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Experimental investigation about the incipient velocity of spherical particles on a hemispherical bed surface

Particuology 2024年第5期88卷 49-61页

作者： Chuannan li Jie Chen Changbo Jiang xie li Zhiyuan Wu School of Hydraulic and Environmental Engineering Changsha University of Science & TechnologyChangsha 410114China Key Laboratory of Dongting Lake Aquatic Eco-Environmental Control and Restoration of Hunan Province Changsha 410114China Key Laboratory of Water-Sediment Sciences and Water Disaster Prevention of Hunan Province Changsha 410114China

The sediment particles play a huge role in shaping the bed load transport.In this research,240 water-tunnel experiments are carried out to investigate the incipient velocity of the observation particles in two particle arrangements.To accurately predict the incipient velocity of the observation particles,the equation is conceived by the rolling instability mechanism.The incipient velocity equations and experimental data are used to analyze the trend of dispersive pressure and the effect of arrangement position on velocity.We find that it is appropriate to choose the coefficient of drag as 0.261 and the coefficient of lift as 0.198 for the incipient velocity equation of spherical particles on the hemispherical bed surface.Furthermore,the dispersive pressure is closely related to the flow state,particle size,and particle arrangement,which leads to the incipient velocity of the observation particle being at a minimum when the interference particle angle is 45°.Finally,the particle spacing and the projected area changed with the arrangements,directly affecting the incipient velocity of the observed particle.The analysis of four aspects for the coefficients,dispersive pressure,different particle spacing,and projected area will facilitate the prediction of particle incipient velocity,especially on hemispherical beds.

关键词： Hemispherical bed surface Observed particle Interference particle Dispersive pressure Incipient velocity

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Vonoprazan 10 mg or 20 mg vs. lansoprazole 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis: A randomized controlled trial

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中华医学杂志(英文版) 2024年第8期137卷 962-971页

作者： Xiao Yinglian Qian Jiaming Zhang Shutian Dai Ning Chun Hoon Jai Chiu Chengtang Chong Chui Fung Funao Nobuo Sakurai Yuuichi Eisner Jessica D. xie li Chen Minhu Beijing 100006 Beijing Friendship Hospital Capital Medical University Beijing 100050 Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310020 Department of Internal Medicine Korea University Anam Hospital Department of Gastroenterology Korea University College of Medicine 73 Goryeodae-ro Seongbuk-gu Seoul 02841 Republic of Korea Department of Gastroenterology & Hepatology linkou Medical Center Chang Gung Memorial Hospital Taoyuan The First Affiliated Hospital Taiwan 33353 Takeda Development Center Asia Singapore 018981 Singapore Takeda Pharmaceutical Company Chuo-ku Osaka 540-8645 Japan Takeda Pharmaceuticals International Company Cambridge Sun Yat-sen University MA 02142 USA China Medical Team Takeda China Beijing 100027 Guangzhou Guangdong 510062 China Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences

Background: Erosive esophagitis (EE) is a gastroesophageal reflux disease characterized by mucosal breaks in the esophagus. Proton pump inhibitors are widely used as maintenance therapy for EE, but many patients still relapse. In this trial, we evaluated the noninferiority of vonoprazanvs. lansoprazole as maintenance therapy in patients with healed EE.Methods: We performed a double-blind, double-dummy, multicenter, phase 3 clinical trial among non-Japanese Asian adults with endoscopically confirmed healed EE from April 2015 to February 2019. Patients from China, South Korea, and Malaysia were randomized to vonoprazan 10 mg or 20 mg once daily or lansoprazole 15 mg once daily for 24 weeks. The primary endpoint was endoscopically confirmed EE recurrence rate over 24 weeks with a noninferiority margin of 10% using a two-sided 95% confidence interval (CI). Treatment-emergent adverse events (TEAEs) were recorded.Results: Among 703 patients, EE recurrence was observed in 24/181 (13.3%) and 21/171 (12.3%) patients receiving vonoprazan 10 mg or 20 mg, respectively, and 47/184 (25.5%) patients receiving lansoprazole (differences: -12.3% [95% CI, -20.3% to-4.3%] and -13.3% [95% CI, -21.3% to -5.3%], respectively), meeting the primary endpoint of noninferiority to lansoprazole in preventing EE recurrence at 24 weeks. Evidence of superiority (upper bound of 95% CI <0%) was also observed. At 12 weeks, endoscopically confirmed EE recurrence was observed in 5/18, 2/20, and 7/20 of patients receiving vonoprazan 10 mg, vonoprazan 20 mg, and lansoprazole, respectively. TEAEs were experienced by 66.8% (157/235), 69.0% (156/226), and 65.3% (158/242) of patients receiving vonoprazan 10 mg, vonoprazan 20 mg, and lansoprazole, respectively. The most common TEAE was upper respiratory tract infection in 12.8% (30/235) and 12.8% (29/226) patients in vonoprazan 10 mg and 20 mg groups, respectively and 8.7% (21/242) patients in lansoprazole group.Conclusion: Vonoprazan maintenance therapy was well-tolerated and noninferior to lansoprazole f

关键词： Erosive esophagitis Lansoprazole Maintenance therapy Potassium-competitive acid blockers Vonoprazan

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Octopus-like DNA nanostructure coupled with graphene oxide enhanced fluorescence anisotropy for hepatitis B virus DNA detection

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Chinese Chemical Letters 2024年第6期35卷 531-535页

作者： Jia-li xie Tian-Jin xie Yu-Jie Luo Kai Mao Cheng-Zhi Huang Yuan-Fang li Shu-Jun Zhen Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationCollege of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China Key Laboratory of Luminescent and Real-Time Analytical Chemistry(Southwest University) Chongqing Science and Technology BureauCollege of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China

Fluorescence Anisotropy(FA)is an effective biochemical detection method based on molecular rotations.Graphene oxide(GO)has been extensively used as an FA amplifier.However,the enhancement of FA by GO alone is limited and the strong scattering of GO will easily make the measurement of FA inaccurate.In order to address these problems,an octopus-like DNA nanostructure(ODN)was designed and coupled with GO to enhance the FA together in this work.By mimicking the multi-clawed structure of the octopus,the ODN can be adsorbed on GO tightly,which not only could improve the sensitivity because of the double FA enhancement abilities of GO and ODN,but also could improve the specificity due to the decrease of the nonspecific interaction in complex samples.Furthermore,ODN could maintain a certain distance between the fluorophore and GO to reduce the fluorescence quenching efficiency of GO,which could improve the accuracy.This method has been applied for the detection of hepatitis B virus DNA(HBV-DNA)in a range of 1-50 nmol/L and the limit of detection(LOD)was 330 pmol/L.In addition,the proposed method has been successfully utilized to detect HBV-DNA in human serum,indicating that this method has a great practical application prospect.

关键词： Fluorescence anisotropy Graphene oxide(GO) Octopus-like DNA nanostructure HBV-DNA

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Specialized endoplasmic reticulum-derived vesicles in plants:Functional diversity,evolution,and biotechnological exploitation

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Journal of Integrative Plant Biology 2022年第4期64卷 821-835页

作者： xie li Xifeng li Baofang Fan Cheng Zhu Zhixiang Chen College of life Science Key Laboratory of Marine Food Quality and Hazard Controlling Technology of Zhejiang ProvinceChina Jiliang UniversityHangzhou 310018China Department of Botany and Plant Pathology Center for Plant BiologyPurdue UniversityWest Lafayette IN 47907-2054USA

A central role of the endoplasmic reticulum(ER)is the synthesis,folding and quality control of secretory proteins.Secretory proteins usually exit the ER to enter the Golgi apparatus in coat protein complex II(COPII)-coated vesicles before transport to different subcellular destinations.However,in plants there are specialized ER-derived vesicles(ERDVs)that carry specific proteins but,unlike COPII vesicles,can exist as independent organelles or travel to the vacuole in a Golgi-independent manner.These specialized ERDVs include protein bodies and precursor-accumulating vesicles that accumulate storage proteins in the endosperm during seed development.Specialized ERDVs also include precursor protease vesicles that accumulate amino acid sequence KDEL-tailed cysteine proteases and ER bodies in Brassicales plants that accumulate myrosinases that hydrolyzes glucosinolates.These functionally specialized ERDVs act not only as storage organelles but also as platforms for signal-triggered processing,activation and deployment of specific proteins with important roles in plant growth,development and adaptive responses.Some specialized ERDVs have also been exploited to increase production of recombinant proteins and metabolites.Here we discuss our current understanding of the functional diversity,evolutionary mechanisms and biotechnological application of specialized ERDVs,which are associated with some of the highly remarkable characteristics important to plants.

关键词： endoplasmic reticulum-derived vesicles ER body glucosinolates myrosinases precursor accumulating vesicles precursor protease vesicles prolamins protein body ricinosomes zeins

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A novel mutation of glycogen synthase kinase-3β leads to a reduced level of GSK3βprotein in a patient with dilated cardiomyopathy

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Genes & Diseases 2024年第1期11卷 84-86页

作者： Ke Gong Zhiping Tan Haidan liu Xiaobo liao Xinmin Zhou Bangliang Yin Shi Zeng Yao Yao Yifeng Yang li xie Department of Cardiovascular Surgery The Second Xiangya Hospital of Central South UniversityCentral South UniversityChangshaHunan410011China Department of Ultrasound The Second Xiangya Hospital of Central South UniversityCentral South UniversityChangshaHunan 410011China Department of Blood Transfusion The Second Xiangya Hospital of Central South UniversityCentral South UniversityChangshaHunan 410011China

Dilated cardiomyopathy(DCM)is a frequently inherited heart condition.A familial transmission rate of 20%-35%has been documented,and most of these cases are autosomal dominant.This condition has a high rate of morbidit... 详细信息

关键词： GSK3β cardiomyopathy mortality

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Prealbumin as a prognostic indicator for hospital readmission of ulcerative colitis patients

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Precision Clinical Medicine 2024年第1期7卷 81-83页

作者： Chao Ye Anmin Wang Wei li Wenyuan li Qi Shen Zhangfei Wang li xie Qiuxia Jiang Kaiguang Zhang Shu Zhu Department of Digestive Disease The First Affliated Hospital of University of Science and Technology of China(USTC)Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230000China Institute of Immunology the Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic DiseaseDivision of Life Sciences and MedicineUniversity of Science and Technology of China(USTC)Hefei 230000China Department of Infectious Diseases The First Affliated Hospital of University of Science and Technology of China(USTC)Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230000China Department of Radiotherapy The First Affliated Hospital of University of Science and Technology of China(USTC)Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230000China clinical laboratory The First Affliated Hospital of University of Science and Technology of China(USTC)Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230000China Institute of Health and Medicine Hefei Comprehensive National Science CenterHefei 230000China School of Data Science University of Science and Technology of China(USTC)Hefei 23000China

Dear Editor,Inflammatory bowel diseases(IBD)such as ulcerative colitis(UC)and Crohn's disease are affecting increasing numbers of patients worldwide.1 These chronic diseases significantly impact patients'quality of life as they are incurable and disabling.1 Patients with IBD have had an increasing rate of hospitalizations,half of all UC patients are hospitalized at least once during their lifetime,and readmissions after a UC-related hospitalization are common.

关键词： patients diseases colitis

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文以致治与符号建构:近代诗中的黄河书写

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河南大学学报（社会科学版） 2024年第3期64卷 99-105,155页

作者：谢丽河南大学文学院河南开封475001

近代诗中的黄河书写呈现出不同于古代书写的新事物、新理念、新精神,从审美取向来看,一扫前朝的纤弱之态,表现出高瞻豪健的美学旨趣,展示了一代士人自作主宰的创造意识;面对近代黄河灾难频发和清王朝治河制度的弱化,文化精英们揭示现实... 详细信息

近代诗中的黄河书写呈现出不同于古代书写的新事物、新理念、新精神,从审美取向来看,一扫前朝的纤弱之态,表现出高瞻豪健的美学旨趣,展示了一代士人自作主宰的创造意识;面对近代黄河灾难频发和清王朝治河制度的弱化,文化精英们揭示现实问题、探究治理策略,将政治感受、变革理念融入黄河书写中,表现出文以致治的创作精神;基于西风东渐和救亡图存的时代背景,他们借助黄河书写救国之志、爱国热忱以及中华自信,推进黄河作为文化符号的建构,彰显了黄河文明的精神价值。近代黄河诗篇有力拓宽了文学的题材内容,折射出晚清民初时局下黄河书写对政治的介入和对文化的建构,表达了近代语境下中国知识分子的思想引领、精神取向与审美选择。

关键词：黄河书写审美取向创作精神符号建构

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Exploring Gender Differences in Adolescent Dissociative Symptoms via A Structural Equation Model

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生物医学与环境科学:英文版 2023年第8期36卷 773-778页

作者： CHENG Qing lin DENG Yuan Yuan ZHAO Gang CHEN Jun Fang xie li WANG Le Hangzhou Center for Disease Control and Prevention Hangzhou 310021ZhejiangChina School of Medicine Hangzhou Normal UniversityHangzhou 310021ZhejiangChina

Adolescent dissociative disorders(ADDs)have been recognized as significant psychological issues with an estimated prevalence of 45.2%in psychiatric outpatient clinics^([1]).Previous studies have demonstrated that dissociative symptoms(DSs)manifest as early signs of dissociative disorders(DDs)^([2]).DSs are characterized as aberrations in one's feelings,experiences,and thoughts in the realm of awareness and memory^([3]).

关键词： Equation Ado realm

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Expression profiles of circulating tRNA-derived small RNAs and their potential role in diabetes

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BIOCELL 2023年第7期47卷 1645-1650页

作者： JING JIN xie li TING QIU LEI SONG YUANYUE CUI GUANGYA ZHANG SHU li WENCHENG ZHAO Department of Ophthalmology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China Department of Ophthalmology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200080China Department of Endocrinology Shanghai Ninth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200011China Department of Cardiology Shanghai Sixth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200233China Department of Medical Oncology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai200433China

This work aimed to reveal the expression profiles of tRNA-derived small RNAs(tsRNAs)in diabetes.Methods:Thirty-five diabetes patients and thirty-three controls were enrolled.The serum samples of 4 diabetes patients and 4 controls were subjected to tRF and tiRNA polymerase chain reaction(PCR)Array analysis.Then quantitative PCR(qPCR)validation was performed on all the samples.Bioinformatics analyses were conducted to explore their functions.Results:We found 115 tsRNAs that significantly differed between the two groups.3′tiR-080-ProTGG(mt)was selected for further qPCR validation in all participants,and it was significantly decreased in diabetes patients compared with controls.Bioinformatics analysis indicated that 3′tiR-080-ProTGG(mt)may play regulatory roles via the cyclic adenosine monophosphate(cAMP)signaling pathway in the pathogenesis and progression of diabetes.Conclusion:Hence,we report that circulating tsRNAs are dysregulated that could be involved in the pathogenesis of diabetes.

关键词： Diabetes Noncoding RNAs tRF tiRNA

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Characterization of Mutations in Genes Related to Rifampicin and Isoniazid Resistance in Multidrug-resistant Mycobacterium tuberculosis Strains from Hangzhou,China

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生物医学与环境科学:英文版 2023年第9期36卷 869-873页

作者： HUANG Yin Yan xie li WU Yi Fei JIA Qing Jun CHENG Qing lin li Qing Chun AI li Yun BAI Xue Xin Department of TB Control and Prevention Hangzhou Center for Disease Control and PreventionHangzhou 310021ZhejiangChina

Tuberculosis(TB),caused by the Mycobacterium tuberculosis complex(MTBC),is the 13^(th)leading cause of death and the second leading cause of infectious killer after COVID-19(above HIV and AIDS),according to the World Health Organization's 2022 Global TB Report.In 2021,10.6 million people were diagnosed with a new episode of TB and 1.6 million people died as a result.

关键词： tuberculosis death Mycobacterium

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