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Urinary metabolic profiles during Helicobacter pylori eradication in chronic gastritis

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World Journal of Clinical Cases 2024年第5期12卷 951-965页

作者： Wen-Ting An yu-Xia Hao Hong-Xia Li xing-Kang Wu Department of Pharmacy Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Department of Gastroenterology Shanxi Provincial People's HospitalTaiyuan 030012Shanxi ProvinceChina Department of Oncology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006Shanxi ProvinceChina

BACKGROUND Helicobacter pylori(***)infection is a major risk factor for chronic gastritis,affecting approximately half of the global *** eradication is a popular treatment method for ***-positive chronic gastritis,but its mecha-nism remains *** metabolomics has been used to elucidate the mechanisms of gastric disease ***,no clinical study has been conducted on urinary metabolomics of chronic *** To elucidate the urinary metabolic profiles during *** eradication in patients with chronic *** We applied LC–MS-based metabolomics and network pharmacology to in-vestigate the relationships between urinary metabolites and ***-positive chronic gastritis via a clinical follow-up *** Our study revealed the different urinary metabolic profiles of ***-positive chronic gastritis before and after *** *** metabolites regulated by *** eradication therapy include cis-aconitic acid,isocitric acid,citric acid,L-tyrosine,L-phenylalanine,L-tryptophan,and hippuric acid,which were involved in four metabolic pathways:(1)Phenylalanine metabolism;(2)phenylalanine,tyrosine,and tryptophan biosynthesis;(3)citrate cycle;and(4)glyoxylate and dicarboxylate *** metabolomics and network pharmacology revealed that MPO,COMT,TPO,TH,EPX,CMA1,DDC,TPH1,and LPO were the key proteins involved in the biological progress of *** eradication in chronic *** Our research provides a new perspective for exploring the significance of urinary metabolites in evaluating the treatment and prognosis of ***-positive chronic gastritis patients.

关键词： LC-MS metabolomics chronic gastritis Helicobacter pylori urinary metabolites

Clinical analysis of 12 cases of ovarian neuroendocrine carcinoma

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World Journal of Clinical Cases 2024年第6期12卷 1111-1119页

作者： Xiao-yu xing Wei Zhang Li-Ya Liu Li-Ping Han Department of Gynecology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina

BACKGROUND Neuroendocrine neoplasms of the female genital tract are *** To enhance our clinical understanding of neuroendocrine carcinoma(NEC)of the *** A retrospective review was conducted on 12 patients diagnosed with NEC of the ovary,analyzing clinicopathological characteristics,treatment modalities,and survival *** The median age at diagnosis was 34.5 years(range:20 to 62 years).Among the 12 cases,9 were small cell carcinoma of the ovary and 3 were large cell *** cases were stage I tumors,one case was stage IV,and six cases were stage *** patients underwent surgery as part of their *** patients received adjuvant *** the 12 patients,one patient received radiotherapy,and one patient with a BRCA2 mutation was administered PARP inhibitor maintenance after *** median progression-free survival was 13 months,and the median overall survival was 19.5 *** cases remained disease-free,while eight cases experienced tumor recurrence,including three cases that resulted in death due to disease *** NEC of the ovary is a rare condition that is more common in women of childbearing age and is associated with aggressive behavior and poor clinical *** resection remains the mainstay of treatment,with some patients benefiting from adjuvant chemoradiation therapy.

关键词： Neuroendocrine carcinoma Ovary Pathology Treatment

Distributed Fault-Tolerant Control of Uncertain Multi-Agent Systems with Connectivity Maintenance

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Journal of Systems Science & Complexity 2024年第1期37卷 40-62页

作者： xing Xueyan HU Guoqiang Continental-NTU Corporate Lab Nanyang Technological UniversitySingapore 639798Singapore Continental-NTU Corporate Lab and the School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore

In this paper,a distributed cooperative control protocol is presented to deal with actuator failures of multi-agent systems in the presence of connectivity *** the developed strategy,each agent can track the reference trajectory of the leader in the presence of actuator failures,disturbances and *** connectivity of the multi-agent system can always be ensured during the control *** achieve the aforementioned control objectives,a potential function is introduced to the distributed adaptive fault-tolerant control algorithm to preserve the initial connected network among the *** uncertainty of the multi-agent system,which is allowed to be described by discontinuous functions,is approximated and compensated using the fuzzy logic *** asymptotic stability of the closed-loop system is demonstrated through the use of Cellina’s approximate selection theorem of nonsmooth *** to the developed adaptive laws,the upper bound of the disturbance is allowed to be uncertain,which facilitates the implementation of the control ***,simulation results are provided to verify the effectiveness of the proposed control scheme.

关键词： Actuator failure connectivity maintenance coordination control uncertainties

Deliberate self-harm among pediatric psychiatric inpatients in China:A single-center retrospective study

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World Journal of Psychiatry 2024年第3期14卷 398-408页

作者： xing-Zhi Jiang Huan-Huan Li Zhen-Zhen yu Chen Wang Department of Child and Adolescent Psychiatry Shenzhen Kangning HospitalShenzhen Mental Health CenterShenzhen Key Laboratory for Psychological Healthcare and Shenzhen Institute of Mental HealthShenzhen 518020Guangdong ProvinceChina Department of Psychiatry Xiamen Xianyue HospitalXiamen 361012Fujian ProvinceChina Department of Geriatric Medicine Dalian Medical UniversityDalian 116000Liaoning ProvinceChina Department of Neurology The Second Affiliated Hospital of Xiamen Medical CollegeXiamen 361000Fujian ProvinceChina Department of Neurology and Department of Neuroscience The First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361000Fujian ProvinceChina

BACKGROUND For children and adolescents,deliberate self-harm(DSH)is becoming a mental health problem of *** several studies on the prevalence and factors of DSH in the world,there is little information on DSH among children and adolescents in *** study explores the prevalence,types,associated risk factors and tendency of DSH in pediatric psychiatric inpatients in *** To understand the situation of DSH among hospitalized children and adolescents and its related *** In this study,we retrospectively studied 1414 hospitalized children and adolescents with mental illness at Xiamen Mental Health Center from 2014 to 2019,extracted the demographic and clinical data of all patients,and analyzed clinical risk factors of *** A total of 239(16.90%)patients engaged in at least one type of DSH in our ***(n=115,48.12%)was the most common type of ***(n=171,71.55%)were more likely to engage in DSH than males(n=68,28.45%).DSH was positively associated with depressive disorders[OR=3.845(2.196-6.732);P<0.01],female[OR=2.536(1.815-3.542);P<0.01],parental marital status[OR=5.387(2.254-12.875);P<0.01]and negative family history of psychiatric illness[OR=7.767(2.952-20.433);P<0.01],but not with occupation,substance use and history of physical *** Our findings suggest that for patients with depression,females,an abnormal marriage of parents,and no history of mental illness,attention should be paid to the occurrence of DSH.

关键词： Deliberate self-harm Children Adolescent Psychiatric inpatients Retrospective study

Dural sinus septum:an underlying cause of cerebral venous sinus stenting failure and complications

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Stroke & Vascular Neurology 2024年第2期9卷 174-180页

作者： Yangang Zhao Xiaolan Zhang bin Lv Jun Wang Xinfeng Liu Zhihua Du Fang Cui Baoming Li xing Chen Xiangyu Cao Beijing Advanced Innovation Center for Biomedical Engineering School of Engineering MedicineBeihang UniversityBeijingChina Department of Neurology Hainan Hospital of Chinese PLA General HospitalSanyaHainanChina Department of Neurology Chinese PLA General HospitalBeijingChina

Objectives The presence of dural sinus septum has long been identified anatomically but is often neglected for its clinical *** findings revealed the association of dural sinus septum with venous sinus stenting failure and complications supported by clinical *** This retrospective study included 185 consecutive patients treated with cerebral venous sinus stenting from January 2009 to May *** identified the dural sinus septa using digital subtraction angiography(DSA)and classified them into three types based on their *** septa at the transverse sinus were defined as typeⅠ,those at the junction between the transverse sinus and sigmoid sinus were defined as typeⅡand those at the sigmoid sinus were defined as typeⅢ.Based on the anatomic features and neuroimaging clues,we investigated the correlation of dural sinus septa with stenting failure and *** 32(17.1%)out of 185 patients(121 with idiopathic intracranial hypertension and 64 with venous pulsatile tinnitus)were identified with dural sinus septa by *** than half of the septa were typeⅠ(18/32,56.2%),followed by typeⅡ(11/32,34.4%)and typeⅢ(3/32,9.4%).The dural sinus septa caused three stenting failures and complications,including one case of venous sinus injury with subdural haemorrhage and two cases of incomplete stent *** analysis revealed that the presence of dural sinus septum(p<0.01)was associated with complications of cerebral venous sinus *** The dural sinus septum is a common structure in the cerebral venous *** found that the presence of dural sinus septa introduces uncertainties to cerebral venous sinus stenting and suggested precautions and ingenious skills in imaging and treatment.

关键词： septum cerebral venous

Nanocomposite: Keggin-type Co_(4)-polyoxometalate@cobaltporphyrin linked graphdiyne for hydrogen evolution in seawater

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Nano Research 2024年第3期17卷 1281-1287页

作者： Jiejie Ping Danyang He Fei Wang Nan Wang Yi-cheng Fu Zihao xing Zhiyu Jia Guo-yu Yang Key Laboratory of Cluster Science Ministry of EducationSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Facluty of Chmeistry Northeast Normal UniversityChangchun 130024China Peking University Third Hospital Beijing 100190China

Polyoxometalate-based nanocomposites with electrocatalytic activity have been applied in hydrogen evolution reactions(HER).Seawater as the main water resource on the earth should be developed as the water electrolysis to prepare high-purity *** this paper,we used two synthesis strategies to prepare the nanocomposite Co_(4)-POM@Co-PGDY(Co_(4)-POM:the Kegging-type microcrystals of K_(10)[Co_(4)(PW_(9)O_(3)4)2]and Co-PGDY:cobalt-porphyrin linked graphdiyne)with excellent activity for ***-PGDY as the porous material is applied not only as the protection of microcrystals towards the metal ion in seawater but also as the co-electrocatalyst of Co_(4)-***_(4)-POM@Co-PGDY exhibits excellent HER performance in seawater electrolytes with low overpotential and high stability at high ***,we have observed a key H_(3)O+intermediate emergence on the surface of nanocomposite during hydrogen evolution process in seawater by Raman synchrotron radiation-based Fourier transform infrared(SR-FTIR).The results in this paper provide an effective strategy for preparing polyoxometalate-based electrocatalysts with high-performance toward hydrogen evolution reaction.

关键词： polyoxometalate graphdiyne seawater hydrogen evolution reaction

Divergent defluorocarboxylation of α-CF_(3) alkenes with formate via photocatalyzed selective mono-or triple C-F bond cleavage

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Science China Chemistry 2024年第1期67卷 368-373页

作者： xing-yu Wang Pei Xu Wen-Wen Liu Hao-Qiang Jiang Song-Lei Zhu Dong Guo Xu Zhu Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy School of PharmacyXuzhou Medical UniversityXuzhou 22100China

Unprecedented divergent synthesis of gem-difluorovinylacetic acid and glutaric acid derivatives fromα-CF_(3)alkenes with formate as the carbonyl source was *** reaction can undergo selective mono-or triple C-F bond cleavage by simply switching the photocatalyst and hydrogen atom transfer(HAT)catalyst under visible-light-induced conditions at room *** acts as both the C1 source and the reductant through the generation of CO_(2)^(·-)species,which underwent Giese radical addition to electron-deficient alkenes to trigger the consecutive C-F bond cleavage and carboxylation process.

关键词： C-F bond activation defluorocarboxylation carbon dioxide radical anion visible light

D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy

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Chinese Chemical Letters 2024年第10期35卷 299-304页

作者： Xuejian xing Pan Zhu E Pang Shaojing Zhao yu Tang Zheyu Hu Quchang Ouyang Minhuan Lan Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Chemistry and Chemical Engineering Neijiang Normal UniversityNeijiang 641100China Medical Department of Breast Cancer Hunan Cancer HospitalChangsha 410083China Medical Department of Breast Cancer The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410083China

Clinical phototheranostic agents suffer from low absorption in near-infrared(NIR)region,decreasing singlet oxygen quantum yield(^(1)O_(2)QY)caused by aggregation in water,and low photothermal conversion efficiency(PCE),all of which are factors weakening their phototheranostic ***,we designed and synthesized a donor-acceptor-donor(D-A-D)structured boron-dipyrromethene derivative(B-2TPA)which exhibited NIR absorption and *** being encapsulated in amphiphilic distearoyl phosphoethanolamine polyethyleneglycol 2000(DSPE-PEG-2000),the water-soluble B-2TPA nanoparticles(NPs)had increasing^(1)O_(2)QY(6.7%)due to the intermolecular aggregation-induced decrease in the energy gap between singlet and triplet excited ***,the quenched fluorescence and stable twisted intramolecular charge transfer in aggregates further increased the PCE of B-2TPA NPs to 60.1%.In vitro and in vivo studies confirmed that B-2TPA NPs could be used in NIR fluorescence and photoacoustic imagingguided synergistic photodynamic and photothermal therapy in tumor treatment.

关键词： Boron-dipyrromethene Aggregation Intersystem crossing Twisted intramolecular charge transfer Photodynamic therapy Photothermal therapy

Global convergence in terrestrial gross primary production response to atmospheric vapor pressure deficit

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Science China(Life Sciences) 2024年第9期67卷 2016-2025页

作者： Chao Huang Jingfeng Huang Jingfeng Xiao xing Li Hong SHe yu Liang Fusheng Chen Hanqin Tian Key Laboratory of National Forestry and Grassland Administration on Forest Ecosystem Protection and Restoration of Poyang Lake Watershed College of ForestryJiangxi Agricultural UniversityNanchang 330045China CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China Institute of Applied Remote Sensing&Information Technology College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Agricultural Remote Sensing and Information Systems Zhejiang ProvinceZhejiang UniversityHangzhou 310058China Earth Systems Research Center Institute for the Study of EarthOceansand SpaceUniversity of New HampshireDurham NH 03824USA Research Institute of Agriculture and Life Sciences Seoul National UniversitySeoul 08826South Korea School of Natural Resources University of Missouri203 ABNR BuildingColumbiaMO 65211USA Schiller Institute for Integrated Science and Society Department of Earth and Environmental SciencesBoston CollegeChestnut HillMA 02467USA

Atmospheric vapor pressure deficit(VPD)increases with climate warming and may limit plant ***,gross primary production(GPP)responses to VPD remain a mystery,offering a significant source of uncertainty in the estimation of global terrestrial ecosystems carbon *** this study,in-situ measurements,satellite-derived data,and Earth System Models(ESMs)simulations were analysed to show that the GPP of most ecosystems has a similar threshold in response to VPD:first increasing and then *** VPD exceeds these thresholds,atmospheric drought stress reduces soil moisture and stomatal conductance,thereby decreasing the productivity of terrestrial *** ESMs underscore CO_(2) fertilization effects but predict significant GPP decline in low-latitude ecosystems when VPD exceeds the *** results emphasize the impacts of climate warming on VPD and propose limitations to future ecosystems productivity caused by increased atmospheric water *** VPD,soil moisture,and canopy conductance interactions into ESMs enhances the prediction of terrestrial ecosystem responses to climate change.

关键词： atmospheric water demands soil moisture stomatal conductance photosynthesis climate warming