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电雾式检测器的研究进展及在药物领域中的应用

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分析测试技术与仪器 2024年第3期30卷 172-188页

作者：邹晓伟刘星杨佩华张建明上海科哲生化科技有限公司上海201108

液相色谱搭配紫外检测器系统是药物检测中最常使用的分析仪器之一,在大多数情况下能够应对各种分析任务.然而在实际应用中,常会遇到待测成分没有紫外吸收的情形,这时其他响应机制的检测器往往能起到很好的检测效果.其中,电雾式检测器(C... 详细信息

液相色谱搭配紫外检测器系统是药物检测中最常使用的分析仪器之一,在大多数情况下能够应对各种分析任务.然而在实际应用中,常会遇到待测成分没有紫外吸收的情形,这时其他响应机制的检测器往往能起到很好的检测效果.其中,电雾式检测器(CAD)近年来倍受青睐.简要介绍了CAD的机理和仪器结构,对比了CAD与其他类型气溶胶类检测器间的异同,汇总了近年来CAD在药物分析领域中的应用,最后展望了CAD未来的发展.

关键词：电雾式检测器气溶胶类检测器药物检测

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Gold nanoparticles cause size-dependent inhibition of embryonic development during murine pregnancy

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Nano Research 2018年第6期11卷 3419-3433页

作者： xiaowei Ma Xiaolong Yang Yufei Wang Juan Liu Shubin Jin Shuyi Li xing-Jie Liang Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology of China No. 11 First North Road Zhongguancun Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China College of Biotechnology Tianjin University of Science & Technology Tianjin 300457 China Tissue Engineering Lab Beijing Institute of Transfusion Medicine Beijing 100850 China Beijing Municipallnstitute of Labour Protection No. 55 Taoranting Road Xicheng District Beijing 100054 China

Gold nanoparticles （Au NPs） have been widely utilized in biomedical appli- cations owing to their attractive features and biocompatibility, which greatly increase the risk of humans＂ being exposed to Au NPs, including pregnant women. In contrast to mature cells, embryos are more susceptible to outside disruptive stimuli. Nonetheless, a possible inhibitory effect of nanomaterials on embryonic development is usually ignored as long as the NPs do not have significant cytotoxic effects. According to our results, a minimal ＂nontoxic＂ concentration of Au NPs during early pregnancy can have lethal inhibitory effects on embryos in vivo and in vitro. We conducted important experiments on the influence of Au NPs on embryonic development and found that Au NPs can disturb embryonic development in a size- and concentration-dependent manner. Au NPs of 15 nm in diameter downregulated the expression pattern of distinct germ layer markers both at mRNA and protein levels; this action prevented differentiation of all three embryonic germ layers. Consequentl~ fetal resorption was observed. Our work reveals the impact of Au NPs on embryonic development and will provide an important guidance and serve as a reference for biomedical applications of Au NPs with minimal side effects.

关键词： gold nanoparticles embryonic development fetal resorption differentiation

A flexible carbon nanotube@V_(2)O_(5) film as a high-capacity and durable cathode for zinc ion batteries

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Journal of Energy Chemistry 2021年第8期30卷 126-133,I0004页

作者： xiaowei Wang Liqun Wang Bao Zhang Jianmin Feng Jiafeng Zhang xing Ou Feng Hou Ji Liang School of Metallurgy and Environment Central South UniversityChangsha 410083China College of Physics and Materials Science Tianjin Normal University300387 TianjinChina Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education School of Materials Science and EngineeringTianjin University300072 TianjinChina Institute for Superconducting&Electronic Materials(ISEM) Australian Institute of Innovative Materials(AIIM)Innovation CampusSquires WayUniversity of Wollongong2522 Australia

Aqueous zinc-ion batteries(ZIBs)are receiving a continuously increasing attention for mobile devices,especially for the flexible and wearable electronics,due to their non-toxicity,non-flammability,and low-cost *** the significant progress in achieving higher capacities for electrode materials of ZIBs,to endow them with high flexibility and economic feasibility is,however,still a significant challenge remaining ***,we present a highly flexible composite film composed of carbon nanotube film and V_(2)O_(5)(CNTF@V_(2)O_(5))with high strength and high conductivity,which is prepared by simply impregnating a porous CNT film with an aqueous V_(2)O_(5)sol under *** this material,intimate incorporation between V_(2)O_(5)and CNTs has been achieved,successfully integrating the high zinc ion storage capability with high mechanical *** a result,this CNTF@V_(2)O_(5)film delivers a high capacity of 356.6 m Ah g^(-1)at 0.4 A g^(-1)and excellent cycling stability with 80.1%capacity retention after 500 cycles at 2.0 A g^(-1).The novel strategy and the outstanding battery performance presented in this work should shed light on the development of high-performance and flexible ZIBs.

关键词： Zinc-ion batteries Carbon nanotube films Flexible cathode Wearable devices

Global analysis of CCT family knockout mutants identifies four genes involved in regulating heading date in rice

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Journal of Integrative Plant Biology 2021年第5期63卷 913-923页

作者： Jia Zhang xiaowei Fan Yong Hu Xiangchun Zhou Qin He Liwen Liang Yongzhong xing National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China College of Life Science Jiangxi Normal UniversityNanchang 330022China

Many genes encoding CCT domain-containing proteins regulate flowering time. In rice(Oryza sativa), 41 such genes have been identified, but only a few have been shown to regulate heading date. Here, to test whether and how additional CCT family genes regulate heading date in rice, we classified these genes into five groups based on their diurnal expression patterns. The expression patterns of genes in the same subfamily or in close phylogenetic clades tended to be similar. We generated knockout mutants of the entire gene family via CRISPR/Cas9. The heading dates of knockout mutants of only 4 of 14 genes previously shown to regulate heading date were altered, pointing to functional redundancy of CCT family genes in regulating this trait. Analysis of mutants of four other genes showed that OsCCT22, OsCCT38, and OsCCT41 suppress heading under long-day conditions and promote heading under short-day conditions. OsCCT03 promotes heading under both conditions and upregulates the expression of Hd1 and Ehd1, a phenomenon not previously reported for other such genes. To date, at least 18 CCT domaincontaining genes involved in regulating heading have been identified, providing diverse, flexible gene combinations for generating rice varieties with a given heading date.

关键词： CCT family genes constant promoter of flowering CRISPR/Cas9 expression patterns knockout mutants rice

A new and high-precision gravity base network in the south of the Tibetan Plateau

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Geodesy and Geodynamics 2020年第4期11卷 258-264页

作者： Lelin xing Lei Bai xiaowei Niu Peng Sang Innovation Academy for Precision Measurement Science and Technology Chinese Academy of SciencesWuhan430077China State Key Laboratory of Geodesy and Earth's Dynamic Chinese Academy of SciencesWuhan430077China

A new gravity base network in the south of the Tibetan Plateau was established with a FG5X absolute gravimeter and three CG-6 *** gravity base network consists of 10 absolute gravity points and 17 relative gravity *** of the absolute data,pre-processing of the relative data and gravity network adjustment model are briefly *** a constrained weighted least squares,the combined adjustment of absolute and relative gravity measurements results in the gravity values with a precision of about±4.1μGal.

关键词： Tibetan plateau Gravity datum Gravity network adjustment

基于GRACE数据评估黄土高原煤炭开采对地下水储量的影响

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江西科学 2024年第2期42卷 264-270页

作者：汪璐璐谢小伟幸茂仁许光煜东华理工大学测绘与空间信息工程学院南昌330013 东华理工大学江西省数字国土重点实验室南昌330013 东华理工大学自然资源部环鄱阳湖区域矿山环境监测与治理重点实验室南昌330013

黄土高原是我国最大的煤炭能源基地,研究煤炭开采与地下水资源消耗之间的关系具有重要意义。首先,基于GRACE/GRACE-FO数据和GLDAS水文模型,反演2006—2020年黄土高原地下水储量变化;其次,结合采煤数据校正GRACE反演结果中因煤炭开采引... 详细信息

黄土高原是我国最大的煤炭能源基地,研究煤炭开采与地下水资源消耗之间的关系具有重要意义。首先,基于GRACE/GRACE-FO数据和GLDAS水文模型,反演2006—2020年黄土高原地下水储量变化;其次,结合采煤数据校正GRACE反演结果中因煤炭开采引起的信号干扰;最后,利用ANN模型模拟黄土高原正常水消耗时空变化趋势,并在此基础上分析煤炭开采对地下水储量变化的影响。研究发现:1)扣除煤炭开采干扰后,2006—2020年黄土高原陆地水储量和地下水储量变化趋势分别为-0.53±0.16 cm/year,-0.66±0.08 cm/year;2)估算黄土高原地区,山西省的矿洞排水分别为-0.17±0.03 cm/year,-0.46±0.05 cm/year,表明黄土高原东部的煤炭开采量造成严重地下水流失;3)在空间上,GRACE反演的地下水扣除拟合的正常水消耗后,地下水消耗值严重的区域与采煤区分布一致,表明煤炭开采是黄土高原东部区域地下水储量消耗的主要驱动因素。揭示了煤炭开采对黄土高原水资源的重要影响,可为黄土高原区域的煤炭资源和水资源管理提供指导。

关键词： GRACE/GRACE-FO 黄土高原地下水储量煤炭开采

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中老年秋冬季不同气候带迁徙相关脑梗死机制研究

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中华保健医学杂志 2020年第6期22卷 568-571页

作者：谭清澈邢小微张家堂鲁向辉徐全刚崔荣太于生元解放军总医院第一医学中心神经内科北京100853 解放军总医院第一医学中心眼科北京100853 解放军总医院海南医院神经内科解放军总医院第二医学中心神经内科

目的对中老年人群秋冬季不同气候带迁徙相关脑梗死的发病机制进行研究,并对其提出保健建议。方法收集2012~2013年秋冬季由东北、华北地区至三亚旅游或过冬的中老年患者共291例,根据至三亚后3周内是否发生脑梗死分为病例组(144例)及对照... 详细信息

目的对中老年人群秋冬季不同气候带迁徙相关脑梗死的发病机制进行研究,并对其提出保健建议。方法收集2012~2013年秋冬季由东北、华北地区至三亚旅游或过冬的中老年患者共291例,根据至三亚后3周内是否发生脑梗死分为病例组(144例)及对照组(147例)。所有患者一般资料、脑血管病危险因素、迁徙相关因素及临床特点均以调查表登记。根据病例组临床及影像学结果分析患者脑梗死类型。应用单因素分析及多因素分析分析中老年冬季不同气候带迁徙相关脑梗死的危险因素。结果中老年秋冬季不同气候带迁徙相关脑梗死独立危险因素包括男性、糖代谢异常、脑动脉狭窄、高同型半胱氨酸血症、温差≥30℃、迁徙后平均动脉压低。分水岭型脑梗死占不同气候带迁徙相关的脑梗死的78.47%,远高于普通脑梗死的10%。结论中老年进行秋冬季不同气候带迁徙前应进行相关危险因素筛查,合并糖代谢异常及脑血管狭窄患者应谨慎迁徙,应通过适当提高血压、减小迁徙前后温差及调整生活方式进行预防,对于发病患者应予扩容为基础的治疗。

关键词：脑梗死危险因素迁徙中老年人

慢性脑缺血大鼠脑组织IL-1β、IL-6、TNF-α及β-淀粉样蛋白1-42的表达研究

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浙江医学 2019年第5期41卷 419-423页

作者：金平王经英邢小炜林敏蔡兆伟许茂盛孙志超佟雅涵浙江中医药大学附属第三医院放射科杭州310005 浙江中医药大学动物实验研究中心/比较医学研究所浙江中医药大学附属第一医院放射科

目的研究慢性脑缺血大鼠脑组织IL-1β、IL-6、TNF-α等免疫炎性因子和β-淀粉样蛋白1-42(Aβ1-42)表达水平的变化及两者的相关性。方法将16只SD大鼠采用随机数字表法分为模型组和假手术组,各8只。模型组大鼠永久结扎双侧颈总动脉,建立... 详细信息

目的研究慢性脑缺血大鼠脑组织IL-1β、IL-6、TNF-α等免疫炎性因子和β-淀粉样蛋白1-42(Aβ1-42)表达水平的变化及两者的相关性。方法将16只SD大鼠采用随机数字表法分为模型组和假手术组,各8只。模型组大鼠永久结扎双侧颈总动脉,建立慢性脑缺血大鼠模型。假手术组大鼠切开颈部皮肤后分离双侧颈总动脉,但不结扎。使用激光多普勒血流仪检测两组大鼠手术前、手术后(30min内)海马CA1区局部脑血流(r CBF)。术后4周处死大鼠,取出大鼠脑组织并分离海马,采用ELISA法检测IL-1β、IL-6、TNF-α和Aβ1-42表达水平。比较两组大鼠手术前后r CBF与脑组织IL-1β、IL-6、TNF-α、Aβ1-42表达水平;分析大鼠脑组织IL-1β、IL-6、TNF-α表达水平与Aβ1-42表达水平的相关性。结果手术前两组大鼠r CBF比较差异无统计学意义(P>0.05),手术后模型组大鼠r CBF明显低于假手术组(P0.05)。模型组大鼠脑组织IL-1β、TNF-α、IL-6等免疫炎性因子表达水平均高于假手术组(均P<0.05),Aβ1-42表达水平亦高于假手术组(均P<0.05)。大鼠脑组织IL-1β、IL-6、TNF-α及Aβ1-42表达水平均呈正相关(r=0.7755、0.5920、0.5536,均P<0.05)。结论慢性脑缺血大鼠脑组织IL-1β、IL-6、TNF-α等免疫炎性因子与Aβ1-42表达水平明显升高,免疫炎性反应或与慢性脑缺血所导致的脑组织Aβ1-42异常沉积有关。

关键词：大鼠炎性反应脑血流灌注 Aβ1-42

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生脉散对糖尿病大鼠胰岛素抵抗的改善作用

上海中医药杂志 2018年第7期52卷 80-84页

作者：邢晓伟陈稚郑博丹李宝红徐美奕吴都督广东医科大学药学院、东莞市重点实验室广东东莞523808

目的观察生脉散对2型糖尿病(T2DM)大鼠胰岛素抵抗的改善作用,并探讨其可能的作用机制。方法采用腹腔注射小剂量链脲佐菌素联合高糖高脂饲料喂养的方法建立胰岛素抵抗型T2DM大鼠模型。将大鼠分为正常组、模型组、二甲双胍组,以及生脉散... 详细信息

目的观察生脉散对2型糖尿病(T2DM)大鼠胰岛素抵抗的改善作用,并探讨其可能的作用机制。方法采用腹腔注射小剂量链脲佐菌素联合高糖高脂饲料喂养的方法建立胰岛素抵抗型T2DM大鼠模型。将大鼠分为正常组、模型组、二甲双胍组,以及生脉散低、中、高剂量组,每组10只。二甲双胍组给予4.0 mg·kg^(-1)二甲双胍,生脉散各剂量组分别给予50、200、400 mg·kg^(-1)生脉散药液,正常组和模型组给予等量0.9%Na Cl溶液。连续给药6周后,试剂盒检测各组大鼠血清空腹血糖(FBG)和空腹胰岛素(FINS)水平,并计算胰岛素敏感指数(ISI),ELISA法检测各组大鼠血清白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平。Western blot检测大鼠骨骼肌组织中胰岛素受体底物-1(IRS-1)、磷脂酰肌醇-3-羟激酶p85亚基(PI3Kp85)和葡萄糖转运蛋白(GLUT4)的表达变化,RTPCR检测骨骼肌组织中Glut4 mRNA表达。结果不同剂量生脉散干预后均可明显降低糖尿病大鼠血清FBG、FINS、TNF-α、IL-6水平(P<0.05),同时显著增加骨骼肌组织中IRS-1和PI3Kp85蛋白表达量,上调GLUT4蛋白和mRNA表达水平(P<0.05),且呈剂量依赖性。与二甲双胍组相比,生脉散高剂量组对TNF-α、IL-6、PI3Kp85和GLUT4的影响无显著差异。结论生脉散可显著改善糖尿病大鼠的胰岛素抵抗作用,其机制可能与减轻炎症反应,增加IRS-1、PI3Kp85和GLUT4的蛋白表达有关。

关键词：生脉散胰岛素抵抗糖尿病大鼠 GLUT4