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A retrospective study on sperm cryopreservation in 1034 patients diagnosed with cancer in southern China

Asian Journal of Andrology 2023年第4期25卷 499-504页

作者： Qi-Ling Wang Gui-Fang Ye Kai-xin zhong xin Wu Wei-xin Lin Lu-Lu Luo xin-Zong Zhang Wei-Jie Zhu NHC Key Laboratory of Male Reproduction and Genetics Guangzhou 510600China Department of Andrology Guangdong Provincial Reproductive Science InstituteGuangdong Provincial Fertility HospitalGuangzhou 510600China Human Sperm Bank of Guangdong Province Guangzhou 510600China Institute of Reproductive Immunology College of Life Science and TechnologyJinan UniversityGuangzhou 510632China

Sperm cryopreservation is an effective fertility preservation method for cancer patients before anticancer treatments. However, thereare little data on fertility preservation in large cohorts of patients with cancer in southern China. This retrospective cross-sectionalstudy aimed to assess the fertility preservation status of 1034 newly diagnosed male patients with cancer in the Human SpermBank of Guangdong Province in southern China (Guangzhou, China). Of these, 302 patients had reproductive system tumors,mostly testicular cancers (99.0%), and 732 had other tumors, including lymphoma (33.1%), gastrointestinal cancer (16.3%),nasopharyngeal carcinoma (15.7%), leukemia (7.7%), sarcoma (3.6%), and others (23.6%). Patients with reproductive systemtumors had lower sperm concentration and prefreezing and post-thawing progressive motility than those with non-reproductive systemtumors (all P < 0.001). Differences in sperm concentration, progressive motility, and normal morphology rate were observed betweenpatients with and without anticancer surgery before sperm cryopreservation (all P < 0.05). As of April 30, 2022, 63 patients usedtheir cryopreserved sperm for assisted reproductive technology treatments and 39 pregnancies were achieved. This study providesvaluable data on the fertility preservation status in newly diagnosed cancer patients in southern China, demonstrating that patientswith reproductive system tumors had poor sperm quality for their pretreatment fertility preservation.

关键词： cancer fertility preservation sperm cryopreservation sperm quality

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Synthesis of Novel Ferrocenyl-containing Thiazole Derivatives

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Chinese Chemical Letters 2006年第8期17卷 1002-1004页

作者： Ling SHAO Yah HU xin ZHOU zhong JIN Jian Bing LIU Jian xin FANG State Key Laboratory of Elemento-Organic Chemistry Institute of Elemento-Organic Chemistry Nankai University Tianjin 300071

Novel ferrocenyl-containing thiazole derivatives have been synthesized from 2-amino-4-ferrocenyl-5-（1H-1, 2, 4-triazole-l-yl）thiazole and acyl chloride. And their structures were determined by 1H NMR and elemental a... 详细信息

关键词： Synthesis thiazole ferrocene.

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Predicting the structure and stability of titanium oxide electrides

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npj Computational Materials 2018年第1期4卷 63-68页

作者： xin zhong Meiling Xu Lili Yang xin Qu Lihua Yang Miao Zhang Hanyu Liu Yanming Ma Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education Jilin Normal UniversityChangchun 130103China National Demonstration Center for Experimental Physics Education Jilin Normal UniversitySiping 136000China Beijing Computational Science Research Center Beijing 100193China School of Physics and Electronic Engineering Jiangsu Normal UniversityXuzhou 221116China Department of Physics School of ScienceBeihua UniversityJilin 132013China State Key Lab of Superhard Materials&Innovation Center for Computational Physics Methods and Software College of PhysicsJilin UniversityChangchun 130012China International Center for Future Science Jilin UniversityChangchun 130012China

The search for new inorganic electrides has attracted significant attention due to their potential applications in transparent conductors,battery electrodes,electron emitters,as well as catalysts for chemical ***,only a few inorganic electrides have been successfully synthesized thus far,limiting the variety of electride ***,we show the stabilization of inorganic electrides in the Ti-rich Ti–O system through first-principles calculations in conjunction with swarm-intelligence-based CALYPSO method for structure *** the known Ti-rich stoichiometries of Ti_(2)O,Ti_(3)O,and Ti_(6)O,two hitherto unknown Ti_(4)O and Ti_(5)O stoichiometries are predicted to be thermodynamically stable at certain pressure *** found that these Tirich Ti–O compounds are primarily zero-dimensional electrides with excess electrons confined in the atom-sized lattice voids or between the cationic layers playing the role as *** underlying mechanism behind the stabilization of electrides has been rationalized in terms of the excess electrons provided by Ti atoms and their accommodation of excess electrons by multiple cavities and layered atomic *** present results provide a viable direction for searching for practical electrides in the technically important Ti–O system.

关键词： inorganic excess stabilization

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Generation of the regulatory protein rtTA transgenic mice

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World Journal of Gastroenterology 2005年第19期11卷 2885-2891页

作者： KangXu xin-YanDeng YingYue zhong-MinGuo BingHuang XunHong DongXiao Xi-GuChen CenterofExperimentalAnimals SunYat-Sen(Zhongshan)UniversityGuangzhou510080GuangdongProvinceChina

AIM: To translate Tet-on system into a conditional mouse model, in which hepatitis B or C virus (HBV or HCV) gene could be spatiotemporally expressed to overcome 'immune tolerance' formed during the embryonic development and 'immune escape' against hepatitis virus antigen(s), an effector mouse, carrying the reverse tetracycline-responsive transcriptional activator (rtTA) gene under the tight control of liver-specific human apoE promoter, is required to be generated. METHODS: To address this end, rtTA fragment amplified by PCR was effectively inserted into the vector of pLiv.7 containing apoE promoter to create the rtTA expressing vector, I.e., pApoE-rtTA. ApoE-rtTA transgenic fragment (-6.9 kb) released from pApoE-rtTA was transferred into mice by pronucleus injection, followed by obtaining one transgene (+) founder animal from microinjection through PCR and Southern blot ***: rtTA transgene which could be transmitted to subsequent generation (F1) derived from founder was expressed in a liver-specific fashion. CONCLUSION: Taken together, these findings demonstrate that rtTA transgenic mice, in which rtTA expression is appropriately targeted to the murine liver, are successfully produced, which lays a solid foundation to 'off-on-off' regulate expression of target gene (s) (e.g., HBV and/or HCV) in transgenic mice mediated by Tet-on system.

关键词： Hepatitis virus Tet-on system Transgenic mice Liver-specific human apoE promoter

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The Need and Its Influence Factors for Community-based Rehabilitation Services for Disabled Persons in One District in Beijing

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Biomedical and Environmental Sciences 2006年第6期19卷 495-497页

作者： HONG DAI HUI XUE ZONG-JIE YIN AND zhong-xin XIAO School of Public Health and Family Medicine Capital Medical University You An Men Beijing 100069 China National Medical Examination Center The Ministry of Public Health Xi Zhi Men Beijing 100044 China

Purpose To explore the needs for basic community-based rehabilitation services for disabled persons in Xuanwu District, Beijing, China, and to identify factors which influence disabled persons to accept rehabilitation services. Method One hundred and eight disabled persons were selected by systematic sampling and simple random sampling to assess their needs for community-based rehabilitation services. Results Of the interviewees, 57A% needed the community-based rehabilitation services, but only 13.9% took advantage of it. The main factors influencing the interviewees to accept these services were cost （P〈0.05）, knowledge about rehabilitation medicine （P〈0.05）; and the belief in the therapeutic benefit of the community-based rehabilitation service （P〈0.05）. Conclusion A considerable gap exists between the supply of community-based rehabilitation services in Beijing and the needs for these services by disabled residents underscoring the need for improved availability, and for additional research.

关键词： Disabled Rehabilitation services Influence factors Functional Independence Measure (FIM)

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Regional climate model downscaling may improve the prediction of alien plant species distributions

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Frontiers of Earth Science 2014年第4期8卷 457-471页

作者： Shuyan LIU xin-zhong LIANG Wei GAO Thomas J. STOHLGREN Earth System Science Interdisciplinary Center University of Maryland College Park MD 20740 USA Department of Atmospheric and Oceanic Sciences University of Maryland College Park MD 20740 USA Department of Ecosystem Science and Sustainability Colorado State University Fort Collins CO 80523 USA Fort Collins Science Center U.S. Geological Survey Fort Collins CO 80526 USA

Distributions of invasive species are commonly predicted with species distribution models that build upon the statistical relationships between observed species presence data and climate data. We used field observations, climate station data, and Maximum Entropy species distribution models for 13 invasive plant species in the United States, and then compared the models with inputs from a General Circulation Model （hereafter GCM-based models） and a downscaled Regional Climate Model （hereafter, RCM-based models）. We also compared species distributions based on either GCM-based or RCM-based models for the present （1990-1999） to the future （2046- 2055）. RCM-based species distribution models replicated observed distributions remarkably better than GCM- based models for all invasive species under the current climate. This was shown for the presence locations of the species, and by using four common statistical metrics to compare modeled distributions. For two widespread invasive taxa （Bromus tectorum or cheatgrass, and Tamarix spp. or tamarisk）, GCM-based models failed miserably to reproduce observed species distributions. In contrast, RCM-based species distribution models closely matched observations. Future species distributions may be significantly affected by using GCM-based inputs. Because invasive plants species often show high resilience and low rates of local extinction, RCM-based species distribution models may perform better than GCM-based species distribution models for planning containment programs for invasive species.

关键词： climate change species distribution model,Maxent downscaling

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Assessment of internal quality of billets using ultrasonic three-dimensional layered characterization

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Journal of Iron and Steel Research International 2024年第11期31卷 2727-2739页

作者： Yan-bo Liu Min Li Zheng Zhao zhong-xin Wang De-bin Yang School of Mechanical Engineering University of Science and Technology BeijingBeijing100083China Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing100083China

To address the challenge of visualizing internal defects within castings, ultrasonic nondestructive testing technology has been introduced for the detection and characterization of internal defects in castings. Ultrasonic testing is widely utilized for detecting and characterizing internal defects in materials, thanks to its strong penetration ability, wide testing area, and fast scanning speed. However, traditional ultrasonic testing primarily relies on one-dimensional waveforms or two-dimensional images to analyze internal defects in billets, which hinders intuitive characterization of defect quantity, size, spatial distribution, and other relevant information. Consequently, a three-dimensional (3D) layered characterization method of billets internal quality based on scanning acoustic microscope (SAM) is proposed. The method starts with a layered focus scanning of the billet using SAM and pre-processing the obtained sequence of ultrasonic images. Next, the ray casting is employed to reconstruct 3D shape of defects in billets, allowing for characterization of their quality by obtaining characteristic information on defect spatial distributions, quantity, and sizes. To validate the effectiveness of the proposed method, specimens of 42CrMo billets are prepared using five different processes, and the method is employed to evaluate their internal quality. Finally, a comparison between the ultrasonic image and the metallographic image reveals a difference in dimensional accuracy of only 2.94%. The results indicate that the new method enables visualization of internal defect information in billets, serving as a valuable complement to the traditional method of characterizing their internal quality.

关键词： Internal quality of billets Ultrasonic testing Scanning acoustic microscope Layered characterization Three-dimensional reconstruction

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Feasibility Study on Recovering Human-Occupied Vehicle with An Offshore Crane

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China Ocean Engineering 2024年第4期38卷 648-662页

作者： HAN Ming-yue XIE Peng XIAN Hao-yi zhong xin-xin CHEN Sheng-lin SUN Tie-rui SUN Feng-lei School of Ocean Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Key Laboratory of Comprehensive Observation of Polar Environment(Sun Yat-sen University) Ministry of EducationZhuhai 519082China Guangzhou Marine Engineering Corporation Guangzhou 510250China

Launching and recovering human-occupied vehicles(HOVs)has always been a challenging *** current recovery process requires staff to manually complete the tethering task,which is inefficient and endangers the lives of *** paper suggests moving the recovery position from the surface to underwater at approximately half the wavelength of the water depth(30−50 m underwater),where the HOV experiences less environmental *** ROV equipped with a ultra-short baseline beacon(USBL)and a manipulator was used to complete the tethering ***,a shackle customized to the shape of the manipulator’s gripper is fitted to the end of the cable to simplify the tethering *** investigate the dynamic response of recovering the HOV using this suggested method,a comprehensive numerical model is developed in this *** effects of wind,surface waves,ocean currents,and nonlinear interaction between the installation vessel and the HOV are quantitatively *** results show that the proposed recovery method can reduce the motion amplitude of the HOV and that the wave has the greatest influence on the dynamic response of the HOV during the recovery *** model provides better insight into the proposed HOV recovery method and confirms the effectiveness of the heave compensation *** proposed approach aims to enhance safety and operational efficiency by reducing direct human involvement in the recovery process and mitigating potential *** finding holds particular significance,especially in environmentally sensitive areas,where reducing the impact on the surrounding ecosystem is crucial.

关键词： human-occupied vehicle recovery dynamic response active heave compensation

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ID effects on beam dynamics in the SSRF-U storage ring

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Nuclear Science and Techniques 2023年第11期34卷 140-154页

作者： Li‑Yuan Tan Shun‑Qiang Tian xin‑zhong Liu Xu Wu Wen‑Zhi Zhang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China

This paper introduces the proposed insertion device(ID)scheme for the Shanghai Synchrotron Radiation Facility *** on this scheme,the influences of the ID radiation on the intra-beam scattering emittance and energy spread were *** distortion caused by the IDs was comprehensively examined and compensated using both local and global ***,a frequency map analysis method was used to identify potentially dangerous resonance *** addition,the dynamic aperture,energy acceptance,and Touschek lifetime were calculated after considering high-order magnetic field errors to ensure that the ID effect did not affect the operation of the storage ring.

关键词： SSRF-U Insertion devices Emittance Beam dynamic

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Mechanism of size effects of a filler on the wear behavior of ultrahigh molecular weight polyethylene

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Chinese Journal of Chemical Engineering 2020年第7期28卷 1950-1963页

作者： Huan Zhang Shicheng Zhao zhong xin Chunlin Ye Zhi Li Jincheng Xia Jiaorong Li Shanghai Key Laboratory of Multiphase Materials Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Polyolefins and Catalysis Shanghai Key Laboratory of Catalysis Technology for Polyolefins(Shanghai Research Institute of Chemical Industry)Shanghai 200062China

Although the size effects of a filler are closely related to the complex multi-level structures of their polymer composites;unfortunately,such relationships remain poorly *** this study,we investigated the effects of various sizes(40-600 nm)of silicon carbide(SiC)fillers on the wear behavior of ultrahigh molecular weight polyethylene(UHMWPE)in the presence of the silane coupling agent *** of these SiC fillers improved the wear resistance of UHMWPE significantly,with a medium size(150 nm)being *** examine the reasons for this behavior,we analyzed the multi-level structures of the samples in terms of their matrix structures(crystalline;amorphous;interphase),matrix-filler interactions(physical adsorption;chemical crosslinking;hybrid network)and the external effects of SiC fillers(bearing loads;transferring frictional heat).The high rigidity and thermal conductivity of SiC fillers and,more importantly,the intrinsic characteristics of the matrix structures(larger crystal grains;higher interphase;stronger amorphous entangled networks)were the key parameters affecting the enhancement in the wear-resistance of the ***,we also provide interpretations of the corresponding physical *** results should improve our understanding of the structure-property relationships and,thus,should guide the formula design of UHMWPE composites.

关键词： Ultrahigh molecular weight polyethylene Wear behavior Structure-property relationships Particle size Silicon carbide Polymer-filler interactions

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