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Chinese Physics Letters 2024年第2期41卷 36-41页

作者：陈诚闫冰谢聚军 Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Sciences and Technology University of Chinese Academy of SciencesBeijing 101408China College of Mathematics and Physics Chengdu University of TechnologyChengdu 610059China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

Within the extended vector meson dominance model,we investigate the𝑒e^(+)e^(-)→Λ_(c)+Λ_(c)^(- ) reaction and the electromagnetic form factors of the charmed baryon𝛬 Λ_(c)^(+)𝑐.The model parameters are determined by fitting them to the cross sections of the process𝑒e^(+)e^(-)→Λ_(c)+Λ_(c)^(- ) and the magnetic form factor|G_(M)|of Λ_(c)^(+) .By considering four charmonium-like states,called𝜓(4500),𝜓(4660),𝜓(4790),and𝜓(4900),we can well describe the current data on the𝑒e^(+)e^(-)→Λ_(c)+Λ_(c)^(- ) reaction from the reaction threshold up to 4.96 *** addition to the total cross sections and|𝐺M|,the ratio|G_(E)/G_(M)|and the effective form factor|Geff|for Λ_(c)^(+) 𝑐are also calculated,and found that these calculations are consistent with the experimental *** the fitted model parameters,we have also estimated the charge radius of the charmed Λ_(c)^(+) baryon.

关键词： fitted radius meson

orecast of peak infection and estimate of excess deaths in COVID-19 transmission and prevalence in Taiyuan City,2022 to 2023

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Infectious Disease Modelling 2024年第1期9卷 56-69页

作者： Jia-lin Wang Xin-Long Xiao Fen-Fen Zhang Xin Pei Ming-Tao Li ju-Ping Zhang juan Zhang gui-Quan Sun Complex Systems Research Center Shanxi UniversityTaiyuan030006China School of Mathematical Sciences Shanxi UniversityTaiyuan030006China School of Mathematics North University of ChinaTaiyuan030051China College of Mathematics Taiyuan University of TechnologyTaiyuan030024China Complex Systems and Data Science Key Laboratory of Ministry of Education Taiyuan030006China

In this paper,with the method of epidemic dynamics,we assess the spread and prevalence of COVID-19 after the policy adjustment of prevention and control measure in December 2022 in Taiyuan City in China,and estimate the excess population deaths caused by *** on the transmission mechanism of COVID-19 among individuals,a dynamic model with heterogeneous contacts is established to describe the change of control measures and the population's social behavior in Taiyuan *** model is verified and simulated by basing on reported case data from November 8th to December 5th,2022 in Taiyuan city and the statistical data of the questionnaire survey from December 1st to 23rd,2022 in Neijiang *** with reported numbers of permanent residents and deaths from 2017 to 2021 in Taiyuan city,we apply the dynamic model to estimate theoretical population of 2022 under the assumption that there is no effect of *** addition,we carry out sensitivity analysis to determine the propagation character of the Omicron strain and the effect of the control *** a result of the study,it is concluded that after adjusting the epidemic policy on December 6th,2022,three peaks of infection in Taiyuan are estimated to be from December 22nd to 31st,2022,from May 10th to june 1st,2023,and from September 5th to October 13th,2023,and the corresponding daily peaks of new cases can reach 400000,44000 and 22000,*** the end of 2022,excess deaths can range from 887 to 4887,and excess mortality rate can range from 3.06%to 14.82%.The threshold of the infectivity of the COVID-19 variant is estimated 0.0353,that is if the strain infectivity is above it,the epidemic cannot be control with the previous normalization measures.

关键词： Taiyuan city COVID-19 Dynamic model Epidemic scale Epidemic peak Excess death

Seismic response and correlation analysis of a pile-supported wharf to near-fault pulse-like ground motions

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Earthquake Engineering and Engineering Vibration 2024年第4期23卷 883-897页

作者： Wang Jianfeng Su Lei xie Libo ling Xianzhang ju Peng School of Civil Engineering Qingdao University of TechnologyQingdao 266500China School of Civil Engineering Harbin Institute of TechnologyHarbin 150006China No.2 Engineering Company Ltd.of CCCC First Harbor Engineering Company Ltd Qingdao 266071China

Earthquake investigations have shown that near-fault pulse-like(NF-P)ground motions have unique characteristics compared to near-fault non-pulse-like(NF-NP)and far-field(FF)ground *** is necessary to study the seismic response of pile-supported wharf(PSW)structures under NF-P ground *** this study,a three-dimensional finite element numerical model is created to simulate a *** imparting three types of ground motion,the engineering demand parameters(EDPs)of PSW under NF-P ground motions were analyzed and compared,in which EDPs are the maximum displacement and bending moment of the *** intensity measures(IMs)were selected to characterize the properties of ground *** correlation between IMs and EDPs was *** results show that the piles present larger displacement and bending moment under NF-P ground motions compared to NF-NP and FF ground *** of the IMs have a high correlation with EDPs under NF-P ground motions,and these IMs are more applicable to FF ground *** correlation coefficients between EDPs and IMs under three types of ground motion were obtained,which will provide a valuable reference for the seismic design of PSWs.

关键词： pile-supported wharf correlation analysis near-fault pulse-like ground motion intensity measure seismic response

SENP3 Promotes Mantle Cell Lymphoma Development through Regulating Wnt10a Expression

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Current Medical Science 2024年第1期44卷 134-143页

作者： Yan-ni MA Yun-ding ZOU zhi-long LIU gui-xian WU Yuan-ze ZHOU Cheng-xin LUO Xiang-tao HUANG Ming-ling xie Shuang-nian XU Xi LI Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Hematology the Third Affiliated Hospital(Daping Hospital)Third Military Medical University(Army Medical University)Chongqing 400042China

Objective SUMO-specific protease 3(SENP3),a member of the SUMO-specific protease family,reverses the SUMOylation of SUMO-2/3 *** of SENP3 has been proven to be involved in the development of various ***,its role in mantle cell lymphoma(MCL),a highly aggressive lymphoma,remains *** study was aimed to elucidate the effect of SENP3 in *** The expression of SENP3 in MCL cells and tissue samples was detected by RT-qPCR,Western blotting or *** cells with stable SENP3 knockdown were constructed using short hairpin *** proliferation was assessed by CCK-8 assay,and cell apoptosis was determined by flow *** sequencing(mRNA-seq)was used to investigate the underlying mechanism of SENP3 knockdown on MCL development.A xenograft nude mouse model was established to evaluate the effect of SENP3 on MCL growth in *** SENP3 was upregulated in MCL patient samples and *** of SENP3 in MCL cells inhibited cell proliferation and promoted cell ***,the canonical Wnt signaling pathway and the expression of Wnt10a were suppressed after SENP3 ***,the growth of MCL cells in vivo was significantly inhibited after SENP3 knockdown in a xenograft nude mouse *** SENP3 participants in the development of MCL and may serve as a therapeutic target for MCL.

关键词： mantle cell lymphoma SENP3 cell proliferation apoptosis

Quantifying the natural growth rate of hepatocellular carcinoma:A real-world retrospective study in southwestern China

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World Journal of Hepatology 2024年第5期16卷 800-808页

作者： Li Tu Hong xie Qi Li Ping-gui Lei Pei-ling Zhao Fan Yang Chi Gong Yuan-lin Yao Shi Zhou Department of General Practice The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Clinical Medicine Soochow UniversitySuzhou 215123Jiangsu ProvinceChina Department of Radiology The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Clinical Laboratory Center The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Key Laboratory of Biology and Medical Engineering Guizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina Department of Radiology Yanhe Tujia Autonomous County People's HospitalTongren 565300Guizhou ProvinceChina Department of Radiology The Qiandongnan Miao and Dong Autonomous Prefecture People's HospitalKaili 556000Guizhou ProvinceChina Department of Interventional Radiology The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

BACKGROUND In recent years,approximately half of the newly diagnosed cases and mortalities attributed to hepatocellular carcinoma(HCC)have been reported in *** the high incidence of HCC,there remains a paucity of data regarding the natural growth pattern and the determination of optimal surveillance intervals specific to the Chinese *** To quantify the natural tumor growth pattern of HCC in regional *** A retrospective analysis was performed on patients from a single institution in Southwest China who had undergone two or more serial dynamic computed tomography or magnetic resonance imaging scans between 2014 and 2020,without having received any anti-cancer *** growth was assessed using tumor volume doubling time(TVDT)and tumor growth rate(TGR),with volumes measured manually by experienced *** univariate linear regression and descriptive analysis were applied to explore associations between growth rates and clinical *** This study identifies the median TVDT for HCC as 163.4 d,interquartile range(IQR)72.1 to 302.3 d,with a daily TGR of 0.42%(IQR 0.206%-0.97%).HCC growth patterns reveal that about one-third of tumors grow indolently with TVDT exceeding 270 d,another one-third of tumors exhibit rapid growth with TVDT under 90 d,and the remaining tumors show intermediate growth rates,with TVDT ranging between 3 to 9 *** The identified TGRs support biannual surveillance and follow-up for HCC patients in certain regions of *** the observed heterogeneity in HCC growth,further investigation is warranted.

关键词： Hepatocellular carcinoma Natural tumor growth pattern Tumor volume doubling time Tumor growth rate Realworld retrospective study

Investigating the molecular mechanism of Chelidonii Herba against liver cancer using network pharmacology and molecular docking validation

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Integrative Medicine Discovery 2024年第22期8卷 1-12页

作者： Ming-zhi Yang Zi-Xuan Yang Zhang Yu ju-Min xie Hubei Key Laboratory of Renal Disease Occurrence and Intervention Medical SchoolHubei Polytechnic UniversityHuangshi 435003China

Background:The molecular mechanism of Chelidonii Herba in treating hepatocellular carcinoma was investigated using network pharmacology and molecular docking ***:The main active components of Chelidonii Herba were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform database,and the targets of these active ingredients were identified using the SwissTargetPrediction *** related to liver cancer were sourced from GeneCards,Therapeutic Targets Database,and Online Mendelian Inheritance in Man *** targets between the active components of Chelidonii Herba and liver cancer were determined using the jvenn online *** protein interaction network was analyzed via STRING database and visualized using Cytoscape *** targets were identified and further analyzed within the protein interaction *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted for the intersection targets using the DAVID database to correlate gene *** bubble diagrams for Gene Ontology enrichment analysis and circular diagrams for Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were generated using CNSknowall and SangerBox online *** docking and visualization were performed using AutoDockTools 1.5.7 and PyMOL 2.5.7 software,*** survival and pan-cancer analysis of core targets were conducted using the GEPIA2 online ***:Twelve active components of Chelidonii Herba were identified through screening.A total of 103 intersection targets and 12 core targets were found between these active constituents of Chelidonii Herba and liver *** Herba may exert its effects on liver cancer through these 12 core *** signaling pathways are implicated,including chemical carcinogen-receptor activation,endocrine resistance,HIF-1 signaling pathway,and proteoglycans in ***

关键词： Chelidonii Herba liver cancer network pharmacology molecular docking

Styrax japonicus functional genomics:an efficient virus induced gene silencing(VIGS)system

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Horticultural Plant Journal 2024年第1期10卷 252-258页

作者： Gangyu Sun Yiqian ju Cuiping Zhang Lulu Li Xinqiang Jiang Xiaoman xie Yizeng Lu Kuiling Wang Wei Li College of Landscape Architecture and Forestry Qingdao Agricultural UniversityQingdaoShandong 266109China Shandong Provincial Center of Forest and Grass Germplasm Resources JinanShandong 250102China

VIGS(Virus-induced gene silencing),a method for posttranscriptional gene silencing,is an effective technique for investigating the activities of genes in *** there is no report for available VIGS system in Styrax japonicus,the application of a VIGS approach that results in a gene knockdown to study gene function is *** this study,we compared the characteristics that could affect the viability of VIGS in ***,including the acetosyringone(AS)concentration,the Agrobacterium’s optical density and the inoculation *** stable reference genes of *** were selected to validate the gene’s knockdown by quantitative *** a result,we successfully constructed 2 VIGS systems based on TRV virus:vacuum with AS concentration of 200μmol·L^(-1)and OD600of 0.5,and friction-osmosis with AS concentration of 200μmol·L^(-1)and OD600of 1.0,which silencing efficiency was 83.33%and 74.19%,*** successfully applied VIGS method provides a rapid and effective reverse gene functional analysis approach in *** to identify unknown gene functions.

关键词： Styrax japonicus VIGS Reference gene

Selective photosynthesis of Z-olefins through crystalline metal-organic cage-initiated expeditious cascade reactions

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Carbon Energy 2024年第3期6卷 118-131页

作者： Jia-Ni Lu Yunze Huang Yuan-Sheng Xia Long-Zhang Dong Lei Zhang Jing-Jing Liu Lan-gui xie Jiang Liu Ya-Qian Lan Jiangsu Key Laboratory of New Power Batteries School of Chemistry and Materials ScienceJiangsu Collaborative Innovation Centre of Biomedical Functional MaterialsNanjing Normal UniversityNanjingChina School of Chemistry South China Normal UniversityGuangzhouChina

The semi-hydrogenation of alkyne to form Z-olefins with high conversion and high selectivity is still a huge challenge in the chemical ***,flammable and explosive hydrogen as the common hydrogen source of this reaction increases the cost and danger of industrial ***,we connect the photocatalytic hydrogen evolution reaction and the semihydrogenation reaction of alkynes in series and successfully realize the high selective production of Z-alkenes using low-cost,safe,and green water as the proton *** the cascade reaction,a series of isomorphic metal–organic cage catalysts(Co_(x)Zn_(8−x)L_(6),x=0,3,4,5,and 8)are designed and synthesized to improve the yield of the photocatalytic hydrogen *** them,Co_(5)Zn_(3)L_(6) shows the highest photocatalytic activity,with a H_(2) generation rate of 8.81 mmol g^(−1) h^(−1).Then,Co_(5)Zn_(3)L_(6) is further applied in the above tandem reaction to efficiently reduce alkynes to Z-alkenes under ambient conditions,which can reach high conversion of>98%and high selectivity of>99%,and maintain original catalytic activity after multiple ***“one-pot”tandem reaction can achieve a highly selective and safe stepwise conversion from water into hydrogen into Z-olefins under mild reaction conditions.

关键词： alkyne semi-hydrogenation hydrogen evolution reaction metal-organic cages photocatalysis Z-olefins

Review of the Low-Lying Excited Baryons∑*(1/2-)

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Chinese Physics Letters 2024年第10期41卷 31-37页

作者： En Wang Li-Sheng Geng Jia-jun Wu ju-jun xie and Bing-Song Zou School of Physics Zhengzhou UniversityZhengzhou 450001China Guangxi Key Laboratory of Nuclear Physics and Nuclear Technology Guangxi Normal UniversityGuilin 541004China School of Physics Beihang UniversityBeijing 102206China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 102206China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China School of Physics University of Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Sciences and Technology University of Chinese Academy of SciencesBeijing 101408China Department of Physics Tsinghua UniversityBeijing 100084China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China

Strong empirical and phenomenological indications exist for large sea-quark admixtures in the low-lying excited *** the low-lying excited baryon∑*(1/2-)is important for determining the nature of the low-lying excited... 详细信息

关键词： excited quark determining

Functional nanoemulsions: Controllable low-energy nanoemulsification and advanced biomedical application

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Chinese Chemical Letters 2024年第2期35卷 57-69页

作者： Maojie Zhang Qiang Cao Yuming Yuan Xiaohan Guo Dawei Pan Rui xie Xiaojie ju Zhuang Liu Wei Wang Liangyin Chu College of Engineering Sichuan Normal UniversityChengdu 610101China School of Chemical Engineering Sichuan UniversityChengdu 610065China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China

Nanoemulsions are widely used as advanced pharmaceutical delivery systems in biomedical field, due to their high encapsulation efficiency and good therapy *** techniques that produce nanoemulsions with controllable sizes and compositions are promising for creating advanced nanoemulsion systems for pharmaceutical *** review summarizes recent advances on low-energy emulsification techniques for producing nanoemulsions, and the use of these nanoemulsions as advanced pharmaceutical delivery systems and as templates to create drug-loaded functional particles for biomedical ***, nanoemulsification techniques that utilize elaborate interfacial physics/chemistry and micro-/nano-fluidics, featured with relatively-low energy input, to produce nanoemulsions with controllable sizes and compositions, are *** of these nanoemulsions to create nanoemulsionincorporated milli-particles, drug-loaded nanoparticles and nanoparticle-incorporated microparticles with sizes ranging from several millimeters to sub-10 nm are *** and efficient use of the nanoemulsions, functional nanoparticles and milli-/micro-particles integrated with nanoemulsions or nanoparticles for advanced pharmaceutical delivery in biomedical field are highlighted, with focus on how the interplay between their sizes and compositions achieve desired pharmaceutical-delivery ***, perspectives on further advances on the controllable production of nanoemulsions are provided.

关键词： Nanoemulsions Interfaces Drug delivery Template synthesis Nanoparticles