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Improving grain yield, nitrogen use efficiency and radiation use efficiency by dense planting, with delayed and reduced nitrogen application, in double cropping rice in South China

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Journal of Integrative Agriculture 2021年第2期20卷 565-580页

作者： FU You-qiang ZHONG Xu-hua ZENG Jia-huan LIANG Kai-ming PAN Jun-feng xin Ying-feng LIU Yan-zhuo HU Xiang-yu PENG Bi-lin CHEN Rong-bing HU Rui huaNG Nong-rong Rice Research Institute Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of New Technology for Rice BreedingGuangzhou 510640P.R.China Guiping Agricultural Technology Extension Station Guiping 537200P.R.China

Improving both grain yield and resource use efficiencies simultaneously is a major challenge in rice ***,few studies have focused on integrating dense planting with delayed and reduced nitrogen application to enhance grain yield,nitrogen use efficiency (NUE) and radiation use efficiency (RUE) in rice (Oryza sativa L.) in the double rice cropping system in South China.A high-yielding indica hybrid rice cultivar (Yliangyou 143) was grown in field experiments in Guangxi,South China,with three cultivation managements:farmers’practice (FP),dense planting with equal N input and delayed N application (DPEN) and dense planting with reduced N input and delayed N application (DPRN).The grain yields of DPRN reached 10.6 and 9.78 t ha^(–1) in the early and late cropping seasons,respectively,which were significantly higher than the corresponding yields of FP by 23.9–29.9%.The grain yields in DPEN and DPRN were *** in DPRN reached 65.2–72.9 kg kg^(–1),which was 61.2–74.1% higher than that in FP and 24.6–30.2% higher than that in *** in DPRN achieved 1.60–1.80 g MJ^(–1),which was 28.6–37.9% higher than that in *** productive tiller percentage in DPRN was 7.9–36.2% higher than that in *** in crop growth rate,leaf area duration,N uptake from panicle initiation to heading and enhancement of the apparent transformation ratio of dry weight from stems and leaf sheaths to panicles all contributed to higher grain yield and higher resource use efficiencies in *** analysis revealed that the agronomic and physiological traits mentioned above were significantly and positively correlated with grain *** trials carried out in Guangdong in 2018 and 2019 also showed that DPRN performed better than *** conclude that DPRN is a feasible approach for simultaneously increasing grain yield,NUE and RUE in the double rice cropping system in South China.

关键词： grain yield resource use efficiencies indica rice planting density nitrogen application strategy

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试析清代缅甸的藩属国地位问题

历史档案 2006年第1期19卷 72-77页

作者：何新华暨南大学东南亚研究所讲师510632

清代文献在对周边国家进行分类时,都把缅甸归类于中国传统的藩属国。清代官方文件乾隆《会典》对此作了总结:“凡四夷朝贡之国,东曰朝鲜,东南曰琉球、苏禄,南曰安南、暹罗,西南曰西洋、缅甸、南掌,皆遣陪臣为使,奉表纳贡来朝”1。作为... 详细信息

清代文献在对周边国家进行分类时,都把缅甸归类于中国传统的藩属国。清代官方文件乾隆《会典》对此作了总结:“凡四夷朝贡之国,东曰朝鲜,东南曰琉球、苏禄,南曰安南、暹罗,西南曰西洋、缅甸、南掌,皆遣陪臣为使,奉表纳贡来朝”1。作为中国的西南邻国,缅甸一直被清政府看作是中?（共6页)

关键词：藩属国缅甸清代地位问题中国传统试析 19世纪末期周边国家中缅关系身份问题

Downregulation of Aquaporin 4 Expression through Extracellular Signal-regulated Kinases1/2 Activation in Cultured Astrocytes Following Scratch-injury

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Biomedical and Environmental Sciences 2015年第3期28卷 199-205页

作者： SHI Zhong Fang ZHAO Wei Jiang XU Li xin DONG Li Ping YANG Shao hua YUAN Fang Department of Pathophysiology Beijing Neurosurgical InstituteBeijing Tiantan HospitalCapital Medical University Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteBeijing Tiantan HospitalCapital Medical University Center for Neuroscience Shantou University Medical College Department of Pharmacology and Neuroscience University of North Texas Health Science Center

Objective To investigate the role of extracellular signal-regulated kinase1/2（ERK1/2） pathway in the regulation of aquaporin 4（AQP4） expression in cultured astrocytes after scratch-injury. Methods The scratch-injury model was produced in cultured astrocytes of rat by a 10-μL plastic pipette tip. The morphological changes of astrocytes and lactate dehydrogenase（LDH） leakages were observed to assess the degree of scratch-injury. AQP4 expression was detected by immunofluorescence staining and Western blot, and phosphorylated-ERK1/2（p-ERK1/2） expression was determined by Western blot. To explore the effect of ERK1/2 pathway on AQP4 expression in scratch-injured astrocytes, 10 μmol/L U0126（ERK1/2 inhibitor） was incubated in the medium at 30 min before the scratch-injury in some groups. Results Increases in LDH leakage were observed at 1, 12, and 24 h after scratch-injury, and AQP4 expression was reduced simultaneously. Decrease in AQP4 expression was associated with a significant increase in ERK1/2 activation. Furthermore, pretreatment with U0126 blocked both ERK1/2 activation and decrease in AQP4 expression induced by scratch-injury. Conclusion These results indicate that ERK1/2 pathway down-regulates AQP4 expression in scratch-injured astrocytes, and ERK1/2 pathway might be a novel therapeutic target in reversing the effects of astrocytes that contribute to traumatic brain edema.

关键词： Astrocytes Aquaporin 4 Scratch-injury Extracellular signal-regulated kinases1/2

Tongxinluo Activates PI3K/AKT Signaling Pathway to Inhibit Endothelial Mesenchymal Transition and Attenuate Myocardial Fibrosis after Ischemia-Reperfusion in Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 608-615页

作者： WEI Ya-ru HOU Yun-long YIN Yu-jie LI Zhen LIU Yi HAN Ning-xin WANG Zi-xuan LIU Lu WANG Xiao-qi HAO Yuan-jie MA Kun GU Jiao-jiao JIA Zhen-hua Graduate School Hebei University of Chinese MedicineShijiazhuang050090China Shijiazhuang Yiling Pharmaceutical New Drug Evaluation Center Shijiazhuang050035China Hebei Institute of Integrated Traditional and Western Medicine Shijiazhuang050035China National Key Laboratory for Innovation and Transformation of Luobing Theory Shijiazhuang050035China Department of Cardiology Hebei Yiling HospitalShijiazhuang050091China Graduate School Hebei Medical UniversityShijiazhuang050017China

Objective To investigate the potential role of Tongxinluo(TXL)in attenuating myocardial fibrosis after myocardial ischemia-reperfusion injury(MIRI)in *** A MIRI mouse model was established by left anterior descending coronary artery ligation for 45 *** to a random number table,66 mice were randomly divided into 6 groups(n=11 per group):the sham group,the model group,the LY-294002 group,the TXL group,the TXL+LY-294002 group and the benazepril(BNPL)*** day after modeling,TXL and BNPL were administered by *** injection of LY-294002 was performed twice a week for 4 consecutive *** was used to measure cardiac function in *** staining was used to evaluate the degree of myocardial fibrosis in *** and quantitative analysis of endothelial mesenchymal transition(EndMT)after MIRI was performed by immunohistochemistry,immunofluorescence staining and flow cytometry,*** protein expressions of platelet endothelial cell adhesion molecule-1(CD31),α-smoth muscle actin(α-SMA),phosphatidylinositol-3-kinase(PI3K)and phospho protein kinase B(p-AKT)were assessed using Western *** TXL improved cardiac function in MIRI mice,reduced the degree of myocardial fibrosis,increased the expression of CD31 and inhibited the expression ofα-SMA,thus inhibited the occurrence of EndMT(P0.05).In addition,the use of the PI3K/AKT pathway-specific inhibitor LY-294002 to block this pathway and combination with TXL intervention,eliminated the protective effect of TXL,further supporting the protective effect of *** TXL activated the PI3K/AKT signaling pathway to inhibit EndMT and attenuated myocardial fibrosis after MIRI in mice.

关键词： myocardial fibrosis endothelial mesenchymal transition myocardial ischemia-reperfusion injury phosphatidylinositol-3-kinase/protein kinase B(PI3K/AKT)pathway

Inhibition of neovascularization and expression shift of pro-/anti-angiogenic vascular endothelial growth factor isoforms after intravitreal bevacizumab injection in oxygen-induced- retinopathy mouse model

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Chinese Medical Journal 2013年第2期126卷 345-352页

作者： SHI Xuan ZHAO Min xie Wan-kun LIANG Jian-hong MIAO Yi-fei DU Wei LI Xiao-xin Department of Ophthalmology Ministry of EducationBeuing 100044 China People's Eye Institute Ministry of EducationBeijing 100044 China PekingUniversity People's Hospital Key Laboratory of Vision Loss andRestoration Ministry of EducationBe~jing 100044 China Department of Physiology and Pathophysiology Peking UniversityHealth Science Center Beijing 100083 China Key Laboratory of Cardiovascular Science of the Ministry ofEducation Beijing 100083 China China Academy of Chinese Medical Sciences Eye Hospital Beijing 100040 China

Background Retinopathy of prematurity （ROP） has become one of the leading causes of visual loss in children. Vascular endothelial growth factor A （VEGF-A） is the principal stimulator of angiogenesis. VEGF was differentially spliced from exon 8 to exons 8a and 8b to form two families： the pro-angiogenic VEGFxxx family and the anti-angiogenic VEGFxxxb family. Previous research has shown variable effeteness of bevacizumab in inhibiting retinal neovascularization in ROP. This study aimed to investigate whether the effectiveness of this inhibition depends on the relative ratio of the two VEGF isoforms. Methods Intravitreal bevacizumab injection （IVB） was performed in the oxygen-induced-retinopathy （OIR） mice on postnatal day 12 （P12）（intravitreal phosphate buffered saline （PBS） injection as control）. The Evans blue perfused retina were used to test the retinal neovascularization-leakage （NVL） area and non-perfusion （NP） area. Results The retinal NVL and NP area in the IVB group were significantly smaller than the intravitreal PBS injection group （IVP group）. On P17, the protein level of total VEGF isoforms was significantly inhibited compared to IVP group （P 〈0.05） while VEGFls5b isoform was slight reduced （P 〉0.05）. The switch from pro-angiogenic isoforms to anti-angiogenic isoforms after IVB could be found. The relative protein expression of VEGF165b isoform was significantly higher in IVB group than in IVP group （P 〈0.05） on P17 which was correlated with the reduced ischemia-induced angiogenesis in OIR mice after IVB. Conclusions The anti-angiogenic effectiveness might depend on the relative high expression of VEGF165b after intravitreal bevacizumab injection. Anti-angiogenic therapy is a more effective therapy for ROP.

关键词： bevacizumab vascular endothelial growth factor retinopathy of prematurity neovascularization

晚清民国旧体诗词结社文献的类型、特点及其价值

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复旦学报（社会科学版） 2015年第1期57卷 80-88页

作者：曹辛华南京师范大学文学院南京210097

就当前笔者目力所及晚清民国存在的旧体诗词社团数目已近千个,而因诗词结社形成的各种文献数量也相当庞大。这是前所未有的,也是当前文学社团研究不应忽视的。晚清民国旧体诗词社团结社类型多样,按社团主要创作文体样式划分,有包罗型、... 详细信息

就当前笔者目力所及晚清民国存在的旧体诗词社团数目已近千个,而因诗词结社形成的各种文献数量也相当庞大。这是前所未有的,也是当前文学社团研究不应忽视的。晚清民国旧体诗词社团结社类型多样,按社团主要创作文体样式划分,有包罗型、专业型、兼顾型三种;按成因、目的划分,有娱乐型、征友型、宗风型、学术型、教学型等多种。就当前研究来看,人们多偏重"社"的一面,对"团"的研究多以群体或群笼统论之,即使如此,成果也相当匮乏。这是当前我们在整理诗词结社文献时应当予以重视的。晚清民国诗词结社文献的类型特征与诗词社团的形成、运作方式、活动以及传播、影响等问题紧密相关,具有杂、广、散、残四大特点。要整理晚清民国旧体诗词结社文献,当采取"抓重点、求完整、有类别、有步骤"四项原则。晚清民国旧体诗词社团文献,不仅能为近代文学史、民国旧体文学史研究提供丰富的史料,还对近现代文学、民国旧体文学的研究具有开拓意义,同时对近现代史研究也有所助资与禆益。

关键词：晚清民国旧体诗词社团文献类型特点意义

IgG4 and IgE co-positive group found in idiopathic orbital inflammatory disease

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 36-42页

作者： Peng-Xiang Zhao Yao Mawulikplimi Adzavon Jian-Min Ma Lei Shang Dan-Ying Chen Fei xie Meng-Yu Liu xin Zhang Bao-Bei Lyu Ming-Zi Zhang Lin-Qi Yang Xue-Mei Ma College of Life Science and Bio-engineering Beijing University of Technology Beijing Ophthalmology & Vision Science Key Lab Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Institute of Infectious Diseases Beijing Ditan Hospital Capital Medical University Department of Plastic Surgery Peking Union Medical College Hospital

AIM： To reveal the cytokines involved in idiopathic orbital inflammatory disease（IOID） and the relationship between Th17 cells, IgE and IOID ***： Whole blood samples were processed immediately after collection and serological IgG4, IgG, and IgE antibodies were tested using ELISA. IOID and orbital cavernous hemangioma（CH） tissue samples underwent Bio-Plex multiplex cytokine detection. Hematoxylin-Eosin（HE） staining of all paraffin samples suggested the histological features of IOIDs, and expressions of IgG4 and IL-17 A in affected tissues were detected by immunohistochemistry. RESULTS： Among 40 IOID plasma samples, 52.5%（21/40） were positive for IgG4 and 25%（10/40） were positive for IgE. Overlapped IgG4 or IgE positive samples accounted for 22.5%（9/40）. Therefore, IOID samples were separated into three groups. The IgE＋/IgG4＋ group had a relevantly lower level of pro-inflammatory cytokine expression. IL-4（Th2 cell related）, IL-10 and TGF-β1（Treg cell immunity related） were elevated in all three groups. Some of the Th17 cell related cytokines（i.e. IL-17 A/F, IL-25, IL-23, and IL-33） displayed higher expression levels in the IgE-/IgG4-group compared to the other two ***： We discovered an IgG4-IgE co-positive group as well as Th17 cell immune involvement in IgG4-IgE co-negative subgtroup in IOID for the first time. The pathogenesis of IOID could differ from different subgroups according to the IgG4 and IgE detection. Therefore, we recommend that, Treatment stratagy should be made according to the clinical assessment of IgG4-IgE and Th17 profile detection.

关键词： idiopathic orbital inflammatory disease IgE IgG4 Th17

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人力资源会计确认与计量研究综述

山东大学学报（哲学社会科学版） 2012年第2期 60-66页

作者：罗新华山东大学管理学院

从人力资本理论的角度把握了人力资本的本质特征,提出了人力资本理论发展的三个阶段,并指出了人力资本理论在每一阶段的发展状况与问题;然后对人力资源会计的产生与发展进行了文献回顾,分别从其发展的四个阶段展开分析;进而围绕其确认... 详细信息

从人力资本理论的角度把握了人力资本的本质特征,提出了人力资本理论发展的三个阶段,并指出了人力资本理论在每一阶段的发展状况与问题;然后对人力资源会计的产生与发展进行了文献回顾,分别从其发展的四个阶段展开分析;进而围绕其确认思路与计量方法,提出了人力资源会计确认与计量的不同角度;最后提出了理论总结与研究展望:在人力资源会计研究中,一定要将人力资本本身的特点与会计要素结合起来,创立适合本国各种制度的人力资源会计制度,使用适当的确认与计量方法。

关键词：人力资本人力资源会计人力资本确认人力资本价值计量

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论唐宋渔父词的文化意蕴与词史意义

南京师大学报（社会科学版） 2007年第6期 117-122页

作者：曹辛华南京师范大学文学院江苏南京210097

以渔父为描写对象、抒情意象或抒情形象的渔父词作,自张志和一曲开始,历唐而宋唱和之作尤多,并且以渔父为题材的词作日渐繁盛。这些词或描写渔父的生活及其生活环境,或借渔父来抒发隐逸之思,或借渔父来参禅悟道。若按唐宋词抒情主人公... 详细信息

以渔父为描写对象、抒情意象或抒情形象的渔父词作,自张志和一曲开始,历唐而宋唱和之作尤多,并且以渔父为题材的词作日渐繁盛。这些词或描写渔父的生活及其生活环境,或借渔父来抒发隐逸之思,或借渔父来参禅悟道。若按唐宋词抒情主人公形象分类,渔父词堪与思妇、游子、志士等类词相颉颃,可以成为一个独立的"渔父"系列,所具有的文化意蕴、词史价值值得重视,这对唐宋词抒情形象研究的全面展开将大有助益。

关键词：渔父词唱和之风文化意蕴词史价值