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Strong metal–support interaction boosts the electrocatalytic hydrogen evolution capability of Ru nanoparticles supported on titanium nitride

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Carbon Energy 2024年第1期6卷 245-254页

作者： xin Wang xiaoli Yang Guangxian Pei Jifa Yang Junzhe Liu Fengwang Zhao Fayi Jin Wei Jiang Haoxi Ben Lixue Zhang College of Chemistry and Chemical Engineering Collaborative Innovation Center for Hydrogen Energy Key Materials and Technologies of Shandong ProvinceQingdao UniversityQingdaoShandongChina State Key Laboratory of Bio-fibers and Eco-Textiles Qingdao UniversityQingdaoShandongChina Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of ScienceQingdaoShandongChina

Ruthenium(Ru)has been regarded as one of the most promising alternatives to substitute Pt for catalyzing alkaline hydrogen evolution reaction(HER),owing to its inherent high activity and being the cheapest platinum-group metal.Herein,based on the idea of strong metal–support interaction(SMSI)regulation,Ru/TiN catalysts with different degrees of TiN overlayer over Ru nanoparticles were fabricated,which were applied to the alkaline electrolytic water.Characterizations reveal that the TiN overlayer would gradually encapsulate the Ru nanoparticles and induce more electron transfer from Ru nanoparticles to TiN support by the Ru–N–Ti bond as the SMSI degree increased.Further study shows that the exposed Ru–TiN interfaces greatly promote the H_(2) desorption capacity.Thus,the Ru/TiN-300 with a moderate SMSI degree exhibits excellent HER performance,with an overpotential of 38 mV at 10 mA cm^(−2).Also,due to the encapsulation role of TiN overlayer on Ru nanoparticles,it displays super long-term stability with a very slight potential change after 24 h.This study provides a deep insight into the influence of the SMSI effect between Ru and TiN on HER and offers a novel approach for preparing efficient and stable HER electrocatalysts through SMSI engineering.

关键词： electronic structure hydrogen evolution reaction ruthenium strong metal-support interaction titanium nitride

Ferroptosis: A therapeutic opportunity of inflammatory bowel disease

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中华医学杂志(英文版) 2024年第7期137卷 874-876页

作者： Ye Yulin Liu Limin Jing Yang Yao Shuangzhe Yang Mo Dai xin Piao Meiyu Xu xin Feng Zelin Wang xiaoli Liu Yifei Miao Junming Gao xingjie Yu Qingxiang Cao Xiaocang Department of Gastroenterology and Hepatology Tianjin Medical University General Hospital Tianjin Medical University Tianjin 300070 China Department of Biochemistry and Molecular Biology School of Basic Medical Science

Expert consensus on irrigation and intracanal medication in root canal therapy

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International Journal of Oral Science 2024年第1期16卷 26-35页

作者： Xiaoying Zou xin Zheng Yuhong Liang Chengfei Zhang Bing Fan Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Zhi Chen Xi Wei Lihong Qiu Wenxia Chen Wenxi He xin Xu Liuyan Meng Chen Zhang Liming Chen Shuli Deng Yayan Lei xiaoli Xie Xiaoyan Wang Jinhua Yu Jin Zhao Song Shen Xuedong Zhou Lin Yue Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Center of Stomatology Peking University HospitalBeijingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Emergency Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Restorative Dental Sciences EndodonticsFaculty of DentistryThe University of Hong KongPok Fu LamHong Kong SARChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanChina Department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Clinical Research Center for Oral DiseasesNational Center for StomatologyShanghai Key Laboratory of StomatologyShanghaiChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghua School of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina State Key Laboratory of Oral&Maxillofacial Reconstruction and R

Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes.

关键词： treatment irrigation Expert

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离子热循环:高效制冷技术的新突破

科学通报 2024年第7期69卷 815-822页

作者：张鑫赵晓莉杨晓伟上海交通大学化学化工学院上海200240 同济大学材料科学与工程学院上海201804

研发安全、高效、环境友好的新型制冷剂或制冷技术,是当今应对全球变暖问题的重要措施.其中,基于热效应的制冷技术,是具有重要发展潜力的制冷手段.然而,这类技术存在外加应力场强大、绝热温度变化小、效率低等不足,从而限制了其广泛应用... 详细信息

研发安全、高效、环境友好的新型制冷剂或制冷技术,是当今应对全球变暖问题的重要措施.其中,基于热效应的制冷技术,是具有重要发展潜力的制冷手段.然而,这类技术存在外加应力场强大、绝热温度变化小、效率低等不足,从而限制了其广泛应用.近期,以离子热循环为原理的新型制冷技术,以低外加场强、高能源效率的优势,打破了热效应制冷存在的瓶颈,并引起了广泛关注.本文将以该工作为出发点,系统介绍离子热效应及其伴随的热力学循环的基本原理,从制冷性能、工作效率等角度出发,详细分析离子热效应制冷技术背后存在的优势,以及可能存在的科学问题与技术难点,并从电化学原理、离子分离等角度提出解决措施,旨在为这一全新制冷手段的进一步发展提供科学依据和参考.

关键词：制冷技术离子热循环制冷性能效率电化学

Mechanism underlying the effect of Liujunzi decoction(六君子汤)on advanced-stage non-small cell lung cancer in patients after first-line chemotherapy

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Journal of Traditional Chinese Medicine 2022年第1期42卷 108-115页

作者： xin xiaoli WANG Guodong HAN Ru JIANG Yi LIU Chang LIU Lingshuang XU Zhenye Department of Oncology Longhua Hospital affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Orthopedics Longhua Hospital affiliated to Shanghai University of Traditional Chinese MedicineShanghai 20032China Department of human resources Shandong Academy of Occupational Health and Occupational MedicineJinan 250000China

OBJECTIVE:To further clarify the anticancer mechanisms of Liujunzi decoction(六君子汤)and provide possible targets for the treatment of advanced-stage nonsmall cell lung cancer(NSCLC)by re-analyzing differential gene expression profile of peripheral blood mononuclear cells(PBMCs)from Liujunzi decoctiontreated NSCLC patients receiving first-line chemotherapy.METHODS:The PBMC gene expression microarray data set GSE61926 was retrieved from a high throughput gene expression database.Differentially expressed genes(DEGs)were screened by paired sample t-test and the multiple ratio method.Gene ontology and Kyoto encyclopedia of genes and genomes(KEGG)pathway analyses were performed using the DAVID database.The protein–protein interaction(PPI)network was constructed using interaction gene library retrieval tools and Cytoscape software.RESULTS:A total of 162 DEGs were identified,with 67 upregulated genes and 95 downregulated genes.The functional distribution of Gene Oncology(GO)genes showed that DEGs were mostly concentrated in extracellular regions,calcium ion binding,and transcriptase activity.KEGG pathway analysis showed that cytokine–cytokine receptor interactions were significantly enriched.PPI network analysis screened out the top 10 central protein-coding genes with the highest nodal degree:IL2,PIWIL4,DICER1,PIWIL2,SAA1,XCL1,IL22RA1,ARHGAP11A,DCP1A,and GDNF.Among them,the central protein-coding gene with the highest node degree was IL2.In addition,the central protein-coding genes with high node degrees and high molecular complex detection(MCODE)scores were PIWIL4,DICER1,PIWIL2,and DCP1A,all of which are related to tumor development.CONCLUSIONS:One signaling pathway and 10 central protein-coding genes related to anticancer mechanisms were screened by re-analysis of GSE61926 data.IL2,PIWIL4,DICER1,PIWIL2,and DCP1 A may have important roles in the mechanism of Liujunzi decoction treatment against NSCLC.Our results suggest that the anticancer mechanism of Liujunzi decoction may be related to gene silencing by RNA and the bi

关键词： carcinoma non-small-cell lung antineoplastic agents computational biology RNA small interfering Liujunzi decoction

IGZO薄膜晶体管生物传感器无标记检测强直性脊柱炎

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西安交通大学学报 2024年第2期58卷 157-163页

作者：吕腾博刘嘉乐刘丽李昕韩传余王小力西安交通大学微电子学院西安710049 西安交通大学物理学院西安710049 沈阳大学师范学院沈阳110003

为了快速检测强直性脊柱炎血清学分子标志物人体白细胞抗原(HLA-B27),开发了一种基于人体白细胞抗原B27(HLA-B27)功能化的氧化铟镓锌(IGZO)薄膜晶体管生物传感器。利用射频磁控溅射技术和微纳加工工艺制备了IGZO薄膜晶体管(IGZO TFT),采... 详细信息

为了快速检测强直性脊柱炎血清学分子标志物人体白细胞抗原(HLA-B27),开发了一种基于人体白细胞抗原B27(HLA-B27)功能化的氧化铟镓锌(IGZO)薄膜晶体管生物传感器。利用射频磁控溅射技术和微纳加工工艺制备了IGZO薄膜晶体管(IGZO TFT),采用3-氨丙基三乙氧基硅烷(APTES)和抗体对IGZO TFT进行修饰,制备出针对HLA-B27检测的生物传感器。实验结果表明,功能化的IGZO TFT生物传感器具有稳定的电学特性和传感性能。传感器对HLA-B27的检测极限为1 pg/mL,在1 pg/mL至100 ng/mL的范围内均有良好的线性响应。这说明所设计的高性能生物传感器能够有效检测出强直性脊柱炎的标志物。此外,IGZO TFT可以扩展为传感器阵列平台,实现对某种疾病多种标志物的联合检测,在便携式床旁诊断设备的应用中具有巨大潜力。

关键词： IGZO 薄膜晶体管生物传感器强直性脊柱炎人体白细胞抗原B27

基于泄漏电流与热失重的盆式绝缘子活化能计算方法

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高压电器 2024年第3期60卷 128-134页

作者：何金辛晓虎邢向上公衍峰孔晓利国网天津市电力公司电力科学研究院天津300384 国网天津市电力公司蓟州供电分公司天津301900 华北电力大学新能源电力系统国家重点实验室北京102206

盆式绝缘子作为气体绝缘金属封闭开关(GIS)的关键部件,长期受电热应力作用易发生绝缘缺陷与老化裂解,是GIS设备故障的主要原因之一。通过活化能表征可以有效地描述盆式绝缘子材料的劣化程度,因此开展盆式绝缘子劣化过程中活化能有效计... 详细信息

盆式绝缘子作为气体绝缘金属封闭开关(GIS)的关键部件,长期受电热应力作用易发生绝缘缺陷与老化裂解,是GIS设备故障的主要原因之一。通过活化能表征可以有效地描述盆式绝缘子材料的劣化程度,因此开展盆式绝缘子劣化过程中活化能有效计算方法的研究具有重要意义。文中首先基于加速老化试验样本,开展热分析动力学研究,采用传统的热失重实验解析盆式绝缘子热解反应过程,并结合Flynn-WallOzawa法对盆式绝缘子的活化能进行计算;进一步地,建立基于泄漏电流计算电导活化能的方法,开展不同老化实验样本的电导活化能计算。最后与传统的Flynn-Wall-Ozawa法进行对比,分析发现两种方法的计算结果以及老化关联规律基本一致,进一步对两种方法在材料老化程度的表征手段与关联规律进行理论分析。上述研究为盆式绝缘子无损伤计算活化能的手段提供了理论指导与实验分析,有助于揭示盆式绝缘子的热解老化机理。

关键词： GIS盆式绝缘子材料老化热失重泄漏电流活化能

Expert consensus on difficulty assessment of endodontic therapy

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International Journal of Oral Science 2024年第1期16卷 15-25页

作者： Dingming Huang Xiaoyan Wang Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou xinmei Chen Jiyao Li Ling Ye Lei Cheng xin Xu Tao Hu Hongkun Wu Bin Guo Qin Su Zhi Chen Lihong Qiu Wenxia Chen Xi Wei Zhengwei Huang Jinhua Yu Zhengmei Lin Qi Zhang Deqin Yang Jin Zhao Shuang Pan Jian Yang Jiayuan Wu Yihuai Pan xiaoli Xie Shuli Deng Xiaojing Huang Lan Zhang Lin Yue Xuedong Zhou State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Operative Dentistry and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Clinical Research Center for Oral DiseasesNational Center for StomatologyShanghai Key Laboratory of StomatologyShanghaiChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghuaSchool of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of StomatologyWuhan UniversityWuhanChina Department of Operative Dentistry&Endodontics School of StomatologyThe Fourth Military Medical UniversityXi’anChina Department of Endodontics Beijing Stomatological HospitalSchool of StomatologyCapital Medical UniversityBeijingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Preventive Dentistry West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Geriatric dentistry West China Hospital of Stomatology

Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy(RCT). Recent research, encompassing bacterial etiology and advanced imaging techniques, contributes to our understanding of the root canal system’s anatomy intricacies and the technique sensitivity of RCT. Success in RCT hinges on factors like patients, infection severity, root canal anatomy, and treatment techniques. Therefore, improving disease management is a key issue to combat endodontic diseases and cure periapical lesions. The clinical difficulty assessment system of RCT is established based on patient conditions, tooth conditions, root canal configuration, and root canal needing retreatment, and emphasizes pre-treatment risk assessment for optimal outcomes. The findings suggest that the presence of risk factors may correlate with the challenge of achieving the high standard required for RCT. These insights contribute not only to improve education but also aid practitioners in treatment planning and referral decision-making within the field of endodontics.

关键词： anatomy difficulty treatment

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骨组织工程支架的制备方法研究进展

中国组织工程研究 2024年第29期28卷 4710-4716页

作者：皇磊王晓丽王思明鲍鑫周鑫王犇娣江苏海洋大学机械工程学院江苏省连云港市222005 连云港市第二人民医院江苏省连云港市222023

背景:由于自体骨源的数量较少,且使用异体骨会产生免疫排斥、疾病扩散等危险,因而人造骨材料在当今的骨移植中起到了不可替代的作用。伴随着功能定制、生物相容性的要求和生物可降解材料的出现,已经出现了多样化的生物材料和多种制备方... 详细信息

背景:由于自体骨源的数量较少,且使用异体骨会产生免疫排斥、疾病扩散等危险,因而人造骨材料在当今的骨移植中起到了不可替代的作用。伴随着功能定制、生物相容性的要求和生物可降解材料的出现,已经出现了多样化的生物材料和多种制备方法。目的:概述目前应用于骨组织工程支架的制备方法,总结各种制备方法的优缺点、研究现状与进展。方法:使用计算机在中国知网、万方数据、PubMed及ScienceDirect数据库检索2008年1月至2023年8月关于骨组织工程支架方面的文献,以“Tissue engineering,Bone scaffold,Gas foaming,Cryotropic gelation,Additive manufacturing等”为英文检索词,以“组织工程,骨支架,气体发泡,低温凝胶,增材制造等”为中文检索词,排除无关和重复性研究,共保留80篇文献进行了总结归纳。结果与结论:①相较于传统支架的制备工艺,近年来新兴的增材制造和静电纺丝技术在用于组织工程的复杂结构如骨和软骨的生产中,表现出了巨大的潜力。②增材制造方法除了在速度、精度和使用的材料范围方面更具优势,还提供了制造高度复杂的几何形状和拓扑优化结构的可行性,实现精确调节和构造结构的高重复性。③静电纺丝是生产一系列纤维垫的最具适应性和前景的技术之一。通过静电纺丝产生的纳米纤维支架是与细胞质基质微观结构非常惊人地相似的生物材料。④目前在陶瓷材料上以羟基磷灰石和磷酸三钙应用性能较好,在高分子材料上目前材料种类多样,以生物相容性优良的材料应用较多。⑤因此,在骨组织工程支架材料的选择上应更好地了解它们的特性,避免复杂化,以生产更具增强功能的支架。然而,目前报告的绝大多数文献对临床的适用性都是探索性的,具体适合哪种疾病的治疗还有待检验。未来骨支架的发展需体现在这几个方面:与缺失骨相匹配的力学性能、降解速率可控、促进骨再生力强以及附有特定功能。

关键词：组织工程骨支架气体发泡低温凝胶增材制造静电纺丝粘合剂喷射选择性激光烧结熔融沉积成型立体光刻数字光处理