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Serum 25(OH)D and Lipid Levels in Chinese Obese and Normal Weight Males before and after Oral Vitamin D Supplementation

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Biomedical and Environmental Sciences 2013年第10期26卷 801-807页

作者： ZHOU Ji Chang zhu Yu Mei GUO Ping CHEN Zheng xie feng zhu LIU Xiao Li HE Shan Molecular Biology Laboratory Shenzhen Center for Chronic Disease Control Health Service Center of Shuiku Community Shenzhen Center for Chronic Disease Control

Objective To study the effect of oral vitamin D （VD） supplementation on VD status and serum lipid in Chinese obese and healthy normal-weight men. Methods Twenty-one obese men with their body mass index （BMI）〉28 kg/m2 served as an obese group and 22 healthy normal-weight men with their BMI〈24 kg/m2 served as a control group in this study. After they were given 50 000 IU of oral VD, once a week for 8 weeks, the serum 25-hydroxyvitamin D [25（OH）D] concentration was measured with an enzyme-immunoassay kit. Results After oral VD supplementation, the serum 25（OH）D concentration significantly increased from 46.1＋9.1 nmol/L to 116.7_＋20.3 nmol/L in the obese subjects （P〈O.01） and from 52.8_＋17.8 nmol/L to 181.3_＋30.2 nmol/L in the control ones （P=0.13）. The serum high-density lipoprotein cholesterol （HDL-C） level was reduced within the normal reference range in the obese group. However, no significant change was observed in the level of other serum lipids （triglycerides, total cholesterol, and low-density lipoprotein cholesterol） in either of the two groups. Conclusion The effect of high-dose oral VD supplementation is weaker on VD status in the obese group than in the control group. High-dose oral VD supplementation has no side effect on serum lipid level in obese and control groups.

关键词： Vitamin D Obesity Serum 25(OH)D Serum lipid

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang feng Gao Yu-Gui Peng Peng Wu Zong-Lin Li Xue-feng zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

A Cross Attention Transformer-Mixed Feedback Video Recommendation Algorithm Based on DIEN

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Computers, Materials & Continua 2025年第1期82卷 977-996页

作者： Jianwei Zhang Zhishang Zhao Zengyu Cai Yuan feng Liang zhu Yahui Sun College of Software Engineering Zhengzhou University of Light IndustryZhengzhou450000China Faculty of Information Engineering Xuchang Vocational Technical CollegeXuchang461000China College of Computer Science and Technology Zhengzhou University of Light IndustryZhengzhou450000China College of Electronics and Information Zhengzhou University of Light IndustryZhengzhou450000China

The rapid development of short video platforms poses new challenges for traditional recommendation *** systems typically depend on two types of user behavior feedback to construct user interest profiles:explicit feedback(interactive behavior),which significantly influences users’short-term interests,and implicit feedback(viewing time),which substantially affects their long-term ***,the previous model fails to distinguish between these two feedback methods,leading it to predict only the overall preferences of users based on extensive historical behavior ***,it cannot differentiate between users’long-term and shortterm interests,resulting in low accuracy in describing users’interest states and predicting the evolution of their *** paper introduces a video recommendationmodel calledCAT-MFRec(CrossAttention Transformer-Mixed Feedback Recommendation)designed to differentiate between explicit and implicit user feedback within the DIEN(Deep Interest Evolution Network)*** study emphasizes the separate learning of the two types of behavioral feedback,effectively integrating them through the cross-attention ***,it leverages the long sequence dependence capabilities of Transformer technology to accurately construct user interest profiles and predict the evolution of user *** results indicate that CAT-MF Rec significantly outperforms existing recommendation methods across various performance *** advancement offers new theoretical and practical insights for the development of video recommendations,particularly in addressing complex and dynamic user behavior patterns.

关键词： Video recommendation user interest cross-attention transformer

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第1期68卷 249-256页

作者： Qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng Yan Yong Liang Weipeng Li Chengjian zhu Jie Han Jin xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

关键词： gold catalysis peptide alkylation C-C coupling radical

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Effect of order–disorder transition on thermodynamic and electronic properties of σ and χ phases in W–Re alloy: the first-principles calculation

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Tungsten 2025年第1期7卷 195-213页

作者： Zhi-Peng zhu Dian Jia William Yi Wang Jun-Lei Yin Xing-Yu Gao Shu-feng Yang Hai-feng Song Jin-Shan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical University Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

The Tungsten-Rhenium(W-Re) alloys,celebrated for their high melting point,strength at elevated temperatures,electrical resistivity,and radiation resistance,have been widely utilized in high-temperature components,aerospace,electronics,and nuclear *** constituents of the topologically close-packed(TCP) phases,the sigma phase(σ) and chi phase(χ) formed within W-Re alloys wield considerable influence on the mechanical properties and the stability of the *** calculations were utilized in the present work to explore the structural,thermodynamic,and electronic properties of both ordered and disordered configurations within the σ and χ phases,culminating in a systematic elucidation of the higher phase stability exhibited by the ordered *** is found that the bulk modulus of these two phases is directly proportional to the concentration of Re in the alloy,while the equilibrium volume is inversely *** thermodynamic parameters of the σ and χ phases are calculated via the mean-field potential *** similar trends observed in the isobaric heat capacity,enthalpy increment,and entropy change curves for these two phases suggest they possess comparable thermodynamic *** is noteworthy that the contribution of ionic vibrations predominantly affects the isobaric heat capacity,while the contribution of thermal electronic excitations increases linearly with *** the structure and thermodynamic properties of TCP phases in W-Re alloys at low temperatures has profound significance for optimizing material performance,microstructures features,establishing theoretical foundations,and predicting material behavior.

关键词： First-principles calculations Phase stability TCP phases Thermodynamic properties W–Re alloy

Ketogenic diet and cancer:multidimensional exploration and research

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Science China Life Sciences 2025年

作者： Shiyun Wan Xiaoxue Zhou feng xie Fangfang Zhou Long Zhang The First Affiliated Hospital the Institutes of Biology and Medical Sciences Suzhou Medical College Soochow University School of Medicine Hangzhou City University Life Sciences Institute and State Key Laboratory of Transvascular Implantation Devices of the Second Affiliated Hospital of Zhejiang University School of Medicine Zhejiang University The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors The First Affiliated Hospital Jiangxi Medical College Nanchang University Cancer Center Zhejiang University

The ketogenic diet(KD) has attracted attention in recent years for its potential anticancer effects. KD is a dietary structure of high fat,moderate protein, and extremely low carbohydrate content. Originally introduced as a treatment for epilepsy, KD has been widely applied in weight loss programs and the management of metabolic diseases. Previous studies have shown that KD can potentially inhibit the growth and spread of cancer by limiting energy supply to tumor cells, thereby inhibiting tumor angiogenesis, reducing oxidative stress in normal cells, and affecting cancer cell signaling and other processes. Moreover, KD has been shown to influence T-cell-mediated immune responses and inflammation by modulating the gut microbiota, enhance the efficacy of standard cancer treatments, and mitigate the complications of chemotherapy. However, controversies and uncertainties remain regarding the specific mechanisms and clinical effects of KD as an adjunctive therapy for cancer. Therefore, this review summarizes the existing research and explores the intricate relationships between KD and cancer treatment.

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东山煤矿71505工作面开采沉陷观测站设计

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科技情报开发与经济 2009年第17期19卷 224-225页

作者：谢锋珠山西煤炭职业技术学院山西太原030006

针对太原东山煤矿71505工作面的情况,探讨了在其地面设立地表移动变形观测站的意义及做法。

关键词：开采沉陷观测站开采沉陷参数太原东山煤矿

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某社区系统管理婴儿贫血监测结果分析与干预

中华全科医学 2015年第5期13卷 829-830,862页

作者：张凤莲谢凤珠广东省深圳市慢性病防治中心社康中心 518020

目的了解婴儿期婴儿贫血发生情况,探讨其影响因素,为干预提供依据。方法收集来深圳市慢性病防治中心社康中心进行系统保健的6个月婴儿631名,按喂养方式不同分组,其中母乳喂养组180名,混合喂养组236名,人工喂养组215名,对贫血患病率进行... 详细信息

目的了解婴儿期婴儿贫血发生情况,探讨其影响因素,为干预提供依据。方法收集来深圳市慢性病防治中心社康中心进行系统保健的6个月婴儿631名,按喂养方式不同分组,其中母乳喂养组180名,混合喂养组236名,人工喂养组215名,对贫血患病率进行分析;对其中165名母乳喂养的婴儿,按及时添加辅食和未及时添加辅食分成2组,对贫血率进行分析。采集婴儿左手无名指末梢血20μl,应用迈瑞BC-2800三分类血球仪测定血红蛋白值。结果母乳喂养组贫血患病率(7.22%)明显低于混合喂养组(22.03%)、人工喂养组(30.23%),母乳喂养组与其他2组比较差异有统计学意义(P<0.01)。母乳喂养的婴儿及时添加辅食组贫血患病率5.93%,未及时添加辅食组,贫血患病率51.06%,差异有统计学意义(P<0.01)。结论不同喂养方式和能否及时添加辅食,对婴儿贫血有着不同的影响。因此,在保健过程中采取相应对策,提倡婴儿期母乳喂养的同时,合理添加辅食,是减少婴儿期贫血的有力措施。

关键词：喂养方式贫血婴儿

深圳部分娱乐休闲场所全面禁烟前后室内空气尼古丁检测结果分析

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中国预防医学杂志 2019年第6期20卷 486-490页

作者：罗霄伟杨杰熊静帆谢凤珠谢尉中国疾病预防控制中心北京100050 深圳市慢性病防治中心

目的了解深圳市部分娱乐休闲场所取消缓冲期前后室内尼古丁浓度变化,评价《深圳经济特区控制吸烟条例》在娱乐场所的执行效果,为下一步修订和执法提供科学依据。方法 2016年12月与2017年12月分别在深圳市(6个行政区)选取60家与52家娱乐... 详细信息

目的了解深圳市部分娱乐休闲场所取消缓冲期前后室内尼古丁浓度变化,评价《深圳经济特区控制吸烟条例》在娱乐场所的执行效果,为下一步修订和执法提供科学依据。方法 2016年12月与2017年12月分别在深圳市(6个行政区)选取60家与52家娱乐场所,采用被动式尼古丁采样器对室内尼古丁浓度进行检测,同时对场所违法吸烟与法规执行情况等进行现场观察。结果取消缓冲期前后提供烟具的场所比例由72.88%降至21.15%,差异有统计学意义(χ^2=29.60,P<0.05);场所禁烟标识张贴率升高(χ^2=17.40,P<0.05);111家娱乐场所282个采样点有281个检测到尼古丁;酒吧、歌舞厅与休闲服务场所室内空气尼古丁浓度均有下降,其中歌舞厅浓度中位数由5.57μg/m^3下降至4.01μg/m^3,下降了28.01%,差异有统计学意义(U=355.00,P<0.05);取消缓冲期前后,酒吧烟草烟雾浓度最高(7.85μg/m^3、 6.49μg/m^3),休闲服务场所浓度最低(1.42μg/m^3、1.10μg/m^3);三类场所室内尼古丁浓度四分位数间距均增大。结论深圳市取消娱乐休闲场所缓冲期后,该类场所室内烟草烟雾浓度有所下降,且场所履行职责的情况好转,但娱乐休闲场所的室内环境烟草烟雾暴露情况依然严重。

关键词：烟草烟雾污染法规娱乐场所空气尼古丁观察全面禁烟