检索结果-南通市图书馆

Angiotensin II stimulates phosphorylation of 4E-binding protein 1 and p70 S6 kinase in cultured vascular smooth muscle cells

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2004年第5期25卷 51-54页

作者： Na LI1, Ke-gui WU, Xiang-yu WANG, Liang-di xie, Chang-sheng xu, Hua-jun WANGHypertension Institute, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China Hypertension Institute First Affiliated Hospital Fujian Medical University Fuzhou 350005

AIM: To examine the regulatory effects of angiotensin II (Ang II) on the phosphorylation of 4E-binding protein 1(4E-BP1) and p70 S6 kinase in cultured vascular smooth muscle cells (VSMC), and the contribution ofphosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathway in this process. METHODS: VSMCobtained from rat thoracic aortas were cultured. The phosphorylation of 4E-BP1 and p70 S6 kinase was detectedby immunoblotting. RESULTS: Ang II significantly increased the phosphorylation of 4E-BP1 and p70 S6 kinase,with the peaks occurring at, respectively, 10 min and 30 min, after stimulation with Ang II. The stimulatory effectof Ang II on 4E-BP1 and p70 S6 kinase phosphorylation was abrogated by Ang II type 1 receptor (AT1 receptor)antagonist losartan, and suppressed by PI3K inhibitor LY294002 in a concentration-dependent ***: Ang II treatment of VSMC induces the phosphorylation of 4E-BP1 and p70 S6 kinase via AT1receptor, and PI3K signaling pathway is involved in this process.

关键词： angiotensin II 4E-binding protein 1 p70 S6 kinase phosphatidylinositol 3-kinase vascular smoothmuscle

Superhydrophobic and corrosion-resistant siloxane-modified MgAl-LDHs coatings on magnesium alloy prepared under mild conditions

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 450-463页

作者： Wenxi Zhang Zhangzelong Zhuo Dan xu Liang Wu Zhihui xie Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province College of Chemistry and Chemical EngineeringChina West Normal UniversityNanchong 637002China College of Materials Science and Engineering/National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

We have developed a superhydrophobic and corrosion-resistant LDH-W/PFDTMS composite coating on the surface of Mg *** composite comprised a tungstate-intercalated(LDH-W)underlayer that was grown at low temperature(relative to hydrothermal reaction conditions)under atmospheric pressure and an outer polysiloxane layer created from a solution containing perfluorodecyltrimethoxysilane(PFDTMS)using a simple immersion *** successful intercalation of tungstate into the LDH phase and the following formation of the polysiloxane layer were confirmed through X-ray diffraction(XRD),Fourier transform infrared(FTIR)spectroscopy,and X-ray photoelectron spectroscopy(XPS).The corrosion resistance of the LDH-W film,both before and after the PFDTMS modification,was evaluated using electrochemical impedance spectroscopy(EIS),Tafel curves,and immersion *** results showed that Mg coated with LDH-W/PFDTMS exhibited significantly enhanced corrosion protection compared to the unmodified LDHW film,with no apparent signs of corrosion after exposure to 3.5wt%NaCl solution for 15 ***,the LDH-W/PFDTMS coating demonstrated superior superhydrophobicity and self-cleaning properties against water and several common beverages,as confirmed by static contact angle and water-repellency *** results offer valuable insights into preparing superhydrophobic and corrosion-resistant LDH-based composite coatings on Mg alloy surfaces under relatively mild reaction conditions.

关键词： Mg alloy corrosion coating layered double hydroxide

在线全文

学校读者我要写书评

暂无评论

川麦冬中的新呋甾皂苷的分离与鉴定

高等学校化学学报 2007年第2期28卷 286-288页

作者：徐暾海陈萍徐雅娟郝羚竹解生旭徐东铭北京中医药大学中药学院北京100102 吉林省中医中药研究院长春130021

Traditional Chinese Medicine "maidong"[Ophiopogon japonicus(Thunb.) Ker-Gawl] is the important medicine used to treat cardiovascular diseases.A new furosteroidal saponin,together with three known steroidal saponins,was isolated from the tuber of Ophiopogon japonicus(Thunb.) *** structure of the new furosteroidal saponin,named Ophiopogoside A,was elucidated as 26-O-β-D-glucopyranosyl-(25S)-1β,3β,22α,26-tetrahydroxyfurot-5-ene 3-O-[-α-L-arabinopyranosyl(1→3)]-α-L-rhamnopyranosyl(1→2)-β-D-fucopyranoside mainly by using 1D,2D NMR techniques,ESI-MS analysis as well as chemical methods.

关键词：川麦冬甾体皂苷麦冬呋甾皂苷A

在线全文

学校读者我要写书评

暂无评论

蒺藜果化学成分的分离和鉴定

高等学校化学学报 2007年第3期28卷 484-486页

作者：徐雅娟黄小蕾解生旭徐暾海徐东铭张玉静吉林大学农学部长春130000 吉林省中医中药研究院重点实验室长春130021 北京中医药大学中药学院中药化学系北京100102

Traditional Chinese Medicine “jili”(Tribulus Terrestris L.) is the important medicine used to treat cardiovascular diseases. A new furosteroidal saponin, together with a known steroidal saponins, were isolated from the fruits of T. Terrestris L The structure of the new furosteroidal saponin, named Tribuluside A, was elucidated as 26-O-β-D-glucopyranosyl-(25R)-5α-furost-3β, 22α,26-triol-3-O-[β-D-Xylopyranosyl(1→3)]-[β-D-xylopyranosyl(1→2)]-β-D-glucopyranosyl(1→4)-[α-L- rhamnopyranosyl(1→2)]-β-D-galactopyranoside mainly by using 1D, 2D NMR techniques, ESI-MS analysis as well as chemical methods.

关键词：蒺藜活性成分甾体皂苷

Overview of in-situ oxygen production technologies for lunar resources

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 233-255页

作者： Youpeng xu sheng Pang Liangwei Cong Guoyu Qian Dong Wang Laishi Li Yusheng Wu Zhi Wang College of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China CAS Key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial ***,crucial for supporting human life on the Moon,can be extracted from lunar regolith,which is highly rich in oxygen and contains polymetallic *** oxygen and metal extraction can be achieved using existing metallurgical ***,the ample reserves of water ice on the Moon offer another means for oxygen *** paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon,drawing from an analysis of lunar resources and environmental *** delves into the principles,processes,advantages,and drawbacks of water-ice electrolysis,two-step oxygen production from lunar regolith,and one-step oxygen production from lunar *** two-step methods involve hydrogen reduction,carbothermal reduction,and hydrometallurgy,while the one-step methods encompass fluorination/chlorination,high-temperature decomposition,molten salt electrolysis,and molten regolith electrolysis(MOE).Following a thorough comparison of raw materials,equipment,technology,and economic viability,MOE is identified as the most promising approach for future in-situ oxygen production on the *** the corrosion characteristics of molten lunar regolith at high temperatures,along with the Moon's low-gravity environment,the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the *** review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

关键词： lunar resources in-situ oxygen production space metallurgy molten lunar regolith electrolysis

在线全文

学校读者我要写书评

暂无评论

一种面向软件定义网络的大流检测机制

北京邮电大学学报 2020年第1期43卷 97-103页

作者：邢长友李东阳谢升旭张国敏魏伟陆军工程大学指挥控制工程学院南京210001 31106部队南京210016

为解决大流检测过程中普遍存在的精度低、耗费高等问题,提出了一种面向软件定义网络的大流检测机制SampleFlow.通过综合sFlow和OpenFlow技术优势,使用粗粒度的采样技术识别出疑似大流,在OpenFlow交换机上安装测量流表项,对这些疑似大流... 详细信息

为解决大流检测过程中普遍存在的精度低、耗费高等问题,提出了一种面向软件定义网络的大流检测机制SampleFlow.通过综合sFlow和OpenFlow技术优势,使用粗粒度的采样技术识别出疑似大流,在OpenFlow交换机上安装测量流表项,对这些疑似大流进行细粒度测量判别,以达到准确检测大流的目标,通过采样点优化选择算法,还可降低采样的冗余性.实验结果表明,SampleFlow能够有效降低测量负载,并提升大流检测的精度.

关键词：软件定义网络网络测量大流检测采样

在线全文

学校读者我要写书评

暂无评论

基于银税联网的税费代收系统

计算机与现代化 2001年第2期 63-67页

作者：谢旭升江西师范大学计算机学院江西南昌330027

介绍了一个基于银税联网的税费代收系统的设计。

关键词：税费代收系统银税联网计算机网络税务体制中国

Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-Fang Wu Yi-sheng Chen Yu-Chun xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

RP-HPLC蒸发光检测法测定蒺藜中蒺藜皂苷D的含量

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中成药 2009年第3期31卷 434-436页

作者：解生旭韩冬赵宏峰司云珊徐雅娟徐东铭吉林省中医药科学院吉林长春130021

目的：建立反相高效液相色谱-蒸发光检测法测定蒺藜皂苷D含量的方法。方法：色谱柱Nova-park C18柱,柱温22°C,流动相：甲醇-水（75∶25）为流动相,流速1 mL/min,SEDEX 55型蒸发光散射检测器。结果：该方法的线性范围为2.736-5.13μg,r=... 详细信息

目的：建立反相高效液相色谱-蒸发光检测法测定蒺藜皂苷D含量的方法。方法：色谱柱Nova-park C18柱,柱温22°C,流动相：甲醇-水（75∶25）为流动相,流速1 mL/min,SEDEX 55型蒸发光散射检测器。结果：该方法的线性范围为2.736-5.13μg,r=0.9994（n=5）,平均回收率为96.86%。结论：方法准确,灵敏度高,专属性强,重现性好。可用于该药材及制剂中该成分的含量测定。

关键词： HPLC法蒺藜蒺藜皂苷D 含量测定