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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underly.ng their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employ.ng astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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Leveraging ROTI map derived from Indonesian GnSS receiver network for advancing study of Equatorial Plasma Bubble in Southeast/East Asia

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Earth and Planetary Physics 2025年第1期9卷 101-116页

作者： Prayitno Abadi Ihsan n.Muafiry Teguh n.Pratama Angga y.Putra Suraina Gatot H.Pramono Sidik T.Wibowo Febrylian F.Chabibi Umar A.Ahmad Wildan P.Tresna Asnawi Research Center for Climate and Atmosphere Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia School of Electrical Engineering Telkom UniversityBandungIndonesia Directorate of Laboratory Management Facilities and Science and Technology Park Indonesian National Research and Innovation Agency(BRIN)PontianakIndonesia Geophysics Laboratory Master Program in PhysicsUniversitas Gadjah Mada(UGM)YogyakartaIndonesia Research Center for Space Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia Indonesian Geospatial Information Agency(BIG) JakartaIndonesia Research Center for Photonics Indonesian National Research and Innovation Agency(BRIN)Tangerang SelatanIndonesia Department of Earth and Planetary Sciences Hokkaido UniversitySapporoJapan

This paper highlights the crucial role of Indonesia’s GnSS receiver network in advancing Equatorial Plasma Bubble(EPB)studies in Southeast and East Asia,as ionospheric irregularities within EPB can disrupt GnSS signals and degrade positioning *** by the Indonesian Geospatial Information Agency(BIG),the Indonesia Continuously Operating Reference Station(Ina-CORS)network comprises over 300 GnSS receivers spanning equatorial to southern low-latitude ***-CORS is uniquely situated to monitor EPB generation,zonal drift,and dissipation across Southeast *** provide a practical tool for EPB research,by sharing two-dimensional rate of Total Electron Content(TEC)change index(ROTI)derived from this *** generate ROTI maps with a 10-minute resolution,and samples from May 2024 are publicly available for further scientific *** preliminary findings from the ROTI maps of Ina-CORS are ***,the Ina-CORS ROTI maps reveal that the irregularities within a broader EPB structure persist longer,increasing the potential for these irregularities to migrate farther ***,we demonstrate that combined ROTI maps from Ina-CORS and GnSS receivers in East Asia and Australia can be used to monitor the development of ionospheric irregularities in Southeast and East *** have demonstrated the combined ROTI maps to capture the development of ionospheric irregularities in the Southeast/East Asian sector during the G5 Geomagnetic Storm on May 11,*** observed simultaneous ionospheric irregularities in Japan and Australia,respectively propagating northwestward and southwestward,before midnight,whereas Southeast Asia’s equatorial and low-latitude regions exhibited irregularities *** sharing ROTI maps from Indonesia and integrating them with regional GnSS networks,researchers can conduct comprehensive EPB studies,enhancing the understanding of EPB behavior across Southeast and East Asia and contributing significantly to ionosphe

关键词： Equatorial Plasma Bubble(EPB) GnSS receivers’network Indonesia Continuously Operating Reference Station(Ina-CORS) ionospheric map Rate of TEC change index(ROTI)map

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Developmental impacts and toxicological hallmarks of silver nanoparticles across diverse biological models

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Environmental Science and Ecotechnology 2024年第3期19卷 60-79页

作者： yán Wāng yapeng Han De-Xiang Xu Department of Toxicology School of Public Health&Key Laboratory of Environmental Toxicology of Anhui Higher Education InstitutesAnhui Medical UniversityHefei230032China

Silver nanoparticles(AgnPs),revered for their antimicrobial prowess,have become ubiquitous in a range of products,from biomedical equipment to food ***,amidst their rising popularity,concerns loom over their possible detrimental effects on fetal development and subsequent adult *** review delves into the developmental toxicity of AgnPs across diverse models,from aquatic species like zebrafish and catfish to mammalian rodents and in vitro embryonic stem *** focus encompasses the fate of AgnPs in different contexts,elucidating associated hazardous results such as embryotoxicity and adverse pregnancy ***,we scrutinize the enduring adverse impacts on offspring,spanning impaired neurobehavior function,reproductive disorders,cardiopulmonary lesions,and *** hallmarks of developmental harm are identified,encompassing redox imbalances,inflammatory cascades,DnA damage,and mitochondrial ***,we explore potential explanations,linking immunoregulatory dysfunction and disrupted epigenetic modifications to AgnPsinduced developmental *** substantial progress,our understanding of the developmental risks posed by AgnPs remains incomplete,underscoring the urgency of further research in this critical area.

关键词： Silver nanoparticles(AgnPs) Developmental toxicity Maternal exposure Fetal development Redox imbalance Mitochondrial dysfunction

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ELECTROHyDRODynAMIC DISPERSIOn OF DEFORMABLE AEROSOLS In THE PRESEnCE OF An ELECTRIC FIELD AnD CHEMICAL REACTIOn USIng TAyLOR DISPERSIOn MODEL

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Journal of Hydrodynamics 2011年第2期23卷 247-257页

作者： RUDRAIAH n. DEVARAJU n. ng Chiu-On UGC-CAS in Fluid Mechanics Department of Mathematics Bangalore University Bangalore-560 001 India National Research Institute for Applied Mathematics (NRIAM) Bangalore-560 070 India Department of Mechanical Engineering The University of Hong Kong

Under the effects of electric field and chemical reaction, the problem of dispersion of aerosols in a poorly conducting fluid in a channel is solved analytically using the mixture theory together with a regular perturbation technique. It is shown that the aerosols are dispersed relative to a plane moving with the mean speed of atmospheric fluid as well as the mean speed of agglomeration of aerosol with a relative diffusion coefficient, called the Taylor dispersion coefficient. This coefficient is numerically computed and the results reveal that it increases with an increase in the electric number, but decreases with increasing porous parameter. The physical explanations for the phenomena are given in this article.

关键词： dispersion aerosols electrohydrodynamics mixture theory

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(E)-1-[4-(2-hydroxy-5-methoxybenzylideneamino)-phenyl]ethanone and (E)-1-[4-(2-hydroxy-4-methoxybenzylideneamino) phenyl]ethanone:X-ray and DFT-calculated structures

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Chinese Journal of Structural Chemistry 2011年第1期30卷 111-119页

作者： SAHn Onur ByKGngR Orhan ALBAyRAK igdem ODABASOGLU Mustafa Department of Physics Faculty of Arts and SciencesOndokuz Mayls University Department of Science Education Sinop University Chemistry Programme Pamukkale University 20159 Denizli

The isomeric structures of（E）-1-[4-（2-hydroxy-5-methoxybenzylideneamino）-phenyl] ethanone（I） and（E）-1-[4-（2-hydroxy-4-methoxybenzylideneamino） phenyl]ethanone（Ⅱ） ,both C16H15nO3,have been determined using X-ray diffraction techniques and characterized by IR,and their molecular structures have also been optimized at the B3LyP/6-31G（d,p） level using density functional theory（DFT） . The energetic behaviors of the title compounds in solvent media have been examined using B3LyP method with the 6-31G（d,p） basis set by apply.ng the polarizable continuum model（PCM） . The total energies of the title compounds decrease with the increasing polarity of the solvent. In addition,DFT calculations of the title compounds＇ molecular electrostatic potentials（MEP） were performed at the B3LyP/6-31G（d,p） level of theory. X-ray study shows that the title compounds both have strong intramolecular O-H…n hydrogen bonds. The molecules of Ⅰ are linked into a one-dimensional framework structure by C-H…π interactions,while in Ⅱ,intermolecular π···π interactions result in the formation of infinite chains running along the [010].

关键词： crystal structure Schiff base DFT molecular electrostatic potential

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Synthesis,Crystal Structure and Conformational Analysis of (E)-5-Methoxy-2-((4-methoxyphenylimino)methyl)phenol

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Chinese Journal of Structural Chemistry 2010年第3期29卷 359-364页

作者： ■AHn Onura ByKGngR Orhana ALBAyRAK i■demb ODABA■O■LU Mustafac Department of Physics Faculty of Arts and SciencesOndokuz Mayis University Department of Science Education Sinop University Chemistry Programme Pamukkale University

The title compound,（E）-5-methoxy-2-（（4-methoxyphenylimino）methyl）phenol（C15H15nO3）,crystallizes in monoclinic,space group P21/c with a=9.4361（6）,b=10.6212（5）,c=12.9338（9）,β=93.064（5）o,V=1294.41（14）3,Z=4,Dc=1.320 g/cm3,F（000）=544,Rint=0.116,T=296 K,μ=0.09 mm-1,the final R=0.051 and wR=0.148 for 1836 observed reflections with I2σ（I）.An extensive two-dimensional network of C–H…O hydrogen bonds and π-ring interactions are responsible for the crystal *** hydrogen bonds and C–H…π interactions produce R22（14）,R44（30） and R44（31） *** addition to the molecular geometry from X-ray experiment,the molecular geometry of the title compound in the ground state has been calculated using the semi-empirical（AM1 and PM3） and density functional theory method（DFT）（B3LyP） with 6-31G（d） basis *** determine the conformational flexibility,molecular energy profile of the title compound was obtained by semi-empirical（PM3 and AM1） and DFT/B3LyP calculations with respect to the selected degree of torsional freedom,which varied from –180° to ＋180° in a step of 10°.

关键词： crystal structure Schiff base PM3 AM1 DFT conformational analysis

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Ground state energy of excitons in quantum dot treated variationally via Hylleraas-like wavefunction

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Chinese Physics B 2009年第4期18卷 1578-1585页

作者： S. Sakiroglu . Dogan A. yιldιz K. Akgngr H. Epik y. Ergn H. Sarι . Skmen Physics Department Dokuz Eyll University Physics Department Anadolu University Physics Department Cumhuriyet University

In this work, the effects of quantum confinement on the ground state energy of a correlated electron-hole pair in a spherical and in a disc-like quantum dot have been investigated as a function of quantum dot size. Under parabolic confinement potential and within effective mass approximation Ritz＇s variational method is applied to Hylleraas-like trial wavefunction. An efficient method for reducing the main effort of the calculation of terms like τekh exp （-λτeh） is introduced. The main contribution of the present work is the introduction of integral transforms which provide the calculation of expectation value of energy and the related matrix elements to be done analytically over single-particle coordinates instead of Hvlleraas coordinates.

关键词： exciton parabolic confinement variational method Hylleraas coordinates

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Fourier transform technique in variational treatment of two-electron parabolic quantum dot

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Chinese Physics B 2009年第8期18卷 3508-3516页

作者： S.Sakiroglu A.yιldιz .Dogan K.Akgngr H.Epik y.Ergn H.Sarι .Skmen Physics Department Dokuz Eyll University Physics Department Anadolu University Physics Department Cumhuriyet University

In this work, we propose an efficient method of reducing the computational effort of variational calculation with a Hylleraas-like trial wavefunction. The method consists of introducing integral transforms for the terms as r12^κ exp （-λτ12） which provide the calculation of the expectation value of energy and the relevant matrix elements to be done analytically over single-electron coordinates instead of Hylleraas coordinates. We have used this method to calculate the ground state energy of a two-electron system in a spherical dot and a disk-like quantum dot separately. Under parabolic confinement potential and within effective mass approximation size and shape effects of quantum dots on the ground state energy of two electrons have been investigated. The calculation shows that our results even with a small number of basis states are in good agreement with previous theoretical results.

关键词： two-electron quantum dot parabolic confinement variational method Hylleraas coor- dinates

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Quaternion methods and models of regular celestial mechanics and astrodynamics

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Applied Mathematics and Mechanics(English Edition) 2022年第1期43卷 21-80页

作者： y.n.CHELnOKOV Institute of Precision Mechanics and Control Russian Academy of SciencesSaratov410031Russia

This paper is a review,which focuses on our work,while including an analysis of many works of other researchers in the field of quaternionic *** regular quaternion models of celestial mechanics and astrodynamics in the Kustaanheimo-Stiefel(KS)variables and Euler(Rodrigues-Hamilton)parameters are *** models are derived by the quaternion methods of mechanics and are based on the differential equations of the perturbed spatial two-body problem and the perturbed spatial central motion of a point *** paper also covers some applications of these *** and Scheifele are known to have doubted that quaternions and quaternion matrices can be used efficiently to regularize the equations of celestial ***,the author of this paper and other researchers refuted this point of view and showed that the quaternion approach actually leads to efficient solutions for regularizing the equations of celestial mechanics and *** paper presents convenient geometric and kinematic interpretations of the KS transformation and the KS bilinear relation proposed by the present *** general(compared with the KS equations)quaternion regular equations of the perturbed spatial two-body problem in the KS variables are *** equations are derived with the assumption that the KS bilinear relation was not *** main stages of the quaternion theory of regularizing the vector differential equation of the perturbed central motion of a point particle are presented,together with regular equations in the KS variables and Euler parameters,derived by the aforementioned *** also present the derivation of regular quaternion equations of the perturbed spatial two-body problem in the Levi-Civita variables and the Euler parameters,developed by the ideal rectangular Hansen coordinates and the orientation quaternion of the ideal coordinate *** paper also gives new results using quaternionic methods in the pertur

关键词： celestial mechanics astrodynamics perturbed spatial two-body problem central motion regularization Levi-Civita and Kustaanheimo-Stiefel(KS)variables Euler parameter quaternion

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Absorption of laser radiation in ultracold plasma

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Chinese Physics B 2016年第10期25卷 128-131页

作者： n y Shaparev Institute of Computational Modeling Russian Academy of Sciences national Research Tomsk State University

In this paper, we analyze the spectral behavior(optical thickness, shape and linewidth) of laser radiation absorption under the correlation heating of ions in an ultracold plasma. The Voigt formula is used to find the absorption *** spectral line width is shown to grow with time while the optical thickness reduces. Our modeling results are in good agreement with the experimental findings reported in the literature.

关键词： absorption laser radiation ultracold plasma

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