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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-Jia Chen xin-Ning Yu hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

Effect of strain rate on the compressive deformation behaviors of lotus-type porous copper

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International Journal of Minerals,Metallurgy and Materials 2014年第7期21卷 687-695页

作者： xin-hua Liu Hai-you huang Jian-xin xie Institute for advanced Materials and Technology University of Science and Technology Beijing Key Laboratory for Advanced Materials Processing(MOE) University of Science and Technology Beijing

Lotus-type porous copper was fabricated by unidirectional solidification, and compressive experiments were subsequently conducted in the strain rate range of 10-3-2400 s-1 with the compressive direction parallel to the pores. A GLEEBLE-1500 thermal-mechanical simulation system and a split Hopkinson pressure bar （SHPB） were used to investigate the effect of strain rate on the compressive deforma-tion behaviors of lotus-type porous copper. The influence mechanism of strain rate was also analyzed by the strain-controlling method and by high-speed photography. The results indicated that the stress-strain curves of lotus-typed porous copper consist of a linear elastic stage, a plateau stage, and a densification stage at various strain rates. At low strain rate （〈1.0 s^-1）, the strain rate had little influence on the stress-strain curves; but when the strain rate exceeded 1.0 s^-1, it was observed to strongly affect the plateau stage, showing obvious strain-rate-hardening characteristics. Strain rate also influenced the densification initial strain. The densification initial strain at high strain rate was less than that at low strain rate. No visible inhomogeneous deformation caused by shockwaves was observed in lotus-type porous copper during high-strain-rate deformation. However, at high strain rate, the bending deformation characteristics of the pore walls obviously differed from those at low strain rate, which was the main mechanism by which the plateau stress exhibited strain-rate sensitivity when the strain rate exceeded a certain value and exhibited less densification initial strain at high strain rate.

关键词： porous materials copper directional solidification strain rate sensitivity deformation modes stress-strain curves

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大米淀粉提取及黏滞性研究

广东农业科学 2006年第12期33卷 11-13页

作者：谢新华李晓方肖昕刘志霞广东省农科院水稻研究所

用NaOH溶液浸泡米粉去除蛋白质提取大米淀粉的试验结果表明,在0.2%NaOH溶液、固液比1:4、浸泡2h的最佳提取条件下,淀粉中的蛋白质含量为0.453%、淀粉得率为74.2%。采用快速粘度分析仪测定以烘箱法和真空冷冻干燥法所得淀粉的黏滞性谱,... 详细信息

用NaOH溶液浸泡米粉去除蛋白质提取大米淀粉的试验结果表明,在0.2%NaOH溶液、固液比1:4、浸泡2h的最佳提取条件下,淀粉中的蛋白质含量为0.453%、淀粉得率为74.2%。采用快速粘度分析仪测定以烘箱法和真空冷冻干燥法所得淀粉的黏滞性谱,结果显示两种淀粉的黏滞性有一定差异。

关键词：大米淀粉提取黏滞性

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糖对稻米淀粉黏滞性的影响

福建农业学报 2009年第5期24卷 475-477页

作者：谢新华李晓方肖昕刘志霞河南农业大学食品科学技术学院河南郑州450002 广东省农业科学院水稻研究所广东广州510640

利用快速粘度分析仪测定葡萄糖、果糖、麦芽糖和蔗糖对稻米淀粉黏滞性的影响,结果显示:随着糖浓度的增加,稻米淀粉峰值粘度下降;随着葡萄糖、果糖、麦芽糖的增加,黏滞谱特征值的最终粘度、热浆粘度和消减值显著降低,而蔗糖对热浆粘度基... 详细信息

利用快速粘度分析仪测定葡萄糖、果糖、麦芽糖和蔗糖对稻米淀粉黏滞性的影响,结果显示:随着糖浓度的增加,稻米淀粉峰值粘度下降;随着葡萄糖、果糖、麦芽糖的增加,黏滞谱特征值的最终粘度、热浆粘度和消减值显著降低,而蔗糖对热浆粘度基本没有影响;葡萄糖、果糖使崩解值显著增加,而麦芽糖使崩解值先下降后上升,蔗糖使崩解值显著下降;4种糖都使糊化温度显著增加。

关键词：稻米淀粉糖黏滞性

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棕榈酸、油酸对糯米淀粉热特性的影响

食品科学 2013年第21期34卷 20-23页

作者：艾志录陈迪谢新华潘治利王娜索标黄忠民河南农业大学食品科学技术学院河南郑州450002 速冻面米及调制食品河南省工程实验室河南郑州450002 速冻面米及调制食品河南省高校重点实验室培育基地河南郑州450002

利用紫外分光光度计、X射线衍射仪和差示扫描量热仪(DSC)对棕榈酸、油酸与糯米淀粉复合物的性质进行测定。结果表明:棕榈酸和油酸均可与糯米淀粉形成复合物,且棕榈酸比油酸更易于与糯米淀粉复合。随着棕榈酸、油酸用量的增大,复合物形... 详细信息

利用紫外分光光度计、X射线衍射仪和差示扫描量热仪(DSC)对棕榈酸、油酸与糯米淀粉复合物的性质进行测定。结果表明:棕榈酸和油酸均可与糯米淀粉形成复合物,且棕榈酸比油酸更易于与糯米淀粉复合。随着棕榈酸、油酸用量的增大,复合物形成量增多,糯米淀粉的吸光度显著降低;DSC分析表明:添加油酸使糯米淀粉的起始糊化温度、峰值温度以及糊化焓减小,而棕榈酸与糯米淀粉复合物的糊化焓随油脂添加量增加而显著增大。

关键词：糯米淀粉脂肪酸吸光度糊化焓

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烟台威海两地旅游产品整合探讨

云南地理环境研究 2011年第2期23卷 26-30页

作者：于巧红李悦铮谢新华辽宁师范大学城市与环境学院辽宁大连116029 东北财经大学工商管理学院辽宁大连116023

地域资源有限性,市场开放性,需求多样性,选择的自由性等因素决定了一地旅游产品要拥有旺盛生命力,获得可持续发展,与其他地区旅游产品进行整合是必然之选。基于此,在对两地旅游产品现状进行对比分析的基础上,尝试从旅游产品市场、旅游... 详细信息

地域资源有限性,市场开放性,需求多样性,选择的自由性等因素决定了一地旅游产品要拥有旺盛生命力,获得可持续发展,与其他地区旅游产品进行整合是必然之选。基于此,在对两地旅游产品现状进行对比分析的基础上,尝试从旅游产品市场、旅游产品类型结构、区际旅游产品3方面给出了各自的整合对策。

关键词：烟台威海旅游产品整合

冷冻胁迫下金黄色葡萄球菌的亚致死及失活规律

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食品科学 2013年第19期34卷 5-9页

作者：王晓杰王娜宋金丽艾志录谢新华潘治利索标河南农业大学食品科学技术学院河南郑州450002

研究-18℃冷冻贮藏、反复冻融和模拟冷链流通下金黄色葡萄球菌的总活性细胞数目、未受损伤细胞数目以及亚致死率的变化,从而了解冷链流通过程中金黄色葡萄球菌的存在状态。结果表明:-18℃冻藏时,随着贮藏时间的增加,金黄色葡萄球菌总活... 详细信息

研究-18℃冷冻贮藏、反复冻融和模拟冷链流通下金黄色葡萄球菌的总活性细胞数目、未受损伤细胞数目以及亚致死率的变化,从而了解冷链流通过程中金黄色葡萄球菌的存在状态。结果表明:-18℃冻藏时,随着贮藏时间的增加,金黄色葡萄球菌总活性细胞数目逐渐减少,亚致死率逐渐升高,但在冻藏56d后活细胞下降速率明显变缓,说明亚致死细胞具有较强的抗冷冻胁迫能力。在反复冻融条件下,总活性细胞数目和未受损伤细胞数目均有所增加,亚致死率降低,在模拟食品冷链的温度波动条件下,总活性细胞数目明显减少,但未受损细胞数目随着温度的变化而有所波动。说明了亚致死状态是金黄色葡萄球菌冷冻失活的中间过渡状态,在适宜的温度条件下,亚致死细胞会快速恢复为正常状态。这种不可避免的温度波动造成的亚致死修复,以及亚致死细胞的抗冷冻调节能力可能都是冷链流通过程速冻食品中金黄色葡萄球菌屡屡检出的重要原因。

关键词：冷冻胁迫金黄色葡萄球菌速冻食品亚致死

Effects of process parameters on surface quality,composition segregation,microstructure and properties of QSn6.5-0.1 alloy slabs fabricated by HCCM horizontal continuous casting

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Journal of Iron and Steel Research International 2017年第3期24卷 273-281页

作者： Yang Liu xin-hua Liu hua-dong Fu Min-xuan Lou Jian-xin xie Institute for Advanced Materials and Technology University of Science and Technology Beijing Beijing 100083 China

Columnar-grained QSn6. 5-0. 1 alloy slabs with a width of 70 mm and thickness of 10 mm were fabricated by heating-cooling combined mold（ HCCM） horizontal continuous casting. The effects of process parameters on solidification microstructure,surface quality,composition segregation and mechanical properties were studied. The results showed that the slabs with good surface quality,excellent mechanical properties and no obvious segregation could be prepared at the melt casting temperature of 1 250 ℃,the heating-mold temperature of 1 150- 1 200℃,the cooling water flow rate of 600 L / h and the casting speed of 20- 80 mm / min. The slabs had the yield strength of 124- 155 MPa,the elongation rate of 46. 6%- 56. 3% and the surface roughness of 0. 22- 0. 55μm,which enabled them to be directly processed without subsequent milling surface. The ratio of Sn content in the surface to that in the core was 0. 83- 1. 10,with an average value close to 1. 0,and not obviously influenced by process parameters. When the casting speed increased from 20 to 80 mm / min,the grain size changed little if the other process parameters were the same. When the heating-mold temperature increased from 1 150 to 1 200℃,the grain size was obviously refined and became more uniform if the casting speed was the same. Within the range of the casting speed at which the columnar grain structure could be obtained,the columnar grain size was mainly influenced by the heating-mold temperature.

关键词： QSn6.5 copper alloy Heating-cooling combined mold Horizontal continuous casting Microstructure Mechanical property Composition segregation

Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-Han Yu Yi-hua Wang Yi-xin Liu Lu Xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report