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Interaction Between Memory Load and Experimental Design on Brain Connectivity and Network Topology

Neuroscience Bulletin 2023年第4期39卷 631-644页

作者： Heming Zhang xin di Bart Rypma Hang Yang Chun Meng Bharat Biswal The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for NeuroinformationCenter for Information in MedicineSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu611731China Department of Biomedical Engineering New Jersey Institute of TechnologyNewark07102USA Department of Psychology University of Texas at DallasDallas75390USA

The conventional approach to investigating functional connectivity in the block-designed study usually concatenates task blocks or employs residuals of task activation.While providing many insights into brain functions,the block design adds more manipulation in functional network analysis that may reduce the purity of the blood oxygenation level-dependent signal.Recent studies utilized one single long run for task trials of the same condition,the so-called continuous design,to investigate functional connectivity based on task functional magnetic resonance imaging.Continuous brain activities associated with the single-task condition can be directly utilized for task-related functional connectivity assessment,which has been examined for working memory,sensory,motor,and semantic task experiments in previous research.But it remains unclear how the block and continuous design influence the assessment of task-related functional connectivity networks.This study aimed to disentangle the separable effects of block/continuous design and working memory load on task-related functional connectivity networks,by using repeated-measures analysis of variance.Across 50 young healthy adults,behavioral results of accuracy and reaction time showed a significant main effect of design as well as interaction between design and load.Imaging results revealed that the cingulo-opercular,fronto-parietal,and default model networks were associated with not only task activation,but significant main effects of design and load as well as their interaction on intra-and inter-network functional connectivity and global network topology.Moreover,a significant behavior-brain association was identified for the continuous design.This work has extended the evidence that continuous design can be used to study task-related functional connectivity and subtle brain-behavioral relationships.

关键词： Working memory Functional connectivity Network topology Block design Continuous design Memory load

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Coherent Chemical Variation Trends of the 55-25 Ma Magmatic Rocks in SE Tibet:N-S direction Lithospheric Stretching of Eurasia during Early Stage of India-Eurasia Collision

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地质学报:英文版 2023年第5期97卷 1283-1305页

作者： YANG Tiannan DONG Mengmeng XUE Chuandong xin di LIANG Mingjuan Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China Chinese MNR Laboratory of Deep Earth Sciences and Technology Beijing 100037China Department of Earth Sciences Kunming University of Science and TechnologyKunming 650093China Geological Museum of Guizhou Guiyang 550081China

The progressive indentation of India into Eurasia generated an E-W-trending orthogonal collision belt and a N-S-trending oblique collision belt.Compiling available data reveals that~70%of the Cenozoic igneous rocks in eastern and southeastern Tibet are concentrated within an ENE-trending,~550-km long and~250-km wide magmatic zone(CMZ)that once separated the orthogonal and oblique collision belts.The Latitude 26°N Line is now its southern boundary.The onset timing of magmatism of the CMZ varies gradually from~55 Ma in the westernmost part to~27 Ma in the easternmost.Then the magmatism successively occurred and suddenly stopped at~25 Ma.The segmented and coherent chemical variation trends found suggest that the CMZ magmatic rocks were formed due to partial melting of the heterogeneous upper mantle and crusts of Eurasia.Subduction of Paleo-and Neotethyan oceanic plates generated this compositional and mineralogical heterogeneity.Combined with available geophysical data,the CMZ was diachronously formed in response to asthenosphere upwelling induced by NNW-SSE-direction lithosphere stretching.The difference in responses of the orthogonal and oblique collision belts to the indentation of the Indian continent has led to this lithosphere stretching.

关键词： tectonics geochemistry magmatic zone temporal/spatial distribution lithospheric stretch Eocene to Oligocene SE Tibet

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Petrogenesis of the Late Eocene to Early Oligocene Yao'an Shoshonitic Complex,Southeastern Tibet:Partial Melting of an Ancient Continental Lithospheric Mantle beneath the Yangtze Block

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Acta Geologica Sinica(English Edition) 2023年第6期97卷 1657-1670页

作者： DONG Mengmeng YANG Tiannan XUE Chuandong xin di LIANG Mingjuan YAN Qinggao Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China School of Earth and Space Sciences Peking UniversityBeijing 100871China Department of Earth Sciences Kunming University of Science and TechnologyKunming 650093China Geological Museum of Guizhou Guiyang 550081China Institute of Mineral Resources Chinese Academy of Geological SciencesBeijing 100037China

Cenozoic potassic-ultrapotassic igneous rocks are widespread in the southeastern Tibetan Plateau.Their petrogenesis and magmatic processes remain subject to debate in spite of numerous publications.Almost all of the Cenozoic extrusive and intrusive rocks in the Yao’an area,western Yunnan Province,SW China,are geochemically shoshonitic,collectively termed here the Yao’an Shoshonitic Complex(YSC).The YSC is located in the(south)easternmost part of the ENE-WSW-trending,~550 km-long and~250 km-wide Cenozoic magmatic zone;the latter separates the orthogonal and oblique collision belts of the India-Eurasia collision orogen.Previously published geochronological and thermochronological data revealed that the rocks of the YSC were emplaced over a short timespan of 34-32 Ma.This and our new data suggest that the primary magma of the YSC likely was formed by partial melting of ancient continental lithospheric mantle beneath the Yangtze Block.This part of the continental lithospheric mantle had likely not been modified by any oceanic subduction.Fractionation crystallization of an Mg-and Ca-bearing mineral and TiFe oxides during the magmatic evolution probably account for the variable lithologies of the YSC.

关键词： Ancient continental lithospheric mantle Partial melting Yao’an Shoshonitic Complex Late Eocene to early Oligocene SE Tibetan Plateau

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Petrogenesis of Early Carboniferous Ultramafic-Mafic Volcanic Rocks in the Southern Changning-Menglian Belt,Southeastern Tibetan Plateau:Implications for the Evolution of the Paleo-Tethyan Ocean

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Acta Geologica Sinica(English Edition) 2022年第3期96卷 858-874页

作者： XIE Zhipeng WU Xuelu WANG Tengfei XUE Chuandong YANG Tiannan WANG Wei SUI Binxi xin di Department of Earth Sciences Kunming University of Science and TechnologyKunming 650093China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China

The Changning-Menglian Belt represents the main Paleo-Tethyan Suture in the southeastern Tibetan Plateau,which divides Gondwana-and Eurasia-derived continental fragments from each other.The belt contains ultramafic-mafic volcanic rocks that provide evidence of the tectonic processes which operated during the evolution of the Paleo-Tethyan Ocean.New geochemical data for Early Carboniferous volcanics in the southern Changning-Menglian Belt show that wehrlites have cumulate and poikilitic textures,and contain low-Fo(84.2-87.2)olivine,clinopyroxene with low Mg#values(79.4-85.6),and spinel with high Cr#values(67.8-72.4).Estimated equilibrium temperatures obtained using olivine-spinel Fe-Mg exchange geothermometry range from 978℃ to 1373℃(mean=1205℃;n=3).These observations combined with a lack of reaction or melt impregnation textures indicate that these units represent magmatic cumulates rather than having formed as a result of mantle-melt reactions.Both wehrlites and basalts in the belt have subparallel rare earth element(REE)-and primitive-mantle-normalized multi-element patterns with slightly positive Nb-Ta anomalies,but negligible Eu and Zr-Hf anomalies.The volcanics have similar Sr-Nd-Pb isotopic compositions withεNd(t)values of 4.2-4.5(mean=4.3;n=3)and 4.0-4.4(mean 4.2;n=4),respectively,and also have similar immobile element ratios,such as Nb/La,Nb/U,Th/La,Zr/Nb,Th/Ta,La/Yb,Nb/Th,Nb/Y,and Zr/Y.These characteristics indicate both units have ocean island basalt(OIB)-like geochemical affinities,consistent with the fact that the clinopyroxene in the wehrlites is compositionally similar to OIB-related cumulus clinopyroxene.This suggests that both the wehrlites and basalts were derived from similar parental magmas that underwent generally closed-system magmatic differentiation dominated by fractionation of the olivine and clinopyroxene.This parental magma was likely generated in an oceanic seamount setting from an OIB-type mantle source(i.e.,asthenospheric mantle)containing garnet-spinel lherzolite material.Combing th

关键词： geochemistry petrogenesis wehrlite OIB Changning-Menglian Belt Paleo-Tethys Tournaisian Manxin Tibetan plateau

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UHPLC-MS/MS analysis of cAMP and cGMP in rat plasma as potential biomarkers of Yin-Yang disharmony in traditional Chinese medicine

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Journal of Pharmaceutical Analysis 2021年第4期11卷 458-464页

作者： xin Wang Yue Du Cuiting Wu Ming Xu Youping Liu xin di Laboratory of Drug Metabolism and Pharmacokinetics School of PharmacyShenyang Pharmaceutical University103 Wenhua RoadShenyang110016PR China Shenyang Analytical Application Center Shimadzu(China)Co.Ltd.Shenyang167 Qingnian StreetShenyang110016PR China

Cyclic 3’,5’-adenosine monophosphate(cAMP)and cyclic 3’,5’-guanosine monophosphate(cGMP)are considered as potential biomarkers for Yin-Yang disharmony in traditional Chinese medicine.However,phosphodiesterase-mediated ex vivo degradation of these molecules in biological samples may result in their underestimation.In the present study,a ultra-high performance liquid chromatography-tandem mass spectrometry(UHPLC-MS/MS)method was developed for determination of cAMP and cGMP in rat plasma,with special consideration of their stability ex vivo.Following precipitation of proteins from plasma samples with 0.4 M perchloric acid,the analytes were chromatographed on a Shimadzu Shimpack-XR-ODS II column with 2.5 mM ammonium acetate and methanol in gradient mode.The MS/MS detection was performed using multiple reaction monitoring in the positive electrospray ionization mode.The lower limit of quantification was 0.27 ng/mL for cAMP and 0.37 ng/mL for cGMP.The method was used to determine the plasma cAMP and cGMP levels in normal and Yin deficiency diabetic rats treated with or without Rehmannia glutinosa.The developed method may be useful for evaluating the regulatory effects of Chinese herbal medicine on the levels of cAMP and cGMP in the body.

关键词： cAMP cGMP Plasma UHPLC-MS/MS Yin-Yang disharmony

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荧光探针在蛋白磷酸化和糖基化检测中的应用

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分析测试学报 2024年第1期43卷 157-165页

作者：常永新李军荣邵娟杨新迪卿光焱中国科学院大连化学物理研究所中国科学院分离分析重点实验室辽宁大连116023 大连理工大学精细化工国家重点实验室辽宁大连116023

蛋白质翻译后修饰在细胞内起着关键的调控作用,对细胞的功能和代谢具有重要影响。近年来,荧光探针在研究蛋白质翻译后修饰中的应用不断发展。该文重点介绍了荧光探针在蛋白磷酸化和糖基化等修饰中的应用,包括其原理、设计策略以及在细... 详细信息

蛋白质翻译后修饰在细胞内起着关键的调控作用,对细胞的功能和代谢具有重要影响。近年来,荧光探针在研究蛋白质翻译后修饰中的应用不断发展。该文重点介绍了荧光探针在蛋白磷酸化和糖基化等修饰中的应用,包括其原理、设计策略以及在细胞和生物体内的应用。荧光探针的发展为研究蛋白质翻译后修饰提供了强有力的工具,有望深化对这些修饰过程的理解,并为药物研发和疾病诊断提供新的途径。

关键词：荧光探针蛋白质翻译后修饰磷酸化糖基化

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簇生番茄果梗超声切割过程仿真与试验

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农业机械学报 2024年第3期55卷 153-161页

作者：张军辛迪蓝伟科党柯华牛子杰崔永杰西北农林科技大学机械与电子工程学院陕西杨凌712100 农业农村部农业物联网重点实验室陕西杨凌712100

为揭示超声技术应用于簇生番茄切割采收的机理及优势,比较了簇生番茄果梗材料在常规切割和超声切割中的切割力和去除特性。首先测定了簇生番茄果梗和自制超声切割刀的参数,然后基于Abaqus进行仿真,将果梗纤维化,在宏观和微观仿真中对比... 详细信息

为揭示超声技术应用于簇生番茄切割采收的机理及优势,比较了簇生番茄果梗材料在常规切割和超声切割中的切割力和去除特性。首先测定了簇生番茄果梗和自制超声切割刀的参数,然后基于Abaqus进行仿真,将果梗纤维化,在宏观和微观仿真中对比常规切割和超声切割过程中的应力及去除机理。最后,自制试验台,通过改变超声切割刀的激振频率、输入电压、切割速度和切割角度进行切割力测定试验并采用响应面法的Box-Behnken进行四因素三水平分析,随后观察果梗断面形貌。结果表明:在自制超声刀工作频率(35~37 kHz)和电压(340~380 V)内,切割速度、角度对切割效果影响最显著,激振频率和输入电压在特定值附近时切割效果最好;在36 kHz、360 V、0.125 cm/s、0°的条件下,仿真中超声切割耗时约为8 s,平均最大切割力为0.635 N,相对于常规切割(1.019 N)降低37.7%;试验中超声切割耗时约为5.3 s,所需切割力最大为0.543 N,相较于常规最大切割力(1.017 N)降低46.6%,同时表面粗糙度降低20.9%,试验与有限元仿真的切割力结果误差为8.9%,基本吻合。超声切割可以降低切割力,缩短切割耗时,同时还提高断面质量,减少果梗组织损伤、水分散失,对延长果实保鲜时间具有一定的意义。

关键词：簇生番茄果梗超声振动切割有限元去除机理

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知识可视化在中职工程制图教学中的应用探析

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张家口职业技术学院学报 2024年第2期37卷 66-69页

作者：刘心迪张家口市职教中心3+4本科专业部河北张家口075000 河北北方学院信息科学与工程学院河北张家口075000

知识可视化是研究如何应用视觉表征改进两个或两个以上人之间复杂知识创造与传递的学科,它在各级各类学校甚至不同专业中具有很强的适应性,潜在价值大。脑科学理论、双重编码理论、图式理论等提供了知识可视化辅助教学的理论依据。当前... 详细信息

知识可视化是研究如何应用视觉表征改进两个或两个以上人之间复杂知识创造与传递的学科,它在各级各类学校甚至不同专业中具有很强的适应性,潜在价值大。脑科学理论、双重编码理论、图式理论等提供了知识可视化辅助教学的理论依据。当前,中职工程制图应用知识可视化辅助教学存在一些困难与不足,通常可采取激发其应用驱动力、科学选择和设计知识可视化工具、改善硬件设备条件进行解决。

关键词：工程制图知识可视化教学

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DPABINet:脑网络和图论分析工具箱

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Science Bulletin 2024年第11期69卷 1628-1631页

作者：严超赣王鑫迪鲁彬邓昭宇高青林 CAS Key Laboratory of Behavioral Science Institute of PsychologyBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100101China International Big-Data Center for Depression Research Institute of PsychologyChinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China McGill Centre for Integrative Neuroscience Montreal Neurological InstituteMcGill UniversityMontréal H3A 2B4Canada

The human brain, a marvel of intricate connections, functions as a complex network comprising structurally and functionally integrated regions. This network orchestrates a multitude of complex patterns through high-le... 详细信息

关键词：图论分析脑网络工具箱

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Late Cretaceous Adakitic Granites of the Southeastern Tibetan Plateau: Garnet Fractional Crystallization of Arc-Like Magmas at the Thickened Neo-Tethyan Continental Margin

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Acta Geologica Sinica(English Edition) 2019年第4期93卷 857-873页

作者： XIANG Kun XUE Chuandong YANG Tiannan XIE Zhipeng xin di JIANG Lili LAI Ruijuan Department of Earth Sciences Kunming University of Science and TechnologyKunming 650093China Institute of Geology Chinese Academy of Geological Sciences(CAGS)Beijing 100037China

The tectonic setting of Cretaceous granitoids in the southeastern Tibet Plateau,east of the Eastern Himalaya Syntax,is debated.Exploration and mining of the Laba Mo–Cu porphyry-type deposit in the area has revealed Late Cretaceous granites.New and previously published zircon U–Pb dating indicate that the Laba granite crystallized at 89–85 Ma.Bulk-rock geochemistry,Sr–Nd isotopic data and in situ zircon Hf isotopic data indicate that the granite is adakitic and was formed by partial melting of thickened lower crust.The Ca,Fe,and Al contents decrease with increasing SiO2 content.These and other geochemical characteristics indicate that fractional crystallization of garnet under high-pressure conditions resulted in the adakitic nature of the Laba granite.Cretaceous granitoids are widespread throughout the Tibetan Plateau including its southeastern area,forming an intact curved belt along the southern margin of Eurasia.This belt is curved due to indenting by the Indian continent during Cenozoic,but strikes parallel to both the Indus–Yarlung suture zone and the Main Frontal Thrust belt.It is therefore likely that Cretaceous granitoids in both the Gangdese and southeastern Tibetan Plateau areas resulted from subduction of Neo-Tethyan lithosphere.

关键词： adakitic granite geochemistry garnet fractional crystallization Cretaceous Neo-Tethyan subduction southeastern Tibetan Plateau

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