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Progress of Microfluidics for Biology and Medicine

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Nano-Micro Letters 2013年第1期5卷 66-80页

作者： Jingdong Chen di Chen Yao xie Tao Yuan Xiang Chen Science and Technology on Micro/Nano Fabrication Laboratory Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong University Key Laboratory for Thin Film and Microfabrication of the Ministry of Education Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong University

Microfluidics has been considered as a potential technology to miniaturize the conventional equipments and technologies. It offers advantages in terms of small volume, low cost, short reaction time and highthroughput. The applications in biology and medicine research and related areas are almost the most extensive and profound. With the appropriate scale that matches the scales of cells, microfluidics is well positioned to contribute significantly to cell biology. Cell culture, fusion and apoptosis were successfully performed in microfluidics. Microfluidics provides unique opportunities for rare circulating tumor cells isolation and detection from the blood of patients, which furthers the discovery of cancer stem cell biomarkers and expands the understanding of the biology of metastasis. Nucleic acid amplification in microfluidics has extended to single-molecule, high-throughput and integration treatment in one chip. DNA computer which is based on the computational model of DNA biochemical reaction will come into practice from concept in the future. In addition, microfluidics offers a versatile platform for protein-protein interactions, protein crystallization and high-throughput screening. Although microfluidics is still in its infancy, its great potential has already been demonstrated and will provide novel solutions to the high-throughput applications.

关键词： Microfluidics Lab-on-a-chip Droplet High-throughput Cell Nucleic acid amplification

Influence of clinical pathways used the hospitals of Traditional Chinese Medicine on patients hospitalized with stroke:a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2017年第2期37卷 159-164页

作者： Wang Bin Chen di Zhou Hongwei Shi Huaxin xie Qi Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Medical Insurance Office China Academy of Chinese Medical Sciences Guang'anmeng Hospital Traditional Chinese Medicine data center China Academy of Chinese Medical Sciences

OBJECTIVE:To evaluate the influence of clinical pathways in the hospitals using the Traditional Chinese Medicine in treatment of stroke in terms of postoperative complications, length of stay(LOS),costs incurred during hospitalization, compared with standard medical ***:Medline, Embase, China National Knowledge Infrastructure(CNKI) platforms, Wanfang databases and the Cochrane Central Register of Controlled Trials were *** search was performed up to August *** study was assessed independently by two *** assessment of methodological quality of the included studies was based on the Methodological index for non-randomized studies ***-analyses were performed using Rev Man software, ***:six studies met the study inclusion criteria and were included in the Meta-analysis for a total sample of 710 *** aggregate overall results showed that shorter length of stay in the clinical pathway group was observed during hospital stay was associated with the use of the clinical *** significant differences were found in other ***:Regardless the possible limitations,our findings show that clinical pathways can significantly reduce *** there is no clear evidence that clinical pathways can reduce hospital costs, but the cost of hospitalization path group for each included study were lower than the control group.

关键词： Medicine Chinese traditional Randomized controlled trial Postoperative complications Length of stay Review

Analysis of factors influencing the Henry Hub natural gas price based on factor analysis

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Petroleum Science 2017年第4期14卷 822-830页

作者： Hong Li Hui-Ming Zhang Yuan-Tao xie di Wang School of Economics Peking UniversityBeijing 100871People's Republic of China Center for National Resource Economy Studies Beijing 100871People's Republic of China School of Insurance and Economics University of International Business and EconomicsBeijing 100029People's Republic of China

Henry Hub as an important transaction hub for natural gas sets the gas price standard in the USA. In this paper, the factors influencing Henry Hub natural gas prices are analyzed, and the major factors determining the price levels in the period between January 1997 and December 2016 are studied. It is found that economic conditions, total energy demand, US dollar exchange rate and gas consumption are the major factors. The mechanism of each factor influencing the Henry Hub natural gas price is also explored in the paper.

关键词： Natural gas Henry Hub Factor analysis

A general and efficient Lewis acid catalysed Mukaiyama-aldol reaction of difluoroenoxysilanes and ketones

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Science Bulletin 2017年第22期62卷 1504-1509页

作者： Fu-Min Liao Xiao-Tong Gao Xiao-si Hu Shi-Liang xie Jian Zhou Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University Shanghai 200062 China State Key Laboratory of Elemento-organic Chemistry Nankai University Tianjin 300071 China Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development School of Chemistry and Chemical Engineering East China Normal University Shanghai 200062 China

We report a general and highly efficient Mukaiyama-aldol reaction of ketones and *** the reaction of aryl ketones worked efficiently in the presence of Bi(OTf)_3, that of aliphatic ketones required the use of Sc(OTf_)3. In addition, Sc(OTf)_3 was capable of achieving excellent 1,2-selectivity in the corresponding reaction of α,β-unsaturated ketones. This method provides a facile access to differently substituted β-hydroxy α,α-difluoro ketones, versatile synthons for difluomethylated tertiary alcohols.

关键词： Lewis acid catalysed Mukaiyama-aldol reaction Ketones difluoroenoxysilanes β-Hydroxy α,α-difluoro ketones

A new scheme of coded ultrasound using Golay codes

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第6期11卷 476-480页

作者： Cheng JIN si-ping CHEN Zheng-di QIN Tian-fu WANG School of Medicine Shenzhen University Shenzhen 518060 China School of Biomedical Engineering and Instrument Science Zhejiang University Hangzhou 310027 China

Golay codes are the most practical code in coded ultrasound imaging *** the trade-off for perfect range sidelobe cancellation is the requirement for two firings, thus resulting in motion-dependent decoding *** view of this, we propose a new scheme using the simultaneous emission of code *** code pair is allocated to different elements of an aperture and transmitted *** process of separating the code pair from the echo received is based on the orthogonality of the code *** last the autocorrelation functions of the individual Golay codes are added *** simultaneous emission of code pairs instead of two firings recovers the frame rate loss, and eliminates the motion-dependent decoding *** theoretical analysis and simulations show that the scheme can be used to eliminate the tissue motion effects.

关键词： Coded ultrasound Golay codes Tissue motion Ultrasonic imaging

Experimental investigation on flow modes of electrospinning

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Acta Mechanica sinica 2012年第3期28卷 644-652页

作者： Ting si Guang-Bin Li Xing-Xing Chen Rui-Jun Tian xie-Zhen Yin Department of Modern Mechanics University of Science and Technology of China230026 HefeiChina

Electrospinning experiments are performed by using a set of experimental apparatus, a stroboscopic system is adopted for capturing instantaneous images of the cone- jet configuration. The cone and the jet of aqueous solutions of polyethylene oxide （PEO） are formed from an orifice of a capillary tube under the electric field. The viscoelastic con- stitutive relationship of the PEO solution is measured and discussed. The phenomena owing to the jet instability are described, five flow modes and corresponding structures are obtained with variations of the fluid flow rate Q, the electric potential U and the distance h from the orifice of the cap- illary tube to the collector. The flow modes of the cone-jet configuration involves the steady bending mode, the rotat- ing bending mode, the swinging rotating mode, the blurring bending mode and the branching mode. Regimes in the Q-U plane of the flow modes are also obtained. These results may provide the fundamentals to predict the operating conditions expected in practical applications.

关键词： Electrospinning - Flow mode Jet instability Non-Newtonian fluid Ultrafine fiber

An air cavity method for increasing the underwater acoustic targets strength of corner reflector

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Defence Technology（防务技术） 2020年第2期16卷 493-501页

作者： Yi Luo Xin Chen Da-wei Xiao Wu-di Wen Tao-tao xie Dept.of Weaponry Eng Naval University of EngineeringWuhan 430033China

In order to improve the underwater acoustic target strength of comer reflectors,according to the principle of acoustic impedance mismatch of the boundary layer,the method of using air cavity to increase the underwater acoustic target strength of corner reflectors is *** acoustic reflection coefficients of underwater air layer and single layer metal sheet are calculated and *** results show that the reflection coefficient of single layer metal sheet is greatly affected by frequency and incidence angle,and the reflection coefficient of air layer in water is large and little affected by frequency and incidence *** this basis,a new kind of airfilled cavity corner reflector is *** acoustic scattering characteristics of underwater airfilled cavity comer reflector are calculated cumulatively,and the results are compared with the monolayer metal sheet corner *** simulation results show that the acoustic reflection effect of the airfilled cavity corner reflector is *** order to verify the correctness of the method,the test was carried out in the silencing *** experimental results show that the simulation results are in good agreement with the experimental results,and the airfilled cavity can improve on acoustic reflection performance of the underwater corner reflector.

关键词： Underwater corner reflector Acoustic target strength Air cavity Acoustic impedance mismatch

Analysis and Improvement on a Mobile Payment Protocol with Outsourced Verification in Cloud Service

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Wuhan University Journal of Natural Sciences 2019年第3期24卷 223-228页

作者： KANG Baoyuan DU Jianqi si Lin xie Mingming School of Computer Science and Technology Tianjin Polytechnic University

Mobile wallet is a very convenient means of mobile payment to allow the clients to conduct the payment via their mobile devices. To reduce the computation burden of resources-constraint mobile devices, a few mobile wallet protocols with outsourced verification in cloud computing were proposed. But in some of the protocols, there exist the risk of a colluding attack of the customer and the untrusted cloud server. In this paper, we propose an improved protocol, in which the payment information is protected by Hash function and random number. The malicious customer and cloud server cannot change the payment information to conduct a collusion forgery attack to defraud the merchant. The security analysis indicates that the proposed improved protocol can enhance the security in terms of correctness, unforgeability and traceability without increasing the computational burden.

关键词： mobile payment cloud service digital signature security bilinear map

Edge effect and interface confinement modulated strain distribution and interface adhesion energy in graphene/si system

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Communications in Theoretical Physics 2021年第1期73卷 122-127页

作者： Ying-di Huang Jia-Ting xie Su-Mei Hu Yan He Guangdong University of Petrochemical Technology Maoming 525000China

In order to clarify the edge and interface effect on the adhesion energy between graphene(Gr)and its substrate,a theoretical model is proposed to study the interaction and strain distribution of Gr/si system in terms of continuum medium mechanics and *** find that the interface separation and adhesion energy are determined by the thickness of Gr and *** disturbed interaction and redistributed strain in the Gr/si system induced by the effect of surface and interface can make the interface adhesion energy decrease with increasing thickness of Gr and diminishing thickness of ***,our results show that the smaller area of Gr is more likely to adhere to the substrate since the edge effect improves the active energy and strain *** predictions can be expected to be a guide for designing high performance of Grbased electronic devices.

关键词： graphene edge effect and interface confinement strain distribution adhesion energy