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Reference values of gait parameters in healthy Chinese university students: A cross-sectional observational study

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World Journal of Clinical Cases 2023年第29期11卷 7061-7074页

作者： jin-Sheng Yu Chen Zhuang Wen-Xuan Guo jun-jie Chen Xiang-Ke wu wei xie xing Zhou Hui Su Yi-Xuan Chen li-Kang Wang Wen-Kai li Kun Tian Ru-jie Zhuang The First School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhejiang Chinese Medical UniversityZhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310003Zhejiang ProvinceChina Alberta Institute Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Gait is influenced by race,age,and diseases *** values for gait are closely related to numerous health *** gain a comprehensive understanding of gait patterns,particularly in relation to race-related pathologies and disorders,it is crucial to establish reference values for gait in daily life considering sex and ***,our objective was to present sex and age-based reference values for gait in daily life,providing a valuable foundation for further research and clinical *** To establish reference values for lower extremity joint kinematics and kinetics during gait in asymptomatic adult women and *** Spatiotemporal,kinematics and kinetics parameters were measured in 171 healthy adults(70 males and 101 females)using the computer-aided soft tissue foot *** curve statistical parametric mapping was performed using independent and paired-samples *** Compared with females,males required more time(cycle time,double-limb support time,stance time,swing time,and stride time),and the differences were statistically *** addition,the step and stride lengths of males were *** to males,female cadence was faster,and statures-per-second and stride-per-minute were *** were no statistical differences in speed and stride width between the two *** adjusting for height,it was observed that women walked significantly faster than men,and they also had a higher ***,in terms of step length,stride length,and stride width,both genders exhibited *** We established reference values for gait speed and spatiotemporal gait parameters in Chinese university *** contributes to a valuable database for gait assessment and evaluation of preventive or rehabilitative programs.

关键词： Gait analysis Gait Reference values Spatiotemporal parameters Kinematics Chinese

The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST

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Research in Astronomy and Astrophysics 2019年第11期19卷 33-48页

作者： Bo Chen Hui li Ke-Fei Song Quan-feng Guo Pei-jie Zhang ling-Ping He Shuang Dai Xiao-Dong Wang Hai-feng Wang Chun-Long liu Hong-ji Zhang Guang Zhang Yunqi Wang Shi-jie liu Hong-Xin Zhang Lei liu Shi-Lei Mao Yang liu jia-Hao Peng Peng Wang liang Sun Yang liu Zhen-wei Han Yan-Long Wang Kun wu Guang-xing Ding Peng Zhou Xin zheng Ming-Yi Xia Qing-Wen wu jin-jiang xie Ya Chen Shu-Mei Song Hong Wang Bo Zhu Chang-Bo Chu Wen-Gang Yang li feng Yu Huang wei-Qun Gan Ying li jing-wei li Lei Lu jian-Chao Xue Bei-li Ying Ming-Zhe Sun cheng Zhu wei-Min Bao Lei Deng Zeng-Shan Yin Changchun Institute of Optics FineMechanics and PhysicsChinese Academy of SciencesChangchun 130033China State Key Laboratory of Applied Optics Changchun 130033China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China Shandong University Weihai 264209China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201210China

As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,*** maximum exposure time can be up to20 s due to precise pointing and image stabilization *** the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attainline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal *** present the up-to-date design for the LST payload.

关键词： telescopes—instrumentation high angular resolution—Sun flares—Sun coronal mass ejections(CMEs)—Sun UV radiation

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen jing-Yu Tang Rui-Rui Fan Qiang li Gong li Dong liu zheng-Yao jin xing-Zhu Cui Tian-Xiang Chen Yi-wei Yang Rong liu Han Yi Yang li Zhen Yang Qi An Hao-Fan Bai jiang-Bo Bai jie Bao Ping Cao Qi-Ping Chen Zhen Chen Zeng-Qi Cui An-Chuan Fan Chang-Qing feng Fan-Zhen feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-jie Han Guo-Zhu He Yong-cheng He Yang Hong Yi-wei Hu Han-Xiong Huang wei-Hua jia Hao-yu jiang wei jiang Zhi-jie jiang ling Kang Bo li Chao li jia-Wen li Xiao li jie liu Shu-Bin liu Guang-Yuan Luan Chang-jun Ning Bin-Bin Qi jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Xin Tan li-jiao Wang Peng-cheng Wang Zhao-Hui Wang Zhong-wei Wen Xiao-Guang wu Xuan wu li-Kun xie Yong-ji Yu Guo-Hui Zhang lin-Hao Zhang Mo-Han Zhang Qi-wei Zhang Xian-Peng Zhang Yu-liang Zhang yue Zhang Zhi-Yong Zhang Mao-Yuan Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

Coexistence of multiple coronaviruses in several bat colonies in an abandoned mineshaft

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Virologica Sinica 2016年第1期31卷 31-40页

作者： xing-Yi Ge Ning Wang wei Zhang Ben Hu Bei li Yun-Zhi Zhang ji-Hua Zhou Chu-Ming Luo xing-Lou Yang li-jun wu Bo Wang Yun Zhang Zong-Xiao li zheng-li Shi Key Laboratory of Special Pathogens Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention Yunnan Institute of Endemic Diseases Control and PreventionDali 671000China School of Public Health Dali UniversityDali 671000China Mojiang Center for Diseases Control and Preventionl Mojiang 654800 China

Since the 2002–2003 severe acute respiratory syndrome(SARS) outbreak prompted a search for the natural reservoir of the SARS coronavirus, numerous alpha- and betacoronaviruses have been discovered in bats around the world. Bats are likely the natural reservoir of alpha- and betacoronaviruses, and due to the rich diversity and global distribution of bats, the number of bat coronaviruses will likely increase. We conducted a surveillance of coronaviruses in bats in an abandoned mineshaft in Mojiang County, Yunnan Province, China, from 2012–2013. Six bat species were frequently detected in the cave: Rhinolophus sinicus, Rhinolophus affinis, Hipposideros pomona, Miniopterus schreibersii, Miniopterus fuliginosus, and Miniopterus fuscus. By sequencing PCR products of the coronavirus RNA-dependent RNA polymerase gene(Rd Rp), we found a high frequency of infection by a diverse group of coronaviruses in different bat species in the mineshaft. Sequenced partial Rd Rp fragments had 80%–99% nucleic acid sequence identity with well-characterized Alphacoronavirus species, including Bt CoV HKU2, Bt CoV HKU8, and Bt CoV1,and unassigned species Bt CoV HKU7 and Bt CoV HKU10. Additionally, the surveillance identified two unclassified betacoronaviruses, one new strain of SARS-like coronavirus, and one potentially new betacoronavirus species. Furthermore, coronavirus co-infection was detected in all six bat species, a phenomenon that fosters recombination and promotes the emergence of novel virus strains. Our findings highlight the importance of bats as natural reservoirs of coronaviruses and the potentially zoonotic source of viral pathogens.

关键词： coronavirus bat coinfection mineshaft

Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang li li‑jiao Wang Xiang‑Biao Qiu jing‑Wen li wei Xu Tao li Ze‑Bin lin Chang‑jun Ning Yong‑Hao Chen Rui‑Rui Fan Kang Sun jing‑Yu Tang Rong Zhang Han‑Tao jing Bo Mei Qi An Hao‑Fan Bai jiang‑Bo Bai jie Bao Ping Cao Qi‑Ping Chen Zhen Chen Zeng‑Qi Cui An‑Chuan Fan Chang‑Qing feng Fan‑Zhen feng Ke‑Qing Gao Min‑Hao Gu Chang‑Cai Han Zi‑jie Han Guo‑Zhu He Yong‑cheng He Yang Hong Yi‑wei Hu Han‑Xiong Huang wei‑Hua jia Hao‑Yu jiang wei jiang Zhi‑jie jiang zheng‑Yao jin ling Kang Bo li Chao li Gong li jia‑Wen li Xiao li Yang li jie liu Rong liu Shu‑Bin liu Guang‑Yuan Luan Bin‑Bin Qi jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑cheng Wang Zhao‑Hui Wang Zhong‑wei Wen Xiao‑Guang wu Xuan wu li‑Kun xie Yi‑wei Yang Han Yi Yong‑ji Yu Guo‑Hui Zhang lin‑Hao Zhang Mo‑Han Zhang Qi‑wei Zhang Xian‑Peng Zhang Yu‑liang Zhang yue Zhang Zhi‑Yong Zhang Mao‑Yuan Zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients

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Science China(life Sciences) 2016年第9期59卷 930-939,938-939+932-937页

作者： jin liu lingling Bian li ji Yang Chen Heng Chen Yong Gu Bingqin Ma wei Gu Xinyu Xu Yun Shi jian Wang Dalong Zhu Zilin Sun jianhua Ma Hui jin xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi wei Tang wei li Dongmei Zhou jun liang xingbo cheng Bimin Shi jixiang Dong ji Hu Chen Fang Shao Zhong weinan Yu weiping Lu chenguang wu li Qian jiancheng Yu jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui jinluo cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun xie Minmin An wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai zheng Fan Yang Qingfang Hu Hao Dai Yu jin zheng Zhang Kuanfeng Xu Yifan li jie Shen Hongwen Zhou wei He Xuqin zheng Xiao Han liping Yu jinxiong She Mei Zhang Tao Yang Department of Endocrinology and Metabolism First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China Barbara Davis Center for Childhood Diabetes University of Colorado Denver Aurora Colorado 80045 USA Key Laboratory of Human Functional Genomics of jiangsu Province Nanjing Medical University Nanjing 210000 China Department of Isotopic Laboratory of Nanjing Medical University Nanjing 210000 China HLA Laboratory of jiangsu Province People's Hospital Nanjing 210029 China Department of Endocrinology and Metabolism Nanjing General Hospital of Nanjing Military Command Nanjing 210002 China Department of Endocrinology and Metabolism Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing 210008 China Department of Endocrinology and Metabolism Zhongda Hospital Southeast University Nanjing 210009 China Department of Endocrinology and Metabolism Nanjing First Hospital Nanjing 210000 China Department of Endocrinology and Metabolism Nanjing Children's Hospital Nanfing 210008 China Department of Endocrinology and Metabolism The Second Affiliated Hospital of Nanjing Medical University Nanjing 210011 China Department of Endocrinology and Metabolism Nanjing Governmental Hospital Nanjing 210008 China Department of Endocrinology and Metabolism Northern Jiangsu People's Hospital Yangzhou 225001 China Department of Endocrinology and Metabolism Wuxi People's Hospital Wuxi 214023 China Department of Endocrinology and Metabolism Jiangsu Jiangyin People's Hospital Wuxi 214400 China Department of Endocrinology and Metabolism The Affiliated Hospital of Xuzhou Medical College Xuzhou 221006 China Department of Endocrinology and Metabolism Xuzhou Central Hospital Xuzhou 221009 China Department of Endocrinology and Metabolism The First Affiliated Hospital of Soochow University Suzhou 215006 China Department of Endocrinology and Metabolism The Second Affiliated Hospital of Soochow University Suzhou 215004 China Department of Endocri

Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus.

关键词： autoantibodies heterogeneity islet failure type 1 diabetes

Solar X-ray and EUV imager on board the FY-3E satellite

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light(Science & Applications) 2022年第12期11卷 2939-2951页

作者： Bo Chen Xiao-Xin Zhang ling-Ping He Ke-Fei Song Shi-jie liu Guang-xing Ding jin-Ping Dun jia-wei li Zhao-Hui li Quan-feng Guo Hai-feng Wang Xiao-Dong Wang Yun-Qi Wang Hong-ji Zhang Guang Zhang Zhen-wei Han Shuang Dai Pei-jie Zhang liang Sun Yang liu software engineer Peng Wang Kun wu Chen Tao Shi-Lei Mao Gui Mei liang Yang li-Heng Chen Chun-Yang Han Bin Huang Yang liu mechanical engineer Shuai Ren Peng Zhou Ze-Xiwei Xiao-Xue Zhang yue Zhang Xin zheng Yang Wang Ya Chen jing-jiang xie Fei He Qiao Song wei-Guo Zong Xiu-Qing Hu Peng Zhang jing-Song Wang Zhong-Dong Yang Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina State Key Laboratory of Applied Optics Chinese Academy of SciencesChangchunChina National Satellite Meteorological Center China Meteorological AdministrationBeijingChina Key Laboratory of Space Weather National Center for Space WeatherChina Meteorological AdministrationBeijingChina Innovation Center for fengyun Meteorological Satellite(FYSIC) BeijingChina Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijingChina

The solar X-ray and Extreme Ultraviolet Imager(X-EUVI),developed by the Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences(CIOMP),is the first space-based solar X-ray and Extreme ultraviolet(EUV)imager of China loaded on the fengyun-3E(FY-3E)satellite supported by the China Meteorological Administration(CMA)for solar *** started work on July 11,2021,X-EUVI has obtained many solar *** instrument employs an innovative dual-band design to monitor a much larger temperature range on the Sun,which covers 0.6-8.0 nm in the X-ray region with six channels and 19.5 nm in the EUV region.X-EUVI has a field of view of 42′,an angular resolution of 2.5″per pixel in the EUV band and an angular resolution of 4.1″per pixel in the X-ray *** instrument also includes an X-ray and EUV irradiance sensor(X-EUVS)with the same bands as its imaging optics,which measures the solar irradiance and regularly calibrates the solar *** radiometric calibration of X-EUVS on the ground has been completed,with a calibration accuracy of 12%.X-EUVI is loaded on the FY-3E satellite and rotates relative to the Sun at a uniform ***-field calibration is conducted by utilizing successive rotation solar *** agreement between preliminarily processed X-EUVI images and SDO/AIA and Hinode/XRT images indicates that X-EUVI and the data processing algorithm operate properly and that the data from X-EUVI can be applied to the space weather forecast system of CMA and scientific investigations on solar activity.

关键词： image instrument Solar

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-liang li Ming-Sheng Huang wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong jun-Hui Sun Zhi-cheng jin jian-jian Chen Nai-jian Ge Wen-Bin Ding Wen-Hui li jin-Hua Huang wei Mu Shan-Zhi Gu jia-Ping li Hui Zhao Shu-wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan wei-Dong Wang Ming Huang wei Zhao jian-Bing wu Song Wang Xu Zhu jian-jun Han wei-Xin Ren Zai-Ming Lu Wen-Ge xing Yong Fan Hai-Lan lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang jin-wei Zhao Ai-Bing Xu jian Xu Qing-Hua wu Huan-Zhang Niu jian Wang feng Dai Dui-Ping feng Qing-Dong li Rong-Shu Shi jia-Rui li Guang Yang Hai-Bin Shi jian-Song ji Yu-E liu zheng Cai Po Yang Yang Zhao Xiao-li Zhu li-Gong Lu Gao-jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

Evolution of incommensurate superstructure and electronic structure with Pb substitution in(Bi2-xPbx)Sr2CaCu2O8+δ superconductors

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Chinese Physics B 2019年第7期28卷 102-110页

作者： jing liu lin Zhao Qiang Gao Ping Ai Lu Zhang Tao xie( jian-wei Huang Ying Ding cheng Hu Hong-Tao Yan Chun-Yao Song Yu Xu Cong li Yong-Qing Cai Hong-Tao Rong Ding-Song wu Guo-Dong liu Qing-Yan Wang Yuan Huang feng-feng Zhang feng Yang Qin-jun Peng Shi-liang li Huai-Xin Yang jian-Qi li Zu-Yan Xu xing-jiang Zhou Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China Songshan Lake Materials Laboratory Dongguan 523808 China Collaborative Innovation Center of Quantum Matter Beijing 100871 China

High-quality Bi2-xPbxSr2 CaCu2O8+δ(Bi2212) single crystals have been successfully grown by the traveling solvent floating zone technique with a wide range of Pb substitution(x = 0–0.8).The samples are characterized by transmission electron microscope(TEM) and measured by high resolution laser-based angle-resolved photoemission spectroscopy(ARPES) with different photon energies.A systematic evolution of the electronic structure and superstructure with Pb substitution has been revealed for the first *** superstructure shows a significant change with Pb substitution and the incommensurate modulation vector(Q) decreases with increasing Pb *** the meantime, the superstructure intensity from ARPES measurements also decreases dramatically with increasing Pb *** superstructure in Bi2212 can be effectively suppressed by Pb substitution and it nearly disappears with a Pb substitution of x = *** also find that the superstructure bands in ARPES measurements depend sensitively on the photon energy of lasers used;they can become even stronger than the main band when using a laser photon energy of 10.897 *** results provide important information on the origin of the incommensurate superstructure and its control and suppression in bismuth-based high temperature superconductors.

关键词： Bi2-xPbxSr2CaCu2O8+δ superstructure electronic structure angle-resolved photoemission spectroscopy(ARPES) modulation