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基于ROCCIPI框架的广西老龄事业发展问题识别及对策研究

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中国公共卫生管理 2024年第1期40卷 81-84页

作者：苏金婷谢琳艺何慧敏广西医科大学信息与管理学院广西南宁530000

人口老龄化背景下,利用ROCCIPI分析框架剖析广西老龄事业发展的机遇和挑战,针对老龄事业发展中老年群体养老健康需求评估制度不完善、专业人才匮乏、养老服务供给短缺、社会参与度不高等问题,从健全老龄政策、培育和发展新产业新技术、... 详细信息

人口老龄化背景下,利用ROCCIPI分析框架剖析广西老龄事业发展的机遇和挑战,针对老龄事业发展中老年群体养老健康需求评估制度不完善、专业人才匮乏、养老服务供给短缺、社会参与度不高等问题,从健全老龄政策、培育和发展新产业新技术、加快资源整合、优化老年友好型社会四个方面提出新时期广西老龄事业进一步发展的对策建议,以期在人口老龄化严重、经济不发达的双重压力下,为促进广西经济发展寻找新的突破口。

关键词：老龄事业 ROCCIPI分析框架问题识别广西

听神经病患者畸变产物耳声发射在自然病程中的变化研究

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中华耳鼻咽喉头颈外科杂志 2024年第5期59卷 423-431页

作者：陈姿伊王洪阳兰兰谢林怡李进李丹阳武凯丽施韬王秋菊浙江中医药大学医学技术与信息工程学院杭州310053 中国人民解放军总医院第六医学中心耳鼻咽喉头颈外科医学部耳鼻咽喉内科北京100048 听觉与平衡觉全国重点实验室、国家耳鼻咽喉疾病临床医学研究中心北京100853

目的:探究听神经病(auditory neuropathy,AN)患者畸变产物耳声发射(DPOAE)的特征,分析影响DPOAE各频率引出率、各耳引出率以及自然病程中首末诊引出率变化的因素。方法:研究对象来自于听神经病临床诊断和干预多中心研究(注册号:ChiCTR21... 详细信息

目的:探究听神经病(auditory neuropathy,AN)患者畸变产物耳声发射(DPOAE)的特征,分析影响DPOAE各频率引出率、各耳引出率以及自然病程中首末诊引出率变化的因素。方法:研究对象来自于听神经病临床诊断和干预多中心研究(注册号:ChiCTR2100050125),AN诊断标准依照2022年中国听神经病临床实践指南。筛选行2次及以上DPOAE测试的双侧AN患者,按照发现年龄分为婴幼儿组(≤3岁)和非婴幼儿组(>3岁),分析入组患者DPOAE各频率引出率、各耳引出率以及自然病程中引出率变化的趋势,并探索其相关影响因素。采用SPSS 26.0软件进行数据处理和分析。结果:共纳入165例(330耳)AN患者,总体DPOAE首诊各耳引出率为77.0%±29.4%,末诊各耳引出率为65.1%±35.2%,其中171耳(51.8%)引出率降低。婴幼儿组共49例(98耳),其中男28例、女性21例,发现年龄0~3岁,中位数0.7岁;DPOAE首诊各耳引出率为57.9%±35.5%,末诊各耳引出率为32.4%±32.1%,69耳(70.4%)引出率降低。非婴幼儿组共116例(232耳),其中男59例、女57例,发现年龄3.9~40岁,中位数14岁;DPOAE首诊各耳引出率为84.6%±23.4%,末诊各耳引出率为78.3%±27.1%,102耳(44.0%)引出率降低。经多分类无序logistic回归分析,发现年龄与DPOAE变化率具有相关性(B=-0.224,OR=0.799,P<0.001)。结论:AN患者DPOAE的引出率会随着病程的增加而降低甚至消失;婴幼儿AN患者DPOAE引出率低于非婴幼儿AN患者。随着病程进展,婴幼儿AN患者DPOAE引出率下降幅度高于非婴幼儿AN患者。故临床上应充分结合DPOAE和耳蜗微音器电位结果进行精准诊断,定期随访,了解其自然病程,给予个性化指导与帮助。

关键词：听神经病畸变产物耳声发射发病年龄

Roll angle of autocollimator measurement method based on hollow cube corner reflector

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Optoelectronics Letters 2022年第2期18卷 91-96页

作者： LIU Yu ZHEN Yan xie linyi WANG Wei YANG Jiawen LI Renpu Chongqing Engineering Research Center of Intelligent Sensing Technology and Microsystem Chongqing University of Post and TelecommunicationsChongqing 400065China School of Biology Chongqing University of Posts and TelecommunicationsChongqing 400065China

In this paper, a method of measuring roll angle with hollow cube corner reflector(HCCR) is proposed. Firstly, the space coordinate vector relationship between the mirror and the autocollimator is established by using the Euler rotation relationship, and the structure of the HCCR is designed. Secondly, through the actual measurement of the HCCR reflector’s angle sensitivity, the specific formula of roll angle measurement is obtained. The experimental results show that the method can be used to measure the roll angle, and the maximum root mean square(RMS) error is 15" in the range of 350", and the repeatability of the experiment is better than 2.7". On the basis of retaining the traditional autocollimator, the plane mirror is replaced with HCCR, which realizes the measurement of the roll angle of the autocollimator. This method does not change the internal structure of the autocollimator system, and there is no process error caused by special processing technology, so as to retain the autocollimator’s own long measurement distance, high measurement accuracy, high system stability, and large range of measurement performance, and it can also be used in industrial production.

关键词： tor angle mirror

Paving continuous heat dissipation pathways for quantum dots in polymer with orangeinspired radially aligned UHMWPE fibers

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Opto-Electronic Advances 2024年第7期7卷 27-38页

作者： Xuan Yang Xinfeng Zhang Tianxu Zhang linyi Xiang Bin xie Xiaobing Luo School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan 430074China School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China

Thermal management of nanoscale quantum dots(QDs)in light-emitting devices is a long-lasting *** existing heat transfer reinforcement solutions for QDs-polymer composite mainly rely on thermal-conductive ***,this strategy failed to deliver the QDs’heat generation across a long distance,and the accumulated heat still causes considerable temperature rise of QDs-polymer composite,which eventually menaces the performance and reliability of lightemitting *** by the radially aligned fruit fibers in oranges,we proposed to eliminate this heat dissipation challenge by establishing long-range ordered heat transfer pathways within the QDs-polymer *** molecular weight polyethylene fibers(UPEF)were radially aligned throughout the polymer matrix,thus facilitating massive efficient heat dissipation of the *** a UPEF filling fraction of 24.46 vol%,the in-plane thermal conductivity of QDs-radially aligned UPEF composite(QDs-RAPE)could reach 10.45 W m^(−1) K^(−1),which is the highest value of QDs-polymer composite reported so *** a proof of concept,the QDs’working temperature can be reduced by 342.5℃ when illuminated by a highly concentrated laser diode(LD)under driving current of 1000 mA,thus improving their optical *** work may pave a new way for next generation high-power QDs lighting applications.

关键词： quantum dots UHMWPE fibers radial alignment heat dissipation light-emitting devices

A novel de novo mutation of ACTG1 in two sporadic non-syndromic hearing loss cases

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Science China(Life Sciences) 2018年第6期61卷 729-732页

作者： Hongyang Wang Jing Guan Lan Lan Lan Yu linyi xie Xu Liu Ju Yang Cui Zhao Dayong Wang Qiuju Wang Chinese PLA Institute of Otolaryngology Chinese PLA General Hospital Medical School of Chinese PLA Beijing 100853 China Beijing Centre for Physical and Chemical Analysis Beijing 100089 China

Dear Editor,Actins are a family of essential cytoskeletal proteins involved in nearly all cellular processes（Lambrechts et al.,2004）.Of the six human genes that encode actins,only ACTG1and ACTB are ubiquitously ***1（OMIM#604717）,which is linked to the DFNA20/26 locus,wasidentified in autosomal dominant, non-syndromic hearing loss （NSHL） cases （Baek et al., 2012; Liu et al., 2008; Park et al., 2013; Yuan et al., 2016）. In addition, some ACTG1 （OMIM #614583） mutations are associated with Baraitser-Winter syndrome, which is characterized by developmental delay, facial dysmorphologies, brain malformations, colobomas, and variable hearing loss （Riviere et al., 2012）.

关键词： A novel de novo mutation of ACTG1 in two sporadic non-syndromic hearing loss cases

半透明玻璃管束吸热芯聚集太阳光传输特性分析

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太阳能学报 2020年第7期41卷 222-226页

作者：戴贵龙夏雨婷谢林毅张慈枝福建工程学院建筑新能源与节能福建省高校重点实验室福州350118

为研究石英玻璃管束吸热芯对聚集太阳光的传输穿透性能,建立石英玻璃管束吸热芯多表面界面反射、折射和介质吸收光路传播模型。采用动态包覆面蒙特卡洛射线踪迹法(MCRTM)加速算法,模拟分析聚集太阳光束在石英玻璃管束吸热芯的传输过程,... 详细信息

为研究石英玻璃管束吸热芯对聚集太阳光的传输穿透性能,建立石英玻璃管束吸热芯多表面界面反射、折射和介质吸收光路传播模型。采用动态包覆面蒙特卡洛射线踪迹法(MCRTM)加速算法,模拟分析聚集太阳光束在石英玻璃管束吸热芯的传输过程,考虑玻璃光束倾斜角度、结构参数和聚集太阳光集中度等因素对聚集太阳光辐射传输性质的影响。结果表明石英玻璃管束吸热芯(长度5 cm,壁厚0.4 mm)对聚集太阳光的吸收比低于5%,是一种较为理想的低吸收换热芯材料,此结论为半透明玻璃管束吸热芯的创新发展提供了参考依据。

关键词：太阳辐射能吸热器光学透过比吸收比数值模拟

A Novel Homozygous Missense Mutation and A Compound Heterozygous Frameshift Mutations of PDZD7 Gene Identified in Two Chinese Families with Nonsyndromic Hearing Loss.

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A Novel Homozygous Missense Mutation and A Compound Heterozy...

Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment

中华医学会第十五次全国医学遗传学学术会议暨中国医师协会医学遗传医师分会第一届全国学术会议暨2016年浙江省医学遗传学年会

作者： Guan Jing Wang Dayong Wang Hongyang xie linyi Yang Ju Zhao Cui Lan Lan Yin Zifang Wang Qiuju Department of Otolaryngology-Head and Neck Surgery Chinese PLA Institute of Otolaryngology Chinese PL A General Hospital

Objective To investigate the genetic etiology of two non-consanguineous Chinese families with a utosomal recessive non-syndromic hearing loss(ARNSHL). Method Two Chinese ARNSHL families with two affected siblings were recruited in this study. Th e families were analyzed for exons, splicing sites and immediate flanking intron sequences by tar geted region capture and high throughput sequencing. Furthermore, 1751 normal Chinese individ uals served as controls and 122 Chinese families segregating apparent ARNSHL, who have been previously excluded common deafness genes, were ascertained for screening candidate mutation s. Result We identified a novel homozygous missense mutation(***66 Leu) and novel compound heterozygous frameshift mutations(***56 fs Ter24 and ***403 fs Ter36) in the both families. W e screened 1751 normal Chinese individuals and 122 unrelated Chinese families segregating app arent ARNSHL failed to detect the three confirmatory mutations. Conclusion We report novel biallelic mutations in PDZD, which is the first study to identify PDZD7 as the ARNSHL-associated gene in Chinese population. Our finding could expand the pathoge nic spectrum and strengthens the role of PDZD7 biallelic mutations cause ARNSHL.

关键词：

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Science China(Life Sciences) 2015年第9期58卷 829-838页

作者： XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing xie linyi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu Department of Otolaryngology-Head and Neck Surgery Chinese PLA Institute of Otolaryngology Chinese PLA General Hospital Center for Reproductive Medicine Shandong Provincial Hospital Affiliated to Shandong University National Research Center for Assisted Reproductive Technology and Reproductive Genetics BGI-Shenzhen Department of Ultrasonography Chinese PLA General Hospital Department of Obstetrics and Gynecology Chinese PLA General Hospital The Key laboratory for Reproductive Endocrinology of Ministry of Education

A couple with a proband child of GJB2 （encoding the gap junction protein connexin 26）-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a cus- tomized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagno- sis （PGD）, noninvasive prenatal testing （NIPT）, and noninvasive prenatal diagnosis （N1PD） into the strategy. Auditory and ge- netic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2c.235delC heterozygous embryo resulted in a sin- gleton pregnancy. At the 13th week of gestation, genomic DNA （gDNA） from the trio family and cell-free DNA （cfDNA） from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by inva- sire procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing im- pairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders.

关键词： preimplantation genetic diagnosis(PGD) noninvasive prenatal testing(NIPT) noninvasive prenatal diagnosis(NIPD) GJB2(encoding the

不同发病年龄听神经病患者的听力学转归与随访方案优化

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中华耳科学杂志 2022年第2期20卷 193-198页

作者：谢林怡王秋菊熊芬刘志成首都医科大学生物医学工程学院北京100069 解放军总医院耳鼻咽喉头颈外科医学部国家耳鼻咽喉疾病临床医学研究中心北京100853

目的分析青少年和成人发病听神经病患者(Auditory Neuropathy, AN)的听力学特征,总结不同发病年龄AN患者的听力转归情况,并对随访方案进行优化。方法门诊确诊为AN的30例(60耳)成人患者和54例(108耳)青少年患者,分析其首诊及复诊的听... 详细信息

目的分析青少年和成人发病听神经病患者(Auditory Neuropathy, AN)的听力学特征,总结不同发病年龄AN患者的听力转归情况,并对随访方案进行优化。方法门诊确诊为AN的30例(60耳)成人患者和54例(108耳)青少年患者,分析其首诊及复诊的听力学特征。检测项目包括:纯音测听、言语识别率、声导抗、听性脑干反应(Auditory Brainstem Response,ABR)、畸变产物耳声发射(Distortion Product Otoacoustic Emission, DPOAE)。结果不同发病年龄AN听力学特征转归情况:(1)纯音听阈:首诊和复诊中成人组的纯音听阈均比青少年组更低;青少年组患者复诊与首诊相比,除250、1000 Hz外,其他频率复诊较首诊升高;成人组患者复诊与首诊相比,除250、2000、4000 Hz外,其他频率复诊较首诊升高;(2)镫骨肌反射引出率:青少年组首诊有9耳(8.3%)部分频率引出,复诊有3耳(2.8%)部分频率引出;成人组镫骨肌反射测试首诊有5耳(8.3%)部分频率引出,复诊有4耳(6.7%)部分频率引出;(3)言语识别率:青少年组复诊相比首诊下降,成人组首复诊无显著差异;(4)ABR:青少年组首诊中有4耳引出反应,成人组首诊中有5耳引出反应,两组患者复诊ABR引出率均下降;(5)DPOAE:两组患者复诊全频引出率降低。结论成人组在首诊和随访中的纯音听阈均比青少年组低,且言语识别率在随访中下降较明显。青少年患者发现听力下降或言语识别不清应及时就诊,以便及时采取干预措施。优化后的随访方案对AN患者的复诊有所帮助,提高了患者的复诊效率以及复诊意愿。

关键词：青少年成人听神经病听力学特征随访方案