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Profile of the RNA in exosomes from astrocytes and microglia using deep sequencing:implications for neurodegeneration mechanisms

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Neural Regeneration Research 2022年第3期17卷 608-617页

作者： Hui-Min xie Xing Su Feng-yuan Zhang Chao-Lun Dai Rong-Hua Wu Yan Li Xiao-Xiao Han Xing-Mei Feng Bin Yu Shun-Xing Zhu Song-Lin Zhou Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Stomatology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Medical College of Nantong University NantongJiangsu ProvinceChina Laboratory Animals Center Nantong UniversityNantongJiangsu ProvinceChina

Glial cells play an important role in signal transduction,energy metabolism,extracellular ion homeostasis and neuroprotection of the central nervous ***,few studies have explained the potential effects of exosomes from glial cells on central nervous system health and *** this study,the genes expressed in exosomes from astrocytes and microglia were identified by deep RNA *** Encyclopedia of Genes and Genomes analysis indicated that several pathways in these exosomes are responsible for promoting neurodegenerative diseases,including Alzheimer's disease,Parkinson's disease and Huntington's *** ontology analysis showed that extracellular exosome,mitochondrion and growth factor activity were enriched in exosomes from the unique astrocyte group,while extracellular exosome and mitochondrion were enriched in exosomes from the unique microglia ***,combined with the screening of hub genes,the protein-protein interaction network analysis showed that exosomes from astrocytes influence neurodegenerative diseases through metabolic balance and ubiquitin-dependent protein balance,whereas exosomes from microglia influence neurodegenerative diseases through immune inflammation and oxidative *** there were differences in RNA expression between exosomes from astrocytes and microglia,the groups were related by the hub genes,ubiquitin B and heat shock protein family A(Hsp70) member *** B appeared to be involved in pleiotropic regulatory functions,including immune regulation,inflammation inhibition,protein catabolism,intracellular protein transport,exosomes and oxidative *** results revealed the clinical significance of exosomes from glia in neurodegenerative *** study was approved by the Animal Ethics Committee of Nantong University,China(approval No.S20180102-152) on January 2,2018.

关键词： astrocyte bioinformatics analysis central nervous system exosomes microglia neurodegenerative disease RNA transcriptomics UBB

Shuxuetong for Prevention of recurrence in Acute Cerebrovascular events with Embolism(SPACE)trial:rationale and design

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Stroke & Vascular Neurology 2020年第3期5卷 311-314页

作者： Hong-Qiu Gu Xue-Wei xie Jing Jing Xia Meng Wei Lv Jian-Dong Yu xiang-Ping Lv Hao Li Yi-Long Wang Yong-Jun Wang China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease BeijingChina Center for Stroke Beijing Institute for Brain DisordersBeijingChina

Backgrounds Embolic stroke is one of the main mechanisms of ischaemic *** if treated with recommended antithrombotic agents,stroke recurrence remains *** Shuxuetong injection,a purified extract of traditional Chinese medicine widely used for thrombus diseases in clinical practice in China,could be a promising agent to prevent stroke *** To describe the design of the Shuxuetong injection for prevention of recurrence in acute ischaemic stroke with embolism *** The Shuxuetong for Prevention of recurrence in Acute Cerebrovascular events with Embolism(SPACE)trial is a multicentre,randomised,double-blind,placebo-controlled,parallel-group,superiority trial to evaluate the efficacy and safety of Shuxuetong injection in reducing recurrence or silent new ischaemic lesions on patients with acute embolic stroke within 10 *** estimated 2416 patients with embolic stroke within 72 hours of symptom onset from 80 hospitals will be randomly assigned to one of two groups receiving Shuxuetong injection or placebo injection for 10 *** primary endpoint is symptomatic or asymptomatic new cerebral infarction within 10 days after *** The SPACE Trial will provide valuable evidence for the efficacy and safety of Shuxuetong injection for the prevention of stroke recurrence in patients with imaging-defined embolic stroke.

关键词： prevention injection acute

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加锑、锡的铸态珠光体球铁在曲轴上的应用

内燃机工程 1984年第1期5卷 47-55页

作者：谢源甫湖南大学

在球铁中添加微量元素锑、锡都能促进珠光体生成。电子探针分析表明,Sb、Sn 都是晶界偏析型元素,因此加 Sb、Sn 球铁的韧性较低,为了获得理想的综合机械性能,采用微量多元合金化是很有效的,可以满足柴油机曲轴对材料的技术要求,因而为... 详细信息

在球铁中添加微量元素锑、锡都能促进珠光体生成。电子探针分析表明,Sb、Sn 都是晶界偏析型元素,因此加 Sb、Sn 球铁的韧性较低,为了获得理想的综合机械性能,采用微量多元合金化是很有效的,可以满足柴油机曲轴对材料的技术要求,因而为生产铸态球铁曲轴提供了一个新的途径。

关键词：球铁断裂韧性破断韧性力学强度铸态球铁曲轴球化率机械性能力学性质石墨球

Prognostic factors and therapeutic effects of different treatment modalities for colorectal cancer liver metastases

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World Journal of Gastrointestinal Oncology 2020年第10期12卷 1177-1194页

作者： Zuo-Hong Ma Yong-Peng Wang Wen-Heng Zheng Ji Ma Xue Bai Yong Zhang yuan-He Wang Da Chi Xi-Bo Fu xiang-Dong Hua Department of Hepatopancreatobiliary Surgery Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042Liaoning ProvinceChina Department of Medical Imaging Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042Liaoning ProvinceChina Department of Pathology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042Liaoning ProvinceChina

BACKGROUND Colorectal cancer(CRC)is one of the most common malignant tumors in China,and the liver is the most common metastatic site in patients with advanced *** is the gold standard treatment for colorectal liver *** patients who cannot undergo radical resection of liver metastases for various reasons,ablation therapy,interventional therapy,and systemic chemotherapy can be used to improve their quality of life and prolong their survival *** To explore the prognostic factors and treatments of liver metastases of *** A retrospective analysis was conducted on 87 patients with liver metastases from CRC treated at the Liaoning Cancer Hospital and Institute between January 2005 and March *** to different treatments,the patients were divided into the following four groups:Surgical resection group(36 patients);ablation group(23 patients);intervention group(15 patients);and drug group(13 patients).The clinicopathological data and postoperative survival of the four groups were *** Kaplan-Meier method was used for survival analysis,and the Cox proportional hazards regression model was used for multivariate *** The median survival time of the 87 patients was 38.747±3.062 mo,and the 1-and 3-year survival rates were 87.5%and 53.1%,*** Cox proportional hazards model showed that the following factors were independent factors affecting prognosis:The degree of tumor differentiation,the number of metastases,the size of metastases,and whether the metastases are close to great *** results of treatment factor analysis showed that the effect of surgical treatment was better than that of drugs,intervention,or ablation alone,and the median survival time was 48.83±4.36 *** drug group had the worst prognosis,with a median survival time of only 13.5±0.7 mo(P<0.05).For patients with liver metastases of CRC near the great vessels,the median survival time(27.3 mo)of patients undergoing surgical resecti

关键词： Colorectal cancer Liver metastasis Prognostic factors Ablation Surgical resection Retrospective study

Prospective study of light dark matter search with a newly proposed DarkSHINE experiment

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Science China(Physics,Mechanics & Astronomy) 2023年第1期66卷 124-138页

作者： Jing Chen Ji-yuan Chen Jun-Feng Chen xiang Chen Chang-Bo Fu Jun Guo Le He Zheng-Ting He Kim Siang Khaw Jia-Lin Li Liang Li Shu Li Meng Lv Dan-Ning Liu Han-Qing Liu Kun Liu Qi-Bin Liu Yang Liu Ze-Jia Lu Cen Mo Si-yuan Song Xiao-Long Wang Yu-Feng Wang Zhen Wang Zi-Rui Wang Wei-Hao Wu Dao xiang Hai-Jun Yang Jun-Hua Zhang Yu-Lei Zhang Zhi-Yu Zhao Xu-Liang Zhu Chun-xiang Zhu Yi-Fan Zhu Tsung-DaoLee Institute Shanghai Jiao Tong UniversityShanghai 201210China Institute of Nuclear and Particle Physics School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Particle Astrophysics and Cosmology(MOE) Shanghai Key Laboratory for Particle Physics and Cosmology(SKLPPC)Shanghai 200240China Center for High Energy Physics Peking UniversityBeijing 10087lChina School of Mechanical and Electronic Engineering Suzhou UniversitySuzhou 234000China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China School of Electronics Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China R&D Center Shanghai Instituteof CeramicsChinese Academyof SciencesShanghai 20189China Key Laboratory of Nuclear Physics and lon-beam Application(MOE) Fudan UniversityShanghai 200443China Institute of Modern Physics Fudan UniversityShanghai 200443China IKey Laboratory for Laser Plasmas(MOE) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Zhangjiang Institute for Advanced Study Shanghai JiaoTong UniversityShanghai 200240.China College of Literature Scienceand the ArtsUniversity of MichiganAnn Arbor MI 48109-1040USA Deparment of Physics Swiss Federal Institnute of Technology ZurichZurich 8093Swizerland

Dark photons have been well motivated as strong candidates for dark force carriers and light dark matter in the sub-GeV mass *** with collider experiments,fixed-target experiments provide a complementary approach to searching for dark photons,particularly in the lower mass *** have studied the physics potential of the electron-on-target experiment based on the Shanghai SHINE facility,which provides 10 MHz single electron beam at 8 GeV *** analysis focuses on dark photons being produced via electron and nucleon interaction and then decays to dark matter candidates,which escape detection as missing momentum in the *** experiment takes advantage of using missing momentum to enhance signal versus background separation *** this study,signal samples as a function of dark photon mass and an inclusive background sample with 2.5 billion events are simulated with *** better background estimates,major rare background processes have also been *** paper presents the experiment and detector design,signal and background simulations,analysis strategy,and the prospective study of the experiment *** 9×10^(14) electron-on-target events(about three years running),this experiment is expected to rule out most of the sensitive regions predicted by popular dark photon models.

关键词： dark matter dark photon electron-on-target experiment

Mapping quantitative trait loci associated with starch paste viscosity attributes by using double haploid populations of rice (Oryza sativa L.)

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Journal of Integrative Agriculture 2020年第7期19卷 1691-1703页

作者： Tahmina SHAR SHENG Zhong-hua Umed ALI Sajid FIAZ WEI xiang-jin xie Li-hong JIAO Gui-ai Fahad ALI SHAO Gao-neng HU Shi-kai HU Pei-song TANG Shao-qing State Key Laboratory of Rice Biology/Key Laboratory of Rice Biology and Breeding Ministry of Agriculture/China National Rice Research InstituteHangzhou 310006P.R.China

The paste viscosity attributes of starch,measured by rapid visco analyzer(RVA),are important factors for the evaluation of the cooking and eating qualities of rice in breeding *** determine the genetic roots of the paste viscosity attributes of rice grains,quantitative trait loci(QTLs)associated with the paste viscosity attributes were mapped,using a double haploid(DH)population derived from Zhongjiazao 17(YK17),a super rice variety,crossed with D50,a tropic japonica ***-four QTLs,for seven parameters of the RVA profiles,were identified in three planting *** 54 QTLs were located on all of the 12 chromosomes,with a single QTL explaining 5.99 to 47.11%of phenotypic *** the QTLs identified,four were repeatedly detected under three environmental conditions and the other four QTLs were repeated under two *** of the QTLs detected for peak viscosity(PKV),trough viscosity(TV),cool paste viscosity(CPV),breakdown viscosity(BDV),setback viscosity(SBV),and peak time(PeT)were located in the interval of RM 6775-RM 3805 under all three environmental conditions,with the exception of pasting temperature(PaT).For digenic interactions,eight QTLs with six traits were identified for additivexenvironment interactions in all three planting *** epistatic interactions were estimated only for PKV,SBV and *** present study will facilitate further understanding of the genetic architecture of eating and cooking quality(ECQ)in the rice quality improvement program.

关键词： RVA profiles eating and cooking quality(ECQ) quantitative trait loci(QTL) DH population rice

Pseudomonas ***35-L enhances tobacco root development and growth by inducing HRGPnt3 expression in plant lateral root formation

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Journal of Integrative Agriculture 2020年第10期19卷 2549-2560页

作者： CAO yuan-yuan NI Hai-ting LI Ting LAY Khien-duc LIU Dai-song U Kang-miao TANG Xin-yun WANG Xiao-bo QIU Li-juan School of Life Sciences Anhui Agricultural UniversityHefei 230036P.R.China Anhui Province Key Laboratory of Farmland Ecological Conservation and Pollution Prevention Anhui Agricultural UniversityHefei 230036P.R.China Shiyan Municipal Tobacco Company of Hubei Province Shiyan 442000P.R.China School of Agronomy Anhui Agricultural UniversityHefei 230036P.R.China Institute of Crop Sciences Chinese Academy of Agricultural Sciences/The National Key Facility for Crop Gene Resources and Genetic Improvement(NFCRI)Bejing 100081P.R.China

Rhizosphere colonization is a key requirement for the application of plant growth-promoting rhizobacteria(PGPR)as a *** molecules are often exchanged between PGPR and plants,and genes in plants may respond to the action of ***,the luciferase luxAB gene was electrotransformed into Pseudomonas *** TK35,a PGPR with an afinity for tobacco,and the labelled TK35(TK35-L)was used to monitor colonization dynamics in the tobacco rhizosphere and evaluate the effects of colonization on tobacco growth and root *** transcript levels of the hydroxyproline rich glycoprotein HRGPnt3 gene,a lateral root induction indicator,in tobacco roots were examined by *** results showed that TK35-L could survive for long periods in the tobacco rhizosphere and colonize new spaces in the tobacco rhizosphere following tobacco root extension,exhibiting significant increases in root development,seedling growth and potassium accumulation in tobacco *** upregulation of HRGPnt3 transcription in the inoculated tobacco suggested that TK35-L can promote tobacco root development by upregulating the transcript levels of the HRGPnt3 gene,which promotes tobacco seedling *** findings lay a foundation for future studies on the molecular mechanism underlying the plant growth-promoting activities of ***,this work provided an ideal potential strain for biofertilizer production.

关键词： Pseudomonas sp.TK35-L rhizosphere colonization tobacco growth promotion root development HRGPnt3

Beam wander relieved optical switch using Bessel beams in turbulent atmosphere

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Chinese Optics Letters 2019年第9期17卷 10-14页

作者： Youpeng xie Ting Lei Chuanwu Yang Luping Du Xiaocong yuan Nanophotonics Research Centre Shenzhen Key Laboratory of Micro-Scale Optical Information TechnologyShenzhen University

The digital micro-mirror device(DMD)-based optical switch has the advantages of high-speed channels reallocation, miniaturization, stability, and large capacity for short reach optical communication in the ***, thermal turbulent atmosphere in the datacenter would cause perturbations and channel crosstalk for the optical switch. The self-healing optical beams such as the Bessel beams have the non-diffraction property to mitigate the turbulence issue. Here, we propose and demonstrate a Bessel beams enabled DMD-based optical switch to improve the stability and performance of optical communication in turbulent atmosphere. We statistically characterize the beam wanders of the Gaussian and Bessel beams in turbulent atmosphere at temperatures of 60°C and 80°C. We build the two-channel optical switch communication system and measure the bit error rate of the 15 Gbit/s on–off keying signals transmitted by the Gaussian and Bessel beams at temperatures of 60°C and 80°C, respectively. The optical switch using the Bessel beams shows lower bit error rates with weaker fluctuations compared with the Gaussian beams. The DMD-based optical switch using the Bessel beams has the potential for practical optical communication applications in the datacenter.

关键词： Beam wander optical switch Bessel beams

南充市饮用水源地水质总放射性水平分布特征与健康评价

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四川环境 2024年第1期43卷 140-145页

作者：吴雪梅田静袁姁李红英鲁朝旭王素华谢怡卿四川省南充生态环境监测中心站四川南充637000

为建立饮用水源地水体放射性水平基线,评估水体辐射安全状况,对2019年南充市9处饮用水源地水质总放射性水平进行了监测,分析了时空变化趋势,并估算了水体核素所致内照射年有效剂量,开展了种群患癌风险评估。结果表明,南充市饮用水源地... 详细信息

为建立饮用水源地水体放射性水平基线,评估水体辐射安全状况,对2019年南充市9处饮用水源地水质总放射性水平进行了监测,分析了时空变化趋势,并估算了水体核素所致内照射年有效剂量,开展了种群患癌风险评估。结果表明,南充市饮用水源地水质总α、总β活度浓度范围分别为8.4~46.8mBq/L与37.9~168.7 mBq/L,数值时空变化趋势明显,与水体核素自然分布、水质环境、地表径流等因素有关。水体核素所致内照射年有效剂量估算的范围在4.39×10^(-2)~6.86×10^(-2)mSv/a,种群患癌风险几率的范围在2.41×10^(-6)~3.77×10^(-6)。分析得出,水质总放射性水平总体达标,剂量估算水平与患癌风险几率均处于正常水平,其数据可为应对环境突发事件、环境质量评价与水质指标预测评价提供依据。

关键词：水质总α、总β活度浓度时空变化趋势年有效剂量种群患癌风险

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