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生命早期孤养对小鼠应激易感性的影响

温州医学院学报 2013年第1期43卷 34-37页

作者：周利飞何静静胡意员邢晓玲何金彩温州医学院附属第一医院神经内科浙江温州325000

目的:观察生命早期母婴分离对小鼠应激易感性及认知能力的影响。方法:新生的小鼠于出生后第2天随机分为正常饲养组(N组:正常饲养,n=9)、长时间母婴分离组(LMS组:分离3 h,n=9)及短时间母婴分离组(BMS组:分离15 min,n=8)。3组小鼠出生后2... 详细信息

目的:观察生命早期母婴分离对小鼠应激易感性及认知能力的影响。方法:新生的小鼠于出生后第2天随机分为正常饲养组(N组:正常饲养,n=9)、长时间母婴分离组(LMS组:分离3 h,n=9)及短时间母婴分离组(BMS组:分离15 min,n=8)。3组小鼠出生后21 d断乳,断乳后常规饲养。小鼠成年后,用幽闭+电击的方法对3组小鼠给予急性应激,应激之后借助旷场实验、高架十字迷宫、水迷宫实验评价小鼠的情绪及学习记忆能力。结果:在旷场实验中,与N组比较,LMS及BMS组小鼠的外周路程明显增加,差异具有统计学意义(P<0.05);在高架十字迷宫中,LMS组较N组进入闭臂次数明显增多,差异具有统计学意义(P<0.05),BMS组与N组比较差异不具有统计学意义;在水迷宫实验中LMS组与BMS组小鼠的成绩与N组比较差异均无统计学意义。结论:①生命早期长时间母婴分离可以增强小鼠应激易感性,而短时间母婴分离影响不显著;②生命早期母婴分离对应激后小鼠的认知能力影响不明显。

关键词：母婴分离应激旷场实验高架十字迷宫实验水迷宫实验小鼠

热敏灸与电针治疗风寒湿型肩关节周围炎的临床观察

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中国中医药现代远程教育 2018年第22期16卷 131-133页

作者：冯赵慧子刘培培石远苹聂启鸿幸小玲江西省赣州市人民医院康复医学科江西赣州341000 赣南医学院第一附属医院药剂科江西赣州341000

目的探讨热敏灸与电针治疗风寒湿型肩关节周围炎的临床效果。方法选取2016年4月—2018年3月我院收治的风寒湿型肩关节周围炎患者82例,随机分为研究组和对照组,各41例。研究组给予热敏灸治疗,对照组给予电针治疗。比较2组患者的临床疗效... 详细信息

目的探讨热敏灸与电针治疗风寒湿型肩关节周围炎的临床效果。方法选取2016年4月—2018年3月我院收治的风寒湿型肩关节周围炎患者82例,随机分为研究组和对照组,各41例。研究组给予热敏灸治疗,对照组给予电针治疗。比较2组患者的临床疗效。结果研究组治愈率、总有效率均明显高于对照组(P0.05)。结论热敏灸与电针治疗风寒湿型肩关节周围炎均有较为满意的临床效果,但热敏灸临床治疗效果更为显著,能更有效降低患者疼痛程度、提高关节功能及活动度,值得临床推广应用。

关键词：热敏灸电针肩关节周围炎风寒湿型痹证

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颞叶癫痫情景记忆损害的研究

温州医学院学报 2012年第4期42卷 313-316页

作者：董乐丹徐惠琴郑荣远邢晓玲何金彩温州医学院附属第一医院神经内科浙江温州325000

目的:研究颞叶癫痫对情景记忆损害的特点及其影响因素。方法:采用听觉词汇测试(auditoryverbal memory test,AVMT),测试62例颞叶癫痫患者(包括29例新诊断颞叶癫痫未服药患者和33例门诊随访且规律服药患者)和年龄、受教育程度相匹配的30... 详细信息

目的:研究颞叶癫痫对情景记忆损害的特点及其影响因素。方法:采用听觉词汇测试(auditoryverbal memory test,AVMT),测试62例颞叶癫痫患者(包括29例新诊断颞叶癫痫未服药患者和33例门诊随访且规律服药患者)和年龄、受教育程度相匹配的30例健康者的情景记忆。结果:颞叶癫痫组自由回忆(27.52±1.23)分、延时回忆(9.21±0.63)分、再认测试(11.83±0.54)分,均低于正常对照组成绩,且两组间差异有统计学意义(t=5.73～6.99;P0.05)。结论:颞叶癫痫患者存在情景记忆的损害,对自由回忆、延时回忆以及再认都有损害,提示颞叶参与情景记忆的神经机制学说;与未服药组相比服药组癫痫患者存在更加明显的情景记忆损害,提示抗癫痫药物是影响记忆的重要因素之一。

关键词：癫痫颞叶情景记忆抗惊厥药

Detection of citrus Huanglongbing based on image feature extraction and two-stage BPNN modeling

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International Journal of Agricultural and Biological Engineering 2016年第6期9卷 20-26页

作者： Deng xiaoling Yubin Lan xing Xiaqiong Mei Huilan Liu Jiakai Hong Tiansheng International Lab of Agricultural Aviation Pesticides Spraying Technology Guangzhou 510642China College of Electronical Engineering South China Agricultural UniversityGuangzhou 510642China College of Engineering South China Agricultural UniversityGuangzhou 510642China

Citrus Huanglongbing(HLB),which is spread by the citrus psyllid,is the most destructive disease of citrus *** no effective cure for the disease has been reported,detection and removal of infected trees can prevent *** indicative of HLB can be present in both HLB-positive trees and HLB-negative trees,making identification of infected trees difficult.A detection method for citrus HLB based on image feature extraction and two-stage back propagation neural network(BPNN)modeling was investigated in this *** identification method for eight different classes including healthy,HLB and non-HLB symptoms was ***-four statistical features including color and texture were extracted for each leaf sample,following the two-stage BPNN to model and identify HLB-positive leaves from HLB-negative *** discrimination accuracy can reach approximately 92%which shows that this method based on visual image processing can perform well in detecting citrus HLB.

关键词： citrus leaf Huanglongbing texture and color features feature extraction two-stage back propagation neural network

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欧洲地区施马伦病毒病疫情动态

中国动物检疫 2014年第5期31卷 27-29页

作者：陈未陈晓兰赵莎莎刘静冯艺邢晓玲周伟伟江苏农牧科技职业学院江苏泰州225300 张家港出入境检验检疫局江苏张家港215600

施马伦贝格病作为新发病已对欧洲的反刍动物养殖业造成了巨大的经济损失和影响。本文从病原特点、流行病学、症状与诊断等方面进行简述,重点收集了该病截至目前在欧洲地区的发生与流行现状,旨在更好阐述疾病发生、发展新特点,为我国进... 详细信息

施马伦贝格病作为新发病已对欧洲的反刍动物养殖业造成了巨大的经济损失和影响。本文从病原特点、流行病学、症状与诊断等方面进行简述,重点收集了该病截至目前在欧洲地区的发生与流行现状,旨在更好阐述疾病发生、发展新特点,为我国进一步加强相关技术储备,针对性地开展该疾病的边境防控,保障国民公共卫生安全,促进畜牧产业健康发展提供积极指导。

关键词：施马伦贝格病毒研究进展疫情动态预防控制

Anti-proliferative effect of the extract of Guangzao (Fructus Choerospondiatis) on cultured rat cardiac fibroblasts

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Journal of Traditional Chinese Medicine 2015年第6期35卷 685-689页

作者： Jia Lei Yang Yumin Zhu Deli Gao Xiaohui Wang xiaoling xing Huihui Bao Junping Shu Liang Department of Cardiology Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine Graduate School Inner Mongolia Medical University

OBJECTIVE: To ascertain if total flavonoids of Guangzao(Fructus Choerospondiatis)(TFFC) extracted from Guangzao(Fructus Choerospondiatis) can inhibit angiotensin Ⅱ-induced proliferation of cardiac fibroblasts(CFs).METHODS: CFs were cultured by the differential attachment method. A model of cell proliferation was established by stimulation with Ang Ⅱ. Cardiac fibroblasts growth was determined using a hemocytometer. Cell proliferation was detected by methyl thiazole tetrazolium. Lactate dehydrogenase activitywas measured by chemical colorimetric ***: Proliferation of TFFC-treated(25, 50,100 mg/L) fibroblasts was significantly less than that of cells in the angiotensin Ⅱ group(P < 0.01),and TFFC inhibited proliferation in a dose-dependent manner. These inhibitory effects were partly blocked by pretreatment with NG-nitro-L-arginine methyl ester(L-NAME) and 1H-[1,2,4]-oxadiazole-[4,3-a]-quinoxalin-1-one(ODQ).CONCLUSION: TFFC inhibited angiotensinⅡ-induced proliferation of cardiac fibroblasts via a mechanism that probably involves activation of the NO-cyclic guanosine monophosphate signaling pathway.

关键词： Flavones Guangzao (Fructus Choero-spondiatis), Angiotensin Ⅱ Fibroblasts Nitric ox-ide Cyclic GMP

The earliest evidence for a microblade adaptation in the remote,high altitude regions of the Tibetan Plateau

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Science China Earth Sciences 2024年第5期67卷 1561-1573页

作者： Yingshuai JIN xiaoling ZHANG Shejiang WANG Junyi GE Wei HE Wa DA Yunyao TAN Ziyi YANG Christopher MORGAN xing GAO Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of SciencesBeijing 100044China University of the Chinese Academy of Sciences Beijing 100049China Cultural Relics Conservation Institute of the Xizang Autonomous Region Lhasa 850000China Nagqu Culture and Tourism Bureau Nagqu 852000China University of Nevada Reno 89557USA

Microblade assemblages are among the most common prehistoric archaeological materials found on the Tibetan Plateau(TP)and are thought to indicate large scale migration to and settlement of the *** microblade sites,however,have been systematically excavated,especially in the remotest,highest-elevation regions of the *** timing of the large-scale arrival,spread,and permanent settlement of people on the TP therefore remains *** this paper,we report on a recently excavated site,Locality 3 of the Nwya Devu Site(ND3),located at 4600 meters above sea level(masl),near the shore of Ngoin Lake,on the interior *** analyses reveal a fairly typical microblade technological orientation and two types of microblade cores:wedge-shaped and semi-conical,which are similar to those found throughout North *** Optically Stimulated Luminescence(OSL)dating and AMS^(14)C dating,the age of ND3 ranges from 11 to 10 *** date range indicates ND3 is the oldest microblade site yet recorded in the remote,high-elevation regions of the TP and thus provides important information about when and how hunter-gatherers using microblades began exploiting the higher altitudes of the *** together,studies at ND3 and throughout the TP suggest that a microblade adaptation is associated with the first prolonged human occupation of the plateau and that microblades played a significant role in mediating the risks and facilitating the mobility necessary to permanently inhabit the TP.

关键词： The interior of Tibetan Plateau Nwya Devu locality 3 Microblade Early Holocene High altitude adaption

Eye location, cranial asymmetry, and swimming behavior of different variants of Solea senegalensis

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Aquaculture and Fisheries 2020年第4期5卷 182-186页

作者： Jubin xing Zhonghe Ke Liping Liu Chenhong Li xiaoling Gong Baolong Bao Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources(Shanghai Ocean University) Ministry of EducationInternational Research Center for Marine Biosciences at Shanghai Ocean UniversityMinistry of Science and TechnologyNational Demonstration Center for Experimental Fisheries Science EducationShanghai Ocean UniversityShanghai201306China Fishery Technical Extension Station of Zhuji City ZhujiZhejiang311800China

Many flatfish species,such as Scophthalmus maximus,Paralichthys olivaceus,Solea senegalensis,are extensively cultured *** flatfishes,eye migration varies among different species and even within the same *** genetic mechanism underlying eye migration is still unclear,and it is the key to improve metamorphosis in flatfish aquaculture and understand flatfish *** this study,the high frequency of eye location variants in an artificial *** population allowed us to investigate the eye preference during migration;completeness of the eye migration;and other related left-right asymmetric characteristics,such as asymmetrical skull remodeling and lying down on one *** different frequencies of eye preference during migration,completeness of the eye migration,and settling side suggest that they are determined by different genotypes and imply independent evolutionary events during flatfish *** found that the swimming time may be related to the completeness of eye migration,and further the migration of the eye,the more time the fish spent at the sea *** left-right asymmetric degrees of not only the frontal bones and lateral ethmoids but also the jaw bone,including the premaxillary,maxillary,and dentary bones,depend on the completeness of eye mi***,we proposed a hypothesis for the asymmetric origin of flatfish that provides reasonable explanations for the selective advantages of primitive flatfish species.

关键词： Flatfish Eye migration Left/right asymmetry Senegalese sole

New dating indicates intermittent human occupation of the Nwya Devu Paleolithic site on the high-altitude central Tibetan Plateau during the past 45,000 years

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Science China Earth Sciences 2024年第2期67卷 531-551页

作者： Junyi GE xiaoling ZHANG Shejiang WANG Linhui LI Wei HE Yingshuai JIN Peiqi ZhANG Bing XU Chenglong DENG John WOLSEN Zhengtang GUO xing GAO Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of SciencesBeijing 100044China University of the Chinese Academy of Sciences Beijing 100049China Tibetan Cultural Relics Conservation Institute Lhasa 850000China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of Sciences.Beijing 100029China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China School of Anthropology University of ArizonaTucson85721USA

The timing and mechanisms of the human occupation of the demanding high-altitude Tibetan Plateau environment are of great ***,we report on our reinvestigations and dating of the Nwya Devu site,located nearly 4600 meters above sea level on the central Tibetan Plateau.A new microblade techno-complex was identified on a lower lake shore at this site,distinct from the previously reported blade tool *** two lithic assemblages were dated to 45.6±2.6 and10.3±0.5 ka using optically stimulated luminescence and accelerator mass spectrometry^(14)C *** represent,respectively,the earliest known Paleolithic and microlithic sites on the interior Tibetan Plateau,indicating multiple occupation episodes of hunter-gatherers during the past 45 *** studies reveal that relatively stable depositional conditions and a paleoenvironment characterized by a comparatively warm climate facilitated these multiple occupations at Nwya *** contemporaneous occurrence of the Upper Paleolithic blade technology on the Tibetan Plateau and most of Eurasia between 50 and 40 ka indicates rapid,large-scale dispersals of humans that profoundly affected human demography on a large *** new archaeological evidence and previously reported genetic data,we conclude that the Tibetan Plateau provided a relatively stable habitat for Upper Paleolithic hunter-gatherers,which may have contributed to the complex and multiple-origin gene pool of present-day Tibetans.

关键词： Tibetan Plateau Paleolithic Nwya Devu High-altitude adaptation Microblade industry Early Upper Paleolithic OSLdating AMS^(14)C dating