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Mathematical models of canine right and left atria cardiomyocytes

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Journal of zhejiang university-Science B(Biomedicine & Biotechnology) 2010年第6期11卷 402-416页

作者： Ling XIA Ying-lan GONG xiu-wei ZHU yu ZHANG qi SUN Heng-gui ZHANG Key Laboratory of Biomedical Engineering of Ministry of Education department of Biomedical Engineering Zhejiang University Hangzhou 310027 China Center of Arrhythmia Diagnosis and Treatment Cardiovascular Institute & Fuwai Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100037 China Biological Physics Group School of Physics and Astronomy The University of Manchester Manchester M13 9PL UK

The aim of this study is to build two mathematical models of canine ionic currents specific to right atria and left *** canine left atria mathematical model was firstly modified from the Ramirez-Nattel-Courtemanche(RNC) model using the recently available experimental data of ionic currents and was further developed based on our own experimental data.A model of right atria was then built by considering the differences between right atria and left *** two developed models well reproduced the experimental data on action potential morphology,the rate dependence,and action potential duration *** are useful for investigating the mechanisms underlying the het-erogeneity of canine regional action potentials and would help the simulation of whole heart excitation propagation and cardiac arrhythmia in the near future.

关键词： Atrial fibrillation Canine atria Mathematical model Action potential duration restitution

General variational solution for seismic and static active earth pressure on rigid walls considering soil tensile strength cut-off

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Journal of zhejiang university-Science A(Applied Physics & Engineering) 2023年第5期24卷 432-449页

作者： Shiguo XIAO yuan qi Pan XIA Key Laboratory of High-Speed Railway Engineering Ministry of EducationSouthwest Jiaotong UniversityChengdu 60031China School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China department of Geological Engineering Southwest Jiaotong UniversityChengdu 610031China

According to the limit equilibrium state of soils behind rigid walls and the pseudo-static approach,a general closed-form solution to seismic and static active earth pressure on the walls,which considers shear and tension failure of the retained soil,is put forward using a variational calculus *** application point of the active resultant force specified in the proposed method is explained with a clear physical meaning related to possible movement modes of the *** respect of the derived nine dependent equations reflecting the functional characteristics of the earth pressure,the proposed method can be performed easily via an implicit *** are 13 basic factors related to the retained soils,walls,and external loads to be involved in the proposed *** tension crack segment of the slip surface is obviously influenced by these parameters,apart from vertical seismic coefficient and geometric bounds of the surcharge,but the shear slip segment maintains an approximately planar shape almost uninfluenced by these ***,the proposed method quantitatively reflects that the resultant of the active earth pressure is always within a limited range under different possible movements of the same wall.

关键词： Active earth pressure Tensile strength cut-off Variational calculus method Pseudo-static method Strip surcharge

高渗氯化钠溶液复苏对失血性休克小肠黏膜细胞HO-1mRNA表达及凋亡的影响(英文)

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高渗氯化钠溶液复苏对失血性休克小肠黏膜细胞HO-1mRNA表达及凋亡...

Relationship between angiogenesis and lymphangiogenesis in recurrent pterygium

2009年浙江省急诊医学学术年会

作者： department of Emergency the First Affiliated Hospital School of Medicine zhejiang university hangzhou(310003 ) china department of General Surgery Sir Run Run Shaw Hospital School of Medicine zhejiang university hangzhou yuan-qiang LU Wei-dong HUANG xiu-jun CAI

Objective To investigate the early effects of hypertonic and isotonic saline solutions on Heme oxygenase-1 (HO-1) mRNA expression and apoptosis of intestinal mucosa in rats with hemorrhagic shock。

关键词： Hemorrhagic shock Resuscitation Sodium chloride solution Hypertonic saline Apoptosis Heme oxygenase-1 mRNA Intestinal mucosa Flow cytometry Reverse transcriptase polymerase chain reaction

来源： cnki会议评论

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International Journal of Ophthalmology(English edition) 2012年第6期5卷 655-660页

作者： Chao-xiu qi Xiao-Dong Zhang Jin yuan Jie-Zhen Yang Yi Sun Tao Wang Hui Ye Shi-qi Ling department of Ophthalmology the Third Affiliated Hospital of Sun Yat-sen University department of Information the Third Affiliated Hospital of Sun Yat-sen University State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University department of Ophthalmology Guangzhou Children's Hospital

AIM: To examine the relationship between angiogenesis and lymphangigenesis in recurrent pterygia. METHODS: Tissues from 34 excised recurrent pterygia (including 12 Grade 1, 10 Grade 2, and 12 Grade 3) were involved in the study and tissues from 7 nasal epibulbar conjunctivae segments were used as controls. Sections from each pterygium were immunostained with CD31 and LYVE-1 monoclonal antibodies to evaluate lymphatic microvessel density (LMVD) and blood microvessel density (BMVD), and the relationship between LMVD and BMVD in the pterygium was examined. RESULTS: There was a large number of CD31(+) LYVE-1((-)) blood vessels but only a few CD31 (+)LYVE-1 ((+)) lymphatic vessels in grades 1 and 2 pterygium. However, lymphatic vessels were dramatically increased in grade 3 pterygium. LMVD correlated dosely with BMVD in all pterygia, including grades 1, 2 and 3 peterygium patients (all P values 1). Although both the density of blood and lymphatic vessels increased in recurrent pterygia, lymphatic vessels developed much faster than blood vessels, especially in grade 3 pterygia. CONCLUSION: There is a significant but not parallel relationship between angiogenesis and lymphangiogenesis in recurrent pterygium. The outgrowth of blood and lymphatic vessels provide evidence that immunological mechanism may play a role in the development and recurrence of pterygium.

关键词： angiogenesis lymphangiogenesis recurrent pterygium

Advances in neuroimaging studies of alcohol use disorder(AUD)

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Psychoradiology 2022年第4期2卷 146-155页

作者： Ji-yu xie Rui-Hua Li Wei yuan Jiang Du Dong-Sheng Zhou yu-qi Cheng Xue-Ming Xu Heng Liu Ti-Fei yuan School of Mental Health Wenzhou Medical UniversityWenzho 325000ZhejianguChina Shandong Mental Health Center Shandong UniversityJinan 250014ShandongChina Shanghai Mental Health Center Shanghai Jiaotong University School of MedicineShanghai 200030China department of Psychiatry Ningbo Kangning HospitalNingbo 315000ZhejiangChina department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunming 650000YunnanChina department of Psychiatry Taizhou Second People’s HospitalTaizhou 318000ZhejiangChina department of Radiology the Affiliated Hospital of Zunyi Medical UniversityMedical Imaging Center of Guizhou ProvinceZunyi 563000GuizhouChina

Alcohol use disorder(AUD)is a worldwide problem and themost common substance use *** alcohol consumptionmay have negative effects on the body,the mind,the family,and even *** the progress of current neuroimaging methods,an increasing number of imaging techniques are being used to objectively detect brain impairment induced by alcoholism and serve a vital role in the diagnosis,prognosis,and treatment assessment of *** article organizes and analyzes the research on alcohol dependence concerning the main noninvasive neuroimaging methods,structural magnetic resonance imaging,functional magnetic resonance imaging,and electroencephalography,as well as the most common noninvasive brain stimulation-transcranial magnetic stimulation,and intersperses the article with joint intra-and intergroup studies,providing an outlook on future research directions.

关键词： alcohol use disorder structural magnetic resonance imaging functionalmagnetic resonance imaging electroencephalography transcranial magnetic stimulation prefrontal cortex

Xiaotan Tongfu granules contribute to the prevention of stress ulcers

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World Journal of Gastroenterology 2013年第33期19卷 5473-5484页

作者： Bing Yan Jun Shi Li-Juan xiu Xuan Liu yu-qi Zhou Shou-Han Feng Can Lv xiu-Xia yuan Yin-Cheng Zhang Yong-Jin Li Pin-Kang Wei Zhi-Feng qin department of Traditional Chinese Medicine Changzheng HospitalSecond Military Medical University

AIM:To investigate the efficacy and potential mechanism of Xiaotan Tongfu granules(XTTF)in stress ***:One hundred sixty rats were randomly divided into 4 groups(n=10)as follows:the model group(MP group),the control group(CP group),the ranitidine group(RP group)and the XTTF granule group(XP group).Rats in the MP group received no drugs,rats in the CP group received 0.2 mL of a 0.9%sodium chloride solution via oral gavage,and rats in the RP and XP groups received the same volume of ranitidine(50 mg/kg)or XTTF granule(4.9 g/kg).The cold-restraint stress model was applied to induce stress ulcers after 7 consecutive days of drug ***,rats were sacrificed at 0,3,6 and24 *** pH was measured by a precise pH meter;gastric emptying rate(GER)was measured by using a methylcellulose test meal;myeloperoxidase activity(MPO),macrophage migration inhibitory factor(MIF),proliferating cell nuclear antigen(PCNA),and heat shock protein 70(HSP70)were measured by immunohistochemical staining;and mucosal cell apoptosis was measured by transferase dUTP nick end ***:In the cold-restraint stress model,the development of stress ulcers peaked at 3 h and basically regressed after 24 *** lesions were significantly different in the RP and XP groups at each time ***,although this index was much lower in the RP group than in the XP group immediately following stress induction(7.00±1.10 vs 10.00±1.79,P3.34±0.28,P3 h:46.84±2.70 vs 61.16±5.12,P1 vs 73.41±6.16,P24 h:77.47±3.17 vs 91.31±4.34,P<0.05).With respect to MPO and MIF,comparisons between the RP and XP groups

关键词： Stress ulcer Xiaotan Tongfu granule Inflammation Heat shock protein 70 Proliferation and apoptosis Gastric emptying rate

基于SWOT-AHP分析的退役运动员转型高校体育教师发展策略研究

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浙江体育科学 2024年第2期46卷 87-94页

作者：袁刚孙启成左乐海军航空大学军事体育教研室山东烟台264001

以退役运动员转型高校体育教师的发展策略为研究对象,运用文献研读法、问卷调查法、德尔菲法等对退役运动员转型高校体育教师后其职业发展进行了优势、劣势、机遇和挑战的定性分析,并在此基础上运用层次分析法构建了SWOT-AHP定量模型,... 详细信息

以退役运动员转型高校体育教师的发展策略为研究对象,运用文献研读法、问卷调查法、德尔菲法等对退役运动员转型高校体育教师后其职业发展进行了优势、劣势、机遇和挑战的定性分析,并在此基础上运用层次分析法构建了SWOT-AHP定量模型,通过对各因素的定量评价,得出退役运动员转型高校体育教师后其职业发展的优势和机会大于劣势与挑战,应采取自身优势与外部机遇相结合的SO增强型发展策略,建议分别实施差异化人才培养、多项技能同步发展、拓展额外就业技能以及在统筹化发展过程中打造局部优势的非均衡发展等策略,为转型高校体育教师的退役运动员实现其职业的良好发展提供科学的理论指导。

关键词：退役运动员高校体育教师 SWOT 层次分析法

Verapamil inhibits scar formation after peripheral nerve repair in vivo

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Neural Regeneration Research 2016年第3期11卷 508-511页

作者： A-chao Han Jing-xiu Deng qi-shun Huang Huai-yuan Zheng Pan Zhou Zhi-wei Liu Zhen-bing Chen department of Hand Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei Province China 457 Hospital of PLA Wuhan Hubei Province China

The calcium channel blocker,verapamil,has been shown to reduce scar formation by inhibiting fibroblast adhesion and proliferation in *** was not clear whether topical application of verapamil after surgical repair of the nerve in vivo could inhibit the formation of excessive scar *** this study,the right sciatic nerve of adult Sprague-Dawley rats was transected and sutured with No.10-0 *** stoma was wrapped with gelfoam soaked with verapamil solution for 4 *** with the control group（stoma wrapped with gelfoam soaked with physiological saline）,the verapamil application inhibited the secretion of extracellular matrix from fibroblasts in vivo,suppressed type I and III collagen secretion and increased the total number of axons and the number of myelinated *** findings suggest that verapamil could reduce the formation of scar tissue and promote axon growth after peripheral nerve repair.

关键词： nerve regeneration nerve injury verapamil scar sciatic nerve type I collagen type III collagen neural regeneration

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筋—土界面循环剪切刚度和阻尼比的试验研究

岩土力学 2016年第S1期37卷 159-165页

作者：刘飞禹王攀王军胡秀青蔡袁强上海大学土木系上海200072 温州大学建筑与土木工程学院浙江温州325035 温州大学浙江省软弱土地基与海涂围垦工程技术重点实验室浙江温州325035 温州大学浙江省海涂围垦及其生态保护协同创新中心浙江温州325035

为了研究筋—土界面在遭受动力作用时的表现,利用大型直剪仪对土工格栅、土工编织布、土工无纺布和砂土界面进行了一系列循环剪切试验,得到了不同工况下界面的剪切刚度和阻尼比,并探究了循环次数与剪切刚度和阻尼比之间的规律。研究结... 详细信息

为了研究筋—土界面在遭受动力作用时的表现,利用大型直剪仪对土工格栅、土工编织布、土工无纺布和砂土界面进行了一系列循环剪切试验,得到了不同工况下界面的剪切刚度和阻尼比,并探究了循环次数与剪切刚度和阻尼比之间的规律。研究结果表明,同一循环次数时格栅—土界面的循环剪切刚度最大,土工编织布—土界面的阻尼比最大;剪切位移幅值为3 mm时3种竖向应力下界面都呈现出循环剪切硬化的特征,随着循环次数的增加,各竖向应力下的界面阻尼比有趋于某一值的趋势;砂土密实度越大,同一循环次数对应的剪切刚度越大,阻尼比越小,且随着循环次数的增加3种砂土密实度的界面阻尼比有趋于同一值的趋势;循环剪切位移幅值为5 mm的界面发生循环剪切软化现象,剪切位移幅值越大,界面同一循环次数的阻尼比也越大。

关键词：加筋土筋土界面循环剪切剪切刚度阻尼比