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L1CAM overexpression promotes tumor progression through recruitment of regulatory T cells in esophageal carcinoma

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Cancer Biology & Medicine 2021年第2期18卷 547-561页

作者： Xuan Zhao Shasha Liu Xinfeng Chen Jianyi Zhao Feng Li qitai Zhao Tan xie Lan Huang Zhen Zhang Yu Qi yang yang Song Zhao Yi Zhang Biotherapy Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Cancer Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Thoracic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Pediatric Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China School of Life Sciences Zhengzhou UniversityZhengzhou 450052China Henan Key Laboratory for Tumor Immunology and Biotherapy Zhengzhou 450052China

Objective:L1 cell adhesion molecule(L1 CAM)exhibits oncogenic activity in ***,the link between L1 CAM and the tumor microenvironment remains poorly understood in patients with esophageal squamous cell carcinoma(ESCC).In this study,we investigated how L1 CAM expression in ESCC affects the oncogenic characteristics of tumor cells and the tumor ***:Human ESCC samples were collected,and the m RNA and protein levels of L1 CAM were examined by real-time PCR and *** and knockdown gene expression assays were used for mechanistic *** cell proliferation and cell cycle were measured with CCK-8 assays and flow *** migration and invasion ability were measured with Transwell *** bead-based assays were performed to identity the factors downstream of L1 *** studies were performed in nude mice to evaluate the effects of L1 CAM on tumor growth and regulatory T cell(Treg)***:L1 CAM expression was significantly elevated in ESCC tissues(P<0.001)and correlated with poorer prognosis(P<0.05).Ablation of L1 CAM in ESCC cells inhibited tumor growth and migration,and increased tumor cell apoptosis(P<0.05).In the tumor microenvironment,L1 CAM expression correlated with Treg infiltration in ESCC by affecting CCL22 ***,L1 CAM facilitated CCL22 expression by activating the PI3 K/Akt/NF-κB signaling ***,CCL22 promoted Treg recruitment to the tumor site;the Tregs then secreted TGF-β,which in turn promoted L1 CAM expression via Smad2/3 in a positive feedback ***:Our findings provide new insight into the mechanism of immune evasion mediated by L1 CAM,suggesting that targeting L1 CAM-CCL22-TGF-βcrosstalk between tumor cells and Tregs may offer a unique means to improve treatment of patients with ESCC.

关键词： L1CAM CCL22 Tregs TGF-β esophageal squamous cell carcinoma

贵州省异戊二烯浓度分布及日变化情况初步分析

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地球与环境 2024年第3期52卷 277-285页

作者：罗皓李启泰左仁慧刘芳谢凯夫曹骅马关琴李函颖章婷贵州环科环保咨询有限公司贵阳550081 贵州省环境科学学会贵阳550081 贵州师范大学生命科学学院贵阳550025 贵州师范大学地理与环境科学学院贵阳550025 贵州中咨环科科技有限公司贵阳550081

为了了解贵州省环境空气异戊二烯的浓度水平及分布情况,以贵州省2019年臭氧污染较为严重的地区为研究区域选取了18个采样点,这18个点位包括了工业区、城市建成区、居民区、交通枢纽等排放人为源挥发性有机物(AVOCs)的区域,和水生植物种... 详细信息

为了了解贵州省环境空气异戊二烯的浓度水平及分布情况,以贵州省2019年臭氧污染较为严重的地区为研究区域选取了18个采样点,这18个点位包括了工业区、城市建成区、居民区、交通枢纽等排放人为源挥发性有机物(AVOCs)的区域,和水生植物种植区、森林植被覆盖区、自然风景区等排放植物源挥发性有机物(BVOCs)的区域,尤其以水生植物种植区的异戊二烯观测为重点,在2020年7~9月期间分批次进行了环境空气异戊二烯的离线采样和臭氧浓度的同步在线监测。结果表明,贵州省大气异戊二烯日均浓度在0.13~6.13μg/m^(3)之间,其中BVOCs采样区域、AVOCs采样区域、水生植物种植区、森林植被覆盖区的异戊二烯日均浓度分别为1.74、0.52、2.26、1.23μg/m^(3),白天平均浓度分别为2.80、0.54、4.03、1.57μg/m^(3),夜间平均浓度分别为0.68、0.50、0.49、0.88μg/m^(3),BVOCs采样区域的异戊二烯日均浓度、白天浓度高于AVOCs采样区,夜间浓度差异不大;水生植物种植区的日均浓度和白天浓度高于森林植被覆盖区,这表明贵州部分地区水生植物在夏季白天的异戊二烯排放比森林植被等陆生植物要高,水生植物(荷花、芦苇、慈姑等)排放的异戊二烯对环境的影响值得关注并深入研究。

关键词：贵州省异戊二烯水生植物

A study on excitation of atmospheric gravity waves from annular solar eclipse

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Chinese Journal of Acoustics 1993年第2期12卷 166-183页

作者： LI qitai(Institute of Environmental Protection ofGuizhou Province. Guizhou 550002)xie jinlai and yang Xunren (Institute of Acoustics. Academia Sinica Beijing 100080)

Utilizing the data of microbarometric waves on ground level, radiosonde reports and solar radiations obtained from various observation stations in China during the annular solar eclipse on September 23, 1987, the mechanism ,of AGWs excited by the eclipse, the spectral characteristics and the local differences have been studied, and the results have been compared with those from the ionospheric sounding at the same time. It turns out that there were AGWs excited certainly during this annular solar eclipse, their periods are obviously in accordance with the duration of the fluctuation in the direct solar radiation.

关键词： Annular solar eclipse Acoustic gravity wave Dynamical spectra.

The effect of solar radiation change on the maize yield gap from the perspectives of dry matter accumulation and distribution

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Journal of Integrative Agriculture 2021年第2期20卷 482-493页

作者： yang Yun-shan GUO Xiao-xia LIU Hui-fang LIU Guang-zhou LIU Wan-mao MING Bo xie Rui-zhi WANG Ke-ru HOU Peng LI Shao-kun The Key Laboratory of Oasis Eco-agriculture Xinjiang Production and Construction Corps/College of AgronomyShihezi UniversityShihezi 832003P.R.China Key Laboratory of Crop Physiology and Ecology Ministry of Agriculture and Rural Affairs/Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081P.R.China College of Agronomy Ningxia UniversityYinchuan 750021P.R.China

The uneven distribution of solar radiation is one of the main reasons for the variations in the yield gap between different regions in China and other countries of the *** this study,different solar radiation levels were created by shading and the yield gaps induced by those levels were analyzed by measuring the aboveground and underground growth of *** experiments were conducted in qitai,Xinjiang,China,in 2018 and *** maize cultivars Xianyu 335 (XY335)and Zhengdan 958 (ZD958) were used with planting density of 12×10^(4) plants ha^(–1) under either high solar radiation (HSR)or low solar radiation (LSR,70%of HSR).The results showed that variation in the solar radiation resulted in a yield gap and different cultivars behaved *** yield gaps of XY335 and ZD958 were 8.9 and 5.8 t ha^(–1) induced by the decreased total intercepted photosynthetically active radiation (TIPAR) of 323.1 and 403.9 MJ m^(–2) from emergence to the maturity stage,*** average yield of XY335 was higher than that of ZD958 under HSR,while the average yield of ZD958 was higher than that of XY335 under *** light intercepted by the canopy and the photosynthetic rates both decreased with decreasing solar *** aboveground dry matter decreased by 11.1% at silking and 21% at maturity,and the dry matter of vegetative organs and reproductive organs decreased by 9.8 and 20.9%at silking and by 12.1 and 25.5% at physiological maturity,*** to the HSR,the root weights of XY335 and ZD958 decreased by 54.6 and 45.5%,respectively,in the 0–60 cm soil layer under LSR at silking *** aboveground and underground growth responses to different solar radiation levels explained the difference in yield *** suitable cultivars can increase maize yield and reduce the yield gaps induced by variation of the solar radiation levels in different regions or under climate change.

关键词： maize solar radiation yield gap cultivar

Pulsar Survey With the qitai 110 m Radio Telescope

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Research in Astronomy and Astrophysics 2022年第7期22卷 151-160页

作者： xie Jintao Wang Jingbo Wang Na Hu Yue Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesUrumqi 830011China Xinjiang Key Laboratory of Radio Astrophysics Urumqi 830011China

With a collecting area of 9400 m^(2),the Xinjiang qitai 110 m radio Telescope(QTT) will allow for a significant advance in the search and observation of *** have updated the galactic electron density model,scattering model,spectral distribution,and radial distribution of PSRPOPPY to generate the population of isolate radio pulsars in the *** spiral arm,including the local spiral arm,is considered when generating pulsar *** simulation,we estimate the number of previously undetected radio pulsars that QTT will discover with its possible receivers for different *** the PAF receiver,2200 previously unknown pulsars could be discovered in43 *** 96-beam PAF receiver can produce~10.56 GB of data per second.

关键词： (stars:)pulsars:general Galaxy:structure telescopes

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启发式教学在病理学教学中的应用与思考

包头医学院学报 2013年第2期29卷 91-93页

作者：胡其泰耿虹沈淑萍郭建国谢立平包头医学院病理学教研室内蒙古包头014060

病理学是基础医学与临床医学的桥梁学科。将比喻、问题、类比、案例、跨学科知识启发式教学等多种方法应用到病理学教学中,激发学生的学习兴趣,调动学生的主观能动性,培养学生独立发现、分析和解决问题的能力,取得了良好的教学效果。

关键词：病理学教学方法启发式教学

杂氮硅三环化合物(Ⅰ)和(Ⅱ)晶体结构的研究

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高等学校化学学报 1987年第7期8卷 629-634页

作者：林秀云郑启泰吴伸张树德沈福岭王积涛谢庆兰廖仁安李靖中国科学院生物物理研究所南开大学元素有机化学研究所

杂氮硅三环化合物Ⅰ(■-COOCH_(2)Si(OCH_(2)CH_(2))_(3)N)和Ⅱ(■OCH_(3),COOSi(OCH_(2)CH_(2))_(3)N)的分子结构用直接法解,经全矩阵最小二乘修正,得到它们的晶体学参数。并对它们的结构进行了比较和讨论。

关键词：晶体结构 (Ⅱ) 分子结构最小二乘 COO

基于X-rayμCT技术的玉米籽粒结构特征的粒位效应分析

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农业工程学报 2021年第7期37卷 8-14页

作者：银学波明博侯俊峰王克如李少昆谢瑞芝中国农业科学院作物科学研究所/农业农村部作物生理生态重点实验室北京100081 浙江省农业科学院/玉米与特色旱粮研究所东阳322100

玉米籽粒因其在果穗上着生位置不同存在较大差异,明确籽粒结构特征的粒位效应为玉米的消费、加工和播种质量等玉米产量和品质性状的评价提供参考。该研究以3个不同籽粒类型的玉米品种登海618(DH618)、KX3564和先玉335(XY335)为材料,利用... 详细信息

玉米籽粒因其在果穗上着生位置不同存在较大差异,明确籽粒结构特征的粒位效应为玉米的消费、加工和播种质量等玉米产量和品质性状的评价提供参考。该研究以3个不同籽粒类型的玉米品种登海618(DH618)、KX3564和先玉335(XY335)为材料,利用X射线计算机断层(X-ray micro-computed tomography,X-rayμCT)技术扫描测试样本,通过图像滤波、阈值分割等图像分析方法重建籽粒3维结构,获取玉米果穗不同粒位籽粒的胚、胚乳、皮下空腔、胚空腔、硬质胚乳、粉质胚乳、胚乳空腔等结构参数。数据分析表明,籽粒不同结构指标在果穗上呈现不同的变化规律,从基部到顶部(不考虑果穗两端的极端籽粒),胚、胚乳及硬质胚乳体积线性下降,各指标在果穗上的变化范围分别为15.82~33.36、180.15~296.50及87.13~166.00 mm^(3);胚乳空腔>皮下空腔>胚空腔,果穗中部籽粒的空腔较小且稳定,3个品种表现一致;胚与胚乳的比值在粒位间基本稳定,粉质胚乳体积、硬质胚乳与粉质胚乳的比值从基部至顶部逐渐减小,但不同指标的变化斜率存在差异。3个供试品种的籽粒结构参数不同:DH618果穗不同部位籽粒胚与胚乳的比值大于KX3564和XY335,XY335籽粒硬质胚乳与粉质胚乳的比值大于DH618和KX3564。在籽粒空腔方面,KX3564皮下空腔的比例较高,而XY335胚乳空腔的比例较高。3个品种胚、胚乳、皮下空腔体积在玉米籽粒中的比例平均分别为9.27%、89.87%、0.86%。X-rayμCT扫描技术为玉米籽粒性状的研究提供新的方法与思路,明确果穗籽粒结构的粒位效应有利于全面地掌握玉米果穗上籽粒的性状特征,为玉米的生产、加工及品种改良等提供借鉴。

关键词：作物玉米粒位效应籽粒结构 X-rayμCT

奇台黑碱土可培养细菌的分离及抑制黑色素合成活性菌株的筛选

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生物加工过程 2017年第6期15卷 74-79页

作者：付建红杨新平谢芹仲晓燕张婉昕甘甜新疆师范大学生命科学学院新疆特殊环境物种多样性应用与调控重点实验室新疆乌鲁木齐830054 新疆农业科学院微生物应用研究所新疆乌鲁木齐830011

黑碱土也称为碱化盐土,形成原因十分复杂,改良也很困难,但是这种高盐环境为嗜盐碱菌、耐盐碱菌的研究提供了得天独厚的条件。本研究中,笔者采用平板稀释法从新疆奇台黑碱土中分离获得95个细菌菌株,通过建立的用比基尼链霉菌CPCC200555... 详细信息

黑碱土也称为碱化盐土,形成原因十分复杂,改良也很困难,但是这种高盐环境为嗜盐碱菌、耐盐碱菌的研究提供了得天独厚的条件。本研究中,笔者采用平板稀释法从新疆奇台黑碱土中分离获得95个细菌菌株,通过建立的用比基尼链霉菌CPCC200555为鉴定菌的黑色素生物合成抑制剂筛选模型,从分离菌株的285个次级代谢产物样品中筛选出21株细菌,其代谢产物对黑色素合成有较强的抑制活性,其中,15株细菌代谢物对蘑菇酪氨酸酶也有明显的抑制活性。本研究为筛选用作美白化妆品的添加剂和治疗皮肤黑色素瘤药物的黑色素生物合成抑制剂奠定科学基础。

关键词：耐盐碱菌分离黑色素合成抑制剂蘑菇酪氨酸酶抑制剂