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Emerging mechanisms of non-alcoholic steatohepatitis and novel drug therapies

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Chinese Journal of Natural Medicines 2024年第8期22卷 724-745页

作者： chen hao ZHOU Yang hao Haiping XIONG Jing Department of Pharmacology School of PharmacyChina Pharmaceutical UniversityNanjing 210009China Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China

Non-alcoholic fatty liver disease(NAFLD)has become a leading cause of chronic liver disease *** initiates with simple steatosis(NAFL)and can progress to the more severe condition of non-alcoholic steatohepatitis(NASH).NASH often advances to end-stage liver diseases such as liver fibrosis,cirrhosis,and hepatocellular carcinoma(HCC).Notably,the transition from NASH to end-stage liver diseases is irreversible,and the precise mechanisms driving this progression are not yet fully ***,there is a critical need for the development of effective therapies to arrest or reverse this *** review provides a comprehensive overview of the pathogenesis of NASH,examines the current therapeutic targets and pharmacological treatments,and offers insights for future drug discovery and development strategies for NASH therapy.

关键词： Metabolic dysfunction Drug development Bile acids Liver-gut axis Inflammation Fibrosis

Boosting zinc anode durability through synergistic inner Helmholtz plane and interfacial electric field regulation

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Science Bulletin 2024年第13期69卷 2025-2029页

作者： hao Tan Chao Meng Tong Sun xing-Long Wu Hong Liu Jian-Jun Wang State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China College of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071China MOE Key Laboratory for UV Light-Emitting Materials and Technology Department of PhysicsNortheast Normal UniversityChangchun 130024China Jinan Institute of Quantum Technology Jinan BranchHefei National LaboratoryJinan 250101China Shenzhen Research Institute Shandong UniversityShenzhen 518057China

As the need for energy storage devices escalates,aqueous zincion batteries(ZIBs)have risen as a promising alternative to the widely used Li-ion batteries,offering intrinsic safety,environmental compatibility,and cost advantages,positioning them as attractive energy storage systems for the future[1,2].However,challenges such as dendrite growth on Zn anodes,stemming from uneven electric fields on the surface and active water side reactions,compromise cycling stability and lifespan,posing significant hurdles for the practical application of ZIBs[3,4].To mitigate these issues,strategies like electrolyte optimization,artificial solid electrolyte interphase(SEI)layers,and current collector modifications have been proposed[5,6].Nevertheless,most long-cycle experiments are conducted at low current densities and deposition capacities,with high current density and capacity operations typically lasting less than 1000 h[7].

关键词： electrolyte durability offering

A dynamic exploratory hybrid modelling framework for simulating complex and uncertain system

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Journal of Safety Science and Resilience 2024年第2期5卷 167-178页

作者： Gangqiao Wang Han xing Yongqiang chen Yi Liu Institute of Big Data Inteligent Management and Decision-making College of ManagementShenzhen UniversityShenzhen 518060China School of Safety Science Tsinghua UniversityBejing 100084China Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBejing 100871China

Complex disaster systems involve various components and mechanisms that could interact in complex ways and change over time,leading to significant deep *** to deep uncertainty,decision-makers have severe inadequacy of knowledge and often encounter unpredictable surprises that may emerge in the future,thus making it difficult to specify appropriate models and parameters to describe the system of *** this paper,we propose a dynamic exploratory hybrid modeling framework that fits data,models,and computational ex-periments together to simulate complex systems with deep *** the framework,one needs to develop multiple plausible models from a hybrid modeling perspective and perform enormous computational experi-ments to explore the diversity of future ***-time data is then incorporated into diverse forecasts to dynamically adjust the simulation *** ultimately enables an ongoing modeling and analysis process in which deep uncertainty would be gradually *** approach has been applied to a human-involved car-following system simulation under complex traffic *** results show that the proposed approach can improve the prediction accuracy while enhancing the sensitivity of the simulation system to uncertain changes in the system of interest.

关键词： Disaster modeling and analysis Deepuncertainty Hybrid modeling Adaptivesimulation

Essential oils improve nursery pigs'performance and appetite via modulation of intestinal health and microbiota

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Animal Nutrition 2024年第1期16卷 174-188页

作者： Bi-chen Zhao Tian-hao Wang Jian chen Bai-hao Qiu Ya-Ru Xu Jin-Long Li College of Veterinary Medicine Northeast Agricultural UniversityHarbin150030China Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine Northeast Agricultural UniversityHarbin150030China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment Northeast Agricultural UniversityHarbin150030China

Optimal intestinal health and functionality are essential for animal health and performance,and simultaneously intestinal nutrient transporters and intestinal peptides are also involved in appetite and feed intake control *** the potential of essential oil(EO)in improving animal performance and improving feed palatability,we hypothesized that dietary supplementation of cinnamaldehyde and carvacrol could improve performance and appetite of nursery pigs by modulating intestinal health and ***(100 mg/kg),carvacrol(100 mg/kg),and their mixtures(including 50 mg/kg cinnamaldehyde and 50 mg/kg carvacrol)were supplemented into the diets of 240 nursery pigs for 42 d,and data related to performance were ***,the influence of EO on intestinal health,appetite and gut microbiota and their correlations were *** supplementation increased(P<0.05)the body weight,average daily gain(ADG)and average daily feed intake(ADFI)of piglets,and reduced(P<0.05)diarrhea rates in nursery ***,EO increased(P<0.05)the intestinal absorption area and the abundance of tight junction proteins,and decreased(P<0.05)intestinal permeability and local *** terms of intestinal development and the mucus barrier,EO promoted intestinal development and increased(P<0.05)the number of goblet ***,we found that piglets in the EO-supplemented group had upregulated(P<0.05)levels of transporters and digestive enzymes in the intestine,which were significantly associated with daily gain and feed *** addition,EO supplementation somewhat improved appetite in nursery pigs,increased the diversity of the gut microbiome and the abundance of beneficial bacteria,and there was a correlation between altered bacterial structure and appetite-related *** findings indicate that EO is effective in promoting growth performance and nutrient absorption as well as in regulating appetite by improving intestinal health and ba

关键词： Nursery pig Essential oil Intestinal health Appetite Microbiota

Strong metal-support interactions between highly dispersed Cu^(+) species and ceria via mix-MOF pyrolysis toward promoted water-gas shift reaction

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Journal of Energy Chemistry 2024年第4期91卷 475-483页

作者： Xiao-chen Sun xing-Chi Li Ze-Wei Xie chen-Yue Yuan De-Jiu Wang Qian Zhang Xiao-Yu Guo hao Dong Hai-Chao Liu Ya-Wen Zhang Beijing National Laboratory for Molecular Sciences(BNLMS) State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing National Laboratory for Molecular Sciences(BNLMS) College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing National Laboratory for Molecular Sciences(BNLMS) State Key Laboratory for Structural Chemistry of Stable and Unstable SpeciesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The modulation of metal-support interfacial interaction is significant but challenging in the design of high-efficiency and high-stability supported ***,we report a synthetic strategy to upgrade Cu-CeO_(2)interfacial interaction by the pyrolysis of mixed metal-organic framework(MOF)*** obtained highly dispersed Cu/CeO_(2)-MOF catalyst via this strategy was used to catalyze water-gas shift reaction(WGSR),which exhibited high activity of 40.5μmolCOgcat^(-1).s^(-1)at 300℃and high stability of about 120 *** on comprehensive studies of electronic structure,pyrolysis strategy has significant effect on enhancing metal-support interaction and then stabilizing interfacial Cu^(+)species under reaction *** Cu^(+)species and generated oxygen vacancies over Cu/CeO_(2)-MOF catalyst played a key role in CO molecule activation and H2O molecule dissociation,*** collaborated closely and then promoted WGSR catalytic performance in comparison with traditio nal supported *** study shall offer a robust approach to harvest highly dispersed catalysts with finely-tuned metal-support interactions for stabilizing the most interfacial active metal species in diverse heterogeneous catalytic reactions.

关键词： Cu-based catalyst MOF derivative Water-gas shift reaction Metal-support interaction

Agronomic performances of biodegradable and non-biodegradable plastic film mulching on a maize cropping system in the semi-arid Loess Plateau,China

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Pedosphere 2024年第1期34卷 88-96页

作者： hao ZHANG Mengqiong chen Ruiquan QIAO Fan DING hao FENG Rui JIANG Research Center for Cultural Landscape Protection and Ecological Restoration China-Portugal Belt and Road Cooperation Laboratory of Cultural Heritage Conservation ScienceGold Mantis School of ArchitectureSoochow UniversitySuzhou 215006China Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China Ministry of AgricultureCollege of Natural Resources and EnvironmentNorthwest A&F UniversityYangling 712100China College of Land and Environment Shenyang Agricultural UniversityShenyang 110866China Institute of Soil and Water Conservation Northwest A&F UniversityYangling 712100China

Biodegradable plastic film mulch (PFM) is considered an alternative to non-biodegradable PFM to mitigate the negative impacts of residual ***,the agronomic performance of biodegradable PFM in comparison to non-biodegradable PFM still needs to be *** this study,we evaluated the effects of biodegradable and non-biodegradable PFM on soil physicochemical properties,microbial community,and enzyme activities,as well as maize growth *** and non-biodegradable PFM both increased soil temperature,water content,N content,and microbial biomass and maize yield by up to 30%,but decreased soil enzyme activities as compared to no mulching (control,CK).Most soil physicochemical properties,microbial community,and enzyme activities were similar under non-biodegradable and biodegradable PFM at the early stages of maize ***,at the late stages,soil temperature,water content,mineral N,NO_(3)^(-)-N,ammonia monooxygenase (AMO) activity,and total phospholipid fatty acids (PLFAs) decreased under biodegradable PFM owing to film *** PFM increased soil temperature,water content,and total PLFAs at the early stages of maize growth but decreased soil mineral N and total PLFAs at the late stages,as compared to black *** soil temperature and N availability were the major factors affecting soil microbial community,microbial activity decreased after the fragmentation of biodegradable PFM,owing to the decreased soil temperature,water content,and mineral ***,biodegradable PFM could decrease NO_(3)^(-)-N accumulation in topsoil by decreasing N transformation due to the lower microbial and N-related enzyme (e.g.,AMO) activities,compared with non-biodegradable PFM,which may avoid negative environmental impacts,such as NO_(3)^(-)-N leaching or gas emission after *** yield,height,aboveground biomass,and N uptake under biodegradable PFM were similar to those under non-biodegradable PFM during maize growth,implying that biodegrad

关键词： black plastic film mulching enzyme activity film fragmentation microbial community phospholipid fatty acid white plastic film mulching

On optimal streaming kernelization algorithms

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Science China(Information Sciences) 2024年第8期67卷 337-338页

作者： hao FENG Wei YANG Jianer chen School of Computer Science Guangzhou University Department of Computer Science and Engineering Texas A&M University

The streaming model has been a popular model in big data computation. Streaming kernelization algorithms can be regarded as data compression processes on streaming data. In this study, we give a general method for developing computational lower bounds for streaming kernelization algorithms that is applicable to a large class of computational problems. As an example, we use the method to prove computational lower bounds for the well-known problem d-Hi TTin GSET.

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Iron single-atom/clusters catalysts derived from iron-rich Enteromorpha after urea-saturation for Fenton-like reaction

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Chinese Chemical Letters 2024年第3期35卷 149-152页

作者： Yujie Zhang Siyi Liu Dongdong chen xing Xu School of Environmental Science and Engineering Shandong UniversityQingdao 266237China

Fabrication of single atom catalysts(SACs)by a green and gentle method is important for their practical Fenton-like *** this work,a high effective iron-based catalyst was prepared from the iron-rich Enteromorpha for NPX degradation via peroxymonosulfate(PMS).Both Fe-SACs and iron-clusters was fabricated from the intrinsic iron element in Enteromorpha after the urea *** Fe-SACs/clusters can achieve 100%of NPX oxidation within 20 min with the k_(obs)of 0.282 min^(-1).Quenching tests indicated that the radical pathways were not dominated in the catalytic systems,and strong electron transfer process can be induced in the Fe-SACs/clusters+PMS system by using the NPX as electron donor and FeSACs/clusters/PMS^*complexes as electron *** result was consistent with the phenomenon observed in the galvanic oxidation *** addition,the Fe-SACs/clusters was deposited onto the ceramic membrane(CM)by the spraying-crosslinking process to form a Fe-SACs/clusters@CM,which showed an effective and continuous NPX degradation in a heterogeneous PMS system.

关键词： SACs Iron Clusters Fenton-like reaction Enteromorpha

Exploring multiple phases and first-order phase transitions in Kármán Vortex Street

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 47-54页

作者： Xu Li xing Xiang Tingting Xue Limin Wang Xiaosong chen School of Systems Science and Institute of Nonequilibrium Systems Beijing Normal UniversityBeijing 100875China State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy ofSciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Kármán Vortex Street, a fascinating phenomenon of fluid dynamics, has intrigued the scientific community for a long time. Many researchers have dedicated their efforts to unraveling the essence of this intriguing flow pattern. Here, we apply the lattice Boltzmann method with curved boundary conditions to simulate flows around a circular cylinder and study the emergence of Kármán Vortex Street using the eigen microstate approach, which can identify phase transition and its order-parameter. At low Reynolds number, there is only one dominant eigen microstate W_(1) of laminar flow. At Re_(c)^(1)= 53.6, there is a phase transition with the emergence of an eigen microstate pair W^(2,3) of pressure and velocity fields. Further at Re_(c)^(2)= 56, there is another phase transition with the emergence of two eigen microstate pairs W^(4,5) and W^(6,7). Using the renormalization group theory of eigen microstate,both phase transitions are determined to be first-order. The two-dimensional energy spectrum of eigen microstate for W^(1), W^(2,3) after Re_(c)^(1), W^(4-7) after Re_(c)^(2) exhibit-5/3 power-law behavior of Kolnogorov's K41 theory. These results reveal the complexity and provide an analysis of the Kármán Vortex Street from the perspective of phase transitions.

关键词： Kármán Vortex Street first-order phase transition eigen microstate approach renormalization group theory of eigen microstate

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