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This work was supported by the European Research Council Advanced Grant(ETAP-742.85 to *** J.F.)and by the Ministry of Science and Technology(grant 110-2.36-B-005-001 to K.-J.L.).

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Plant Communications 2024年第1期5卷 130-147页

作者： yu Zhang yuan Fu {2. Xian Xiuli Li Yong Feng Fengjiao Bu Yan Shi Shiyu Chen Robin van Velzen Kai Battenberg Alison M.Berry Marco G.Salgado Hui Liu Tingshuang yi Pascale Fournier Nicole Alloisio Petar Pujic Hasna Boubakri M.Eric Schranz Pierre-Marc Delaux Gane Ka-Shu Wong Valerie Hocher Sergio Svistoonoff Hassen Gherbi Ertao Wang Wouter Kohlen Luis G.Wall Martin Parniske Katharina Pawlowski Philippe Normand Jeffrey J.Doyle Shifeng Cheng Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124China Biosystematics Group Department of Plant SciencesWageningen University6708PB Wageningenthe Netherlands Department of Plant sciences University of CaliforniaDavisDavisCA 95616USA Department of Ecology Environment and Plant SciencesStockholm University10691 StockholmSweden Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesLanhei RoadKunming 650201China Universite´de Lyon Universite´Lyon 1CNRSUMR5557Ecologie MicrobienneINRAUMR 141843 bd du 11 novembre 191869622 VilleurbanneFrance Laboratoire de Recherche en sciences Ve´ge´tales(LRSV) Universite´de ToulouseCNRSUPS24 chemin de Borde RougeAuzevilleBP4261731326 Castanet TolosanFrance Department of Biological sciences University of AlbertaEdmontonAB T6G 2E9Canada French National Research Institute for Sustainable Development(IRD) UMR LSTM(IRD/CIRAD/INRAe/Montpellier University/Supagro)-Campus International BaillarguetTA A-82/J34398 Montpellier Cedex 5France National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologySIBSChinese Academy of SciencesShanghaiChina Laboratory of Molecular Biology Department of Plant SciencesWageningen University6708PB Wageningenthe Netherlands Laboratory of Biochemistry Microbiology and Soil Biological InteractionsDepartment of Science and TechnologyNational University of QuilmesCONICETBernalArgentina Faculty of Biology GeneticsLMU MunichGroßhaderner Strasse 2-482152 MartinsriedGermany School of Integrative Plant Science Sections of Plant Biology and Plant Breeding&GeneticsCornell UniversityIthacaNY 14853USA State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China Univer

Plant root-nodule symbiosis(RNS)with mutualistic nitrogen-fixing bacteria is restricted to a single clade of angiosperms,the Nitrogen-Fixing Nodulation Clade(NFNC),and is best understood in the legume *** species share many commonalities,explained either by divergence from a common ancestor over 100 million years ago or by convergence following independent origins over that same time ***,comparative analyses of diverse nodulation syndromes can provide insights into constraints on nodulation—what must be acquired or cannot be lost for a functional symbiosis—and the latitude for Plant Communications Genomic landscape of nodulation variation in the ***,much remains to be learned about nodulation,especially outside of ***,we employed a large-scale phylogenomic analysis across 88 species,complemented by 151 RNA-seq libraries,to elucidate the evolution of *** phylogenomic analyses further emphasize the uniqueness of the transcription factor NIN as a master regulator of nodulation and identify key muta-tions that affect its function across the *** transcriptomic assessment revealed nodule-specific upregulated genes across diverse nodulating plants,while also identif{2.ng nodule-specific and nitrogen-response *** 70%of symbiosis-related genes are highly conserved in the four representative species,whereas defense-related and host-range restriction genes tend to be lineage *** study also identified over 900000 conserved non-coding elements(CNEs),over 300000 of which are unique to sampled NFNC ***-specific CNEs are enriched with the active H3K9ac mark and are correlated with accessible chromatin regions,thus representing a pool of candidate regula-tory elements for genes involved in ***,our results provide novel insights into the evolution of nodulation and lay a foundation for engineering of RNS traits in agriculturally important crops.

关键词： nitrogen-fixing root-nodule symbiosis two competing hypotheses phylogenomics phylotranscrip-tomics conserved non-coding elements convergence deep homology

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Bimodal growth of Fe islands on graphene

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chinese Physics B 2024年第6期33卷 553-557页

作者：顾翊晟俞俏滟刘荡孙蓟策席瑞骏陈星森薛莎莎章毅杜宪宁旭辉杨浩管丹丹刘晓雪刘亮李耀义王世勇刘灿华郑浩贾金锋 Key Laboratory of Artificial Structures and Quantum Control TD Lee InstituteShenyang National Laboratory for Materials ScienceSchool of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Department of Physics Southern University of Science and TechnologyShenzhen 518055China Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area(Guangdong) Shenzhen 518045China

Magnetic metals deposited on graphene hold the key to applications in spintronics. Here, we present the results of Fe islands grown on graphene/Si C(0001) by molecular beam epitaxy, which are investigated by scanning tunneling microscopy. The two types of islands distinguished by flat or round tops are revealed, indicating bimodal growth of Fe. The atomic structures on the top surfaces of flat islands are also clearly resolved. Our results may improve the understanding of the mechanisms of metals deposited on graphene and pave the way for future spintronic applications of Fe/graphene systems.

关键词： graphene magnetism molecular beam epitaxy scanning tunneling microscopy

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Effects of Ginkgo biloba extract 50 on myocardial function in myocardium ischemic rats

Effects of Ginkgo biloba extract 50 on myocardial function i...

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中国生理学会第2.届全国会员代表大会暨生理学学术大会

作者： Ai-Hua LIU,yi-Min BAO,xing-{2. WANG,Zhi-Xiong ZHANG~* shanghai University of Traditional chinese Medicine,shanghai 2.12.3

＜正＞Objective:To study the effects of Ginkgo biloba extract 50（GBE50） on myocardial function,area at risk and myocardial ultra-structure in myocardium ischemic ***:Myocardium ischemia was induced by the left anterior descending（LAD） coronary artery occlusion and myocardial function was *** vitro myocardial infarction was measured by 2.3,5-triphenyltetrazolium chloride（TTC） and Evans blue staining of heart *** hematoxylin and eosin（HE） staining was used for morphological evaluation by light microscopy. Results:Hemodynamic experiments in vivo showed that postischemic cardiac contractile function was reduced in ischemic ***（7.5 g/kg/d×7） and GBE50（100 mg/kg/d×7） improved postischemic cardiac diastolic dysfunction. The area at risk was significantly reduced and myocardial structure was better-preserved in hearts of GBE50 group and SM ***:GBE50 could attenuate myocardium damage induced by ischemia and provide potent myocardial protection.

关键词： GBE50 cardiac ischemia myocardial function area at risk ultra-structure

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The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-yun Zhao Shao-Lin Xiong Xiang-Yang Wen Xin-Qiao Li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-yuan Liao Yan-Qiu Zhang yue Huang Lu Li xing Wen Fei Zhang Jing Duan Chen-Wei Wang Dong-Li Shi Peng Zhang Qi-Bin yi Chao-Yang Li Yan-Bing Xu Xiao-Hua Liang Ya-Qing Liu Da-Li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-yu Wang Sheng Yang Xiao-Jing Liu Min Gao Mao-Shun Li Jin-Zhou Wang xing Zhou yi Zhao Wang-Chen Xue Chao Zheng Jia-Cong Liu xing-Bo Han Jin-Ling Qi Jia Huang Ke-Ke Zhang Can Chen Xiong-Tao Yang Dong-Jie Hou yu-Sa Wang Rui Qiao Xiang Ma Xiao-Bo Li Ping Wang Xin-ying Song Li-Ming Song Shi-Jie Zheng Bing Li Hong-Mei Zhang yue Zhu Wei Chen Jian-Jian He Zhen Zhang Jin Hou Hong-Jun Wang Yan-Chao Hao Xiang-yu Wang Zong-yuan Yang Zhi-Long Wen Zhi Chang yuan-yuan Du Rui Gao Xiao-Fei Lan Yan-Guo Li Gang Li Xu-Fang Li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui Wang Hui-Zhen Wang yu-Peng Xu Jia-Wei Yang Xue-Juan Yang Shuang-Nan Zhang Chao-yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of chinese academy of sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China chinese academy of sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2.2. December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

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Regulation of Ginkgo biloba extract 50 on NF-κB,p38MAPK signaling pathways and related genes in rat’s myocardial ischemia-reperfusion model

Regulation of Ginkgo biloba extract 50 on NF-κB,p38MAPK sig...

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中国生理学会第2.届全国会员代表大会暨生理学学术大会

作者： yi-Min BAO,Mei LI,Ai-Hua LIU,Zhi-Xiong ZHANG~*,yun LI,{2.-yu WANG Department of Physiology,shanghai University of Traditional chinese Medicine,shanghai 2.12.3,china

＜正＞Objective:To observe the effect of Ginkgo biloba extract 50（GBE50） on NF-kB,p38MAPK signaling pathways and related genes in rats with myocardial ischemia-reperfusion（I/R）,and investigate its mechanism against inflammatory reaction after I/***:Twenty-four SD rats were divided into sham-operated group, model group,Salviae miltiorrhizae（SM） injection group and GBE50 group *** drug administration by intragastric route for 7 days,the left anterior descending（LAD） coronary artery was occluded for 30 minutes followed by 60 minutes of reperfusion to induce ischemia-reperfusion *** protein expression of nuclear factor-kappa B（NF-kB）,p38 mitogen-activated protein kinase（p38MAPK） in myocardium were measured by immunohistochemical method;the gene expression of tumor necrosis factor-alpha（TNF-α）,inducible nitric oxide synthase（iNOS）,cycloxygenase-2.COX-2. were detected by Real-time ***:In model group,the protein expression of NF-kB in myocardium was obviously higher than those in sham-operated group（P＜0.001）, the protein expression of p38MAPK was higher than sham-operated group too,but without significant difference. Compared with model group,rats in GBE50 group had a lower expression of NF-kB（OD value P＜0.05,positive area P＜0.001）,lower expression of p38MAPK（OD value P＜0.05,positive area P＜0.01）.The gene expression of COX-2.iNOS and TNF-αin myocardium were significantly up-regulated in model group than those in sham-operated group（P＜0.05-0.001）.Compared with model group,GBE50 could down-regulate the gene expression of COX-2.and TNF-αin myocardium after I/R（P＜0.01）,and reduce the gene expression of iNOS partly（P＞0.05）. Conclusion:GBE50 can down-regulate gene expression of inflammatory reaction key enzyme COX-2.and proinflammatory cytokine TNF-α,partly down-regulate gene expression of oxidative stress key enzyme iNOS via inhibition of NF-kB and p38MAPK signaling *** suggests that GBE50 could regulate the inflammatory reaction after I/R.

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从基础智能到通用智能:基于大模型的GenAI和AGI之现状与展望

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自动化学报 2024年第4期50卷 674-687页

作者：缪青海王兴霞杨静赵勇王雨桐陈圆圆田永林俞怡林懿伦鄢然马嘉琪那晓翔王飞跃中国科学院大学人工智能学院北京100049 中国科学院自动化研究所复杂系统管理与控制国家重点实验室北京100190 国防科技大学系统工程学院长沙410000 上海人工智能实验室上海200232 南洋理工大学土木与环境工程学院新加坡639798 加州大学洛杉矶分校萨穆埃利工程学院美国洛杉矶90095 剑桥大学工程系英国剑桥CB21TN

本文对生成式AI(Generative artificial intelligence,GenAI)的国内外发展现状进行了概述,重点分析了中美之间在算力、数据、算法、生态等方面存在的差距.为改变我国在生成式AI领域的落后现状,提出高能效算力建设、联邦数据、专业领域... 详细信息

本文对生成式AI(Generative artificial intelligence,GenAI)的国内外发展现状进行了概述,重点分析了中美之间在算力、数据、算法、生态等方面存在的差距.为改变我国在生成式AI领域的落后现状,提出高能效算力建设、联邦数据、专业领域模型、基于TAO的联邦生态等应对策略,对大模型时代AI安全治理进行了论述,对通用人工智能(Artificial general intelligence,AGI)的未来发展进行了展望.

关键词：生成式人工智能大语言模型基础模型通用人工智能基础智能平行智能 Sora

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Diagnosis,treatment and prevention of severe acute respiratory syndrome coronavirus 2.infection in children:experts'consensus statement updatedforthe Omicron variant

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World Journal of Pediatrics 2024年第3期20卷 272-286页

作者： Rong-Meng Jiang Zheng-De Xie yi Jiang Xiao-Xia Lu Run-Ming Jin yue-Jie Zheng yun-Xiao Shang Bao-Ping Xu Zhi-Sheng Liu Gen Lu Ji-Kui Deng Guang-Hua Liu Xiao-Chuan Wang Jian-She Wang Lu-Zhao Feng Wei Liu yi Zheng Sai-Nan Shu Min Lu Wan-Jun Luo Miao Liu yu-Xia Cui Le-Ping Ye A-Dong Shen Gang Liu Li-Wei Gao Li-Juan Xiong Yan Bai Li-Kai Lin Zhuang Wei Feng-Xia Xue Tian-You Wang Dong-Chi Zhao Jian-Bo Shao Daniel Kwok-keung Ng Gary Wing-kin Wong Zheng-Yan Zhao xing-Wang Li Yong-Hong Yang Kun-Ling Shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Pediatrics Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Respiratory Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Respiratory Shenzhen Children's HospitalShenzhen 518038China Department of Pediatric Respiratory Shengjing Hospital Affiliated to China Medical UniversityShenyang 110004China Department of Respiratory Beijing Children's HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China Department of Neurology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Respiratory Guangzhou Women and Children's Medical CenterGuangzhou 510623China Department of Infectious Diseases Shenzhen Children's HospitalShenzhen 518038China Department of Pediatrics Fujian Branch of Shanghai Children's Medical CenterFujian Children's HospitalFuzhou350005China Department of Clinical Immunology and Allergy Children's Hospital of Fudan UniversityNational Center for Children's HealthShanghai 201102China Department of Infectious Diseases Children's Hospital of Fudan UniversityNational Center for Children's Health.Shanghai

It has been more than 3 years since the novel coronavirus(SARS-CoV-2.pandemic raged *** coronavirus disease 2.19(COVID-19)has greatly influenced human *** to data from the World Health Organization(WHO),there were ove... 详细信息

关键词： prevention infection statement

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Micro/nanoscale tools for neurobiology

Micro/nanoscale tools for neurobiology

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： yi SUN~(1 2. Shi-Ge xing~(1 2. Wen-Wen LIU~(1 2. xing-yu JIANG~(1 *) 1 CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience & Technology Beijing 100190 china 2.Graduate School of the chinese academy of sciences Beijing 100864 china

＜正＞By combining an arsenal of micro/nanoscale tools including self-assembled monolayer,microcontact printing and microfluidics,we have been able to precisely pattern cells into virtually any geometry on two dimensional surfaces, from single cell to thousands of cells,from single type to multiple species,from cell lines to primary cells,and release them afterwards,***,we have patterned primary neurons and astrocytes and release them afterwards from their original *** patterns can be employed for constructing neural networks in ***,we have been able to reliably create spatial gradients of both soluble and surface-bound *** have devised a substratebound gradient of laminin for studying neuronal polarity,and revealed that laminin gradient orients axon specification. Besides,by creating a zebra-striped pattern of laminin with characteristic dimension of tens of micrometers onto which primary neurons are seeded,we have discovered that neuritogenesis favors the edges of the stripes which corresponds to steepest point of the gradient *** conclusion,by adapting these micro/nanoscale tools to specific problems,they hold promise for solving a range of issues in understanding the formation and function of the nervous system.

关键词： microfluidics surface chemistry cell patterning gradient

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π-π堆叠构建钙钛矿光伏高效电荷通道

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Science Bulletin 2024年第1期69卷 26-29页

作者：陈春浩胡凡王凯礼陈静滕天禹史怡然夏宇苏圳煌高兴宇 Ilhan Yavuz 王照奎廖良生 Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory of Advanced Negative Carbon TechnologiesJiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201204China Department of Physics Marmara UniversityIstanbul 34722Turkey

Perovskite solar cells(PSCs)have emerged as strong potential candidates for future photovoltaic *** power conversion efficiency(PCE)of PSCs has already surpassed 2.%,approaching their theoretical limit[1].The commonly used device structure for PSCs is ITO/SnO_(2./perovskite/2.2.,7,7'-tetrakis-(N,N-di-4-methox yphenylamino)-9,9'-spirobifluorene(spiro-OMeTAD)/Au[2..

关键词：钙钛矿 approaching perovskite

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Bc-tIGF-1对NOD小鼠T细胞亚群的调节作用

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复旦学报（医学版） 2002年第1期29卷 15-17,29,T001页

作者：刘芳俞茂华朱秋毓颜怡谦许祖德杨秀芳朱禧星上海市第五人民医院内分泌科上海200240 复旦大学附属华山医院内分泌科上海200040 中国科学院上海生理研究所上海200031 复旦大学医学院病理学教研室上海200032

目的　了解Bc tIGF 1是否能预防NOD小鼠糖尿病 (DM )的发生并探讨其免疫机制。方法　 4周龄时给NOD雌性小鼠腹腔注射 (ip)Bc tIGF 17.5 μg/ (kg·d) ,连续应用 2. (n =10 ) ;同时等体积生理盐水ip 2.作为对照组 (n =10 )。 4 0周龄... 详细信息

目的　了解Bc tIGF 1是否能预防NOD小鼠糖尿病 (DM )的发生并探讨其免疫机制。方法　 4周龄时给NOD雌性小鼠腹腔注射 (ip)Bc tIGF 17.5 μg/ (kg·d) ,连续应用 2. (n =10 ) ;同时等体积生理盐水ip 2.作为对照组 (n =10 )。 4 0周龄处死小鼠 ,测定血清C 肽和谷氨酸脱羧酶抗体 (GAD -Ab) ,并观察脾脏T细胞亚群、胰岛病理和淋巴细胞免疫组化变化。结果　Bc tIGF 1组DM发病率 ( 5 0 % )明显低于NS组 ( 90 % ,P <0 .0 5 ) ,且发病时间延缓 ,胰岛炎症程度也明显减轻 ;脾脏CD+4T淋巴细胞较NS组明显降低 ,CD+8细胞比例则显著升高 (P <0 .0 1)。免疫组化显示Bc tIGF 1组胰岛CD+4T细胞浸润较对照组减少且局限在胰岛周围。两组的GAD -Ab阳性率无显著性差异。结论　早期应用Bc tIGF 1可减少和延缓NOD小鼠糖尿病发病 ,其机制可能与恢复CD+4和CD+8T细胞亚群平衡。

关键词：牛初乳短链IGF-1 非肥胖糖尿病小鼠 Ⅰ型糖尿病 T细胞亚群 DM Bc-tIGF-1

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