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Discovery of Novel Anthranilic Diamide Derivatives Bearing Sulfoximine Group as Potent Insecticide Candidates

Chemical Research in Chinese Universities 2024年第1期40卷 96-108页

作者： ZHANG Hongyuan PENG Jinmin ZHONG Yuanhan CHEN Yue WANG Qing Haditullah HADIATULLAH xie weibin XIONG Lixia YUCHI Zhiguang LIU Jingbo LI Yuxin State Key Laboratory of Elemento-Organic Chemistry College of ChemistryNankai UniversityTianjin300071P.R.China Nankai University&Cangzhou Bohai New Area Institute of Green Chemical Engineering Changzhou062550P.R.China College of Horticulture and Landscape Architecture Tianjin Agricultural UniversityTianjin300392P.R.China Tianjin Key Laboratory for Modern Drug Delivery and High-efficiency Collaborative Innovation Center of Chemical Science and EngineeringSchool of Pharmaceutical Science and TechnologyTianjin UniversityTianjin300072P.R.China

The fall armyworm,Spodoptera frugiperda(***),represents the most resistant insect species and poses serious threat to grain ***(CHL),which targets the ryanodine receptors(RyRs)in insects,has demonstrated the efficacy in controlling ***,this has led to emerging resistance in several *** counter this resistance,a viable approach involves the development of novel compounds that bind against RyRs via distinct binding sites or *** this study,a series of 22 novel anthranilic diamide derivatives was designed and synthesized,and their insecticidal activities were *** of these derivatives showed moderate to good insecticidal activity against *** and Mythimna ***-lapse fluorescence measurements of endoplasmic reticulum luminal calcium revealed that most derivatives elicited cellular responses similar as CHL when assessed on HEK293 cells expressing *** ryanodine receptors(SfRyRs).The mode of action of compound 13a was studied and verified on the isolated neurons by calcium imaging ***,molecular docking analysis was employed to predict the binding mechanism of compound 13a against ***,these novel diamide derivatives hold promise as a valuable resource for guiding the future design of insecticidal compounds targeting RyRs.

关键词： Anthranilic diamide derivative Sulfoximine Spodoptera frugiperda Mode of action Molecular docking

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基于遗传算法的路网级桥梁养护与安全分析

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黑龙江交通科技 2024年第7期47卷 81-85页

作者：谢卫斌湖南省高速公路集团有限公司湘潭分公司湖南湘潭411100

随着交通网络的发展和桥梁结构的老化,养护工作变得更加重要,而传统的养护决策存在工作繁琐、效率低下的问题。因此,研究提出建立桥梁安全风险分析体系,并借助带精英策略的非支配排序遗传算法进行路网级桥梁养护决策。试验结果显示,研... 详细信息

随着交通网络的发展和桥梁结构的老化,养护工作变得更加重要,而传统的养护决策存在工作繁琐、效率低下的问题。因此,研究提出建立桥梁安全风险分析体系,并借助带精英策略的非支配排序遗传算法进行路网级桥梁养护决策。试验结果显示,研究方法在150次迭代后完成收敛,共得出100种有关竹埠港湘江大桥养护的决策。选择其中具有代表性的决策进行分析,考虑次要结构时最优决策经费为252万元,效益费用比达到0.99,不考虑次要结构的最优决策经费为129万元,效益费用比为1.60。且养护后撞击力降低了44.91%,吸收撞击能量提高了38.13%。研究为路网级桥梁的养护与安全风险分析提供了系统、科学的方法,对于提高桥梁养护效益、减少养护成本,以及确保桥梁结构安全具有积极意义。

关键词：路网级桥梁安全风险遗传算法效益费用比养护成本

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环泊酚复合舒芬太尼用于不同人群胃镜检查的半数有效剂量

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中国现代应用药学 2024年第12期41卷 1717-1722页

作者：潘敏范正达左小明王程马静谢伟斌常州市第三人民医院药事科江苏常州213001 常州市第三人民医院内镜中心江苏常州213001 常州市第三人民医院麻醉科江苏常州213001

目的测定并比较环泊酚用于不同性别、不同年龄的患者进行无痛胃镜检查时的半数有效剂量(median effective dose,ED_(50);)。方法选择2023年3~4月拟行胃镜检查或治疗的患者,按分层随机法纳入4组:第1组中青年男性患者,第2组中青年女性患者... 详细信息

目的测定并比较环泊酚用于不同性别、不同年龄的患者进行无痛胃镜检查时的半数有效剂量(median effective dose,ED_(50);)。方法选择2023年3~4月拟行胃镜检查或治疗的患者,按分层随机法纳入4组:第1组中青年男性患者,第2组中青年女性患者,第3组老年男性患者,第4组老年女性患者。所有患者均先静脉注射0.1μg·kg^(-1);的舒芬太尼。4组患者的环泊酚起始剂量均为0.4 mg·kg^(-1);,相邻剂量比值为1:1.1。待患者睫毛反射消失后行胃镜检查,根据Dixon改良序贯法,若前一位患者在进镜过程中出现阳性反应(呛咳、皱眉、体动等),则该组的下一位患者接受环泊酚的剂量递增10%;否则判为阴性反应,该组的下一位患者接受环泊酚的剂量递减10%。将阳性反应转为阴性反应定义为转折点,每组出现7个转折点时终止该组试验。同时记录4组患者在胃镜检查中,不同时间点的血流动力学参数、血氧饱和度以及发生的不良反应。采用Probit回归分析法分别计算4组患者使用环泊酚的ED_(50);,并进行组间比较。结果环泊酚复合0.1μg·kg^(-1);舒芬太尼用于中青年男性、中青年女性、老年男性和老年女性患者胃镜检查的ED_(50);分别为0.409、0.373、0.356、0.327 mg·kg^(-1)。中青年男性组环泊酚的ED_(50);显著高于中青年女性组和老年男性组(P<0.05);老年女性组环泊酚的ED_(50);显著低于中青年女性组和老年男性组(P<0.05)。结论环泊酚用于不同性别、不同年龄的患者胃镜检查的ED_(50);不同,女性患者低于男性患者,老年患者低于中青年患者。

关键词：环泊酚舒芬太尼胃镜半数有效剂量(ED_(50)) 量效关系

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电子式电压互感器检定装置测量结果的不确定度评定方法

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仪器仪表标准化与计量 2023年第5期 41-45页

作者：谢卫彬河北省计量监督检测研究院石家庄市050000

电子式互感器具有体积小、重量轻、频带响应宽、无饱和现象、抗电磁干扰性能佳、无油化结构、绝缘可靠、便于向数字化、微机化发展等诸多优点,将在数字化变电站中得到广泛应用。为了能够确保电子式电压互感器的检定或校准结果准确性,本... 详细信息

电子式互感器具有体积小、重量轻、频带响应宽、无饱和现象、抗电磁干扰性能佳、无油化结构、绝缘可靠、便于向数字化、微机化发展等诸多优点,将在数字化变电站中得到广泛应用。为了能够确保电子式电压互感器的检定或校准结果准确性,本文主要就对电子式电压互感器检定装置测量结果的不确定度评定方法进行了论述。

关键词：电子式电压互感器检定装置测量结果不确定度评定方法

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Association of chromosome 7 aneuploidy measured by fluorescence in situ hybridization assay with muscular invasion in bladder cancer

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Cancer Communications 2020年第4期40卷 167-180页

作者： Xiayao Diao Jinhua Cai Junjiong Zheng Jianqiu Kong Shaoxu Wu Hao Yu Hao Huang weibin xie Xiong Chen Chengran Huang Lifang Huang Haide Qin Jian Huang Tianxin Lin Department of Urology Sun Yat-sen Memorial HospitalSun Yat-senUniversityGuangzhouGuangdong510120P.R.China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouGuangdong510120P.R.China Department of Neurology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong510120P.R.China State Key Laboratory of Oncology in South China GuangzhouGuangdong510120P.R.China

Background:The preoperative prediction of muscular invasion status is important for adequately treating bladder cancer(BC)but nevertheless,there are some existing dilemmas in the current preoperative diagnostic accuracy of BC with muscular ***,we investigated the potential association between the fluorescence in situ hybridization(FISH)assay and muscular invasion among patients with BC.A cytogenetic-clinical nomogram for the individualized preoperative differentiation of muscle-invasive BC(MIBC)from non-muscle-invasive BC(NMIBC)is also ***:All eligible BC patients were preoperatively tested using a FISH assay,which included 4 sites(chromosome-specific centromeric probe[CSP]3,7,and 17,and gene locus-specific probe[GLP]-p16 locus).The correlation between the FISH assay and BC muscular invasion was evaluated using the Chi-square *** the training set,univariate and multivariate logistic regression analyses were used to develop a cytogenetic-clinical nomogram for preoperative muscular invasion ***,we assessed the performance of the nomogram in the training set with respect to its discriminatory accuracy and calibration for predicting muscular invasion,and clinica usefulness,which were then validated in the validation ***,model comparison was set to evaluate the discrimination and clinical usefulness between the nomogram and the individual variables incorporated in the ***:Muscular invasion was more prevalent in BC patients with positive CSP3,CSP7 and CSP17 status(OR[95%CI],2.724[1.555 to 4.774],P<0.001;3.406[1.912 to 6.068],P<0.001 and 2.483[1.436 to 4.292],P=0.001,respectively).Radiologydetermined tumor size,radiology-determined clinical tumor stage and CSP7 status were identified as independent risk factors of BC muscular invasion by the multivariate regression analysis in the training ***,a cytogenetic-clinical nomogram incorporating these three independent risk factors was constructed and was observed

关键词： chromosome aneuploidy fluorescence in situ hybridization muscular invasion nomogram preoperative prediction urinary bladder neoplasms

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一种基于U^(2)⁃Net的红外热成像与可见光图像融合方法

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现代电子技术 2024年第2期47卷 100-104页

作者：谢迅程为彬长江大学地球物理与石油资源学院湖北武汉430100

为解决红外热成像分辨率低且成本高昂的问题,结合可见光图像分辨率高、成本低的特点,提出一种采用U^(2)‐Net结构模型对红外热成像与可见光图像中显著目标检测的方法。针对图像中显著目标,通过图像裁剪、轮廓提取、仿射变换、形心计算... 详细信息

为解决红外热成像分辨率低且成本高昂的问题,结合可见光图像分辨率高、成本低的特点,提出一种采用U^(2)‐Net结构模型对红外热成像与可见光图像中显著目标检测的方法。针对图像中显著目标,通过图像裁剪、轮廓提取、仿射变换、形心计算、尺寸变换、匹配定位与融合等操作,实现目标物体在红外图像与可见光图像中的融合。实验结果表明,通过所提方法将低分辨率红外热成像中目标物体与高分辨率可见光图像融合,能够有效提升目标物体在整体图像中的可视性。

关键词：红外热成像可见光图像图像融合 U^(2)‐Net 显著目标检测图像匹配定位

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微量Ni元素添加对Cu-Cr合金析出行为及性能的影响

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金属热处理 2023年第7期48卷 49-54页

作者：吴凡龚清华谢伟滨吴语陈辉明汪航江西理工大学先进铜产业学院江西鹰潭335000 江西理工大学材料冶金化学学部江西赣州341000 国家稀土功能材料创新中心江西赣州341000 江西省科学院应用物理研究所江西南昌330096

采用真空熔炼设备在氩气环境下制备了Cu-Cr和Cu-Cr-Ni合金,然后进行950℃×1 h固溶和450℃时效处理。使用维氏硬度计、直流数字电阻测试仪、光学显微镜和透射电镜对两种合金的性能和组织进行了分析和表征。结果表明,Cu-Cr-Ni合金在450... 详细信息

采用真空熔炼设备在氩气环境下制备了Cu-Cr和Cu-Cr-Ni合金,然后进行950℃×1 h固溶和450℃时效处理。使用维氏硬度计、直流数字电阻测试仪、光学显微镜和透射电镜对两种合金的性能和组织进行了分析和表征。结果表明,Cu-Cr-Ni合金在450℃时效8 h后的硬度达到峰值,为124.6 HV0.5,此时导电率为83.2%IACS,而Cu-Cr合金在450℃时效1 h后的硬度达到峰值,为116.7 HV0.5,说明Ni的添加提高了Cu-Cr合金的硬度,且能保持较高的导电率。Cu-Cr-Ni合金在时效初期(1 h)即观察到bcc-Cr相,表明Ni的添加加快了析出相的析出速率,并促进析出相由fcc-Cr结构向bcc-Cr结构转变。另外,Cu-Cr-Ni合金在时效12 h后Cr析出相仍与基体保持半共格关系。

关键词： Cu-Cr-Ni合金析出相硬度导电率

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北大漢簡《蒼頡篇》文字辨析兩則

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出土文献综合研究集刊 2023年第1期17卷 142-147页

作者：陳松長謝偉斌湖南大學嶽麓書院/“古文字與中華文明傳承發展工程”協同攻關創新平臺湖南410082

文章分别對北大漢簡《蒼頡篇》中第44號簡中的和第54號簡中■的兩字的字形進行了重新隸定,並對其字義進行了辨析。我們認爲,簡文中■的當隸定爲啎;字本是楣的訛寫,當直接隸定爲楣,它具體是指棟(即正中檩條)左右兩側的檩條。

关键词：釋啎釋楣字形字義

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A nomogram for individualized estimation of survival among adult patients with adrenocortical carcinoma after surgery:a retrospective analysis and multicenter validation study

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Cancer Communications 2019年第1期39卷 683-695页

作者： Jianqiu Kong Junjiong Zheng Jinhua Cai Shaoxu Wu Xiayao Diao weibin xie Xiong Chen Chenyi Liao Hao Yu Xinxiang Fan Chaowen Huang Zhuowei Liu Wei Chen Qiang Lv Haide Qin Jian Huang Tianxin Lin Department of Urology Sun Yat-Sen Memorial HospitalSun Yat-Sen University107 Yan Jiang West RoadGuangzhou 510120GuangdongP.R.China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120GuangdongP.R.China Department of Neurology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120GuangdongP.R.China Department of Obstetrics and Gynecology Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630GuangdongP.R.China Department of Urology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Urology First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080GuangdongP.R.China Department of Urology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029JiangsuP.R.China State Key Laboratory of Oncology in South China Guangzhou 510120GuangdongP.R.China

Background:Clinical outcome of adrenocortical carcinoma(ACC)varies because of its heterogeneous nature and reliable prognostic prediction model for adult ACC patients is *** objective of this study was to develop and externally validate a nomogram for overall survival(OS)prediction in adult patients with ACC after ***:Based on the data from the Surveillance Epidemiology,and End Results(SEER)database,adults patients diagnosed with ACC between January 1988 and December 2015 were identified and classified into a training set,comprised of 404 patients diagnosed between January 2007 and December 2015,and an internal validation set,com-prised of 318 patients diagnosed between January 1988 and December *** endpoint of this study was *** nomogram was developed using a multivariate Cox proportional hazards regression algorithm in the training set and its performance was evaluated in terms of its discriminative ability,calibration,and clinical *** nomogram was then validated using the internal SEER validation,also externally validated using the Cancer Genome Atlas set(TCGA,82 patients diagnosed between 1998 and 2012)and a Chinese multicenter cohort dataset(82 patients diag-nosed between December 2002 and May 2018),***:Age at diagnosis,T stage,N stage,and M stage were identified as independent predictors for OS.A nomo-gram incorporating these four predictors was constructed using the training set and demonstrated good calibration and discrimination(C-index 95%confidence interval[CI],0.715[0.679-0.751]),which was validated in the internal validation set(C-index[95%CI],0.672[0.637-0.707]),the TCGA set(C-index[95%CI],0.810[0.732-0.888])and the Chi-nese multicenter set(C-index[95%CI],0.726[0.633-0.819]),***,the nomogram was able to successfully distinguished patients with a high-risk of mortality in all enrolled patients and in the subgroup *** curve analysis indicated that the nomogram wa

关键词： Adrenocortical carcinoma Adult patients Overall survival Nomogram Validation Decision curve analysis Surveillance Epidemiology and End Results(SEER) The Cancer Genome Atlas(TCGA) Multicenter

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Non-invasive estimation of pulmonary hypertension and clinical deterioration risk in pediatric congenital heart disease:Development and validation of predictive tools

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Chinese Medical Journal 2024年第11期137卷 1384-1386页

作者： Ting Wang Dansha Zhou Yuqin Chen Suhua Kuang Yue Xing Qijian Yi Zhengxia Pan weibin Xu Jiao Rao Yunqi Liu Guoliang Lu Ziying Lin Xiang Li Yi xie Yulong Wu Peng An Xiaoxiao Deng Jiayue He Jiayi xie Chenxi Li Gang Geng Daiyin Tian Enmei Liu Jingsi Huang Zhou Fu Jian Wang Department of Respiratory Chongqing Higher Institution Engineering Research Center of Children’s Medical Big Data Intelligent ApplicationNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China State Key Laboratory of Respiratory Diseases National Center for Respiratory MedicineGuangdong Key Laboratory of Vascular DiseasesNational Clinical Research Center for Respiratory DiseasesGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouGuangdong 510120China Department of Cardiac Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouGuangdong 510120China Department of Cardiovascular Medicine Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Thoracic and Cardiac Surgery Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Cardiac Center of Guangdong Women and Children Hospital Guangzhou GuangzhouGuangdong 511400China Department of Guangzhou Laboratory Guangzhou International Bio IslandGuangzhouGuangdong 510005China

To the Editor:Owing to the heterogeneity of congenital heart disease-associated pulmonary hypertension(CHDPH)disease and the development of the pulmonary vascular system in pediatric patients,the management of CHD-PH in children is signicantly different from that in adults.[1]Early identication and intervention of CHD-PH are of great signicance for disease management in children with CHD,and non-invasive,accurate clinical tools are urgently needed to predict PH risk in children with ***,the applicability of the current risk-scoring system to pediatric CHD-PH remains ***,there are presently no user-friendly,non-invasive online tools available for predicting CHD-PH,and there is a scarcity of related studies in Asian *** study aimed to develop and validate the prediction tools for estimating the risk of pulmonary hypertension and clinical deterioration in children with congenital heart disease.

关键词： pediatric congenital hypertension

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