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Visual characterization of targeted effect of holo-transferrin-tagged dihydroartemisinin on human breast cancer cells

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Chinese Science Bulletin 2010年第22期55卷 2390-2395页

作者： xie weiling YANG PeiHui ZENG Xin WANG Hui CAI HuaiHong CAI JiYe Department of Chemistry Jinan University Guangzhou 510632 China Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes Jinan University Guangzhou 510632 China

Targeted drugs could significantly reduce cytotoxic effect and increase therapeutic activity. Dihydroartemisinin (DHA) has been shown to be effective in killing cancer cells. However, it exhibits non-targeted property. Holo-transferrin (TF) is a suitable drug-carrier to target cancer cells, because cancer cells need iron uptake by the TF-mediated mechanism to maintain their uncontrolled growth. Furthermore, TF receptors (TF-R) are highly expressed on cancer cell surfaces. In this paper, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to evaluate the different killing effect of 4-(12-Dihydroartemisininoxy) Benzoic Acid Hydrozide-transferrin (DBAH-TF) on human breast cancer cells (MCF-7) cells and human normal breast (HNB) cells, and atomic force microscopy (AFM) was used to visually observe the targeted effect of DBAH-TF on MCF-7 cells. MTT results show that DBAH-TF is 172 times more potent than DHA in killing MCF-7 cells, while the cytotoxic effect of DBAH-TF on HNB cells is merely 1/33 to DHA. Also, the killing effect of DBAH-TF on MCF-7 cells is 286 times that on HNB cells, showing targeted effect. Moreover, there are distinct differences in ultrastructures of cellular surfaces after DBAH-TF and DHA treatment. Through AFM imaging, many characteristic holes were observed on the cancer cell surface after being effected by DBAH-TF, which differ from the holes with irregular shapes affected by DHA. These results visually show that the DBAH-TF targeted drug has more potent killing effect on MCF-7 cells compared with DHA.

关键词：人乳腺癌细胞双氢青蒿素视觉特性全息转铁蛋白受体原子力显微镜转移因子细胞毒作用

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主动健康信息化平台在老年友善体检服务全流程管理中的应用及效果评价

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广西医学 2024年第6期46卷 941-944页

作者：蓝盈盈黄冬清李小珍王章安谢伟玲陈丽平蒋茜茜罗颖华广西医学科学院·广西壮族自治区人民医院健康管理中心广西南宁市530021

目的探讨主动健康信息化平台在老年友善体检服务全流程管理中的应用效果。方法选取接受健康体检的2000例老年人作为研究对象,并将其随机分为对照组和观察组,各1000例。对照组接受常规健康体检管理,观察组在常规健康体检管理基础上,采用... 详细信息

目的探讨主动健康信息化平台在老年友善体检服务全流程管理中的应用效果。方法选取接受健康体检的2000例老年人作为研究对象,并将其随机分为对照组和观察组,各1000例。对照组接受常规健康体检管理,观察组在常规健康体检管理基础上,采用主动健康信息化平台实施老年友善体检服务全程管理。比较两组老年人的体检依从性、不良反应事件发生率和纠纷事件发生率、体检总体满意度、体检总时间和体检报告等候时间。结果观察组老年人的体检依从性优于对照组,不良事件和纠纷事件发生率低于对照组,体检满意度高于对照组,体检总时间和体检报告等候时间短于对照组(P<0.05)。结论基于主动健康信息化平台实施老年友善体检服务全程管理,可提升老年人的体检依从性及满意度,缩短老年人体检总时间和体检报告等候时间,降低不良事件和纠纷事件发生率。

关键词：体检信息化平台主动健康全流程管理老年人

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New insights into the correlations between circulating tumor cells and target organ metastasis

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Signal Transduction and Targeted Therapy 2024年第1期9卷 211-233页

作者： Qinru Zhan Bixia Liu Xiaohua Situ Yuting Luo Tongze Fu Yanxia Wang Zhongpeng xie Lijuan Ren Ying Zhu weiling He Zunfu Ke Department of Pathology The First Affiliated Hospital of Sun Yat-sen University510000 GuangzhouGuangdongP.R.China Institute of Precision Medicine The First Affiliated Hospital of Sun Yat-sen University510000 GuangzhouGuangdongP.R.China Zhongshan School of Medicine Sun Yat-sen University510000 GuangzhouGuangdongP.R.China Department of Radiology The First Affiliated Hospital of Sun Yat-sen University510000 GuangzhouGuangdongP.R.China Department of Microbiology and Immunology Weill Cornell MedicineNew YorkNY 10065USA School of Medicine Xiang’an Hospital of Xiamen UniversityXiamen University361000 XiamenFujianP.R.China

Organ-specific metastasis is the primary cause of cancer patient *** distant metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of the tumor cells and extrinsic factors in their *** an intermediate stage of metastasis,circulating tumor cells(CTCs)are released into the bloodstream from primary and metastatic *** harboring aggressive or metastatic features can extravasate to remote sites for continuous colonizing growth,leading to further *** the past decade,numerous studies demonstrated that CTCs exhibited huge clinical value including predicting distant metastasis,assessing prognosis and monitoring treatment response et ***,increasingly numerous experiments are dedicated to identifying the key molecules on or inside CTCs and exploring how they mediate CTC-related organ-specific *** on the above molecules,more and more inhibitors are being developed to target CTCs and being utilized to completely clean CTCs,which should provide promising prospects to administer advanced ***,the application of various nanomaterials and microfluidic technologies in CTCs enrichment technology has assisted to improve our deep insights into the phenotypic characteristics and biological functions of CTCs as a potential therapy target,which may pave the way for us to make practical clinical *** the present review,we mainly focus on the role of CTCs being involved in targeted organ metastasis,especially the latest molecular mechanism research and clinical intervention strategies related to CTCs.

关键词： metastasis organs insight

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A Distributed Adaptive Second-Order Latent Factor Analysis Model

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IEEE/CAA Journal of Automatica Sinica 2024年第11期11卷 2343-2345页

作者： Jialiang Wang weiling Li Xin Luo the School of Computer Science and Technology Dongguan University of Technology the College of Computer and Information Science Southwest University

Dear Editor,This letter presents a distributed adaptive second-order latent factor(DAS) model for addressing the issue of high-dimensional and incomplete data representation. Compared with first-order optimizers, a second-order optimizer has stronger ability in approaching a better solution when dealing with the non-convex optimization problems, thus obtaining better performance in extracting the latent factors(LFs) well representing the known information from high-dimensional and incomplete data.

关键词： Particle swarm optimization (PSO)

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Blautia producta displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice

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Food Science and Human Wellness 2024年第2期13卷 709-720页

作者： Bingyong Mao weiling Guo Shumao Cui Qiuxiang Zhang Jianxin Zhao Xin Tang Hao Zhang State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

Blautia has attracted attention because of its potential efficacy in ameliorating host energy metabolism and *** study aims to investigate the influences of Blautia producta D4 on colitis induced by dextran sulfate sodium(DSS)and to reveal the underlying *** showed that *** D4 intervention significantly relieved body weight loss,and suppressed the elevation of pro-inflammatory cytokines(including interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and interleukin-1β(IL-1β))and excessive oxidative stress(myeloperoxidease(MPO)activity,superoxide dismutase(SOD)activity,glutathione peroxidase(GSH-Px)activity,and malondialdehyde(MDA)level)in colitis ***,the concentrations of tight junction proteins(occludin,claudin-1,and ZO-1)related to the intestinal barrier were obviously elevated,and colitis-related TLR4/NF-κB pathway activation was remarkably inhibited after *** D4 *** intestinal microbial disorder was evidently ameliorated by increasing the relative abundance of Clostridium sensu stricto 1,Bifidobacterium,GCA-900066225,Enterorhabdus,and reducing the relative abundance of Lachnospiraceae NK4A136 *** conclusion,oral administration of *** D4 could ameliorate DSS-induced colitis by suppressing inflammatory responses,maintaining the intestinal barrier,inhibiting TLR4/NF-κB pathway,and regulating intestinal microbiota *** results are conducive to accelerate the development of *** D4 as a functional probiotic for colitis.

关键词： Blautia producta D4 Colitis Intestinal mechanical barrier TLR4/NF-κB pathway Intestinal microbiot

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Investigation into the analysis method for assessing contact stress in joint prosthesis

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Medicine in Novel Technology and Devices 2024年第2期22卷 51-58页

作者： weiling Cui Xushu Zhang Weiyi Chen Ji Qiu College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan030024China College of Aeronautics and Astronautics Taiyuan University of TechnologyTaiyuan030024China

Contact stress is the important cause of wear and failure of knee joint prostheses implanted in the human body during *** calculation of contact stress on joint prostheses is often inaccurate due to the deviation of joint position during *** paper proposes a correction method for contact stress based on finite element ***,the contact stress and contact radius between femoral and tibial prostheses of knee joint were calculated and analyzed by Hertz contact ***,individualized finite element models based on the individualized geometry of the joint prosthesis and individualized loading were constructed,and the finite element contact stress was *** finite element results were calibrated utilizing the Hertz contact ***tionally,this study investigated the impact of three gait patterns(normal gait,medial thrust gait,and bouncing gait)on the contact stress experienced by the tibial *** research methods and results can provide ideas for theoretical analysis and finite element simulation of prosthetic joint contact,as well as offer theoretical support and analysis methods for evaluating the lifespan of prosthetic joints.

关键词： Contact stress Joint prosthesis Hertz contact Finite element model

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铝合金缺口件载荷谱小载荷删除与试验验证

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南京航空航天大学学报 2017年第1期49卷 60-66页

作者：谢飞姚卫星金甲许力蒲南京航空航天大学飞行器先进设计技术国防重点学科实验室南京210016 南京航空航天大学机械结构力学及控制国家重点实验室南京210016

小载荷删除方法是加速疲劳试验技术中的一种,现有的删除方法往往忽略了结构疲劳性能的随机性。本文将疲劳寿命看作连续的随机变量,采用概率距离定量描述小载荷删除前后疲劳寿命分布的差异程度,以删除谱与原始谱的疲劳寿命同分布为标准... 详细信息

小载荷删除方法是加速疲劳试验技术中的一种,现有的删除方法往往忽略了结构疲劳性能的随机性。本文将疲劳寿命看作连续的随机变量,采用概率距离定量描述小载荷删除前后疲劳寿命分布的差异程度,以删除谱与原始谱的疲劳寿命同分布为标准作为小载荷删除的方法。该方法考虑了结构疲劳性能的分散性,可根据结构的p-S-N曲线和载荷谱的应力分布函数计算相应的小载荷删除水平。对LC4CS铝合金缺口件在5种载荷谱下进行疲劳试验,结果表明,计算得到的删除谱与原始谱的疲劳寿命同分布,载荷循环数为原始谱的8.4%,节省了试验时间。

关键词：疲劳试验铝合金缺口件小载荷删除删除水平

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Accurate Shortwave Radiation Simulation with a Two-Layer Aerosol Model in Xinjiang Region

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Journal of Meteorological Research 2024年第1期38卷 69-87页

作者： Guan HUANG Yonghang CHEN Qiong LIU Pengtao WANG Qianshan HE Qing HE Shuai LI weiling SHAO Ting FAN School of Tourism&Research Institute of Human Geography Xi’an International Studies UniversityXi’an 710128 Center for Silk Road and Eurasian Civilization Studies Xi’an International Studies UniversityXi’an 710128 College of Environmental Science and Engineering Donghua UniversityShanghai 201620 Shanghai Meteorological Service Shanghai 200030 Shanghai Key Laboratory of Meteorology and Health Shanghai 200030 Taklimakan Desert Meteorology Field Experiment Station of China Meteorological Administration Institute of Desert MeteorologyUrumqi 830002 Xinjiang Climate Centre Xinjiang Meteorological ServiceUrumqi 830002

To harness the rich solar energy resources in Xinjiang Region of Northwest China,this study tries to address the issue of lack of downward surface shortwave radiation(DSSR)observations and the need to improve the accuracy of satellite retrieval and numerical simulation of DSSR under varied sky and meteorological conditions.(1)A two-layer aerosol model specific to Xinjiang was developed to capture the vertical distributions of aerosols based on multiple data sources including lidar,GPS sounding,ground meteorological observations,and profiles from the ECMWF reanalysis version 5(ERA5)*** results show that the ERA5/PBLH(planetary boundary layer height)and ERA5/ALH(aerosol layer height)could be used to establish the two-layer aerosol model and characterize the vertical distribution of aerosols in Xinjiang Region.(2)Using the Santa Barbara Discrete Atmospheric Radiative Transfer(SBDART)model,a localized inverse model of clear-sky DSSR was *** parameter adjustment and using the optimal combination of input parameters for DSSR simulation together with the two-layer aerosol model,the model-simulated DSSR(DSSRSBD)under clear-sky conditions improved significantly compared to the initial results,with all fitting indices greatly improved.(3)In addition,the study demonstrated that the impact of the two-layer aerosol model on DSSR was more pronounced under dust conditions than clear-sky conditions.(4)Using the localized clear-sky DSSR inversion model and its required parameters,simulations were also conducted to capture the spatiotemporal distribution of DSSR under clear-sky conditions in Xinjiang from 2017 to *** annual average DSSR_(SBD)under clear-sky conditions in Xinjiang during 2017–2019 was 606.78 W m^(-2),while DSSR from CERES(DSSR_(CER))under the same conditions was generally higher(703.95 W m^(-2)).(5)It is found that satellite remote sensing products experienced data loss in high-altitude snow areas,where numerical simulation technology could ser

关键词： downward surface shortwave radiation(DSSR) aerosol vertical distribution Clouds and the Earth’s Radiant Energy System(CERES) Santa Barbara Discrete Atmospheric Radiative Transfer(SBDART) Xinjiang

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Molybdenum Concentration and the Risk of Spontaneous Preterm Birth: A Nested Case-Control Study — Beijing Municipality, China, 2018–2020

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China CDC weekly 2024年第13期6卷 261-266,I0005,I0006页

作者： Junhua Huang Wei Zheng Aili Wang weiling Han Junxi Chen Hang An Lailai Yan Zhiwen Li Guanghui Li Division of Endocrinology and Metabolism Department of ObstetricsBeijing Obstetrics and Gynecology HospitalCapital Medical University.Beijing Maternal and Child Health Care HospitalBeijingChina Department of Obstetrics and Gynecology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Institute of Reproductive and Child Health National Health Commission Key Laboratory of Reproductive HealthPeking UniversityBeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Department of Laboratorial Science and Technology School of Public HealthPeking UniversityBeijingChina

What is already known about this topic?The level of molybdenum(Mo)in a mother’s urine has been linked to the growth rate of the fetus and the blood pressure levels in *** is added by this report?We evaluated the variations in maternal plasma Mo concentrations throughout pregnancy and their potential association with the risk of spontaneous preterm birth(SPB).What are the implications for public health practice?Future research must determine the Mo levels in pregnant women across various regions in ***,particular attention needs to be given to the potential increase in Mo concentration throughout pregnancy and its possible adverse impacts on the health of both the mother and the fetus.

关键词： mother urine pregnancy

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多层螺旋CT三维重建技术与X线影像学检查在骨盆骨折的诊断应用比较

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广东微量元素科学 2017年第1期24卷 60-63页

作者：谢伟玲佛山市高明区中医院广东佛山528500

目的比较多层螺旋CT三维重建技术与X线影像学两种检查方式在骨盆骨折诊断中的应用效果。方法选取2013年8月—2015年2月佛山市高明区中医院收治的70例骨盆骨折患者,所有患者均进行多层螺旋CT三维重建和X线影像学检查,比较两种检查方法的... 详细信息

目的比较多层螺旋CT三维重建技术与X线影像学两种检查方式在骨盆骨折诊断中的应用效果。方法选取2013年8月—2015年2月佛山市高明区中医院收治的70例骨盆骨折患者,所有患者均进行多层螺旋CT三维重建和X线影像学检查,比较两种检查方法的结果。结果采用X线平片扫描共检出43例骨折,检出率为61.43%;采用多层螺旋CT三维重建技术共检出70例骨折,检出率为100.00%;多层螺旋CT三维重建技术骨盆骨折检出率高于X线影像学检查,差异显著(P<0.05)。结论多层螺旋CT三维重建技术可更好的对骨盆骨折进行诊断,诊断率较高,可准确反映患者骨折具体情况,对提高手术成功率和改善患者预后具有重要的意义,在临床应用中值得推广。

关键词：多层螺旋CT三维重建 X线影像学骨盆骨折

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