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Black fungus derived aerogel with double faced properties

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Chinese Chemical Letters 2019年第6期30卷 1178-1181页

作者： Bixing Fang Lina Dong xingwei Ding YingZi Ren Zhongsheng Lv Kuan Liu Feng Zhang Wei Zhang Jianjian Deng hongbo xin Xiaolei Wang Department of Otolaryngology Head&Neck Surgery The Third Affiliated Hospital of Sun Yat-sen University Guangzhou 510630 China College of Chemistry Nanchang University Nanchang 330088 China The National Engineering Research Center for Bioengineering Drugs and Technologies Institute of Translational Medicine Nanchang University Nanchang 330088 China Department of Orthopedic Surgery The Affiliated Stomatological Hospital of Nanchang University The Key Laboratory of Oral Biomedicine Nanchang 330006 China Department of Orthopedic Surgery The Second Affiliated Hospital of Nanchang University Nanchang 330006 China

Black fungus derived carbonaceous aerogel (BFA) was prepared via a convenient and energy efficient ultrasonic disposal process. The adsorption experiments of atmospheric pollutants demonstrated the superior adsorbability of black fungus aerogel on PM2.5, PM10 and formaldehyde. More importantly, black fungus aerogel (BFA) exhibited intriguing double-faced properties. We explored properties of each side of the black fungus from three aspects: water contact angle measurements, liquid selective absorption capacity and air pollutant adsorption abilities. The subsequent modification of ZnO nanosheets endowed the prepared black fungus aerogel with several valuable properties, including broad-spectrum antibacterial capability and high-efficient adsorption ability. These valuable characters implied the BFA to be a promising bacteriostat and cleaner for air and water pollution treatment.

关键词： Aerogels Double faced properties Liquid selective absorption Air and water pollution treatment Antibacterial

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岩土边坡地震崩滑及其初判准则

岩土工程学报 1999年第5期21卷 591-594页

作者：辛鸿博王余庆冶金工业部建筑研究总院北京100088

根据我国过去近８００年间地震诱发天然岩土边坡崩滑的事例，研究了我国岩土边坡地震崩滑的特征，以及边坡地震崩滑与地震动参数的关系。通过对１２５次历史地震造成的２８５例典型滑坡进行分析，提出了预测天然岩土边坡地震崩滑... 详细信息

根据我国过去近８００年间地震诱发天然岩土边坡崩滑的事例，研究了我国岩土边坡地震崩滑的特征，以及边坡地震崩滑与地震动参数的关系。通过对１２５次历史地震造成的２８５例典型滑坡进行分析，提出了预测天然岩土边坡地震崩滑的初判标准。

关键词：边坡地震滑动崩塌判别标准

CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice

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Signal Transduction and Targeted Therapy 2021年第7期6卷 2172-2185页

作者： Lu Gan Demin Liu Jing Liu Erya Chen Chan Chen Lian Liu Hang Hu Xiaohui Guan Wen Ma Yanzi Zhang Yarong He Bofu Liu Songling Tang Wei Jiang Jianxin Xue hongbo xin Research Laboratory of Emergency Medicine Department of Emergency MedicineNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduPeopled Republic of China Cardiology Department The Second Hospital of Hebei Medical UniversityShijiazhuangPeopled Republic of China Department of Endocrinology The Second Hospital of Shanxi Medical UniversityTaiyuanPeople’s Republic of China Department of Anesthesiology Laboratory of Anesthesia and Critical Care MedicineTranslational Neuroscience CenterWest China HospitalSichuan UniversityChengduPeople's Republic of China The National Engineering Research Center for Bioengineering Drugs and the Technologies Institute of Translational MedicineNanchang UniversityNanchangPeople's Republic of China State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduPeopled Republic of China Department of Thoracic Oncology Cancer CenterWest China HospitalSichuan UniversityChengduPeople’s Republic of China

CD38 is the main enzyme for nicotinamide adenine dinucleotide(NAD)degradation in mammalian *** NAD levels are closely related to metabolic syndromes and aging-related *** study showed that CD38 deficiency significantly alleviated angiotensin II(Ang ll)-induced vascular remodeling in mice,as shown by decreased blood pressures;reduced vascular media thickness,media-to-lumen ratio,and collagen deposition;and restored elastin ***,our bone marrow transplantation assay showed that CD38 deficiency in lymphocytes led to lack of protection against Ang ll-induced vascular remodeling,suggesting that the effects of CD38 on Ang ll-induced vascular remodeling might rely primarily on vascular smooth muscle cells(VSMCs),not *** addition,we observed that CD38 deficiency or NAD supplementation remarkably mitigated Ang ll-induced vascular senescence by suppressing the biogenesis,secretion,and internalization of senescence-associated small extracellular vesicles(SA-sEVs),which facilitated the senescence of neighboring non-damaged ***,we found that the protective effects of CD38 deficiency on VSMC senescence were related to restoration of lysosome dysfunction,particularly with respect to the maintenance of sirtuin-mediated mitochondrial homeostasis and activation of the mitochondria-lysosomal axis in *** conclusion,our findings demonstrated that CD38 and its associated intracellular NAD decline are critical for Ang ll-induced VSMC senescence and vascular remodeling.

关键词： CD38 Ang remodeling

AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism

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Journal of Genetics and Genomics 2018年第2期45卷 111-120页

作者： Chun Song Han Yan Hanming Wang Yan Zhang Huiqing Cao Yiqi Wan Lingbao Kong Shenghan Chen Hong Xu Bingxing Pan Jin Zhang Guohuang Fan hongbo xin Zicai Liang Weiping Jia Xiao-Li Tian Laboratory of Human Population Genetics Institute of Molecular Medicine Peking University Beijing 100871 China State Key Laboratory of Membrane Biology Institute of Molecular Medicine Peking University Beijing 100871 China Beijing Key Laboratory of Cardiometabolic Molecular Medicine Peking University Beijing 100871 China Laboratory of Nucleic Acid Technology Institute of Molecular Medicine Peking University Beijing 100871 China Human Population Genetics Human Aging Research Institute and School of Life Sciences Nanchang University Nanchang 330006 China Institute of Life Science and School of Life Science Nanchang University Nanchang 330031 China School of Basic Medical Sciences Nanchang University Nanchang 330006 China Institute of Translational Medicine Nanchang University Nanchang 330031 China Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233 China

Type 2 diabetes mellitus（T2 DM） is a common metabolic disease influenced by both genetic and environmental factors. In this study, we performed an in-house genotyping and meta-analysis study using three independent GWAS datasets of T2 DM and found that rs3743121, located 1 kb downstream of AQR,was a novel susceptibility SNP associated with T2 DM. The risk allele C of rs3743121 was correlated with the increased expression of AQR in white blood cells, similar to that observed in T2 DM models. The knockdown of AQR in HepG2 facilitated the glucose uptake, decreased the expression level of PCK2,increased the phosphorylation of GSK-3β, and restored the insulin sensitivity. Furthermore, the suppression of AQR inhibited the mTOR pathway and the protein ubiquitination process. Our study suggests that AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism.

关键词： Type 2 diabetes AQR Glucose metabolism Ubiquitination

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关于软弱粉质粘土地震液化或震陷的判别标准

世界地震工程 2011年第1期27卷 153-156页

作者：辛鸿博周锡元中冶建筑研究总院北京100088 中国建筑科学研究院北京100013

文中简要介绍了判别细粒土地震液化分析方法的发展历程,指出了工程建设中考虑细粒土地震液化问题的必要性。基于已有研究成果,阐述了可用于工程设计的软弱粉质粘土地震液化简化判别方法,并对建筑抗震设计新规范中增加的相关条款进行了... 详细信息

文中简要介绍了判别细粒土地震液化分析方法的发展历程,指出了工程建设中考虑细粒土地震液化问题的必要性。基于已有研究成果,阐述了可用于工程设计的软弱粉质粘土地震液化简化判别方法,并对建筑抗震设计新规范中增加的相关条款进行了说明解释。

关键词：细粒土地震液化界限含水量简化判别法

西藏尼雄铁矿成矿花岗岩成因及其对成矿构造背景的启示

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大地构造与成矿学 2015年第2期39卷 286-299页

作者：范淑芳曲晓明宋扬辛洪波中国地质科学院矿产资源研究所北京100037

本文分析了西藏尼雄铁矿与成矿有关花岗闪长岩的主量元素、微量元素、稀土元素及Sr-Nd-Pb同位素特征,并做了锆石LA-ICPMS U-Pb年龄测定。岩石地球化学分析结果显示样品为亚铝质中钾–高钾钙碱性岩系列,属I-型花岗岩。地球化学组成上其... 详细信息

本文分析了西藏尼雄铁矿与成矿有关花岗闪长岩的主量元素、微量元素、稀土元素及Sr-Nd-Pb同位素特征,并做了锆石LA-ICPMS U-Pb年龄测定。岩石地球化学分析结果显示样品为亚铝质中钾–高钾钙碱性岩系列,属I-型花岗岩。地球化学组成上其富集大离子亲石元素（LILE）Rb、Ba、Sr、Th、U、K、Pb,亏损高场强元素（HFSE）Nb、Ta、Ti,具有典型的岛弧岩浆作用的特征；稀土元素球粒陨石标准化图解表现为富集轻稀土的右倾型式（LREE/HREE=5.67~8.37）,无 Eu异常,显示活动大陆边缘岩浆岩的稀土配分特征。岩体ISr为0.707625~0.710997,εNd（t）为–6.6~–8.7,206Pb/204Pb,207Pb/204Pb,208Pb/204Pb 比值分别为18.786~18.955、15.694~15.726、39.355~39.676,显示出富集地幔特征（EMⅡ）,表明地壳组分对岩浆生成有重要影响。所测岩体的锆石206Pb/238U 加权平均年龄为112.09±0.54 Ma（MSWD=0.45）,表明尼雄花岗岩体形成于早白垩世晚期。综合分析班公湖–怒江中特提斯洋和雅鲁藏布江新特提斯洋的演化历史,作者认为尼雄铁矿是早白垩世雅鲁藏布江洋壳板块向北侧拉萨地块之下俯冲的构造背景下的产物。而成矿岩体主要是俯冲组分（流体和熔融）对地幔楔交代改造的结果,是地幔岩浆底侵引起下地壳物质部分熔融,两种岩浆混合而形成的。

关键词：岩石地球化学 Sr-Nd-Pb同位素锆石U-Pb年龄尼雄铁矿西藏

藏西措勤县日阿与斑(玢)岩有关的铜矿床的矿床地质特征与成矿时代

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矿床地质 2006年第4期25卷 477-482页

作者：辛洪波曲晓明中国地质科学院矿产资源研究所北京100037

藏西地区措勤县日阿铜矿产于拉萨地块内,是一个与二长花岗斑岩岩株有关的矽卡岩型铜矿床。由矿体中金云母测得的40Ar/39Ar成矿年龄为(87.69±0.64)Ma,MSWD=0.42,与二长花岗斑岩的锆石U_PbSHRIMP年龄(90.1Ma)一致。同时,矿区内的辉绿玢岩... 详细信息

藏西地区措勤县日阿铜矿产于拉萨地块内,是一个与二长花岗斑岩岩株有关的矽卡岩型铜矿床。由矿体中金云母测得的40Ar/39Ar成矿年龄为(87.69±0.64)Ma,MSWD=0.42,与二长花岗斑岩的锆石U_PbSHRIMP年龄(90.1Ma)一致。同时,矿区内的辉绿玢岩脉,与二长花岗斑岩具有相近的年龄(87.2Ma)及相似的岩石地球化学特征,它们共同构成了一套含铜的双峰式岩石组合,代表了中—晚白垩世拉萨地块内的伸展构造环境下的铜成矿事件。文章指出,造成该矿区铜矿化的双峰式岩系(二长花岗斑岩—辉绿玢岩组合)是由班公湖—怒江洋壳向南俯冲,在碰撞后伸展阶段形成的。该矿床的发现表明,西藏高原除了与板块缝合带有关的斑岩型铜矿(包括玉龙、冈底斯、班公湖—怒江3条斑岩铜矿带)外,拉萨地块内部还有一期与双峰式岩系有关的斑岩_矽卡岩型铜矿成矿事件。

关键词：地质学矽卡岩型铜矿床矿床地质特征金云母^40Ar/^39Ar年龄成矿构造环境藏西措勤

Fluorescent bovine serum albumin-silver nanoclusters loaded with paclitaxel can traverse the blood-brain barrier to inhibit the migration of glioma

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Journal of Bio-X Research 2020年第4期3卷 183-192页

作者： Yu Liu Yu Liu Yini Zhang Weichang Xie Yalan Yang Kaigeng Hu hongbo xin Ping Hu Fanrong Ai School of Mechanical&Electronic Engineering Nanchang UniversityNanchangJiangxi ProvinceChina Rehabilitation Department The Second Affiliated HospitalNanchang UniversityNanchangJiangxi ProvinceChina Institute of Translational Medicine Nanchang UniversityNanchangJiangxi ProvinceChina

Objective::Glioma is the most common and aggressive primary brain tumor. Here, we aimed to establish a nano-drug carrier system to traverse the blood-brain barrier for the treatment and inhibition of glioma ***::The synthesis of bovine serum albumin protected-silver nanoclusters (BSA-AgNCs) was performed using chemical reduction. The drug paclitaxel (PTX) can be loaded into BSA-AgNCs through electrostatic and hydrophobic interactions to formulate spherical BSA-AgNC-PTX nanoparticles (BSA-AgNC-PTX NPs). A glioma mouse model was established by injecting U251-GFP-Luc cells into the mouse striatum, and all surgical procedures were approved by the Animal Ethics Committee of Nanchang University (SYXK2019-0003) on December 29, ***::The BSA-AgNC-PTX NPs were able to efficiently pass through the blood-brain barrier, both in vitro and in vivo, to deliver the drug to the tumor site. The in vivo assessment of BSA-AgNC-PTX NPs in glioblastoma multiforme-bearing mice revealed the significant inhibition of tumor growth and migration, prolonging the survival of the ***::These results indicated that BSA-AgNCs might represent an ideal nanocarrier for the treatment of glioma and has the potential to be used in the treatment of a variety of central nervous system diseases.

关键词： blood-brain barrier glioma paclitaxel renal clearable silver nanoclusters

SEAD场景异构无人机配置与任务规划联合优化方法

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国防科技大学学报 2024年第1期46卷 32-41页

作者：王建峰贾高伟辛宏博郭正侯中喜国防科技大学空天科学学院湖南长沙410073

对敌防空压制(suppression of enemy air defenses, SEAD)场景是多无人机协同的典型应用,针对该场景特点,在任务规划问题基础上将各类型无人机数量也作为决策变量,充分表征目标、任务和无人机的多种约束,建立异构无人机编队路径问题模... 详细信息

对敌防空压制(suppression of enemy air defenses, SEAD)场景是多无人机协同的典型应用,针对该场景特点,在任务规划问题基础上将各类型无人机数量也作为决策变量,充分表征目标、任务和无人机的多种约束,建立异构无人机编队路径问题模型。设计了双层联合优化方法求解该模型:上层设计了任务衔接参数指标,精确评估各类型无人机需求,指导无人机配置调整;下层设计了改进遗传算法,高效处理多类型约束并能结合无人机数量变化对任务方案进行精细调整;双层相互协调获得满足需求的无人机配置和执行方案。仿真结果表明,该方法可以在避免遍历无人机配置组合的前提下获得合理的无人机配置方案和高效可行的执行方案。

关键词： SEAD场景异构无人机无人机配置任务规划任务衔接参数