can be used for skin burn wounds and diabetic wounds are summarised.Lastly,the prospects of advanced hydrogels for wound healing are elaborated.

关键词： adhesive property antibacterial biomaterials biomedical application functionalisation wound healing

The recent research progress of polyphenol-derived biomaterials in wound repair

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Biosurface and Biotribology 2023年第4期9卷 114-128页

作者： Shuya Zhao lu Han Liwei Yan xiong lu Institute of Biomedical Engineering College of MedicineSouthwest Jiaotong UniversityChengduSichuanChina Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuanChina School of Medicine and Pharmaceutics Key Laboratory of Marine DrugsMinistry of EducationOcean University of ChinaQingdaoShandongChina

The clinical requirements for wound care are increasing daily, and the global wound dressing market is expanding;however, the research and development of new wound dressings are imminent. Natural biomolecules such as polyphenols, have been widely used in this field of vision. Owing to their unique anti-oxidative, adhesive, antibacterial and other bioactive functions, researchers have developed a series of wound dressings with excellent performance and applied them to a variety of biomaterials, such as hydrogels, nanofibers, films and scaffolds. They can effectively promote angiogenesis and fibroblast migration and proliferation, scavenge active oxygen free radicals, inhibit excessive in-flammatory reactions at wound sites and ultimately accelerate wound healing. The authors summarise the latest progress in polyphenol-derived biomaterials in skin wound repair to provide inspiration for future wound dressing research.

关键词： biomaterials biomedical application injectable hydrogels physically cross-linked gel polydopamine wound healing

Natural polymer-based adhesive hydrogel for biomedical applications

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Biosurface and Biotribology 2022年第2期8卷 69-94页

作者： Siyu Long Chaoming Xie xiong lu Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduChina Yibin Research Institute Southwest Jiaotong UniversityYibinChina

Hydrogel is a polymer network system that can form a hydrophilic three-dimensional network structure through different cross-linking methods.In recent years,hydrogels have received considerable attention due to their good biocompatibility and biodegradability by introducing different cross-linking mechanisms and functional components.Compared with synthetic hydrogels,natural polymer-based hydrogels have low biotoxicity,high cell affinity,and great potential for biomedical fields;however,their mechanical properties and tissue adhesion capabilities have been unable to meet clinical requirements.In recent years,many efforts have been made to solve these issues.In this review,the recent progress in the field of natural polymer-based adhesive hydrogels is highlighted.The authors first introduce the general design principles for the natural polymer-based adhesive hydrogels being used as excellent tissue adhesives and the challenges associated with their design.Next,their usages in biomedical applications are summarised,such as wound healing,haemostasis,nerve repair,bone tissue repair,cartilage tissue repair,electronic devices,and other tissue repairs.Finally,the potential challenges of natural polymer-based adhesive hydrogels are presented.

关键词： biomedical applications design principles mechanical properties natural polymer-based adhesive hydrogels tissue adhesion

Enhanced hydrogen storage properties of Mg by the synergistic effect of grain refinement and NiTiO_(3)nanoparticles

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Journal of Magnesium and Alloys 2022年第12期10卷 3542-3552页

作者： Nianhua Yan xiong lu Zhiyu lu Haijie Yu Fuying Wu Jiaguang Zheng Xiuzhen Wang Liuting Zhang School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang212003China Analysis and Testing Center Jiangsu University of Science and TechnologyZhenjiang212003China

As a promising hydrogen storage material,the practical application of magnesium is obstructed by the stable thermodynamics and sluggish kinetics.In this paper,three kinds of NiTiO3catalysts with different mole ratio of Ni to Ti were successfully synthesized and doped into nanocrystalline Mg to improve its hydrogen storage properties.Experimental results indicated that all the Mg-NiTiO3composites showed prominent hydrogen storage performance.Especially,the Mg-NiTiO3/TiO2composite could take up hydrogen at room temperature and the apparent activation energy for hydrogen absorption was dramatically decreased from 69.8±1.2(nanocrystalline Mg)k J/mol to 34.2±0.2 k J/mol.In addition,the hydrogenated sample began to release hydrogen at about 193.2℃and eventually desorbed 6.6 wt%H2.The desorption enthalpy of the hydrogenated Mg-NiTiO3-C was estimated to be 78.6±0.8 k J/mol,5.3 k J/mol lower compared to 83.9±0.7 k J/mol of nanocrystalline Mg.Besides,the sample revealed splendid cyclic stability during 20 cycles.No obvious recession occurred in the absorption and desorption kinetics and only 0.3 wt%hydrogen capacity degradation was observed.Further structural analysis demonstrates that nanosizing and catalyst doping led to a synergistic effect on the enhanced hydrogen storage performance of Mg-NiTiO3-C composite,which might serve as a reference for future design of highly effective hydrogen storage materials.

关键词： Hydrogen storage NiTiO3 Nanocrystalline Mg Reversibility Synergistic effect

Deep reinforcement learning-based drift parking control of automated vehicles

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Science China(Technological Sciences) 2023年第4期66卷 1152-1165页

作者： LENG Bo YU YiZe LIU Ming CAO Lei YANG Xing xiong lu School of Automotive Studies Tongji University

Drift parking usually requires precise control of a vehicle by a professional driver,which can reflect the performance of the vehicle under critical conditions.The obstacles to implementing this action include the high coupling between the longitudinal and lateral states,the high precision required for the vehicle initial state when the drift is triggered,and the difficulty in determining the reference state variables in the drift process.A two-segment drift parking control system is proposed in this paper.In the approaching control segment,the vehicle achieves the drift-triggered vehicle speed and pose,which relies on a pathtracking algorithm based on linear time-varying model predictive control.In the drifting control segment,the deep reinforcement learning algorithm twin-delayed deep deterministic policy gradient is creatively introduced to the controller design.It solves the precise vehicle motion control problem under the condition of the rear wheels having locked brakes.Through various simulations,the superiority and robustness to different initial conditions and abrupt changes in the parking space are verified.The effectiveness of the proposed control system is verified by a ground test.

关键词： automated vehicles deep reinforcement learning drifting control vehicle dynamics control

Significantly improved hydrogen storage behaviors in MgH_(2) with Nb nanocatalyst

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International Journal of Minerals,Metallurgy and Materials 2022年第9期29卷 1788-1797页

作者： Farai Michael Nyahuma Liuting Zhang Mengchen Song xiong lu Beibei Xiao Jiaguang Zheng Fuying Wu School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China Analysis and Testing Center Jiangsu University of Science and TechnologyZhenjiang 212003China

The study explores the excellent modification effect of Nb nanocatalyst prepared via surfactant assisted ball milling technique(SABM)on the hydrogen storage properties of MgH_(2).Optimal catalyst doping concentration was determined by comparing onset decomposition temperature,released hydrogen capacity,and reaction rate for different MgH_(2)-ywt%Nb(y=0,3,5,7,9)composites.The MgH_(2)-5wt%Nb composite started releasing hydrogen at 186.7℃ and a total of 7.0wt%hydrogen was released in the dehydrogenation process.In addition,5wt%Nb doped MgH_(2) also managed to release 4.2wt%H_(2) within 14 min at 250℃ and had the ability to absorb 4.0wt%hydrogen in 30 min at 100℃.Cycling tests revealed that MgH_(2)-5wt%Nb could retain 6.3wt%H_(2) storage capacity(89.2%)after 20 cycles.Dehydrogenation and hydrogenation activation energy values were decreased from 140.51±4.74 and 70.67±2.07 kJ·mol^(−1) to 90.04±2.83 and 53.46±3.33 kJ·mol^(−1) after doping MgH_(2) with Nb,respectively.Microstructure analysis proved that homogeneously distributed NbH acted as active catalytic unit for improving the hydrogen storage performance of MgH_(2).These results indicate SABM can be considered as an option to develop other nanocatalysts for energy related areas.

关键词： hydrogen storage magnesium hydride surfactant assisted ball milling Nb nanosheets

Preparation of metal‐organic frameworks and their derivatives for supercapacitors

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Biosurface and Biotribology 2022年第3期8卷 151-164页

作者： Youjian Li Donglin Gan Xu Deng Lili Jiang Chaoming Xie xiong lu Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuanChina Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‐functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjingJiangsuChina Institute of Fundamental and Frontier Science University of Electronic Science and Technology of ChinaChengduChina Key Laboratory of Fluid and Power Machinery of Ministry of Education School of Materials Science and EngineeringXihua UniversityChengduChina

To satisfy the requirements of social power development,it is urgently necessary to develop innovative and sustainable new energy storage devices.Supercapacitors have attracted considerable attention as a new type of energy storage device,owing to their high energy density,high power density,fast charging and discharging speeds,and long cycle life.The electrode material is an important factor in determining the electrochemical performance of supercapacitors.In recent years,researchers explored the application of metal‐organic frameworks(MOFs)and their derivatives as electrode materials for supercapacitors.In this paper,the preparation of monometallic,bimetallic,and conductive MOFs,and their derivatives for application in supercapacitors are reviewed.In addition,challenges facing MOFs in the field of supercapacitors and their future development prospects are discussed.

关键词： bimetallic MOFs conductive MOFs derivatives monometallic MOFs supercapacitors

Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes

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Bioactive Materials 2022年第12期7卷 213-227页

作者： Yazhen Li lu Yang Yue Hou Zhenzhen Zhang Miao Chen Maoxia Wang Jin Liu Jun Wang Zhihe Zhao Chaoming Xie xiong lu State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengduSichuan610041China Key Lab of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuan610031China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Oral ImplantologyWest China Hospital of StomatologySichuan UniversityChengduSichuan610041China Lab for Aging Research and National Clinical Research Center for Geriatrics West China HospitalSichuan UniversityChengduSichuan610041China

Regenerating periodontal bone tissues in the aggravated inflammatory periodontal microenvironment under diabetic conditions is a great challenge.Here,a polydopamine-mediated graphene oxide(PGO)and hydroxyapatite nanoparticle(PHA)-incorporated conductive alginate/gelatin(AG)scaffold is developed to accelerate periodontal bone regeneration by modulating the diabetic inflammatory microenvironment.PHA confers the scaffold with osteoinductivity and PGO provides a conductive pathway for the scaffold.The conductive scaffold promotes bone regeneration by transferring endogenous electrical signals to cells and activating Ca2+channels.Moreover,the scaffold with polydopamine-mediated nanomaterials has a reactive oxygen species(ROS)-scavenging ability and anti-inflammatory activity.It also exhibits an immunomodulatory ability that suppresses M1 macrophage polarization and activates M2 macrophages to secrete osteogenesis-related cytokines by mediating glycolytic and RhoA/ROCK pathways in macrophages.The scaffold induces excellent bone regeneration in periodontal bone defects of diabetic rats because of the synergistic effects of good conductive,ROS-scavenging,anti-inflammatory,and immunomodulatory abilities.This study provides fundamental insights into the synergistical effects of conductivity,osteoinductivity,and immunomodulatory abilities on bone regeneration and offers a novel strategy to design immunomodulatory biomaterials for treatment of immune-related diseases and tissue regeneration.

关键词： Polydopamine Graphene oxide Conductive scaffold ROS-Scavenging Macrophage polarization

Atomic layer deposition of zinc oxide onto 3D porous iron scaffolds for bone repair:in vitro degradation,antibacterial activity and cytocompatibility evaluation

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Rare Metals 2022年第2期41卷 546-558页

作者： Yu-Lei Li Jin He Hai-Xia Ye Can-Can Zhao Wei-Wei Zhu xiong lu Fu-Zeng Ren Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Institute of Applied Physics and Materials Engineering Faculty of Science and TechnologyUniversity of MacaoMacao 999078China Key Lab of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

3D porous iron(Fe)scaffolds with interconnected open pores are promising candidates for bone repair.However,the bare 3D porous Fe scaffolds lack of antibacterial activity and the ability for cell adhesion.Herein,atomic layer deposition technique was used to deposit nanometer-thick zinc oxide(ZnO)layer onto the skeleton of 3D porous Fe scaffolds with interconnected open pores.The effect of ZnO thin film on the in vitro degradation behavior,antibacterial activity and cytocompatibility of 3D porous Fe scaffolds was systematically evaluated.The results showed that a dense ZnO thin film with a thickness of 76 nm was uniformly deposited on the skeleton of the porous Fe scaffolds.The thickness of ZnO thin film could be easily controlled by the deposition cycles.The deposited ZnO thin film significantly reduced the degradation rate of porous Fe scaffolds and the fabricated ZnO coated porous Fe scaffolds demonstrated strong antibacterial ability against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus,while did not significantly affect cytocompatibility and could also promote cell adhesion.

关键词： Atomic layer deposition Porous iron scaffolds ZnO Antibacterial activity