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平潭综合实验区闽台农文旅融合发展对策分析

台湾农业探索 2024年第1期 8-12页

作者：林心悦吴毅辉郑心怡林畅福建农林大学经济与管理学院福建福州350002

【目的/意义】平潭因其独特的地理位置与得天独厚的条件,在闽台融合发展中具有重要优势,发挥着对台交流的前沿平台作用。研究平潭与台湾地区农文旅融合情况,有利于更好地推动闽台农文旅融合发展。【方法/过程】通过实地调研等方式,梳理... 详细信息

【目的/意义】平潭因其独特的地理位置与得天独厚的条件,在闽台融合发展中具有重要优势,发挥着对台交流的前沿平台作用。研究平潭与台湾地区农文旅融合情况,有利于更好地推动闽台农文旅融合发展。【方法/过程】通过实地调研等方式,梳理闽台农文旅融合基本情况,剖析平潭农文旅融合存在的问题,并提出促进平潭农文旅融合发展的对策建议。【结果/结论】结果显示,闽台农文旅融合政策不断创设、融合内容不断拓展,平潭在对台农文旅融合方面有区位、资源、政策方面的优势,但平潭与台湾地区农文旅融合发展中存在市场不旺、程度不深、成效不明显的问题,提出突出文化特色、促进深度融合、提高服务水平、加大宣传力度等对策建议,为进一步推动闽台农文旅融合发展提供参考。

关键词：平潭闽台融合农文旅融合

Leptin Modulates the Differentiation of Keratinocytes via Autophagy in Psoriasis Patients With Metabolic Syndrome

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International Journal of Dermatology And Venereology 2024年第03期

作者： Song Cui-Hao Wang Rui Zhao Zhen-Kai Zhang Yuan Sun Jie Zhang Xu Ding Xiang-Yu Bai Jia Liang Xiao-Qiang Wei Xuan-Jin Liu Xiao-ling Yang Tao Liang xin-lin Li Cheng-xin lin Bi-Wen Department of Dermatology PLA General Hospital Beijing China Department of Clinical Laboratory PLA General Hospital Beijing China Department of Dermatology Southern Medical University Guangzhou Guangdong China

Objective: Psoriasis is associated with a high prevalence of metabolic syndrome (MS), and patients with concomitant psoriasis and MS are more severely affected and less responsive to treatment. However, the molecular mechanisms behind these effects are unknown. Recent studies have shown that leptin may serve as a molecular link between psoriasis and MS, suggesting that high leptin concentrations may exacerbate psoriasis. However, the molecular mechanism of this effect is still unclear. We aimed to investigate the effect of leptin on autophagy in patients with ***: From January 2021 to June 2022 in PLA General Hospital, we enrolled 51 patients with psoriasis, including 21 patients with MS and 30 without MS, and 30 healthy controls who had undergone nevus surgery. We measured the epidermal leptin, P62, and LC3B concentrations of patients by immunohistochemistry, and measured the serum leptin concentration by enzyme-linked immunosorbent assay. We then performed correlation analyses to compare these proteins’ concentrations between patients with concomitant psoriasis and MS, patients with psoriasis alone, and healthy control groups. Additionally, we performed western blotting afterin vitro culture of HaCaT cells with different concentrations of leptin and measured the expression levels of the autophagy markers Beclin1, LC3B, and P62; the differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signaling pathway-related proteins of HaCat cells. Next, we transfected ATG5 into HaCaT cells to revert autophagy and used the specific PI3K inhibitor LY294002 to block PI3K/AKT/mTOR signaling. The expression levels of K10, K16, and K17 of HaCat cells were again measured. One-way analysis of variance was used for the comparison of means of multiple samples, and LSD-t post hoc test was used for comparison between the 2 groups. The counting data were analyzed by the chisquare test. Correlations were evaluated by Pearson correlation ***: The serum lepti

关键词： psoriasis metabolic syndrome leptin autophagy keratinocyte differentiation signal pathway PI3K/AKT/mTOR

转录因子对丹参酮类物质调控作用及机制研究进展

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药学学报 2024年第5期59卷 1218-1228页

作者：白艳红辛林林曾婷韩凤霞张永清蒲高斌陈雪刘谦山东中医药大学药学院山东济南250355 黄冈师范学院李时珍中医学院湖北黄冈438000

丹参是临床常用的活血化瘀药,主要用于心脑血管疾病的治疗,其关键活性物质丹参酮的合成和调控机制一直为研究热点。本文对近年来有关转录因子(AP2/ERF、bHLH、MYB、bZIP、WRKY等)调节丹参酮类成分生物合成的研究成果进行了归纳总结,指... 详细信息

丹参是临床常用的活血化瘀药,主要用于心脑血管疾病的治疗,其关键活性物质丹参酮的合成和调控机制一直为研究热点。本文对近年来有关转录因子(AP2/ERF、bHLH、MYB、bZIP、WRKY等)调节丹参酮类成分生物合成的研究成果进行了归纳总结,指出了丹参转录调控研究存在的问题,探讨了转录因子在丹参酮类活性成分生物合成调控中的研究方向,为进一步发现和利用丹参酮类活性物质调控功能基因提供理论依据。

关键词：转录因子丹参酮调控作用分子机制

On one-sided torsion pair

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Science China Mathematics 2007年第1期50卷 13-26页

作者： Ya-nan lin lin xin Department of Mathematics Xiamen UniversityXiamen 361005China Department of Mathematics Fujian Normal UniversityPuzhou 350007China

Motivated by the concept of a torsion pair in a pre-triangulated category induced by Beligiannis and Reiten, the notion of a left (right) torsion pair in the left (right) triangulated category is introduced and investigated. We provide new connections between different aspects of torsion pairs in one-sided triangulated categories, pre-triangulated categories, stable categories and derived categories.

关键词： triangulated category triangle torsion pair stable category 18E30 18E40 18E05

校园足球与思政教育协同演进的三重逻辑及未来展望

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体育研究与教育 2024年第4期39卷 63-68页

作者：赵继明蔺新茂淮阴师范学院体育学院江苏淮安223300

采用文献资料法和逻辑分析法,从历史逻辑、理论逻辑和实践逻辑三个维度探讨了校园足球与思政教育协同演进的必要性、可能性和实施策略。研究指出:解决“以体育人”难题、推进思政教育一体化建设以及实现教育现代化的协同发展是校园足球... 详细信息

采用文献资料法和逻辑分析法,从历史逻辑、理论逻辑和实践逻辑三个维度探讨了校园足球与思政教育协同演进的必要性、可能性和实施策略。研究指出:解决“以体育人”难题、推进思政教育一体化建设以及实现教育现代化的协同发展是校园足球与思政教育协同演进的现实诉求;“人的全面发展”“具身认知”和“自组织”理论为协同演进提供了理论支撑;实践中,通过明确共同目标、构建协同机制、展现实践成效和追求系统生态,可实现校园足球与思政教育的深度融合。展望未来,通过校园足球与思政教育的协同演进,不仅可逐步改善中国足球的环境,还能激发多元教育主体的活力,持续提升教育改革的成效,为体育事业发展和教育现代化建设提供新思路。

关键词：校园足球思政教育协同演进教育现代化体教融合

C_(4)F_(7)N/CO_(2)混合气体自由燃弧特性仿真研究

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高压电器 2024年第9期60卷 11-19页

作者：李爽理乐陈圣毕海涛林莘庚振新国网辽宁省电力有限公司电力科学研究院沈阳110055 沈阳工业大学电气工程学院沈阳110870

目前电力行业中采用C_(4)F_(7)N/CO_(2)混合气体作为绝缘介质替代SF_(6)的可推广性较高,但对其灭弧性能的研究仍有待深入。文中基于磁流体动力学(MHD)理论模拟了棒—棒电极间隙的自由燃弧动态过程,计算了0.6 MPa的C_(4)F_(7)N/CO_(2)混... 详细信息

目前电力行业中采用C_(4)F_(7)N/CO_(2)混合气体作为绝缘介质替代SF_(6)的可推广性较高,但对其灭弧性能的研究仍有待深入。文中基于磁流体动力学(MHD)理论模拟了棒—棒电极间隙的自由燃弧动态过程,计算了0.6 MPa的C_(4)F_(7)N/CO_(2)混合气体(C_(4)F_(7)N占比分别为7%、10%、20%)和SF_(6)的电弧伏安特性。研究结果表明:C_(4)F_(7)N/CO_(2)混合气体在轴向的扩散能力强于SF_(6)气体;与C_(4)F_(7)N/CO_(2)混合气体相比,SF_(6)气体的燃弧温度更低,增大C_(4)F_(7)N的比例可降低燃弧温度;在燃弧过程中SF_(6)气体的电弧电压最低,增加C_(4)F_(7)N的比例对降低混合气体的电弧电压效果明显。

关键词： C_(4)F_(7)N/CO_(2)混合气体 SF_(6)替代气体 MHD 自由燃弧

On the Fourth Power Mean of the Generalized Quadratic Gauss Sums

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Acta Mathematica Sinica,English Series 2018年第6期34卷 1037-1049页

作者： Wen Peng ZHANG xin lin School of Mathematics Northwest University

The main purpose of this paper is to use elementary methods and properties of the classical Gauss sums to study the computational problem of one kind of fourth power mean of the generalized quadratic Gauss sums mod q ... 详细信息

关键词： The generalized quadratic Gauss sums the fourth power mean analytic method computational formula

Topology and Shape Optimization of 2-D and 3-D Micro-ArchitecturedThermoelastic Metamaterials Using a Parametric Level Set Method

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Computer Modeling in Engineering & Sciences 2021年第6期127卷 819-854页

作者： Ellie Vineyard xin-lin Gao PepsiCo R&D Center ValhallaNY 10595USA Department of Mechanical Engineering Southern Methodist UniversityDallasTX 75275-0337USA

2-D and 3-D micro-architectured multiphase thermoelastic metamaterials are designed and analyzed using a parametric level set method for topology optimization and the finite element *** asymptotic homogenization approach is employed to obtain the effective thermoelastic properties of the multiphase ***ε-constraint multi-objective optimization method is adopted in the *** coefficient of thermal expansion(CTE)and Poisson’s ratio(PR)are chosen as two objective functions,with the CTE optimized and the PR treated as a *** optimization problems are solved by using the method of moving *** isotropic and anisotropic CTEs and stiffness constants are obtained for the topologically optimized metamaterials with prescribed values of PR under the constraints of specified effective bulk modulus,volume fractions and material *** solid materials along with one additional void phase are involved in each of the 2-D and 3-D optimal design *** numerical results reveal that the newly proposed approach can integrate shape and topology optimizations and lead to optimal microstructures with distinct topological *** current method can topologically optimize metamaterials with a positive,negative or zero CTE and a positive,negative or zero Poisson’s ratio.

关键词： Topology optimization thermoelastic metamaterial level set method sensitivity analysis Poisson’s ratio coefficient of thermal expansion effective elastic properties

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评价泼尼松治疗急性间质性肾炎的临床疗效

中国现代药物应用 2024年第13期18卷 81-83页

作者：林莘蔡佳盈泉州医学高等专科学校附属人民医院内科 362000 福建医科大学附属泉州第一医院肾内科 362000

目的评价急性间质性肾炎(AIN)应用泼尼松治疗的临床效果。方法选择急性间质性肾炎患者80例,采用随机数字表法分为对照组和观察组,各40例。对照组行常规对症治疗,观察组在对照组基础上配合泼尼松治疗。对比两组患者临床疗效、生活质量评... 详细信息

目的评价急性间质性肾炎(AIN)应用泼尼松治疗的临床效果。方法选择急性间质性肾炎患者80例,采用随机数字表法分为对照组和观察组,各40例。对照组行常规对症治疗,观察组在对照组基础上配合泼尼松治疗。对比两组患者临床疗效、生活质量评分及治疗前后肾功能指标[血尿素氮(BUN)、血肌酐(SCr)、尿β_(2)微球蛋白(β_(2)-MG)、24 h尿蛋白定量(24 h UP)、尿酸(UA)]。结果观察组总有效率95.00%高于对照组的80.00%(P<0.05)。观察组躯体功能、躯体角色、机体疼痛、总体健康、活力、社会功能、情绪角色、心理健康评分分别为(90.03±3.30)、(91.30±2.30)、(91.05±2.35)、(91.30±3.20)、(91.80±2.80)、(92.20±3.15)、(91.02±3.15)、(92.20±3.30)分,均明显高于对照组的(84.40±2.50)、(85.50±2.20)、(86.02±2.22)、(85.50±2.60)、(86.50±2.30)、(86.60±2.60)、(86.50±2.55)、(86.60±2.30)分(P<0.05)。治疗后,两组BUN、SCr、β_(2)-MG、24 h UP、UA水平均较治疗前下降,且观察组治疗后BUN(6.66±1.88)mmol/L、SCr(215.70±5.50)μmol/L、β_(2)-MG(0.25±0.10)mg/L、24 h UP(0.38±0.30)g/24 h、UA(339.40±9.01)μmol/L均低于对照组的(10.20±2.60)mmol/L、(410.50±8.80)μmol/L、(0.36±0.15)mg/L、(1.22±0.40)g/24 h、(444.02±9.50)μmol/L(P<0.05)。结论泼尼松治疗急性间质性肾炎的临床效果显著,可促进患者肾功能改善,且能提升患者的生活质量。

关键词：泼尼松急性间质性肾炎肾功能治疗效果