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Differential analysis of lymph node metastasis in histological mixed-type early gastric carcinoma in the mucosa and submucosa

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World Journal of Gastroenterology 2018年第1期24卷 87-95页

作者： qian Zhong qi Sun Gui-fang Xu xiu-qin Fan yuan-yuan Xu Fei Liu Shi-Yi Song Chun-Yan Peng Lei Wang department of Gastroenterology the Affiliated Drum Tower Hospital of Nanjing University Medical School department of Pathology the Affiliated Drum Tower Hospital of Nanjing University Medical School

AIM To investigate the relationship between histological mixed-type of early gastric cancer(EGC) in the mucosa and submucosa and lymph node metastasis(LNM).METHODS This study included 298 patients who underwent gastrectomy for EGC between 2005 and 2012. Enrolled lesions were divided into groups of pure differentiated(pure D), pure undifferentiated(pure U), and mixed-type according to the proportion of the differentiated and undifferentiated components observed under a microscope. We reviewed the clinicopathological features, including age, sex, location, size, gross type, lymphovascular invasion, ulceration, and LNM, among the three groups. furthermore, we evaluated the predictors of LNM in the mucosa-confined *** Of the 298 patients, 165(55.4%) had mucosa-confined EGC and 133(44.6%) had submucosa-invasive EGC. Only 13(7.9%) cases of mucosa-confined EGC and 30(22.6%) cases of submucosa-invasive EGC were observed to have LNM. The submucosal invasion(OR = 4.58, 95%CI: 1.23-16.97, P = 0.023), pure U type(OR = 4.97, 95%CI: 1.21-20.39, P = 0.026), and mixedtype(OR = 5.84, 95%CI: 1.05-32.61, P = 0.044) were independent risk factors for LNM in EGC. The rate of LNM in mucosa-confined EGC was higher in the mixedtype group(P = 0.012) and pure U group(P = 0.010) than in the pure D group, but no significant difference was found between the mixed-type group and pure U group(P = 0.739). Similarly, the rate of LNM in the submucosa-invasive EGC was higher in the mixedtype(P = 0.012) and pure U group(P = 0.009) than in the pure D group but was not significantly different between the mixed-type and pure U group(P = 0.375). Multivariate logistic analysis showed that only female sex(OR = 5.83, 95%CI: 1.64-20.70, P = 0.028) and presence of lymphovascular invasion(OR = 13.18, 95%CI: 1.39-125.30, P = 0.020) were independent risk factors for LNM in mucosa-confined EGC, while histological type was not an independent risk factor for LNM in mucosa-confined EGC(P = 0.106).CONCLUSION fo

关键词： early gastric carcinoma mixed-type lymph node metastasis mucosa lymphovascular invasion

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Hypobaric Hypoxia Aggravates Renal Injury by Inducing the Formation of Neutrophil Extracellular Traps through the NF-κB Signaling Pathway

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当代医学科学(英文) 2023年第3期43卷 469-477页

作者： Jun-yu WEI Miao-yue HU xiu-qi CHEN Jin-shuang WEI Jie CHEN Xuan-kai qiN Feng-ying LEI Jia-sen ZOU Shi-qun ZHU yuan-han qiN department of Pediatrics the First Affiliated HospitalGuangxi Medical UniversityNanning 530021China Children's Hospital of Chongqing Medical university Chongqing 400015China Shenzhen Children's Hospital Shenzhen 518034China

Objective The hypersensitivity of the kidney makes it susceptible to hypoxia *** involvement of neutrophil extracellular traps(NETs)in renal injury resulting from hypobaric hypoxia(HH)has not been *** this study,we aimed to investigate the expression of NETs in renal injury induced by HH and the possible underlying *** A total of 24 SD male rats were divided into three groups(n=8 each):normal control group,hypoxia group and hypoxia+pyrrolidine dithiocarbamate(PDTC)*** in hypoxia group and hypoxia+PDTC group were placed in animal chambers with HH which was caused by simulating the altitude at 7000 meters(oxygen partial pressure about 6.9 kPa)for 7 *** was administered at a dose of 100 mg/kg intraperitoneally once daily for 7 *** changes of the rat renal tissues were observed under a light microscope;the levels of serum creatinine(SCr),blood urea nitrogen(BUN),cell-free DNA(cf-DNA)and reactive oxygen species(ROS)were measured;the expression levels of myeloperoxidase(MPO),citrullinated histone H3(cit-H3),B-cell lymphoma 2(Bcl-2),Bax,nuclear factor kappa B(NF-κB)p65 and phospho-NF-κB p65(p-NF-κB p65)in rat renal tissues were detected by qRT-qPCR and Western blotting;the localization of NF-κB p65 expression in rat renal tissues was observed by immunofluorescence staining and the expression changes of NETs in rat renal tissues were detected by multiplex fluorescence immunohistochemical *** After hypoxia,the expression of NF-κB protein in renal tissues was significantly increased,the levels of SCr,BUN,cf-DNA and ROS in serum were significantly increased,the formation of NETs in renal tissues was significantly increased,and a large number of tubular dilatation and lymphocyte infiltration were observed in renal *** PDTC was used to inhibit NF-κB activation,NETs formation in renal tissue was significantly decreased,the expression level of Bcl-2 in renal tissues was significantly increased,the expres

关键词： hypobaric hypoxia neutrophil extracellular traps hypoxia kidney injury NF-κB apoptosis

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Calculation method of ship collision force on bridge using artificial neural network

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Journal of zhejiang university-Science A(Applied Physics & Engineering) 2008年第5期9卷 614-623页

作者： Wei FAN Wan-cheng yuan qi-wu FAN State Key Laboratory for Disaster Reduction in Civil Engineering Tongji University Shanghai 200092 China department of Civil Engineering Southwest Jiaotong University Chengdu 610031 China

Ship collision on bridge is a dynamic process featured by high nonlinearity and instantaneity. Calculating ship-bridge collision force typically involves either the use of design-specification-stipulated equivalent static load, or the use of finite element method (FEM) which is more time-consuming and requires supercomputing resources. In this paper, we proposed an alternative approach that combines FEM with artificial neural network (ANN). The radial basis function neural network (RBFNN) employed for calculating the impact force in consideration of ship-bridge collision mechanics. With ship velocity and mass as the input vectors and ship collision force as the output vector, the neural networks for different network parameters are trained by the learning samples obtained from finite element simulation results. The error analyses of the learning and testing samples show that the proposed RBFNN is accurate enough to calculate ship-bridge collision force. The input-output relationship obtained by the RBFNN is essentially consistent with the typical empirical formulae. Finally, a special toolbox is developed for calculation efficiency in application using MATLAB software.

关键词： Ship-bridge collision force Finite element method (FEM) Artificial neural network (ANN) Radial basis function neural network (RBFNN)

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Subcellular daunorubicin distribution and its relation to multidrug resistance phenotype in drug-resistant cell line SMMC-7721/R

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World Journal of Gastroenterology 2002年第4期8卷 644-649页

作者： Jia-Yin Yang Hua-You Luo qi-yuan Lin Zi-Ming Liu Lu-Nan Yan department of General Surgery,West china Hospital,Sichuan university,Chengdu 610044,Sichuan Province,china Ping Lin Cancer Research Institution,West china Hospital,Sichuan university,610044,Sichuan Province,china Jie Zhang department of Confocal Laser Scanning Microscopy,West china Hospital,Sichuan university,610044,Sichuan Province,china Shong Lei Cancer Biotechnological Treatment Center,West china Hospital,Sichuan university,610044,Sichuan Province,china department of General surgery First Affiliated Hospital Zhejiang University College of Medicine Hangzhou 310003 China. yjy7429@***

AIM: To investigate the correlation between subcellulardaunorubicin distribution and the multidrug resistancephenotype in drug-resistant cell line SMMC-7721/***: The multidrug resistant cell line SMMC-7721/R, a human hepatocellular carcinoma cell line,was established. Antisense oligonudeotides (AS-ODN)were used to obtain different multidrug resistancephenotypes by inhibiting the expression of mdr1 geneand/or multidrug resistance-related protein gene(mrp)using Lipofectamine as delivery agent. Expression ofmdr1 and mrp genes was evaluated by RT-PCR andWestern blotting. Intracellular daunorubicin (DNR)concentration was measured by flow *** DNR distribution was analyzed by confocallaser scanning microscopy. Adriamycin (ADM) and DMRsensitivity was examined by MTT ***: Low level expression of mdr1 and mrp mRNAsand no expression of P-Glycoprotein(P-gp) andmultidrug resistance-related protein (P190) weredetected in parental sensitive cells SMMC-7721/S, butover-expression of these two genes was observed indrug-resistant cell SMMC-7721/R. The expression ofmdr1 and mrp genes in SMMC-7721/R cells was downregulated to the level in the SMMC-7721/S cells by AS-ODN. Intracellular DNR concentration in SMMC-7721/S cells was 10 times higher than that in SMMC-7721/Rcells. In SMMC7721/S cells intracellular DNRdistributed evenly in the nucleus and cytoplasm, whilein SMMC-7721/R cells DNR distributed in a punctatepattern in the cytoplasm and was reduced in thenucleus. DNR concentration in SMMC-7721/R cells co-transfected with AS-ODNs targeting to mdr1 and mrpmRNAs recovered to 25 percent of that in SMMC7721/Scells. Intracellular DNR distribution pattern in drug-resistant cells treated by AS-ODN was similar to drug-sensitive cell, and the cells resistance index (RI) to DNRand ADM decreased at most from 88.0 and 116.0 to 4.0and 2.3, respectively. Co-Transfection of two AS-ODNsshowed a stronger synergistic effect than ***: P-gp

关键词：柔红素 SMMC-7721/R细胞多药耐药发生机制 RT-PCR

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Corynoxine B targets at HMGB1/2 to enhance autophagy forα-synuclein clearance in fly and rodent models of Parkinson's disease

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药学学报:英文版 2023年第6期13卷 2701-2714页

作者： qi Zhu Juxian Song Jia-yue Chen Zhenwei yuan Liangfeng Liu Li-Ming xie qiwen Liao Richard D.Ye xiu Chen Yepiao Yan Jieqiong Tan Chris Soon Heng Tan Min Li Jia-Hong Lu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China Medical College of Acupuncture-Moxibustion and Rehabilitation Guangzhou University of Chinese MedicineGuangzhou 510006China Mr.and Mrs.Ko Chi Ming Centre for Parkinson's Disease Research School of Chinese MedicineHong Kong Baptist UniversityHongKong 999077China Guangdong Corporate Key Laboratory of High-end Liquid Medicine R&D IndustrializationShaoguan 512028China Limin Pharmaceutical Factory Livzon Pharmaceutical Group Inc.Shaoguan 512028China Kobilka Institute of Innovative Drug Discovery School of Medicinethe Chinese University of Hong KongShenzhen 518172China Center for Medical Genetics Life Science SchoolCentral South UniversityChangsha 410031China department of Chemistry College of ScienceSouthern University of Science and TechnologyShenzhen 518055China

Parkinson's disease(PD)is the most common neurodegenerative movement *** is featured by abnormal alphα-synuclein(α-syn)aggregation in dopaminergic neurons in the substantia ***(autophagy)is an evolutionarily conserved cellular process for degradation of cellular contents,including protein aggregates,to maintain cellular *** B(Cory B),a natural alkaloid isolated from Uncaria rhynchophylla(Miq.)Jacks.,has been reported to promote the clearance ofα-syn in cell models by inducing ***,the molecular mechanism by which Cory B induces autophagy is not known,and theα-syn-lowering activity of Cory B has not been verified in animal ***,we report that Cory B enhanced the activity of Beclin 1/VPS34 complex and increased autophagy by promoting the interaction between Beclin 1 and HMGB1/*** of HMGB1/2 impaired Cory B-induced *** showed for the first time that,similar to HMGB1,HMGB2 is also required for autophagy and depletion of HMGB2 decreased autophagy levels and phosphatidylinositol 3-kinaseⅢactivity both under basal and stimulated *** applying cellular thermal shift assay,surface plasmon resonance,and molecular docking,we confirmed that Cory B directly binds to HMGB1/2 near the C106 ***,in vivo studies with a wild-typeα-syn transgenic drosophila model of PD and an A53Tα-syn transgenic mouse model of PD,Cory B enhanced autophagy,promotedα-syn clearance and improved behavioral *** together,the results of this study reveal that Cory B enhances phosphatidylinositol 3-kinaseⅢactivity/autophagy by binding to HMGB1/2 and that this enhancement is neuroprotective against PD.

关键词： Corynoxine B Parkinson's disease Neurodegenerative disease α-Synuclein Autophagy PI3KC3 HMGB1 HMGB2

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Nocardia cyriacigeorgica infection in a patient with repeated fever and CD4+T cell deficiency:A case report

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World Journal of Clinical Cases 2023年第5期11卷 1175-1181页

作者： Xin Hong You-qi Ji Meng-yuan Chen Xiao-yu Gou yu-Mei Ge department of Green Pharmaceutical Collaborative Innovation Center School of PharmacyZhejiang University of TechnologyHangzhou 310014Zhejiang ProvinceChina School of Medical Technology and Information Engineering Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina The Second Clinical Medical College Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina department of Clinical Laboratory Zhejiang Provincial People's Hospital(Affiliated People's HospitalHangzhou Medical College)Hangzhou 310014Zhejiang ProvinceChina

BACKGROUND Nocardia pneumonia shares similar imaging and clinical features with pulmonary tuberculosis and lung neoplasms,but the treatment and anti-infective medication are completely ***,we report a case of pulmonary nocardiosis caused by Nocardia cyriacigeorgica(***),which was misdiagnosed as community-acquired pneumonia(CAP)with repeated *** SUMMARY A 55-year-old female was diagnosed with community-acquired pneumonia in the local hospital because of repeated fever and chest pain for two *** the anti-infection treatment failed in the local hospital,the patient came to our hospital for further *** computed tomography showed multiple patchy,nodular and strip-shaped high-density shadows in both lungs.A routine haematological examination was performed and showed abnormalities in CD19+B cells and CD4+T *** acid-fast bifurcating filaments and branching gram-positive rods were observed in the bronchoalveolar lavage fluid of the patient under an oil microscope,which was identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry as *** patient’s condition quickly improved after taking 0.96 g compound sulfamethoxazole tablets three times a *** The antibiotic treatment of Nocardia pneumonia is different from that of common *** should be given to the pathogenic examination results of patients with recurrent *** pneumonia is an opportunistic *** with CD4+T-cell deficiency should be aware of Nocardia infection.

关键词： Nocardia pneumonia Nocardia cyriacigeorgica Matrix-assisted laser desorption ionization-time of flight mass spectrometry Infection Lung CD4+T-cell Case report

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熔融织构法制备Y-Ba-Cu-O(123)块状样品的交流磁化研究

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物理学报 1992年第2期41卷 311-316页

作者：王顺喜王玉贵程香爱袁松柳周先意曹烈兆张其瑞中国科学院等离子体物理研究所合肥230031 中国科学技术大学物理系合肥230026

对熔融织构法制备的Y-Ba-Cu-O(123)块状样品作交流磁化研究,并与一般烧结样品进行比较,结果发现,对应一般烧结样品的晶粒和晶界,在交流磁化率虚部上有两个峰,而对织构(即定向排列生长)较好的样品,其交流磁化率虚部上仅有一个对应晶粒峰... 详细信息

对熔融织构法制备的Y-Ba-Cu-O(123)块状样品作交流磁化研究,并与一般烧结样品进行比较,结果发现,对应一般烧结样品的晶粒和晶界,在交流磁化率虚部上有两个峰,而对织构(即定向排列生长)较好的样品,其交流磁化率虚部上仅有一个对应晶粒峰,对于有一定织构但织构不理想的样品,其交流磁化率虚部上也有两个峰,不过它们对立于不同方向生长的晶粒,未观察到频率效应,表明损耗与磁通运动有关。

关键词： MTG法超导体磁化率高Tc YBaCuO

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指定接收者恢复消息的抗抵赖数字签名体制

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浙江大学学报（理学版） 2005年第4期32卷 382-385页

作者：谢琪于秀源杭州师范学院信息工程学院杭州师范学院

抗抵赖的签密方案在一些应用中有重要的价值.已有的方案如认证加密方案和签密方案在解决签名者事后抵赖的问题时,必须把恢复的消息提供给第三方,从消息的保密方面看,效果并不理想.基于离散对数问题提出了安全有效的指定接收者恢复消息... 详细信息

抗抵赖的签密方案在一些应用中有重要的价值.已有的方案如认证加密方案和签密方案在解决签名者事后抵赖的问题时,必须把恢复的消息提供给第三方,从消息的保密方面看,效果并不理想.基于离散对数问题提出了安全有效的指定接收者恢复消息的抗抵赖数字签名体制,其特点是只有指定接收者才可以恢复消息,任何人可以验证签名的合法性,在解决签名者事后抵赖的问题中克服了已有方案的缺陷,不需要签名者的合作、不需要向第三方提供恢复的消息、不需要与第三方执行交互的零知识证明,在保持恢复消息秘密的同时能揭穿签名者的抵赖行为.同时把该方案扩充到了指定的一群接收者恢复消息的抗抵赖的多重签名的情形.

关键词：数字签名多重签名消息恢复离散对数

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基于ID的一次性盲公钥的密码学分析

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浙江大学学报（理学版） 2005年第6期32卷 644-645,720页

作者：谢琪于秀源浙江大学数学系浙江杭州310027 杭州师范学院

为保护用户的隐私又可以避免用户犯罪,ZHANG等提出了基于ID的一次性盲公钥协议.本文给出了两种伪造攻击方案,任何注册用户和非注册用户都可以伪造私钥和证书并可以对任何消息产生有效的签名,而可信中心无法在法院授权的情况下揭示签名... 详细信息

为保护用户的隐私又可以避免用户犯罪,ZHANG等提出了基于ID的一次性盲公钥协议.本文给出了两种伪造攻击方案,任何注册用户和非注册用户都可以伪造私钥和证书并可以对任何消息产生有效的签名,而可信中心无法在法院授权的情况下揭示签名者的真实身份,从而指出他们的方案无法阻止用户犯罪,而且是全局可伪造的.

关键词：盲签名盲公钥因子分解问题离散对数问题

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三七总皂苷调控巨噬细胞sortilin表达及胆固醇代谢的研究

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中国临床药理学杂志 2024年第13期40卷 1893-1897页

作者：高磊孙秀华金钦阳薛奇叶利方郑建雷蚌埠医科大学研究生院安徽蚌埠233030 浙江省人民医院、杭州医学院附属人民医院心脏中心心血管内科浙江杭州310014

目的探讨三七总皂苷(PNS)对巨噬细胞分拣蛋白(sortilin)、腺苷三磷酸结合盒转运子A1(ABCA1)表达的影响和抑制泡沫细胞形成的作用及机制。方法将巨噬细胞分为A组(常规培养)、B组(转染空载慢病毒)、C组(转染过表达sortilin慢病毒)、D组(... 详细信息

目的探讨三七总皂苷(PNS)对巨噬细胞分拣蛋白(sortilin)、腺苷三磷酸结合盒转运子A1(ABCA1)表达的影响和抑制泡沫细胞形成的作用及机制。方法将巨噬细胞分为A组(常规培养)、B组(转染空载慢病毒)、C组(转染过表达sortilin慢病毒)、D组(转染过表达sortilin慢病毒+60μg·mL^(-1)PNS)和E组(转染过表达sortilin慢病毒+10μmol·L^(-1)PD98059+60μg·mL^(-1)PNS)。用蛋白质印迹法检测各组巨噬细胞中sortilin、ABCA1、细胞外调节蛋白激酶(ERK)和磷酸化ERK(p-ERK)蛋白的表达水平;用50μg·mL^(-1)氧化低密度脂蛋白刺激巨噬细胞形成泡沫细胞,用油红O染色评估各组巨噬细胞的脂质含量。结果A、B、C、D、E组的sortilin蛋白相对表达水平分别为1.00±0.08、0.91±0.15、2.28±0.13、1.62±0.09和2.01±0.08,ABCA1蛋白相对表达水平分别为1.00±0.01、0.92±0.07、0.29±0.04、0.66±0.09和0.44±0.07,p-ERK/ERK比值分别为1.00±0.09、0.92±0.05、1.03±0.12、2.00±0.12和1.64±0.14,脂质含量分别为(4.82±2.19)%、(6.70±0.88)%、(44.56±4.15)%、(27.66±3.25)%和(41.67±5.45)%。除p-ERK/ERK外,C组的其他指标与A组相比,在统计学上差异均有统计学意义(均P1);D组的上述指标与C组、E组比较,在统计学上差异均有统计学意义(P1,P1表达,从而减少泡沫细胞的形成;ERK是参与PNS调节sortilin和ABCA1表达的主要信号通路之一。

关键词：三七总皂苷分拣蛋白腺苷三磷酸结合盒转运子A1 泡沫细胞信号通路

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