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The Differentiation-and Proliferation-Inhibitory Effects of Sporamin from Sweet Potato in 3T3-L1 Preadipocytes

Agricultural Sciences in China 2009年第6期8卷 671-677页

作者： xiong zhi-dong LI Peng-gao MU Tai-hua Laboratory of Food Chemistry and Nutrition Science Institute of Agro-Food Science and Technology Chinese Academy of Agricultural Sciences Beijing 100193 P.R.China Department of Nutrition and Food Hygiene School of Public Health and Family Medicine Capital Medical University Beijing 100069 P.R. China

The aim of this study was to investigate the effect of different concentrations of sporamin on the differentiation and proliferation of 3T3-LI preadipocytes, providing the theoretical basis for the development of food to treat obesity and diabetes, The isolation and purification of sporamin from sweet potato species 55-2 were performed by ammonium sulphate precipitation in combination with ion-exchange and gel filtration chromatography. With berberine as a positive control, different concentrations ofsporamin （0.000, 0.125, 0.025, 0.250, 0.500, and 1.000 mg·mL^-1 were used to treat 3T3-L1 preadipocytes. Intracellular fat accumulation and the degree of adipogenesis were quantified using Oil Red O staining and colorimetry, Preadipocytes differentiation was measured by 3（4,5-dimethylthiazolyl-2-yl）-2,5-diphenyltetrazolium bromide （MTT） spectrophotometric assay. Two sporamin proteins, which were separated into sporamin A （31 kD） and sporamin B （22 kD）, could be purified by ion-exchange and gel filtration chromatography. After being treated by different concentrations of sporamin, the differentiation of 3T3-L1 preadipocytes was significantly inhibited, compared with the positive control. When the sporamin solution concentration was 0.500 mg mL-1, the accumulation of lipid droplets within the cells was significantly decreased and the optical density （OD） value of the solution from destained Oil Red O reached to 0.35, which was the lowest value （P〈 0.05）. The proliferation of 3T3-L1 preadipocytes was significantly inhibited by treating at higher sporamin concentrations. In addition, the inhibitory effect was more obvious with the prolonged treatment time （P〈 0.05）. The differentiation and proliferation of 3T3-L1 preadipocytes could be inhibited significantly by the addition of higher concentration sporamin. It was, therefore, suggested that the sporamin was potentially effective for weight loss.

关键词： sweet potato sporamin 3T3-L1 preadipocytes

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Stability Study on the Bucket Foundation with Multi-Compartment During the Floating-up Process Considering Air Compressibility

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China Ocean Engineering 2023年第6期37卷 975-988页

作者： YE Fang-di LIAN Ji-jian GUO Yao-hua WANG Hai-jun XIAO Tian-run xiong dong-zhi YU Tong-shun State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation Tianjin UniversityTianjin 300072China School of Civil Engineering Tianjin UniversityTianjin 300072China Tianjin University of Technology Tianjin 300384China College of Engineering Ocean University of ChinaQingdao 266100China

In the process of developing offshore wind power towards deeper waters,the advantages of the bucket foundation in terms of integrated construction and economy are becoming increasingly *** contrast to conventional floating bodies,the air-floating bucket foundations can achieve self-floating with the help of the air in the compartment and adjust its buoyancy and stability by controlling the air volume in the *** construction process of the bucket foundation involves the control of air in the compartment,thus making it more difficult to *** after the prefabrication of the bucket foundation,the stability of the bucket foundation at the floating-up stage is particularly *** stability of a multi-compartment bucket foundation during the floating-up process cannot be accurately evaluated as the existing theoretical method of air-floating structures does not adequately consider air *** ensure the safety of the floating-up process,a theoretical method based on the idea of intact stability has been developed to analyze the stability of the air-floating bucket foundations,which will allow accurate calculation of the righting arm for different tilt states and critical air leakage *** the same time,accuracy and feasibility of the proposed theoretical method are verified through indoor model tests and practical operation of the prototype structure during the floating-up *** addition,measures to enhance the stability of the bucket foundation are proposed through sensitivity analysis of influencing factors.

关键词： offshore wind power bucket foundation air-floating structure stability

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Effect of stress-relief annealing on thermal fatigue cracks for die-casting die steels

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Journal of Iron and Steel Research International 2024年第5期31卷 1164-1176页

作者： zhi-xiong Bai Xiao-chun Wu School of Materials Science and Engineering Shanghai UniversityShanghai200444China

The effect of stress-relief annealing at different stages of thermal fatigue tests on crack growth was investigated using a self-built thermal cycle *** results showed that annealing could limit crack expansion *** reduced dislocation density and released the accumulation of residual *** addition,the strain accumulation in carbides was reduced by this *** was also found that double annealing was even more effective at inhibiting crack expansion compared to single stress-relief *** 1000 cycles,the maximum crack length was reduced by 31.1%and 45.2%for the samples after using the optimal single and double annealing processes,*** single stress-relief annealing,earlier annealing provides more benefit in delaying crack ***,effective double stress-relief annealing requires a suitable time interval between the annealing ***,after 800 cycles,surface hardness decreased significantly accompanied by an increase in the size and number of carbides,and cracks expanded predominantly along grain boundaries.

关键词： Thermal fatigue Steel Carbide Stress-relief annealing Dislocation Residual stress

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Autonomous navigation method of satellite constellation based on adaptive forgetting factors

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Chinese Journal of Aeronautics 2024年第7期37卷 317-332页

作者： dong WANG Jing YANG Kai xiong School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China Science and Technology on Space Intelligent Control Laboratory Beijing Institute of Control EngineeringBeijing 100094China

To address the problem that model uncertainty and unknown time-varying system noise hinder the filtering accuracy of the autonomous navigation system of satellite constellation,an autonomous navigation method of satellite constellation based on the Unscented Kalman Filter with Adaptive Forgetting Factors(UKF-AFF)is *** process noise covariance matrix is estimated online with the strategy that combines covariance matching and adaptive adjustment of forgetting *** adaptive adjustment coefficient based on squared Mahalanobis distance of state residual is employed to achieve online regulation of forgetting factors,equipping this method with more *** intersatellite direction vector obtained from photographic observations is introduced to determine the constellation satellite orbit together with the distance measurement to avoid rank deficiency *** that the number of available measurements varies online with intersatellite visibility in practical applications such as time-varying constellation configurations,the smooth covariance matrix of state correction determined by innovation and gain is adopted and constructed *** analysis of the proposed method is also *** effectiveness of the proposed method is verified by the Monte Carlo simulation and comparison *** estimation accuracy of constellation position and velocity of UKF-AFF is improved by 30%and 44%respectively compared to those of the extended Kalman filter,and the method proposed is also better than other several adaptive filtering methods in the presence of significant model uncertainty.

关键词： Constellation autonomous navigation Unscented Kalman filter Adaptive forgetting factor Model uncertainty Stability analysis

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Improvement of impact properties of Al-Si-Mg alloy via solution treatment and joint modification with Sr and La

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Rare Metals 2024年第7期43卷 3301-3313页

作者： xiong-Ling Zheng Shao-Xiang Li Jia-Le Ma Qing-Yan Xu Hai-dong Zhao zhi-Qiang Han Key Laboratory for Advanced Materials Processing Technology Ministry of EducationSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China National Engineering Research Center of Near-Net Shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510641China

An effort to obtain superior impact properties for Al-7Si-0.35 Mg alloy is presented,where modification with 0.02 wt% Sr and 0.1 wt% La as well as solution treatment was jointly *** samples were solution treated at 535℃ for 15 min to 12 *** microstructure,fracture mechanism,and their correlation with the impact properties of the alloy were studied in detail mainly through optical microscopy(OM),scanning electron microscopy(SEM) and oscillography impact *** results show that the addition of Sr and La refined the eutectic Si particles significantly from~ 2.05 μm(modified with Sr alone) to~ 0.75 μm in as-cast microstructure,leading to a very homogeneous distribution of spheroidized Si particles in the alloy solution treated at 535℃ for 8 *** alloy exhibits excellent impact toughness up to 75 J·cm^(-2),which is much higher than the maximum impact toughness of the alloys modified by Sr alone(~ 46 J·cm^(-2)).The major reason for this remarkable increase in the impact property is the dramatic increase in crack initiation *** dispersoid-free zones(DFZs)near the eutectic regions mainly consist of the ductile Al-matrix,which exhibits excellent *** ductile Al-matrix of the DFZs hinders the crack propagation,resulting in a significant increase in crack propagation energy.

关键词： Aluminum alloys Modification Solution treatment Microstructure Impact properties Fracture mechanism

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Enhanced memristor performance via coupling effect of oxygen vacancy and ferroelectric polarization

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Journal of Materials Science & Technology 2024年第4期171卷 139-146页

作者： zhi Yun Yue zhi dong Zhang Zhan Jie Wang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

As a new type of nonvolatile memory,the resistive memristor has broad application prospects in in-formation storage and neural computing based on its excellent resistive switching(RS)*** present,it is still a great challenge to improve both ferroelectric polarization and leakage current to achieve a high RS on/offratio of ferroelectric ***,epitaxial Pb(Zr_(0.40)Ti_(0.60))O_(3)(PZT)thin films with low content Ca doping were deposited on the Nb:SrTiO_(3)substrate to prepare PCZT/NSTO het-erostructures and their RS behaviors were *** research findings show that compared with pure PZT film,the ferroelectric polarization of 1-mol%-Ca-doped PZT film is slightly improved,while the leak-age current is increased by three orders of ***,the RS on/offratio reaches 2.5×10^(5),about three orders of magnitude higher than pure PZT *** theoretical analysis reveals that the RS behavior of PCZT/NSTO heterostructures is controlled by the PCZT/NSTO interfacial barrier and the space charge-limited current *** results demonstrate that the ferroelectricity and electricity of ferroelectric thin films can be improved simultaneously by doping low-content Ca ions to increase the RS performance,which provides a good reference for the development of high-performance ferroelectric memristor devices.

关键词： Ferroelectric memristor Ca-doped PZT Ferroelectric polarization Oxygen vacancies Resistive switching

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马克思人民主体思想及其当代价值——兼论习近平新时代“以人民为中心”思想的马克思主义之源

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河南大学学报（社会科学版） 2019年第1期59卷 23-29页

作者：熊治东华中科技大学哲学系/国家治理研究院湖北武汉430074

人民主体思想是马克思哲学的重要内容。马克思通过对以往哲学和资本主义私有制生产关系的多重批判,恢复了人民的历史主体地位,揭示出人民在社会历史发展进程中的重要作用和特殊地位,深刻阐释了人民主体与人的自由而全面发展之间的辩证... 详细信息

人民主体思想是马克思哲学的重要内容。马克思通过对以往哲学和资本主义私有制生产关系的多重批判,恢复了人民的历史主体地位,揭示出人民在社会历史发展进程中的重要作用和特殊地位,深刻阐释了人民主体与人的自由而全面发展之间的辩证关系。习近平新时代"以人民为中心"的发展思想是对马克思人民主体思想的继承与创新。在新的历史背景下,探讨马克思人民主体思想的历史生成与现实意义,既可以帮助我们更好地理解马克思人民主体思想在当今时代所具有的独特现实价值和丰富内涵,也有助于从理论维度透视习近平新时代"以人民为中心"的发展思想的马克思主义之源。

关键词：马克思人民主体新时代以人民为中心

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Unlocking T cell exhaustion:Insights and implications for CAR-T cell therapy

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3416-3431页

作者： Dian xiong Haijun Yu zhi-Jun Sun State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyFrontier Science Center for Immunology and MetabolismTaikang Center for Life and Medical ScienceWuhan UniversityWuhan 430079China Department of Radiation and Medical Oncology Hubei Province Cancer Clinical Study CenterHubei Key Laboratory of Tumor Biological BehaviorsZhongnan Hospital of Wuhan UniversityWuhan 430071China

Chimeric antigen receptor T(CAR-T)cell therapy as a form of adoptive cell therapy(ACT)has shown significant promise in cancer treatment,demonstrated by the FDA-approved CAR-T cell therapies targeting CD19 or B cell maturation antigen(BCMA)for hematological malignancies,albeit with moderate outcomes in solid ***,despite these advancements,the efficacy of CAR-T therapy is often compromised by T cell exhaustion,a phenomenon that impedes the persistence and effector function of CAR-T cells,leading to a relapse rate of up to 75%in patients treated with CD19 or CD22 CAR-T cells for hematological *** to overcome CAR-T exhaustion employ state-of-the-art genomic engineering tools and single-cell sequencing *** this review,we provide a comprehensive understanding of the latest mechanistic insights into T cell exhaustion and their implications for the current efforts to optimize CAR-T cell *** insights,combined with lessons learned from benchmarking CAR-T based products in recent clinical trials,aim to address the challenges posed by T cell exhaustion,potentially setting the stage for the development of tailored next-generation approaches to cancer treatment.

关键词： Cancer immunotherapy CAR-T therapy T cell exhaustion Tumor immune microenvironment Spatial immune contexture Single-cell technologies CAR-T engineering Combination therapy

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C-F insertion reaction sheds new light on the construction of fluorinated compounds

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Chinese Chemical Letters 2024年第8期35卷 163-169页

作者： dong-Sheng Deng Su-Qin Tang Yong-Tu Yuan Ding-xiong Xie zhi-Yuan Zhu Yue-Mei Huang Yun-Lin Liu Henan Key Laboratory of Function-Oriented Porous Materials and College of Chemistry and Chemical EngineeringLuoyang Normal UniversityLuoyang 471934China School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

The atom-economical C-F insertion chemistry is emerged as a promising technology for the synthesis of various fluorinated scaffolds,which have wide applications both in the academic and the industrial *** past three years have witnessed rapid developments in this *** highlight provides an overview on the evolution according to the fluorinating agents used.

关键词： C-F insertion Benzyl fluoride Acyl fluoride gem-Difluorocyclopropane Fluorinated scaffold

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伟大建党精神的生成逻辑、科学内涵与弘扬路径

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南通大学学报（社会科学版） 2021年第6期37卷 10-17页

作者：熊治东武汉纺织大学马克思主义学院湖北武汉430073 华中科技大学国家治理研究院湖北武汉430074

伟大建党精神作为中国共产党精神谱系的源和本、根和魂,是全面认识和科学把握中国共产党百年历程的精神密码,有着极为深刻的理论逻辑、文化逻辑、历史逻辑和实践逻辑,其内涵包括理想和信仰层面的“坚持真理、坚守理想”,价值和行动层面... 详细信息

伟大建党精神作为中国共产党精神谱系的源和本、根和魂,是全面认识和科学把握中国共产党百年历程的精神密码,有着极为深刻的理论逻辑、文化逻辑、历史逻辑和实践逻辑,其内涵包括理想和信仰层面的“坚持真理、坚守理想”,价值和行动层面的“践行初心、担当使命”,精神特质层面的“不怕牺牲、英勇斗争”,政治品格层面的“对党忠诚、不负人民”,构成了层层递进的严密整体。当前,弘扬伟大建党精神,要以“四史”教育为切入点,厚植伟大建党精神的历史基础;以理想信念培育为着力点,夯实伟大建党精神的思想基础;以全面从严治党为立足点,筑牢伟大建党精神的政治基础;以强化舆论宣传为连接点,拓展伟大建党精神的社会基础。

关键词：中国共产党伟大建党精神生成逻辑科学内涵弘扬路径

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