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Chinese Chemical Letters 2024年第6期35卷 531-535页

作者： Jia-li xie Tian-Jin xie Yu-Jie Luo Kai Mao Cheng-Zhi Huang Yuan-Fang li Shu-Jun Zhen Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationCollege of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China Key Laboratory of Luminescent and Real-Time Analytical Chemistry(Southwest University) Chongqing Science and Technology BureauCollege of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China

Fluorescence Anisotropy(FA)is an effective biochemical detection method based on molecular *** oxide(GO)has been extensively used as an FA ***,the enhancement of FA by GO alone is limited and the strong scattering of GO will easily make the measurement of FA *** order to address these problems,an octopus-like Dna nanostructure(ODN)was designed and coupled with GO to enhance the FA together in this *** mimicking the multi-clawed structure of the octopus,the ODN can be adsorbed on GO tightly,which not only could improve the sensitivity because of the double FA enhancement abilities of GO and ODN,but also could improve the specificity due to the decrease of the nonspecific interaction in complex ***,ODN could maintain a certain distance between the fluorophore and GO to reduce the fluorescence quenching efficiency of GO,which could improve the *** method has been applied for the detection of hepatitis B virus Dna(HBV-Dna)in a range of 1-50 nmol/L and the limit of detection(LOD)was 330 pmol/*** addition,the proposed method has been successfully utilized to detect HBV-Dna in human serum,indicating that this method has a great practical application prospect.

关键词： Fluorescence anisotropy Graphene oxide(GO) Octopus-like Dna nanostructure HBV-Dna

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后现代主义视野下课程设计的转向

河北师范大学学报（教育科学版） 2010年第6期12卷 98-101页

作者：谢丽娜西南大学教育学院重庆400715

建立在对现代理性主义批判和反思基础上的后现代主义,为完善我国课程设计提供了新的视角。课程设计主体所表现的价值取向、课程设计对象所涉及的人性观、课程设计内容的重要构成部分知识观均受到后现代主义的影响,于是重新从这三个层面... 详细信息

建立在对现代理性主义批判和反思基础上的后现代主义,为完善我国课程设计提供了新的视角。课程设计主体所表现的价值取向、课程设计对象所涉及的人性观、课程设计内容的重要构成部分知识观均受到后现代主义的影响,于是重新从这三个层面诠释课程设计的后现代转向就有着深远意蕴。

关键词：课程设计价值取向人性观知识观

乡村振兴背景下涉农高职人才培养模式:实践样态与改革路径

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黑龙江高教研究 2021年第8期39卷 104-108页

作者：谢丽娜重庆三峡职业学院重庆404155 西南大学重庆400715

乡村振兴的关键在于人才培养,涉农高职作为人才培养的主要基地,承载着为乡村振兴培养各类人才的使命。而目前涉农高职的人才培养模式存在社会需求和培养目标之间的落差、理想的主体合力与现实的主体合力的落差、培养过程与生产过程的落... 详细信息

乡村振兴的关键在于人才培养,涉农高职作为人才培养的主要基地,承载着为乡村振兴培养各类人才的使命。而目前涉农高职的人才培养模式存在社会需求和培养目标之间的落差、理想的主体合力与现实的主体合力的落差、培养过程与生产过程的落差等问题。为了改善人才培养模式的困境,需要基于“输入—过程—输出”的序列来厘清人才培养模式的形成过程、结构要素与运行机制。改革路径优化是:深化专业供给改革,优化培养目标定位;深化体制机制改革,激发培养主体协同;深化培养模式改革,实现培养过程对接。

关键词：乡村振兴人才培养供需错配改革路径

新时代高校劳动教育体系构建研究:逻辑理路与实践路径

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黑龙江高教研究 2021年第3期39卷 1-5页

作者：谢丽娜西南大学教育学部重庆400715 重庆三峡职业学院重庆404155

新时代高校劳动教育的重提和回归有着极其深刻的时代背景和价值意蕴,在深入分析的基础上,重新诠释了高校劳动教育新的内涵、定位及形态。并进一步指明了高校劳动教育体系构建的逻辑理路,需要遵循以劳树德,塑造和涵养社会主义劳动观;以... 详细信息

新时代高校劳动教育的重提和回归有着极其深刻的时代背景和价值意蕴,在深入分析的基础上,重新诠释了高校劳动教育新的内涵、定位及形态。并进一步指明了高校劳动教育体系构建的逻辑理路,需要遵循以劳树德,塑造和涵养社会主义劳动观;以劳增智,把握"知行合一"的原则和方法;以劳强体,明确劳动是增强体质的重要途径;以劳育美,在劳动中"审美"和"创美"。最终通过"学校—专业—课程—活动"等四个层面,构建了高校劳动教育体系的实践路径。

关键词：高校劳动教育逻辑理路实践路径

Effects of interactions between arbuscular mycorrhizal fungi and bacteria on the growth of Lotus corniculatus L.:From the perspective of regulating rhizosphere fungal community

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Pedosphere 2024年第2期34卷 411-423页

作者： Qing ZHANG Jin CHEN Yingyue li Tao HUANG Kailing xie Jing ZHOU Xiaoyu li Schools of life Sciences Anhui Agricultural UniversityHefei 230036China national Engineering Laboratory of Crop Stress Resistance Breeding Anhui Agricultural UniversityHefei 230036China Anhui Province Key Laboratory of Crop Biology Anhui Agricultural UniversityHefei 230036China

Arbuscular mycorrhizal fungi(AMF)provide essential nutrients to crops and are affected by ***-solubilizing bacteria(PSB),nitrogen-fixing bacteria(NFB),and AMF have mutually beneficial relationships with plants,but the effects of their interactions on plant growth by regulating rhizosphere fungal community have not been sufficiently *** this study,a greenhouse pot experiment was conducted to investigate the interactions between AMF and bacteria(PSB and NFB)on the growth of Lotus corniculatus ***,the role of rhizosphere fungal community in the growth of Lotus corniculatus *** explored using Illumina MiSeq high-throughput *** results showed that combined inoculation of AMF with PSB and NFB increased plant biomass,plant height,and fungal colonization *** richness,complexity,and stability of rhizosphere fungal community also increased after combined inoculation of AMF with PSB and/or NFB,particularly with *** addition,combined inoculation of AMF with PSB and NFB enriched the abundance of beneficial microorganisms,with Chaetomium and Humicola showing the greatest *** structural equation model showed that the interactions of AMF with PSB and NFB promoted plant growth by affecting fungal network structure and soil enzyme activities involved in carbon,nitrogen,and phosphorus *** findings provide evidence for the effects of interactions of AMF with PSB and NFB on rhizosphere fungal community and plant growth.

关键词： colonization intensity colonization rate combined inoculation enzyme activity network structure nitrogen-fixing bacteria phosphatesolubilizing bacteria

A guidance strategy for rendezvous and docking to the space station in the Earth-Moon NRHO orbit

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中国空间科学技术（中英文） 2024年第4期44卷 29-39页

作者： xie Yongchun CHEN Changqing li Xiangyu li Zhenyu Beijing Institute of Control Engineering Beijing 100094China School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China

With the development of space technology,it is possible to build a space station in Earth-Moon space as a transit for Earth-Moon round-trip and entering in the deep *** and docking is one of the key technologies for building an Earth-Moon space station.A guidance strategy for rendezvous and docking from the Earth orbit to the space station in the Earth-Moon NRHO orbit is proposed in this paper,which is suitable for engineering ***,the rendezvous and docking process is divided into three sections,i.e.,the large-range orbit transfer section,far-range guidance section,and close-range approaching *** suitable terminal of large-range orbit transfer is selected according to the eigenvalue of NRHO orbit state transition *** two-impulse guidance method based on the relative motion equation in the three-body problem is adopted for the far-range guidance *** impulse time and amplitude are solved with the optimization *** linear constant three-body relative motion equation is proposed for the close-range approaching section,and the rendezvous and docking is completed by a two-stage linear ***,a simulation analysis is carried out,and the simulation results show that the adopted dynamics equations and the designed guidance law are effective,and the three flight phases are naturally connected to accomplish the rendezvous and docking mission from the Earth orbit to the space station on the Earth-Moon NRHO.

关键词： Earth-Moon space station rendezvous and docking NRHO orbit relative motion guidance strategy

3D digital-image correlation insight into generalized relaxation behavior of sandstone under stress and pore pressure coupling

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2516-2536页

作者： Cancan Chen Heping xie Jiang Xu Seisuke Okubo Shoujian Peng Cunbao li Minghui li State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering Shenzhen UniversityShenzhen518060China Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and GreenEnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen518060China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing400044China

The occurrence of geological hazards and the instability of geotechnical engineering structures are closely related to the time-dependent behavior of ***,the idealization boundary condition for constant stress in creep or constant strain in relaxation is not usually attained in natural geological ***,generalized relaxation tests that explore the simultaneous changes of stress and strain with time under different stress levels with constant pore-water pressure are conducted in this *** results show that in area Ⅰ,area Ⅱ,and area Ⅲ,the stress and strain both change synchronously with time and show similar evolutionary laws as the strain-time curve for creep or the stress-time curve for *** the applied stress level surpasses the δ_(ci) or δ_(cd) threshold,the variations in stress and strain and their respective rates of change exhibit a significant *** radial deformation and its rate of change exhibit greater sensitivity in response to stress *** apparent strain deforms homogeneously at the primary stage,and subsequently,gradually localizes due to the microcrack development at the secondary ***,interconnection of the microcracks causes the formation of a shear-localization zone at the tertiary *** strain-time responses inside and outside the localization zone are characterized by local strain accumulation and inelastic unloading during the secondary and tertiary stages,*** width of the shear-localization zone is found to range from 4.43 mm to 7.08 mm and increased with a longer *** electron microscopy(SEM)reveals a dominant coalescence of intergranular cracks on the fracture surface,and the degree of physiochemical deterioration caused by water-rock interaction is more severe under a longer *** brittle sandstone’s time-dependent deformation is essentially controlled by microcrack development during generalized relaxation,and its expectancy-life is dete

关键词： Generalized relaxation Stress level Direction coefficient Major-strain field Microcrack damage Stress threshold

Anisotropic coherence induced nonuniform amplification in N

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Hongqiang xie Qian Zhang Hongbin Lei na Wang Yuhan Zheng Zhiming Chen Guihua li Zengxiu Zhao School of Science East China University of Technology Department of Physics National University of Defense Technology School of Science East China Jiaotong University

The continuous progress in N2+lasing recently stimulates a great deal of interest in nonlinear and quantum optics of molecular ions, while a complete description of the ionic polarization is still lacking to date. In this work, we are dedicated to constructing the fundamental ionic polarization theory where several ubiquitous strong-field processes including ionization, electronic couplings and molecular alignment jointly determine the spatial arrangement of ions. With the model, the elusive polarization of N2+lasing can be well interpreted. Our results show that the different electronic transition rules for strong-field ionization and resonant couplings result in peculiar population distributions of various electronic states of N2+in space. Meanwhile, the spatial nonuniformity of population distribution can be aggravated or mitigated during field-free evolutions of coherent molecular rotational wave packets. Furthermore, when a follow-up resonant seed pulse interacts with the prepared ionic system, the anisotropic quantum coherence determining the polarization of subsequent N2+lasing can be established. The qualitative agreement between experiments and simulations confirms the validity of the proposed model. The findings provide critical insights into the polarization and radiation mechanisms of molecular ions constructed via ultrafast laser pulses.

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Prox1 Suppresses Proliferation and Drug Resistance of Retinoblastoma Cells via Targeting Notch1

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Current Medical Science 2024年第1期44卷 223-231页

作者： Hong-li ZHANG na li lin DONG Hong-xia MA Mo-chi YANG Department of Ophthalmology General Hospital of Ningxia Medical UniversityYinchuan 750004China

Objective Retinoblastoma(RB)is a prevalent type of eye cancer in *** homeobox 1(Prox1)is a homeobox transcriptional repressor and downstream target of the proneural gene that is relevant in lymphatic,hepatocyte,pancreatic,heart,lens,retinal,and cancer *** goal of this study was to investigate the role of Prox1 in RB cell proliferation and drug resistance,as well as to explore the underlying Notch1 *** Human RB cell lines(SO-RB50 and Y79)and a primary human retinal microvascular endothelial cell line(ACBRI-181)were used in this *** expression of Prox1 and Notch1 mRna and protein in RB cells was detected using quantitative real time-polymerase chain reaction(RT-qPCR)and Western *** proliferation was assessed after Prox1 overexpression using the Cell Counting Kit-8 and the MTS ***-resistant cell lines(SO-RB50/vincristine)were generated and treated with Prox1 to investigate the role of Prox1 in drug *** employed pcDna-Notch1 to overexpress Notch1 to confirm the role of Notch1 in the protective function of ***,a xenograft model was constructed to assess the effect of Prox1 on RB in *** Prox1 was significantly downregulated in RB *** of Prox1 effectively decreased RB cell growth while increasing the sensitivity of drug-resistant cells to ***1 was involved in Prox1’s regulatory ***1 was identified as a target gene of Prox1,which was found to be upregulated in RB cells and repressed by increased Prox1 *** pcDna-Notch1 was transfected,the effect of Prox1 overexpression on RB was ***,by downregulating Notch1,Prox1 overexpression slowed tumor development and increased vincristine sensitivity in *** These data show that Prox1 decreased RB cell proliferation and drug resistance by targeting Notch1,implying that Prox1 could be a potential therapeutic target for RB.

关键词： Proxl Notch1 retinoblastoma cells proliferation drug resistance

Seismic performance and resilience of composite damping self-centering braced frame structures

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Fundamental Research 2024年第3期4卷 603-610页

作者： Longhe Xu Xingsi xie Zhongxian li School of Civil Engineering Beijing Jiaotong UniversityBeijing 100044China Key Laboratory of Coast Civil Structure Safety of China Ministry of Education Tianjin UniversityTianjin 300072China

A magnetorheological self-centering brace(MR–SCB)has been proposed to improve the energy dissipation capability of the *** this paper,a 15-story MR–SCB braced frame is numerically analyzed to examine its seismic performance and *** MR–SCB provides higher lateral stiffness than the buckling restrained brace and greater energy dissipation capability than the existing self-centering *** brace also exhibits a reliable recentering *** rare earthquakes,the maximum average residual deformation ratio of the structure is less than the 0.5%*** mega earthquakes,the maximum average interstory drift ratio of the structure does not exceed the 2.0%elastoplastic limit,and its maximum average floor acceleration ratio is *** effects of mainshock and aftershock on the structural behavior are also *** interstory drift and residual deformation of the structure increase with the increase of the intensity of the *** aftershocks with the same intensity as the mainshocks,the maximum increment of the residual deformation ratio of the structure is 81.8%,and the average interstory drift ratios of the 12^(th),7^(th),and 3^(rd)stories of the structure are increased by 13.4%,9.2%and 7.5%,*** strong aftershock may significantly cause increased damage to the structure,and increase its collapse risk and residual deformation.

关键词： Braced frame structure Self-centeringbrace Magnetorheological fluid Disc spring Seismic performance Seismic resilience Mainshock-aftershock