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难治性肺炎支原体肺炎患儿合并栓塞的危险因素分析及列线图预测模型的构建

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中国当代儿科杂志 2024年第5期26卷 486-492页

作者：谢利娜冯特郭燕军张玉会李远哲张万存郑州大学附属儿童医院儿科呼吸内科河南郑州450018

目的分析难治性肺炎支原体肺炎(refractory Mycoplasma pneumoniae pneumonia,RMPP)患儿合并栓塞的危险因素,并构建列线图预测模型。方法回顾性纳入2019年1月—2023年10月在郑州大学附属儿童医院确诊为RMPP的175例患儿,根据是否合并栓塞... 详细信息

目的分析难治性肺炎支原体肺炎(refractory Mycoplasma pneumoniae pneumonia,RMPP)患儿合并栓塞的危险因素,并构建列线图预测模型。方法回顾性纳入2019年1月—2023年10月在郑州大学附属儿童医院确诊为RMPP的175例患儿,根据是否合并栓塞,分为栓塞组(n=62)和非栓塞组(n=113),采用多因素logistic回归分析筛选RMPP患儿合并栓塞的危险因素,并应用R软件构建列线图预测模型。结果多因素logistic回归分析显示,高D-二聚体、高白细胞介素-6、高中性粒细胞与淋巴细胞比值、肺坏死、胸腔积液是RMPP合并栓塞的危险因素(P<0.05)。根据上述危险因素构建列线图模型的曲线下面积为0.912(95%CI:0.871~0.952,P<0.05)。Hosmer-Lemeshow拟合优度检验结果表明,该模型与实际情况拟合较好(P<0.05)。校准曲线和决策曲线结果显示,该模型的预测效能和临床应用价值较高。结论高D-二聚体、高白细胞介素-6、高中性粒细胞与淋巴细胞比值、肺坏死、胸腔积液是RMPP合并栓塞的危险因素,根据上述危险因素构建列线图模型用于预测RMPP合并栓塞具有较高的临床价值。

关键词：难治性肺炎支原体肺炎列线图预测模型危险因素儿童

腹腔镜下阴式全子宫切除术与经阴道全子宫切除术对子宫肌瘤患者疼痛程度及并发症的影响

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当代医学 2024年第9期30卷 64-68页

作者：游选文范嫦妤谢丽娜丰城市人民医院妇科江西宜春331100

目的探讨腹腔镜下阴式全子宫切除术与经阴道全子宫切除术对子宫肌瘤患者疼痛程度及并发症的影响。方法选取2019年1月至2022年5月于丰城市人民医院接受全子宫切除术的80例子宫肌瘤患者作为研究对象,随机分为A组与B组,每组40例。A组行经... 详细信息

目的探讨腹腔镜下阴式全子宫切除术与经阴道全子宫切除术对子宫肌瘤患者疼痛程度及并发症的影响。方法选取2019年1月至2022年5月于丰城市人民医院接受全子宫切除术的80例子宫肌瘤患者作为研究对象,随机分为A组与B组,每组40例。A组行经阴道全子宫切除术治疗,B组行腹腔镜下阴式全子宫切除术。比较两组手术及康复相关指标、疼痛程度、并发症发生情况、治疗满意度。结果B组手术时间短于A组,术中出血量少于A组,差异有统计学意义(P<0.05)。术后12、24、48h,两组VAS评分均低于前一时间点,差异有统计学意义(P<0.05);术后6、12、24、48h,两组VAS评分比较差异无统计学意义。B组并发症发生率为2.50%,低于A组的15.00%,差异有统计学意义(P<0.05)。B组治疗满意度为97.50%,高于A组的80.00%,差异有统计学意义(P<0.05)。结论相比于经阴道全子宫切除术,腹腔镜下阴式全子宫切除术可缩短手术时间、减少术中出血量,降低术后早期疼痛感受及并发症发生率,提升患者治疗满意度,整体治疗效果更具优势。

关键词：子宫肌瘤腹腔镜下阴式全子宫切除术经阴道全子宫切除术

外周血细胞参数检测对儿童难治性肺炎支原体肺炎的诊断价值

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医药论坛杂志 2024年第6期45卷 578-582页

作者：谢利娜冯特张万存郭燕军郑州大学附属儿童医院儿科郑州450018

目的探究外周血细胞参数检测对儿童难治性肺炎支原体肺炎(refractory mycoplasma pneumoniae pneumonia, RMPP)的诊断价值。方法对郑州大学附属儿童医院呼吸科2020年1月至2022年12月确诊的212例肺炎支原体肺炎患儿进行回顾性分析,根... 详细信息

目的探究外周血细胞参数检测对儿童难治性肺炎支原体肺炎(refractory mycoplasma pneumoniae pneumonia, RMPP)的诊断价值。方法对郑州大学附属儿童医院呼吸科2020年1月至2022年12月确诊的212例肺炎支原体肺炎患儿进行回顾性分析,根据是否为RMPP分为难治组(n=108)和非难治组(n=104);收集所有患儿的一般临床资料和相关实验室检查并进行分析。结果难治组患儿中性粒细胞/淋巴细胞比值(NLR)、血小板计数/淋巴细胞比值(PLR)、平均血小板体积/淋巴细胞比值(MPVLR)、白细胞介素-6(IL-6)、铁蛋白水平均高于非难治组,多因素logistic回归分析NLR、PLR、MPVLR、IL-6、铁蛋白均为RMPP的影响因素(均P<0.05);受试者工作特征(ROC)分析显示NLR、PLR、MPVLR联合曲线下面积(AUC)为0.779,高于IL-6(AUC为0.668)、铁蛋白(AUC为0.739)。结论 NLR、PLR、MPVLR联合检测有望成为诊断RMPP的新指标,能够为临床医生及时诊断和早期干预提供理论依据。

关键词：难治性肺炎支原体肺炎儿童外周血细胞参数诊断价值

Neutrophil peptide 1 accelerates the clearance of degenerative axons during Wallerian degeneration by activating macrophages after peripheral nerve crush injury

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Neural Regeneration Research 2024年第8期19卷 1822-1827页

作者： Yuhui Kou Yusong Yuan Qicheng li Wenyong xie Hailin Xu na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina national Center for Trauma Medicine BeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina Department of Central Laboratory and Institute of Clinical Molecular Biology Peking University People’s HospitalBeijingChina

Macrophages play an important role in peripheral nerve regeneration,but the specific mechanism of regeneration is still *** preliminary findings indicated that neutrophil peptide 1 is an innate immune peptide closely involved in peripheral nerve ***,the mechanism by which neutrophil peptide 1 enhances nerve regeneration remains *** study was designed to investigate the relationship between neutrophil peptide 1 and macrophages in vivo and in vitro in peripheral nerve crush *** functions of RAW 264.7 cells we re elucidated by Cell Counting Kit-8 assay,flow cytometry,migration assays,phagocytosis assays,immunohistochemistry and enzyme-linked immunosorbent *** debris phagocytosis was observed using the CUBIC(Clear,Unobstructed Brain/Body Imaging Cocktails and Computational analysis)optical clearing technique during Wallerian *** inflammatory factor expression in different polarization states was detected using a protein *** results showed that neutrophil peptide 1 promoted the prolife ration,migration and phagocytosis of macrophages,and CD206 expression on the surfa ce of macrophages,indicating M2 *** axonal debris clearance rate during Wallerian degeneration was enhanced after neutrophil peptide 1 *** peptide 1 also downregulated inflammatory factors interleukin-1α,-6,-12,and tumor necrosis factor-αin invo and in ***,the results suggest that neutrophil peptide 1 activates macrophages and accelerates Wallerian degeneration,which may be one mechanism by which neutrophil peptide 1 enhances peripheral nerve regeneration.

关键词： axonal debris inflammatory factors macrophages neutrophil peptide 1 peripheral nerve injury peripheral nerve regeneration RAW 264.7 cells sciatic nerve Wallerian degeneration

The naC-like transcription factor Si naC110 in foxtail millet(Setaria italica L.) confers tolerance to drought and high salt stress through an ABA independent signaling pathway

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Journal of Integrative Agriculture 2017年第3期16卷 559-571页

作者： xie li-na CHEN Ming MIN Dong-hong FENG Lu XU Zhao-shi ZHOU Yong-bin XU Dong-bei li lian-cheng MA You-zhi ZHANG Xiao-hong College of Agronomy North west A &F University Yangling 712100 P.R. China national Key Facility for Crop Gene Resources and Genetic Improvement Ministry of Agriculture/Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 P.R. China College of Sciences Northwest A&F University Yangling 712100 P.R. China

Foxtail millet（Setaria italica（L.）***）is a naturally stress tolerant *** to other gramineous crops,it has relatively stronger drought and lower nutrition stress tolerance *** date,the scope of functional genomics research in foxtail millet（*** L.）has been quite ***（naM,ATAF1/2 and CUC2）-like transcription factors are known to be involved in various biological processes,including abiotic stress *** our previous foxtail millet（*** L.）Rna seq analysis,we found that the expression of a naC-like transcription factor,SinaC110,could be induced by drought stress;additionally,other references have reported that SinaC110 expression could be induced by abiotic ***,we here selected SinaC110 for further characterization and functional ***,the predicted SinaC110 protein encoded indicated SinaC110 has a conserved naM（no apical meristem）domain between the 11–139 amino acid *** analysis then indicated that SinaC110 belongs to subfamily III of the naC gene *** localization analysis revealed that the SinaC110-GFP fusion protein was localized to the nucleus in Arabidopsis *** expression profiling analysis indicated that expression of SinaC110 was induced by dehydration,high salinity and other abiotic *** functional analysis using SinaC110 overexpressed Arabidopsis plants indicated that,under drought and high salt stress conditions,the seed germination rate,root length,root surface area,fresh weight,and dry weight of the SinaC110 overexpressed lines were significantly higher than the wild type（WT）,suggesting that the SinaC110 overexpressed lines had enhanced tolerance to drought and high salt ***,overexpression of SiN AC110 did not affect the sensitivity of SinaC110 overexpressed lines to abscisic acid（ABA）*** analysis of genes involved in proline synthesis,na＋/K＋transport,drought responses,and aqueous transport proteins were higher in th

关键词： foxtail millet (Setaria italica (L.) naC-like transcription factor drought stress high salt stress ABA-independent pathway

Advanced oxidation via the synergy of C-defective/C-O band modified ultrathin porous g-C3N4 and PMS for efficient photothermal degradation of bisphenol pollutants and lignin derivatives

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Green Energy & Environment 2024年第7期9卷 1159-1170页

作者： liquan Jing Meng xie Yuanguo Xu Chun Tong Xia Du Heng Zhao na Zhong Huaming li Jinguang Hu School of Chemistry and Chemical Engineering Jiangsu University Department of Chemical and Petroleum Engineering University of Calgary School of Pharmacy Jiangsu University School of Material Science & Chemical Engineering Harbin University of Science and Technology Institute for Energy Research Jiangsu University

This work uses thermal polymerization of urea nitrate, oxyacetic acid and urea as the raw material to prepare ultra-thin porous carbon nitride with carbon defects and C-O band（OA-UN-CN）. Density functional theory（DFT） calculations showed OA-UN-CN had narrower band gap,faster electron transport and a new internal construction electric field. Additionally, the prepared OA-UN-CN significantly enhanced photocatalytic activation of peroxymonosulfate（PMS） due to enhanced light absorption performance and faster electron overflow. As the result, the OA-UN-CN/PMS could entirely degrade bisphenol A（BPA） within 30 min, where the photodegradation rate was 81.8 and 7.9 times higher than that of g-C3N4and OA-UN-CN, respectively. Beyond, the OA-UN-CN/PMS could likewise degrade other bisphenol pollutants and sodium lignosulfonate efficiently. We suggested possible photocatalytic degradation pathways accordingly and explored the toxicity of its degradation products. This work provides a new idea on the development of advanced photocatalytic oxidation processes for the treatment of bisphenol pollutants and lignin derivatives, via a metal-free photothermal-catalyst.

关键词： Photothermal-catalytic G-C 3 N 4 Peroxymonosulfate Bisphenol Sodium lignosulfonate

CRABP1-mediated non-canonical retinoic acid signaling in motor neurons and neural stem cells

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Neural Regeneration Research 2024年第6期19卷 1169-1170页

作者： li-na Wei Department of Pharmacology University of Minnesota Medical SchoolMinneapolisMNUSA

Retinoic acid(RA),the active metabolite of vitamin A(the retinoids),elicits a wide spectrum of biological activities critical to the development and health of most of the organ systems including the nervous systems(Corcoran et al.,2002).The effects of RA are mediated by two very distinct pathways;the first is manifested in the nucleus by binding to a large family of nuclear RA receptors(RARs)to regulate proper expression of RAtargeted genes.

关键词： canonical spectrum critical

Electrolytes additives for Zn metal anodes: regulation mechanism and current perspectives

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Rare Metals 2024年第9期43卷 4162-4197页

作者： Yu-Zhe Zhang Huai-Sheng Ao Qi Dong Shao-Jie Zhang Zhi-Guo Hou na-na Wang Xue-Song xie Jian Rong Zhong-Yu li School of Environmental Science and Engineering Changzhou University School of Petrochemical Engineering Changzhou University Hefei national Laboratory for Physical Science at Microscale School of Chemistry and Materials Science University of Science and Technology of China Institute for Superconducting and Electronic Materials Australian Institute for Innovative Materials Innovation Campus University of Wollongong Department of Chemical and Materials Engineering University of Alberta

With distinct advantages such as high gravimetric and volumetric capacity(5855 mAh·cm-3and 820mAh·g-1), low redox potential(-0.762 V vs. standard hydrogen electrode（SHE）), high abundance, low toxicity and intrinsic safety of Zn metal anode, Zn-ion batteries have become a potential alternative to li-ion ***, several challenges still need to be addressed prior to the practical applications of Zn-ion batteries, such as dendrite growth during Zn plating/stripping and interfacial side reactions on the Zn surface. Such issues can be addressed by introducing additives to regulate the components and structures of the electrolyte. In this review, we systematically discussed the core issues of metallic Zn anodes and comprehensively summarized a novel perspective of the regulation mechanism of inhibiting dendrite growth or interfacial side reactions in Zn anodes by introducing additives into aqueous ***, some discussions and prospects for aqueous Zn ion batteries（AZIBs） are presented for future research.

关键词： AZIBs Current perspectives Electrolyte additives Regulation mechanism Zn metal anode

Partial linear Model Averaging Prediction for Longitudinal Data

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Journal of Systems Science & Complexity 2024年第2期37卷 863-885页

作者： li na FEI Yu ZHANG Xinyu Faculty of Science Kunming University of Science and TechnologyKunming 650500China School of Statistics and Mathematics Yunnan University of Finance and EconomicsKunming 650221China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China

Prediction plays an important role in data *** averaging method generally provides better prediction than using any of its *** though model averaging has been extensively investigated under independent errors,few authors have considered model averaging for semiparametric models with correlated *** this paper,the authors offer an optimal model averaging method to improve the prediction in partially linear model for longitudinal *** model averaging weights are obtained by minimizing criterion,which is an unbiased estimator of the expected in-sample squared error loss plus a *** properties,including asymptotic optimality and consistency of averaging weights,are established under two scenarios:(i)All candidate models are misspecified;(ii)Correct models are available in the candidate *** studies and an empirical example show that the promise of the proposed procedure over other competitive methods.

关键词： Asymptotic optimality longitudinal data model averaging estimator partially linear model prediction